Tag: M.W=150-200

Hasegawa, Tadashi published the artcileNovel biradical cyclization via remote-hydrogen transfer in photochemistry of 2-(dialkylamino)ethyl 3-benzoylacrylates, Computed Properties of 101-98-4, the publication is Bulletin of the Chemical Society of Japan (1993), 66(10), 3128-31, database is CAplus.

2-(Dibenzylamino)ethyl and 2-(benzylmethylamino)ethyl 3-benzoylacrylate underwent photocyclization via remote-proton transfer from their (Z)-forms competing with (E)-(Z) isomerization. The quantum yield for the cyclization when both (E)- and (Z)-isomers absorb the irradiating light was estimated to be 0.05 by applying the steady-state approximation

Bulletin of the Chemical Society of Japan published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Computed Properties of 101-98-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ni, Ruijie published the artcileCharacterization of key odorants in fried red and green huajiao (Zanthoxylum bungeanum maxim. and Zanthoxylum schinifolium sieb. et Zucc.) oils, Recommanded Product: cis-3,7-Dimethyl-2,6-Octadien-1-Ol, the publication is Food Chemistry (2022), 131984, database is CAplus and MEDLINE.

Fried huajiao oil (FHO) samples prepared with red or green huajiao are widely applied in different Chinese cuisines due to their own aroma characteristics. To investigate their different aroma profiles, 2 red and 3 green FHOs were analyzed by quant. descriptive sensory anal. (QDA) and gas chromatog.-olfactometry/aroma intensity (GC-O/AI). QDA results showed a distinct difference among FHOs in terms of all sensory attributes. Thirty odorants with high OAVs and AIs were screened from 5 FHOs, among which β-myrcene, (E)-2-heptenal, limonene, α-terpineol and p-cymene were the major characteristic compounds of FHOs. In addition, through orthogonal partial least square discriminate anal. (OPLS-DA), linalool, linalyl acetate, and 1,8-cineole were considered as the volatile markers for classification of FHOs with red and green huajiao. Thereafter, aroma recombination and omission tests were performed to characterize the key aroma compounds of red and green FHOs.

Food Chemistry published new progress about 106-25-2. 106-25-2 belongs to alcohols-buliding-blocks, auxiliary class Natural product, name is cis-3,7-Dimethyl-2,6-Octadien-1-Ol, and the molecular formula is C10H18O, Recommanded Product: cis-3,7-Dimethyl-2,6-Octadien-1-Ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Huimin published the artcileOptimization of ultrasound and microwave-assisted extraction of sweet cherry tree branches and chemical component analysis by UPLC-MS/MS, Computed Properties of 621-37-4, the publication is Trees (Heidelberg, Germany) (2021), 35(4), 1247-1256, database is CAplus.

Key message: Sweet cherry tree branches have important food and medicinal value. The ultrasound and microwave-assisted extraction method is more efficient with higher yield than conventional extraction methods (heat-reflux, Soxhlet, etc.). Plant byproducts are known as sources of natural bioactive compounds The objective of this study was to rationally use sweet cherry tree branches (SCTB) discarded during pruning. Ultrasonication and microwaves are considered green techniques, and an ultrasound and microwave-assisted extraction (UMAE) method was established to obtain extracts from SCTB by response surface methodol. A math. model was established using the Box-Behnken design, and the effects of various factors and their interactions were analyzed as well. Taking the yield (weight/weight) as the objective, the optimal process conditions for UMAE of SCTB were 56 mL·g^-1 liquid-solid ratio, 34 min extraction time, and 40-50 mesh particle size. The yield of SCTB extracts was 5.02%, which was close to the theor. prediction. The optimized extraction process can obtain a higher yield than that of conventional extraction methods. The chem. composition of the extracts was identified by HPLC-MS/MS, and 400 metabolites, including carboxylic acids and derivatives (29%), fatty acyls (19%), organooxygen compounds (15%), flavonoids (12%), benzene and substituted derivatives (12%), phenols (8%), and imidazopyrimidines (5%), were annotated and classified. L-arginine and mannitol were the main chem. components of the SCTB extracts, suggesting their potential uses in the food and medical industries.

Trees (Heidelberg, Germany) published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C15H14O, Computed Properties of 621-37-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Bi, Jianlu published the artcilePlasma metabonomic analysis of healthy qi-deficiency constitution after the intervention by Buzhongyiqi pills, Recommanded Product: (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, the publication is Chongqing Yike Daxue Xuebao (2014), 39(8), 1124-1127, database is CAplus.

Objective: To compare the endogenous metabolites in the plasma of people with qi-deficiency constitution after the intervention by Buzhongyiqi pills using NMR (NMR)-based metabonomics and to find the possible specific metabolites. Methods: healthy people with qi-deficiency constitution were recruited and divided into control group and intervention group. Buzhongyiqi pills were used to do the intervention and the plasma was tested by NMR-based metabonomics before and after the intervention. Multivariate statistical anal. was done to find the serum-derived metabolic differences after the intervention by Buzhongyiqi pills. Results: The plasma before and after the intervention was analyzed by Simca-P and 45 changed chem. shift values (VIP > 1, P < 0.05) were selected. Thirty specific metabolites were found through human metabolite database. Conclusion: These differences in metabolites are related to the tricarboxylic acid cycle. Buzhongyiqi pills can improve the disorder of energy metabolism, memory deterioration and fatigue of qi-deficiency population, which may associated with its regulation of GABA, phosphatidylcholine, blood ammonia concentration

Chongqing Yike Daxue Xuebao published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C6H10O7, Recommanded Product: (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Lou, Geer published the artcileGC-MS based metabolomics uncovers the mechanism of Curcumae rhizoma and Sparganii rhizome on blood stasis syndrome in liver dialysis, Category: alcohols-buliding-blocks, the publication is Pakistan Journal of Pharmaceutical Sciences (2020), 33(Suppl.2), 771-777, database is CAplus.

Blood stasis syndrome (BSS) is characterized by blood retardation and is the major cause of some deadly diseases. Some factors that affect BSS have been identified. However, the small mol. that related to BSS is still largely unknown. Traditional Chinese Medicine (TCM), such as Sanleng and Ezhu, has been used for a long time in treating BSS and promising outcomes have been achieved. However, the mechanism of how they work is unclear. Thus, we constructed the Rat BSS model and treated them with Sanleng and Ezhu. Then, the liver dialysis of those rats was collected and the small mol. metabolites were analyzed by GC-MS based metabolomics approach. Our results showed after Sanleng and Ezhu treatment, several small mol. metabolites were significantly changed metabolites (VIP>1 and P<0.05). Pathway enrichment anal. also showed that Sanleng and Ezhu share the similar mechanism in treating BSS, such as regulating Glyoxylate and dicarboxylate metabolism pathway and energy metabolism Besides, we also identified some key metabolites that were significantly correlated with BSS. In conclusion, those findings uncover the mechanism of Sanleng and Ezhu in treating BSS.

Pakistan Journal of Pharmaceutical Sciences published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C6H10O7, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Du, Lijuan published the artcileAICAr suppresses cell proliferation by inducing NTP and dNTP pool imbalances in acute lymphoblastic leukemia cells, Category: alcohols-buliding-blocks, the publication is FASEB Journal (2019), 33(3), 4525-4537, database is CAplus and MEDLINE.

Here, we knocked out TP53 or PRKAA1 gene (encoding AMPKa1) in NALM-6 and Reh cells by using the clustered regularly interspaced short palindromic repeats/Cas9 system and found that AICAr-induced proliferation inhibition was independent of AMPK activation but dependent on p53. Liquid chromatog.-mass spectrometry anal. of nucleotide metabolites indicated that AICAr caused an increase in ATP, deoxyadenosine triphosphate, and deoxyguanosine triphosphate levels by up-regulating purine biosynthesis, while AICAr led to a decrease in cytidine triphosphate, uridine triphosphate, deoxycytidine triphosphate, and deoxythymidine triphosphate levels because of reduced phosphoribosyl pyrophosphate production, which consequently impaired the pyrimidine biosynthesis. Ribonucleoside triphosphate (NTP) pool imbalances suppressed the rRNA transcription efficiency. Furthermore, deoxy-ribonucleoside triphosphate (dNTP) pool imbalances induced DNA replication stress and DNA double-strand breaks, followed by cell cycle arrest and apoptosis in ALL cells. Exogenous uridine could rebalance the NTP and dNTP pools by supplementing pyrimidine and then attenuate AICAr-induced cytotoxicity. Our data indicate that RNA transcription inhibition and DNA replication stress induced by NTP and dNTP pool imbalances might play a key role in AICAr-mediated cytotoxic effects on ALL cells, suggesting a potential clin. application of AICAr in future ALL therapy.

FASEB Journal published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C9H21NO3, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zheng, Zifeng published the artcileTick-borne encephalitis virus nonstructural protein NS5 induces RANTES expression dependent on the RNA-dependent RNA polymerase activity, Recommanded Product: Triisopropanolamine, the publication is Journal of Immunology (2018), 201(1), 53-68, database is CAplus and MEDLINE.

Tick-borne encephalitis virus (TBEV) is one of the flaviviruses that targets the CNS and causes encephalitis in humans. The mechanism of TBEV that causes CNS destruction remains unclear. It has been reported that RANTES-mediated migration of human blood monocytes and T lymphocytes is specifically induced in the brain of mice infected with TBEV, which causes ensuing neuroinflammation and may contribute to brain destruction. However, the viral components responsible for RANTES induction and the underlying mechanisms remain to be fully addressed. In this study, we demonstrate that the NS5, but not other viral proteins of TBEV, induces RANTES production in human glioblastoma cell lines and primary astrocytes. TBEV NS5 appears to activate the IFN regulatory factor 3 (IRF-3) signaling pathway in a manner dependent on RIG-I/MDA5, which leads to the nuclear translocation of IRF-3 to bind with RANTES promoter. Further studies reveal that the activity of RNA-dependent RNA polymerase (RdRP) but not the RNA cap methyltransferase is critical for TBEV NS5-induced RANTES expression, and this is likely due to RdRP-mediated synthesis of dsRNA. Addnl. data indicate that the residues at K359, D361, and D664 of TBEV NS5 are critical for RdRP activity and RANTES induction. Of note, NS5s from other flaviviruses, including Japanese encephalitis virus, West Nile virus, Zika virus, and dengue virus, can also induce RANTES expression, suggesting the significance of NS5-induced RANTES expression in flavivirus pathogenesis. Our findings provide a foundation for further understanding how flaviviruses cause neuroinflammation and a potential viral target for intervention.

Journal of Immunology published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C10H16Br3N, Recommanded Product: Triisopropanolamine.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chen, Jinxiang published the artcileStructure-antioxidant activity relationship of methoxy, phenolic hydroxyl, and carboxylic acid groups of phenolic acids, Formula: C8H8O3, the publication is Scientific Reports (2020), 10(1), 2611, database is CAplus and MEDLINE.

The antioxidant activities of 18 typical phenolic acids were investigated using 2, 2′-diphenyl-1-picrylhydrazyl (DPPH) and ferric ion reducing antioxidant power (FRAP) assays. Five thermodn. parameters involving hydrogen atom transfer (HAT), single-electron transfer followed by proton transfer (SET-PT), and sequential proton-loss electron transfer (SPLET) mechanisms were calculated using d. functional theory with the B3LYP/UB3LYP functional and 6-311++G (d, p) basis set and compared in the phenolic acids. Based on the same substituents on the benzene ring, -CH₂COOH and -CH = CHCOOH can enhance the antioxidant activities of phenolic acids, compared with -COOH. Methoxyl (-OCH₃) and phenolic hydroxyl (-OH) groups can also promote the antioxidant activities of phenolic acids. These results relate to the O-H bond dissociation enthalpy of the phenolic hydroxyl group in phenolic acids and the values of proton affinity and electron transfer enthalpy (ETE) involved in the electron donation ability of functional groups. In addition, we speculated that HAT, SET-PT, and SPLET mechanisms may occur in the DPPH reaction system. Whereas SPLET was the main reaction mechanism in the FRAP system, because, except for 4-hydroxyphenyl acid, the ETE values of the phenolic acids in water were consistent with the exptl. results.

Scientific Reports published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C8H8O3, Formula: C8H8O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Hao, Yuxin published the artcileStability and mechanism of phenolic compounds from raspberry extract under in vitro gastrointestinal digestion, SDS of cas: 621-37-4, the publication is LWT–Food Science and Technology (2021), 110552, database is CAplus.

Raspberry extract (RE) is a raspberry product with high anthocyanins and low sugar. In the present study, to evaluate the metabolic behavior of phenolic compounds of RE under in vitro digestion (gastric (GF), gastric to intestinal (G-IF), and colonic fermentation (CF)), the changes of 30 phenolic compounds were investigated by High Performance Liquid Chromatog.-Mass Spectrometry. The results showed that phenolic compounds were relatively stable in GF, but rapidly decreased in G-IF and CF. Five anthocyanins accounted for 61.1% of total polyphenol contents (TPCs). Among them, anthocyanins bound to glucose or with two hydroxyl groups on B-ring were metabolized more quickly. The catabolic activity of the human microbiota resulted in the production of a series of low mol. weight phenolics, such as hydroxybenzoic acids. Ellagic acid, accounting for 17.7% of TPCs, was rapidly metabolized to urolithin B and urolithin C in CF. Moreover, urolithin C showed the highest antioxidant activity in all ellagic acid metabolites by DPPH assay. Consequently, the metabolic behavior of phenolic compounds was mainly influenced by pH and intestinal microbiota, which provided the basis for further in vivo and in vitro study and efficient utilization of the extract

LWT–Food Science and Technology published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C8H8O3, SDS of cas: 621-37-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Dominguez-Fernandez, Maite published the artcileQuantitative Assessment of Dietary (Poly)phenol Intake: A High-Throughput Targeted Metabolomics Method for Blood and Urine Samples, Product Details of C8H8O3, the publication is Journal of Agricultural and Food Chemistry (2021), 69(1), 537-554, database is CAplus and MEDLINE.

Many studies have associated the consumption of (poly)phenol-rich diets with health benefits. However, accurate high-throughput quant. methods for estimating exposure covering a broad spectrum of (poly)phenols are lacking. We have developed and validated a high-throughput method for the simultaneous quantification of 119 (poly)phenol metabolites in plasma and urine using ultra high-performance liquid chromatog. coupled with triple quadrupole mass spectrometry, with a very fast sample treatment and a single run time of 16 min. This method is highly sensitive, precise, accurate, and shows good linearity for all compounds (R² > 0.992). This novel method will allow a quant. assessment of habitual (poly)phenol intake in large epidemiol. studies as well as clin. studies investigating the health benefits of dietary (poly)phenols.

Journal of Agricultural and Food Chemistry published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C8H8O3, Product Details of C8H8O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts