Tag: M.W=150-200

Xiao, Meng published the artcileEffect of hydroxypropyl-β-cyclodextrin on the cometabolism of phenol and phenanthrene by a novel Chryseobacterium sp., Application of 1-Hydroxy-2-naphthoic acid, the publication is Bioresource Technology (2019), 56-62, database is CAplus and MEDLINE.

Cometabolic degradation is an effective method to remove the polycyclic aromatic hydrocarbons (PAHs) with phenol as growth substrate from coal chem. wastewater (CCW). Unfortunately, the toxicity and low solubility of PAHs always restrict their degradation In this study, Chryseobacterium sp. H202 was firstly isolated from the aerobic segment of CCW. Then, to improve the cometabolic degradation of PAHs, the effects of hydroxypropyl-β-cyclodextrin (HPCD) were investigated. Phenanthrene removal was accelerated in the presence of phenol; however, the degradation of phenol was inhibited because of the toxicity of phenanthrene. Addition of 50 mg/L HPCD accelerated the degradation of phenol and effectively improved the phenanthrene removal rate by about 55%. Inclusion of HPCD appeared to increase the apparent solubility and reduce the toxicity of phenanthrene, thereby improving the cometabolic degradation of phenol and phenanthrene. Therefore, HPCD can enhance the degradation of phenanthrene with phenol as the growth substrate during CCW treatment.

Bioresource Technology published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C4H6N2, Application of 1-Hydroxy-2-naphthoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wei, Yuming published the artcileImproving the flavor of summer green tea (Camellia sinensis L.) using the yellowing process, Recommanded Product: cis-3,7-Dimethyl-2,6-Octadien-1-Ol, the publication is Food Chemistry (2022), 132982, database is CAplus and MEDLINE.

Summer green tea (SGT) has poor flavor due to its high levels of bitterness and astringency. The present study aimed to improve the flavor of SGT using the yellowing process. The results showed that after the yellowing process, the sweetness and overall acceptability increased, and the content of gallated catechins and flavonol glycosides decreased by 30.2% and 27.4%, resp., as did the bitterness and astringency of SGT. Yellowing caused a decrease in the concentration of some aroma compounds, such as (z)-3-hexen-1-ol, 1-hexanol, pentanal, heptanal and 1-octanol, which caused grassy, floral and fruity aromas. In contrast, the concentrations of 1-octen-3-ol, benzene acetaldehyde and β-ionone increased, which have mushroom and sweet aromas. Meanwhile, the sweetness and umami of SGT were enhanced by the addition of selected aroma compounds (1-octen-3-ol, benzene acetaldehyde and β-ionone), demonstrating that the yellowing process improves the flavor of SGT through odor-taste interactions.

Food Chemistry published new progress about 106-25-2. 106-25-2 belongs to alcohols-buliding-blocks, auxiliary class Natural product, name is cis-3,7-Dimethyl-2,6-Octadien-1-Ol, and the molecular formula is C40H36O4P2, Recommanded Product: cis-3,7-Dimethyl-2,6-Octadien-1-Ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Katakawa, Kazuaki published the artcileSelective Synthesis of Benzyl Enol Ethers of β-Dicarbonyl Compounds in Basic Condition and the Application towards Synthesis of Naphthoquinones, Safety of Triisopropylsilanol, the publication is Heterocycles (2014), 88(1), 817-825, database is CAplus.

Selective synthesis of benzyl enol ether of β-tetronic acids and β-dicarbonyl compounds in basic condition was examined The benzylation of α-methyl-β-tetronic acid with benzyl tosylate in the presence of potassium carbonate selectively gave the benzyl enol ether. The reaction of β-tetronic acid and cyclic 1,3-diketones also gave the O-benzyl adducts preferentially over C,O-dibenzylation. The Diels-Alder reactions of furans derived from the benzyl enol ether of α-methylβ-tetronic acid and benzyne gave functionalized naphthoquinones I (R = PhCH₂, H).

Heterocycles published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C9H22OSi, Safety of Triisopropylsilanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Tan, Haisong published the artcileExperimental and Theoretical Study of Oxygen Insertion into Trialkylsilanes by Methyltrioxorhenium Catalyst, Quality Control of 17877-23-5, the publication is Organometallics (1999), 18(23), 4753-4757, database is CAplus.

Among the reactions of H₂O₂ that are catalyzed by methyltrioxorhenium, the oxidation of alkylsilanes is unique. It is not a reaction in which an O atom is added to a substrate, but one featuring a net insertion, R₃Si-H + H₂O₂ → R₃Si-OH + H₂O. Kinetics studies were carried out on 10 compounds Rate constants were determined for the bimol. reaction of the silane with the peroxo compound CH₃Re(O)(η²-O₂)₂(H₂O). The variation of rate constant with the alkyl groups R follows two trends: the values of log(k) are linear functions of (a) the stretching frequency of the Si-H group and (b) the total Taft constant for these substituents. The reactions of Bu₃Si-H and Bu₃Si-D exhibit a kinetic isotope effect of 2.1 at 0°. A model for the transition state was formulated in which O-H and Si-O bond making accompany Si-H bond breaking. Quantum mech. calculations were carried out on the gas-phase reaction between Et₃SiH and CH₃Re(O)₂(η²-O₂). These results support this structure, calculating a structure and energy that are in agreement. The theor. activation energy is 28.5 kcal mol^-1, twice the exptl. value in aqueous MeCN, 12.4 kcal mol^-1. The difference can be attributed to the solvation of the polar transition state in this medium.

Organometallics published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C2H8Cl2N4S2, Quality Control of 17877-23-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Fan, Tian-Yun published the artcileStructure-activity relationship and biological evaluation of berberine derivatives as PCSK9 down-regulating agents, Recommanded Product: 2-Methoxy-4-(2-nitroethyl)phenol, the publication is Bioorganic Chemistry (2021), 104994, database is CAplus and MEDLINE.

Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a secreted protein and its deficiency markedly enhances the survival rate of patients with cardiovascular diseases (CVDs). Forty berberine (BBR) derivatives I (R¹ = H, MeO, R² = MeO, OH, PhCH₂O, EtO, R³ = MeO, OH, EtO, R²R³ = OCH₂O, R⁴ = H, MeO, R⁵ = H, Cl, MeO, PhCH₂O, cyclobutylmethoxy, etc., R⁶ = MeO, OH, R⁷ = MeO, EtO, H) were synthesized and evaluated for their activity on down-regulating the transcription of PCSK9 in HepG2 cells, taking BBR as the lead. Structure-activity relationship (SAR) anal. revealed that the 2,3-dimethoxy moiety might be beneficial for activity. Among them, I (R¹ = R⁴ = R⁷ = H, R² = R³ = R⁶ = MeO, R⁵ = p-F₃CSC₆H₄CH₂O) (II) displayed the most potent activity with an IC₅₀ value of 9.5 ± 0.5μM, better than that of BBR. Also, it significantly decreased the PCSK9 protein level at the cellular level, as well as in the liver and serum of mice in vivo. Furthermore, II markedly increased LDLR expression and LDL-C clearance via down-regulating PCSK9 protein. The mechanism of action of II is targeting HNF1α and/or Sp1 cluster modulation upstream of PCSK9, a different one from BBR. Therefore, II might have the potential to be a novel PCSK9 transcriptional inhibitor for the treatment of atherosclerosis, worthy for further investigation.

Bioorganic Chemistry published new progress about 528594-30-1. 528594-30-1 belongs to alcohols-buliding-blocks, auxiliary class Nitro Compound,Benzene,Phenol,Ether, name is 2-Methoxy-4-(2-nitroethyl)phenol, and the molecular formula is C9H11NO4, Recommanded Product: 2-Methoxy-4-(2-nitroethyl)phenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Strunskaya, E. I. published the artcileElectrochemical Reduction and Oxidation of 3,4-Disubstituted 1,2,5-Thiadiazoles, Category: alcohols-buliding-blocks, the publication is Russian Journal of General Chemistry (Translation of Zhurnal Obshchei Khimii) (2003), 73(5), 806-815, database is CAplus.

The electron-acceptor N and S atoms in 3,4-disubstituted 1,2,5-thiadiazoles are responsible for much decreased reduction potentials and much increased oxidation potentials of these compounds compared with the corresponding carbocyclic derivatives The thiadiazole ring is resistant to oxidation, and the reversible electron transfer gives rise to fairly stable radical cations. Reductive stability of the heterocycle depends on the nature of its substituents and on the medium: when nucleophile substituents are present, 2-electron transfer in aprotic media results in heterocycle ring opening with iminonitrile formation, whereas in the presence of 2 readily leaving groups, the electron transfer induces cleavage of the complete heterocycle ring into inorganic anions.

Russian Journal of General Chemistry (Translation of Zhurnal Obshchei Khimii) published new progress about 30165-97-0. 30165-97-0 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Thiadiazole,Alcohol, name is 4-Morpholino-1,2,5-thiadiazol-3-ol, and the molecular formula is C6H8O6, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Diaw, A. K. D. published the artcileSynthetic routes, characterization, electrochemical and spectral properties of p-substituted N-phenylpyrroles, HPLC of Formula: 23351-09-9, the publication is ARKIVOC (Gainesville, FL, United States) (2008), 122-144, database is CAplus.

A series of p-substituted N-phenylpyrroles, including 4-(1H-pyrrol-1-yl)phenol, 1-(4-methoxyphenyl)-1H-pyrrole, 1,1′-benzene-1,4-diylbis(1H-pyrrole), 1,1′-biphenyl-4,4′-diylbis(1H-pyrrole), and 1-(4-bromophenyl)-1H-pyrrole (I), was prepared by means of a modified Clauson-Kaas method. Two new sym. and asym. end-capped pyrrole thiophenes, namely 1-[4-(thiophen-2-yl)phenyl]-1H-pyrrole and 1,1′-(bithiophen-5,5”-diyldibenzene-4,1-diyl)bis(1H-pyrrole), were synthesized by using I as a building block and the Stille method as cross-coupling reaction. For both methods, the chem. yields ranged from 36 to 81% and the desired products were characterized by ¹H and ¹³C NMR, IR, and mass spectrometry. Electrochem. properties and UV-visible absorption spectra were also investigated in order to evaluate the substituent electron-donor effects on the physicochem. parameters.

ARKIVOC (Gainesville, FL, United States) published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, HPLC of Formula: 23351-09-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Martin-Montero, Raul published the artcileNi-catalyzed Reductive Deaminative Arylation at sp³ Carbon Centers, Category: alcohols-buliding-blocks, the publication is Organic Letters (2019), 21(8), 2947-2951, database is CAplus and MEDLINE.

A Ni-catalyzed reductive deaminative arylation at unactivated sp³ carbon centers is described. This operationally simple and user-friendly protocol exhibits excellent chemoselectivity profile and broad substrate scope, thus complementing existing metal-catalyzed cross-coupling reactions to forge sp³ C-C linkages. These virtues have been assessed in the context of late-stage functionalization, hence providing a strategic advantage to reliably generate structure diversity with amine-containing drugs.

Organic Letters published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H19NO2, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zong, Shuai published the artcilePolysaccharides from Lachnum sp. Inhibited colitis-associated colon tumorigenesis in mice by modulating fecal microbiota and metabolites, Synthetic Route of 621-37-4, the publication is International Immunopharmacology (2022), 108656, database is CAplus and MEDLINE.

It is still uncertain whether the consumption of Lachnum sp. polysaccharides (LEP) alleviates colorectal cancer (CRC) through the gut microbiota. In this study, our efforts are focused on the influence of LEP on CRC, intestinal barrier and inflammation, and fecal microbiota and the metabolites, in azoxymethane (AOM)/dextran sodium sulfate (DSS)-induced CRC mice. Results showed that LEP inhibited CRC mouse colon shortening and weight loss, decreased tumor incidence, restored intestinal barrier integrity, and reduced excessive inflammation. LEP consumption significantly altered microbiota overall structure and community, with reduced pernicious bacteria (such as Parabacteroides, Escherichia_Shigella, Desulfovibrio and Helicobacter), and increased beneficial bacterium (such as Alistipes, Alloprevotella and Ruminiclostridium). Fecal-metabolome profile indicated that a total of 43 metabolites were clearly changed, with 10 down-regulated and 33 up-regulated metabolites. In addition, short-chain fatty acids (SCFAs), including acetic acid, propionic acid and n-butyric acid, were significantly increased after LEP administration. Moreover, a strong correlation between the fluctuant gut microbiota and metabolites was found. These findings provided not only deeper insights into the responsibility of LEP for CRC alleviation, and but also the potential of LEP as a promising candidate for CRC prevention and treatment.

International Immunopharmacology published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C37H30ClIrOP2, Synthetic Route of 621-37-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ma, Yao published the artcileNonpeptidic quinazolinone derivatives as dual nucleotide-binding oligomerization domain-like receptor 1/2 antagonists for adjuvant cancer chemotherapy, Name: 3-Morpholinophenol, the publication is European Journal of Medicinal Chemistry (2020), 112723, database is CAplus and MEDLINE.

Nucleotide-binding oligomerization domain-containing protein 1 and 2 (NOD1/2) receptors are potential immune checkpoints. In this article, a quinazolinone derivative, I, as a NOD1/2 dual antagonist was identified that significantly sensitizes B16 tumor-bearing mice to paclitaxel treatment by inhibiting both nuclear factor κB (NF-κB) and mitogen-activated protein kinase inflammatory signaling that mediated by NOD1/2.

European Journal of Medicinal Chemistry published new progress about 27292-49-5. 27292-49-5 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Benzene,Phenol, name is 3-Morpholinophenol, and the molecular formula is C10H13NO2, Name: 3-Morpholinophenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts