Tag: M.W=150-200

Jaskowska, Jolanta published the artcileNew pharmaceutical salts of trazodone, Recommanded Product: 1-Hydroxy-2-naphthoic acid, the publication is Molecules (2021), 26(3), 769, database is CAplus and MEDLINE.

New pharmaceutically acceptable salts of trazodone (trazodone hydrogen bromide and trazodone 1-hydroxy-2-naphthonic acid) for the treatment of central nervous system disorders are synthesized and described. Although trazodone salts are poorly crystalline, single-crystal X-ray diffraction data for trazodone 1-hydroxy-2-naphthonic acid were collected and analyzed as well as compared to the previously described crystal structure of com. available trazodone hydrochloride. The powder samples of all new salts were characterized by Fourier transform IR spectroscopy, X-ray diffraction and ¹³C solid-state NMR spectroscopy. Spectroscopic studies were supported by gauge including projector augmented wave (GIPAW) calculations of carbon chem. shielding constants The main goal of our research was to find salts with better physicochem. properties and to make an attempt to associate them with both the anion structure and the most prominent interactions exhibited by the protonated trazodone cation. The dissolution profiles of trazodone from tablets prepared from various salts with lactose monohydrate were investigated. The studies revealed that salts with simple anions show a fast release of the drug while the presence of more complex anion, more strongly interacting with the cation, effects a slow-release profile of the active substance and can be used for the preparation of the tables with a delay or prolonged mode of action.

Molecules published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, Recommanded Product: 1-Hydroxy-2-naphthoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Savela, Risto published the artcileIron-Catalyzed Chlorination of Silanes, Category: alcohols-buliding-blocks, the publication is Organometallics (2012), 31(8), 3199-3206, database is CAplus.

A simple and highly efficient Fe-catalyzed method for the chlorination of silanes was developed. Using 0.5-2% of the Fe(III)-based catalyst FeCl₃ or Fe(acac)₃ in the presence of 1-1.5 equiv of acetyl chloride as the Cl donor, a large number of silanes, alkoxysilanes, and silanols were converted to the corresponding chlorosilanes in 50-93% yields. In contrast to earlier reported methods often suffering from expensive catalysts or use of stoichiometric metal salts, hazardous reagents, and reaction conditions, the presently described methodol. allows benign reaction conditions and simple workup while using only catalytic amounts of a readily available and economically viable Fe catalyst.

Organometallics published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C9H22OSi, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Smirnov, Vladimir I. published the artcileCrystal and molecular structures of Si-(iodomethyl)silatranes with methyl substituents in β-position relative to the nitrogen atom, COA of Formula: C9H21NO3, the publication is Mendeleev Communications (2018), 28(3), 278-280, database is CAplus.

Crystal and mol. structures of two silatranes, 1-iodomethyl-3-methyl- and 1-iodomethyl-3,7,10-trimethyl-2,8,9-trioxa-5-aza-1-silabicyclo[3.3.3]undecanes, were determined by X-ray anal. Comparison of their structural and geometrical characteristics with those of other silatranes shows that the presence of Me substituents β-positioned to nitrogen atoms increases the length of the dative Si←N bond, whereas the introduction of iodine into the axial position of the silatrane slightly decreases the length of the Si←N bond.

Mendeleev Communications published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C16H20N2, COA of Formula: C9H21NO3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Jiao, Song published the artcileCore element characterization of Rhodococcus promoters and development of a promoter-RBS mini-pool with different activity levels for efficient gene expression, Application of Triisopropanolamine, the publication is New Biotechnology (2018), 41-49, database is CAplus and MEDLINE.

To satisfy the urgent demand for promoter engineering that can accurately regulate the metabolic circuits and expression of specific genes in the Rhodococcus microbial platform, a promoter-ribosome binding site (RBS) coupled mini-pool with fine-tuning of different activity levels was successfully established. Transcriptome analyses of R. ruber TH revealed several representative promoters with different activity levels, e.g., Pami, Pcs, Pnh, P50sl36, PcbiM, PgroE and Pniami. β-Galactosidase (LacZ) reporter measurement demonstrated that different gene expression levels could be obtained with these natural promoters combined with an optimal RBS of ami. Further use of these promoters to overexpress the nitrile hydratase (NHase) gene with RBSami in R. ruber THdAdN produced different expression levels consistent with the transcription analyses. The -35 and -10 core elements of different promoters were further analyzed, and the conserved sequences were revealed to be TTGNNN and (T/C)GNNA(A/C)AAT. By mutating the core elements of the strong promoters, Pnh and Pami, into the above consensus sequence, two even stronger promoters, PnhM and PamiM, were obtained with 2.2-fold and 7.7-fold improvements in transcription, resp.

New Biotechnology published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C9H21NO3, Application of Triisopropanolamine.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Torres, Nazareth published the artcileShifts in the phenolic composition and aromatic profiles of Cabernet Sauvignon (Vitis vinifera L.) wines are driven by different irrigation amounts in a hot climate, Application In Synthesis of 106-25-2, the publication is Food Chemistry (2022), 131163, database is CAplus and MEDLINE.

Wine final color, taste and aroma are closely related to the accumulation of secondary metabolites that may be affected by deficit irrigation applied in viticulture. A two-year study was conducted to assess the different fractions of crop evapotranspiration (ET_c) irrigation replacement on wine composition, addressing the anal. of flavonoids and volatiles under context of global warming. Irrigating with 100% ET_c (full grapevine demand) enhanced wine hue, antioxidant capacity, and some aromas; however, it came with a diminution of flavonoids and a less stable flavonoid profile. Replacing 25 and 50% ET_c in wine grape improved wine color intensity, concentration of flavonoids, and shifted the aromatic profiles. These treatments increased some terpenes and esters which may enhance the desirable aromas for Cabernet Sauvignon, and decreased C6 alcs. related to unpleasant ones. Therefore, despite the warming trends in Mediterranean climates, 100% ET_c irrigation would be not advisable to improve or maintain wine quality, and 50% ET_c was sufficient.

Food Chemistry published new progress about 106-25-2. 106-25-2 belongs to alcohols-buliding-blocks, auxiliary class Natural product, name is cis-3,7-Dimethyl-2,6-Octadien-1-Ol, and the molecular formula is C18H34N4O5S, Application In Synthesis of 106-25-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Liu, Juan published the artcileIntegrating disulfides into a polyethylenimine gene carrier selectively boosts significant transfection activity in lung tissue enabling robust IL-12 gene therapy against metastatic lung cancers, Quality Control of 122-20-3, the publication is Materials Science & Engineering, C: Materials for Biological Applications (2021), 112358, database is CAplus and MEDLINE.

Bioreducible polyethylenimines (SSPEIs) are promising non-viral carriers for cancer gene therapy. However, the availability of significant gene transfection activity by SSPEIs remains a challenge. Herein, an essential step was taken to ascertain whether or not the disulfide bonds of SSPEIs play a critical role in promoting significant gene transfection activity in different tissues. Initially, a disulfide-linked linear polyethylenimine (denoted as SSLPEI) consisting of one 5.0 kDa LPEI main chain and three disulfide-linked 5.7 kDa LPEI grafts was designed and prepared to possess similar mol. weight with commercialized 25 kDa LPEI as a pos. control. The SSLPEI could induce superior in vitro transfection activity in different cells to the LPEI control as well as low cytotoxicity. Notably, such enhanced in vitro transfection effect by the SSLPEI was more marked in type-II alveolar epithelial cells compared to different cancer cells. In a Balb/c nude mouse model bearing SKOV-3 tumor, the SSLPEI caused parallel level of transgene expression with the LPEI control in the tumor but significantly higher level in the mouse lung. Furthermore, the SSLPEI and LPEI groups afforded an identical antitumor efficacy against the SKOV-3 tumor via i.v. delivery of a shRNA for silencing VEGF expression in the tumor. However, via i.v. delivery of an interleukin-12 (IL-12) gene into metastatic lung cancers in a C57BL/6 mouse model, the SSLPEI group exerted markedly higher IL-12 expression level in the mouse lung and peripheral blood as compared to the LPEI group, thereby boosting IL-12 immunotherapy against the lung metastasis with longer medium survival time. The results of this work elicit that the disulfide bonds of SSPEIs play a pivotal role in enhancing gene transfection activity selectively in the lung tissue rather than solid tumor, enabling high translational potential of SSPEIs for non-viral gene therapy against metastatic lung cancers.

Materials Science & Engineering, C: Materials for Biological Applications published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C9H21NO3, Quality Control of 122-20-3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Polat, Merve Pamukcu published the artcileMetallophthalocyanines bearing four 3-(pyrrol-1-yl)phenoxy units as photosensitizer for dye-sensitized solar cells, Quality Control of 23351-09-9, the publication is Dyes and Pigments (2018), 267-275, database is CAplus.

In this article, the synthesis of non-peripheral metallophthalocyanines (cobalt, zinc, and manganese) bearing four 3-(pyrrol-1-yl)phenoxy units was reported. The new compounds have been characterized using UV-Vis, FT-IR, ¹H NMR, and mass spectroscopic data. Aggregation behaviors of phthalocyanines were investigated in concentrations ranging from 14 × 10^-6 to 2 × 10^-6 M. Electrochem. measurements gave well illustrated redox activities of MnClPc and CoPc. Electrochem. and spectroelectrochem. studies showed that MnClPc gives two metal-based reduction processes in addition to the one ring-based reduction and one ring-based oxidation process. Distinct color differences between the electrogenerated MnClPc species were observed during in situ spectroelectrochem. measurements. The potential of these compounds as photosensitizers and dependence of the photovoltaic performance on the thickness of photoanode layer were investigated. For this purpose, DSSC devices were fabricated with the structure of FTO/TiO₂:4-6/Electrolyte/Pt/FTO and characterized under AM 1.5 illuminations. By using 6 as dye a photovoltaic conversion efficiency of 2.44% with short circuit c.d. of 7.17 mA cm^-2 and open circuit voltage of 0.68 V was observed

Dyes and Pigments published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, Quality Control of 23351-09-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhou, Jian published the artcileMetabolomic Analysis of the Positive Effects on Ketogulonigenium vulgare Growth and 2-Keto-L-Gulonic Acid Production by Reduced Glutathione, Application of (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, the publication is OMICS (2012), 16(7-8), 387-396, database is CAplus and MEDLINE.

Ketogulonigenium vulgare has long been used in industry to produce 2-keto-L-gulonic acid (2KGA), the precursor of vitamin C. This fermentation process involves co-culture of K. vulgare and a Bacillus species. Early studies demonstrated that the presence of the Bacillus strain can enhance the cellular growth and 2KGA production of K. vulgare. However, the mol. mechanism behind how Bacillus affects the growth of K. vulgare and 2KGA production remains unclear. In addition, the inclusion of Bacillus in the fermentation process presents difficulties for the post-separation and purification of 2KGA. To address these issues, efforts have been made to replace the Bacillus strain with chem. compounds In this study, we found that adding thiol compounds such as reduced glutathione (GSH) and dithiothreitol (DTT) to the K. vulgare mono-culture system can increase the growth of K. vulgare about twofold, and increase 2KGA production by about fivefold. The effects of thiols on the concentrations of some cellular metabolites were determined using gas chromatog. coupled to time-of-flight mass spectrometry. The results showed that the levels of intracellular amino acids and intermediates in the pentose phosphate pathway increased significantly after thiol addition Interestingly, when GSH was added, the levels of key intracellular metabolites in primary metabolic pathways and the cell biomass both reached their maximum in the first 36 h, and then decreased when the thiol was exhausted. These findings indicate that cell growth needs the assistance of a high concentration of thiols. This study is the first report that chem. defined compounds were used to enhance the growth of K. vulgare and 2KGA production Furthermore, it also provides new insights into the possible cellular interaction between Bacillus species and K. vulgare.

OMICS published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C24H20Ge, Application of (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Park, Myung Jun published the artcileDirect preparation of hexaalkyldisiloxanes from trialkylsilanes and cyclosiloxanes from dialkylsilanes using potassium superoxide-crown ether, Application of Triisopropylsilanol, the publication is Main Group Metal Chemistry (1999), 22(12), 713-714, database is CAplus.

Trialkysilanes, R¹R²R³SiH (R¹/R²/R³ = ⁱPr/ⁱPr/ⁱPr, Et/Et/Et, Ph/Me/Me), were readily transformed to the corresponding hexaalkyldisiloxane in high yields with KO₂-18-crown-6. Dialkylsilanes, R¹R²SiH₂ (R¹/R² = Ph/Ph, Ph/Me, n-Oct/Me, c-hex/Me, Et/Et) gave mainly octaalkylcyclotetrasiloxanes under the same reaction conditions.

Main Group Metal Chemistry published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C9H22OSi, Application of Triisopropylsilanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Guo, Jielong published the artcileThe influence of oxygen on the metabolites of phenolic blueberry extract and the mouse microflora during in vitro fermentation, Safety of 3-Hydroxyphenylacetic acid, the publication is Food Research International (2020), 109610, database is CAplus and MEDLINE.

The elevated intestinal oxygen in certain unhealthy conditions (e.g., mucosa injury) enhances the expansion of aerobic/facultative anaerobic bacteria (mainly Proteobacteria) in gut microbiota (GM) and is strongly linked to various diseases. The alteration of GM, influenced by oxygen, may affect the bioavailability of dietary polyphenols. In vitro digestion, dialysis and fermentation of phenolic blueberry extract (BE) were performed here using the GM of mice under different oxygen conditions. Oxygen delayed the degradation of the main phenolic components, including quercetin, kaempferol and their rutinose-conjugates, in BE during in vitro fermentation In addition, the metabolites of BE were also influenced by oxygen. Oxygen skewed the production of 3-hydroxyphenylacetatic acid to 4-hydroxyphenylacetatic acid. Moreover, oxygen also blunted hippuric, 3-phenylpropionic, and 3-hydroxycinnamic acids production Furthermore, oxygen enhanced the expansion of Salmonella and Escherichia belonging to phylum Proteobacteria and suppressed the proliferation of the anaerobic bacteria Clostridium and Bacteroides belonging to phyla Firmicutes and Bacteroidetes, resp., which was reversed by BE supplementation.

Food Research International published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C8H8O3, Safety of 3-Hydroxyphenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts