Hu, Weichao’s team published research in International Journal of Biological Macromolecules in 2019-07-15 | 3458-28-4

International Journal of Biological Macromolecules published new progress about Antioxidants. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Product Details of C6H12O6.

Hu, Weichao; Zhao, Yuqing; Yang, Yong; Zhang, Huifang; Ding, Chunbang; Hu, Chao; Zhou, Lijun; Zhang, Zhongwei; Yuan, Shu; Chen, Yanger; Yuan, Ming published the artcile< Microwave-assisted extraction, physicochemical characterization and bioactivity of polysaccharides from Camptotheca acuminata fruits>, Product Details of C6H12O6, the main research area is Camptotheca fruit polysaacharide CAP3 antioxidant immunomodulatory activity; Antioxidant activity; Camptotheca acuminate polysaccharides; Immunomodulatory activity; Microwave-assisted extraction.

Microwave-assisted extraction of polysaccharides from Camptotheca acuminate (CAPs) was optimized by response surface methodol. The optimal parameters were as follows: microwave power, 600 W; liquid-solid ratio, 40:1 g/mL; extraction time, 14 min; and extraction temperature, 70 °C. Under these conditions, the yield of CAPs reached up to 8.61%. CAP-3, an acidic polysaccharide with a mol. weight of 121.34 kDa, was separated and purified from CAPs, which was only composed of glucose and mannose. CAP-3 exhibited strong antioxidant activity against DPPH (IC50: 0.78 mg/mL), hydroxyl radicals (IC50: 0.84 mg/mL) and also showed synergistic antioxidative effect with ascorbic acid in vitro. Meanwhile, CAP-3 could protect plasmid DNA from oxidative damage. Moreover, CAP-3 could improve immunomodulatory activity of RAW264.7 cells through promoting the phagocytosis and nitric oxide release. Therefore, CAP-3 had a strong potential in functional food, pharmaceuticals and cosmetics industries.

International Journal of Biological Macromolecules published new progress about Antioxidants. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Product Details of C6H12O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Mizushima, Taiga’s team published research in Advanced Synthesis & Catalysis in 2022-07-19 | 699-12-7

Advanced Synthesis & Catalysis published new progress about Chemoselectivity. 699-12-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H10OS, Name: 2-(Phenylthio)ethanol.

Mizushima, Taiga; Oka, Marina; Imada, Yasushi; Iida, Hiroki published the artcile< Low-Voltage-Driven Electrochemical Aerobic Oxygenation with Flavin Catalysis: Chemoselective Synthesis of Sulfoxides from Sulfides>, Name: 2-(Phenylthio)ethanol, the main research area is sulfoxide preparation chemoselective green chem electrochem; sulfide electrochem aerobic oxygenation flavin catalyst.

The chemoselective electrochem. oxygenation of sulfides RSR1 (R = Ph, Bu, pyridin-2-yl, etc.; R1 = Me, cyclopropyl, prop-2-en-1-yl, etc.) and dithiane to sulfoxides RS(O)R1 and 1,3-dithiane 1-oxide was performed using a biomimetic flavin catalyst that enables the activation of mol. oxygen under a low cathode potential. Diverse functional groups, including alcs., ketones, aldehydes, cyclopropane, carboxylic acids, pyridine, alkenes, and alkynes, are well tolerated under low-voltage electrolytic conditions.

Advanced Synthesis & Catalysis published new progress about Chemoselectivity. 699-12-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H10OS, Name: 2-(Phenylthio)ethanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Jung, Jong-Woon’s team published research in Chinese Chemical Letters in 2017-05-31 | 4396-13-8

Chinese Chemical Letters published new progress about Anti-inflammatory agents. 4396-13-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H6O5, Related Products of 4396-13-8.

Jung, Jong-Woon; Damodar, Kongara; Kim, Jin-Kyung; Jun, Jong-Gab published the artcile< First synthesis and in vitro biological assessment of isosideroxylin, 6,8-dimethylgenistein and their analogues as nitric oxide production inhibition agents>, Related Products of 4396-13-8, the main research area is isosideroxylin preparation nitric oxide inhibitory antiinflammatory activity; dimethylgenistein preparation nitric oxide inhibitory antiinflammatory activity; Vilsmeier Haack Friedel Crafts acylation Gammill protocol Suzuki.

A modular and efficient synthesis of the biol. significant C-methylisoflavones isosideroxylin (I), 6,8-dimethylgenistein (II) and their analogs is established for the first time. The synthesis is realized in 7-8 steps in overall yields of 16%-24% from com. inexpensive phloroglucinol and features a high yielding Vilsmeier-Haack reaction, Friedel-Crafts acylation, Gammill’s protocol and Suzuki coupling as the pivotal transformations. Next, these compounds evaluated for their inhibitory potency on the production of nitric oxide (NO) in lipopolysaccharide (LPS)-activated RAW-264.7 cells as an indicator of anti-inflammatory activity. The results showed that all the compounds decreased NO production in a dose-dependent manner without marked cytotoxicity and IC50 values are found in the range of 10.17-33.88 μmol/L. Of note, some compounds show comparable inhibitory activity with pos. control (N-monomethyl-L-arginine, L-NMMA).

Chinese Chemical Letters published new progress about Anti-inflammatory agents. 4396-13-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H6O5, Related Products of 4396-13-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Bharate, Sandip B’s team published research in Bioorganic & Medicinal Chemistry in 2008-02-01 | 4396-13-8

Bioorganic & Medicinal Chemistry published new progress about Antimalarials. 4396-13-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H6O5, SDS of cas: 4396-13-8.

Bharate, Sandip B.; Khan, Shabana I.; Tekwani, Babu L.; Jacob, Melissa; Khan, Ikhlas A.; Singh, Inder Pal published the artcile< S-Euglobals: Biomimetic synthesis, antileishmanial, antimalarial, and antimicrobial activities>, SDS of cas: 4396-13-8, the main research area is euglobal analog preparation antileishmanial antimalarial antimicrobial structure.

Several new euglobal analogs (named as S-euglobals) were synthesized from phloroglucinol using a biomimetic three-component reaction involving Knoevenagel condensation and Diels-Alder cycloaddition with a monoterpene. Newly synthesized euglobal analogs involve monoterpenes that have not yet been encountered in natural euglobals. S-Euglobals along with previously synthesized robustadial A and B were evaluated for in vitro antileishmanial, antimalarial, antimicrobial, and cytotoxic activities. Out of sixteen analogs prepared, nine analogs were found to exhibit antileishmanial activity against Leishmania donovani promastigotes. A 2-carene-derived S-euglobal was the most potent antileishmanial with IC50 of 2.4 μg/mL and IC90 of 8 μg/mL, followed by a second 2-carene-derived S-euglobal and a nopol-derived S-euglobal (IC50 5.5 and 9.5 μg/mL). Antileishmanial activity of robustadial A (5) and B (6) was moderate with IC50 of 20 and 16 μg/mL, resp. Robustadial A and B and a 2-carene-derived S-euglobal exhibited weak antimalarial activity against Plasmodium falciparum (IC50 of 2.7-4.76 μg/mL). Few of the euglobal analogs showed antibacterial activity against methicillin-resistant Staphylococcus aureus. Amongst these, a nopol-derived S-euglobal was the most potent with IC50 of 1.0 μg/mL and MIC of 5.0 μg/mL. Most of the compounds were not cytotoxic up to 25 μg/mL in a panel of cell lines consisting of both cancer (SK-MEL, KB, BT-549, and SK-OV-3) as well as non-cancer kidney (Vero and LLC-PK11) cells.

Bioorganic & Medicinal Chemistry published new progress about Antimalarials. 4396-13-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H6O5, SDS of cas: 4396-13-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Do, Thi Bich Thuy’s team published research in ACS Omega in 2020-12-29 | 492-62-6

ACS Omega published new progress about Exopolysaccharides Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Safety of (2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol.

Do, Thi Bich Thuy; Tran, Bao Khanh; Tran, Thi Van Thi; Le, Trung Hieu; Cnockaert, Margo; Vandamme, Peter; Nguyen, Thi Hong Chuong; Nguyen, Chinh Chien; Hong, Sung Hyun; Kim, Soo Young; Van Le, Quyet published the artcile< Decoding the Capability of Lactobacillus plantarum W1 Isolated from Soybean Whey in Producing an Exopolysaccharide>, Safety of (2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol, the main research area is exopolysaccharide Lactobacillus soybean whey.

This study aims at producing exopolysaccharides (EPS) from a lactic acid bacterial strain. The soybean whey-isolated Lactobacillus plantarum W1 (EPS-W1), which belongs to genus Lactobacillus, is identified using the phenylalanyl-tRNA sequencing method. Of all the examined strains, R-49778 (as numbered by BCCM/LMG Bacteria Collection, Ghent University, Belgium) showed the highest capability of producing exopolysaccharides. Structural characterization revealed a novel exopolysaccharide consisting of repeating units of →6)-D-Glcp-(1→; →3)-D-Manp-(1→; →3)-D-Glcp-(1→ and a branch of →6)-D-Manp-(1→; →2)-D-Glcp-(1→. This discovery opens up avenues for the production of EPS for food industries, functional foods, and biomedical applications.

ACS Omega published new progress about Exopolysaccharides Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Safety of (2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Alinezhad, Heshmatollah’s team published research in Applied Organometallic Chemistry in 2019 | 699-12-7

Applied Organometallic Chemistry published new progress about Aryl halides Role: RCT (Reactant), RACT (Reactant or Reagent). 699-12-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H10OS, Recommanded Product: 2-(Phenylthio)ethanol.

Alinezhad, Heshmatollah; Pakzad, Khatereh published the artcile< C-S Cross-coupling reaction using novel and green synthesized CuO nanoparticles assisted by Euphorbia maculata extract>, Recommanded Product: 2-(Phenylthio)ethanol, the main research area is copper oxide nanoparticle green catalyst preparation; aqueous Euphorbia maculata copper sulfate extract green biosynthesis; thioether preparation green chem; thiol aryl halide cross coupling CuO nanoparticle catalyst.

In the present study, biosynthesis of CuO nanoparticles using a rapid, eco-friendly, cost-effective and efficient method was reported employing aqueous Euphorbia maculata extract as mild, renewable and non-toxic reducing and capping agents without adding any surfactants. This biogenic and green method had some benefits compared to conventional phys. and chem. methods. The biosynthesized CuO NP displayed a color change pattern (from sky blue to black) on preparation and presented its resp. broad peak at 365 nm, which was analyzed by UV-vis spectroscopy. Using FT-IR anal., biomols. in E. maculata extract which were responsible for bioreduction activity and synthesized CuO NP, were identified. XRD, EDX and FESEM results confirmed successful synthesis of CuO nanoparticles of 18 nm sizes, with spherical and sponge crystal structure. Catalytic activity of biosynthesized CuO NPs was studied in C-S cross-coupling reaction of thiols with aryl halides. This method had the advantages of high yields, easy work-up, and simple reusability. The recovered CuO NP could be reused four times without any considerable loss of its catalytic activity.

Applied Organometallic Chemistry published new progress about Aryl halides Role: RCT (Reactant), RACT (Reactant or Reagent). 699-12-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H10OS, Recommanded Product: 2-(Phenylthio)ethanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Molaei, Somayeh’s team published research in Solid State Sciences in 2020-03-31 | 699-12-7

Solid State Sciences published new progress about Green chemistry. 699-12-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H10OS, COA of Formula: C8H10OS.

Molaei, Somayeh; Ghadermazi, Mohammad published the artcile< Heterogeneously catalyzed selective aerobic oxidation of sulfides with supported Dy on SBA-15 as recyclable catalyst under green condition>, COA of Formula: C8H10OS, the main research area is dysprosium oxopyrrolidine carboxylic acid silica catalyst sulfide green oxidation.

This manuscript presents a simple, efficient and environmentally benign room temperature aerobic catalytic process to the selective oxidation of sulfides to sulfoxides by Dy (III)-substituted 5-oxopyrrolidine-2-carboxylic acid (Glp) immobilized on SBA-15(SBA-15-Glp-Dy). The catalyst could be reused seven cycles without any loss in performance. This is the first selective aerobic oxidation of sulfides using a Dy-based heterogeneous system.

Solid State Sciences published new progress about Green chemistry. 699-12-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H10OS, COA of Formula: C8H10OS.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chen, Qincao’s team published research in Food Chemistry in 2019-02-15 | 78-70-6

Food Chemistry published new progress about Drying process. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Product Details of C10H18O.

Chen, Qincao; Zhu, Yin; Dai, Weidong; Lv, Haipeng; Mu, Bing; Li, Pengliang; Tan, Junfeng; Ni, Dejiang; Lin, Zhi published the artcile< Aroma formation and dynamic changes during white tea processing>, Product Details of C10H18O, the main research area is aroma compound white tea withering drying; Amino acid; Aroma; GC × GC-TOFMS; Glycosidically bound volatile; White tea.

The formation of and dynamic changes in aroma during white tea processing have not previously been systematically investigated. In this study, advanced comprehensive two-dimensional gas chromatog.-time-of-flight mass spectrometry was employed to investigate the mechanism of white tea aroma formation. A total of 172 volatiles were identified and mainly comprising endogenous volatiles, which displayed diverse change trends during the withering period. In this process, free aroma precursor amino acids and glycosidically bound volatiles (GBVs) were found to contribute to the formation of white tea aroma, with the differential expression of aroma-related key genes accounting for various accumulation of endogenous volatiles and GBVs. In addition, the drying was also shown to play an important role in the formation of white tea aroma. Our study provides the first characterization of white tea aroma formation and establishes a theor. basis for quality control during white tea processing operations.

Food Chemistry published new progress about Drying process. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Product Details of C10H18O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chaudhuri, Susri Ray’s team published research in International Journal of Pharmaceutical Applications in 2011 | 4396-13-8

International Journal of Pharmaceutical Applications published new progress about Antioxidants. 4396-13-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H6O5, Related Products of 4396-13-8.

Chaudhuri, Susri Ray; Modak, Arindam; Bhaumik, Asim; Swarnakar, Snehasikta published the artcile< Phloroglucinol derivatives as potential anti-ulcer compound that inhibits matrix metalloproteinase-9>, Related Products of 4396-13-8, the main research area is antiulcer phloroglucinol derivative matrix metalloproteinase 9 gastric ulceration.

Three phloroglucinol based polyphenolic compounds have been synthesized and their potential efficacy against gastric ulceration in mice was investigated. Polyphenol (I, II, III) were synthesized through Vilsmeier-Haack formylation, Schiff-base condensation of diformyl- phloroglucinol with 4-amino salicylic acid and Duff formylation reactions resp. We administered indomethacin, a non-steroidal anti inflammatory drug (NSAID), to induce gastric ulceration in Balb/c mice and tested antiulcer efficacy of synthesized phloroglucinol derivatives The pathogenesis of NSAID-induced ulceration is known to be associated to upregulation of matrix metalloproteinase (MMP)-9. All derivatives of phloroglucinol were found to prevent gastric ulceration in mice through depletion of oxidative stress in gastric tissue. Phloroglucinol derivatives also possessed antioxidant activity and they suppressed antioxidant enzymes in gastric tissues to almost normalcy during gastroprotection. Compound III was found to be most efficient anti-ulcer agent among others that inhibited the MMP-9 activity near to control value during prevention of NSAID-induced gastric ulceration. Thus, new polyphenolic compounds derived from phloroglucinol have antioxidant as well as anti-ulcer activity. We conclude that phloroglucinol derivatives as potent anti-ulcer compound in prevention of indomethacin induced gastric ulceration via attenuation of MMP-9 activity.

International Journal of Pharmaceutical Applications published new progress about Antioxidants. 4396-13-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H6O5, Related Products of 4396-13-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Guo, Huan’s team published research in Polymers (Basel, Switzerland) in 2019 | 3458-28-4

Polymers (Basel, Switzerland) published new progress about Antioxidants. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, SDS of cas: 3458-28-4.

Guo, Huan; Yuan, Qin; Fu, Yuan; Liu, Wen; Su, Ya-Hong; Liu, Hui; Wu, Chao-Yi; Zhao, Li; Zhang, Qing; Lin, De-Rong; Chen, Hong; Qin, Wen; Wu, Ding-Tao published the artcile< Extraction optimization and effects of extraction methods on the chemical structures and antioxidant activities of polysaccharides from snow chrysanthemum (Coreopsis tinctoria)>, SDS of cas: 3458-28-4, the main research area is coreopsis polysaccharide uronic acid monosaccharide antioxidant UAE MAE; Coreopsis tinctoria; antioxidant activity; chemical structure; extraction optimization; polysaccharide.

In order to explore snow chrysanthemum polysaccharides (SCPs) as functional food ingredients and natural antioxidants for industrial applications, both microwave-assisted extraction (MAE) and ultrasonic-assisted extraction (UAE) were firstly optimized for the extraction of SCPs. Furthermore, the effects of conventional hot water extraction, UAE, and MAE on the chem. structures and antioxidant activities of SCPs were investigated. The maximum extraction yields of SCPs extracted by UAE (4.13 ± 0.24%) and MAE (4.26 ± 0.21%) were achieved at the optimized extraction parameters as follows: ultrasound amplitude (68%) and microwave power (500 W), ultrasound extraction time (21 min) and microwave extraction time (6.5 min), and ratio of liquid to raw material (42.0 mL/g for UAE and 59.0 mL/g for MAE). In addition, different extraction methods significantly affected the contents of uronic acids, the mol. weights, the molar ratio of constituent monosaccharides, and the degree of esterification of SCPs. SCPs exhibited remarkable DPPH (IC50 = 1.702 mg/mL), ABTS (IC50 = 1.121 mg/mL), and nitric oxide (IC50 = 0.277 mg/mL) radical scavenging activities, as well as reducing power (= 80.17 ± 4.8μg Trolox/mg), which suggested that SCPs might be one of the major contributors toward the antioxidant activities of snow chrysanthemum tea. The high antioxidant activities (DPPH, IC50 = 0.693 mg/mL; ABTS, IC50 = 0.299 mg/mL; nitric oxide, IC50 = 0.105 mg/mL; and reducing power, 127.79 ± 2.57μg Trolox/mg) observed in SCP-M extracted by the MAE method might be partially attributed to its low mol. weight and high content of unmethylated galacturonic acids. Results suggested that the MAE method could be an efficient technique for the extraction of SCPs with high antioxidant activity, and SCPs could be further explored as natural antioxidants for industrial application.

Polymers (Basel, Switzerland) published new progress about Antioxidants. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, SDS of cas: 3458-28-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts