Tag: M.W=150-200

Chen, Yi-yong; Xue, Yi-ting published the artcile< Optimization of microwave assisted extraction, chemical characterization and antitumor activities of polysaccharides from porphyra haitanensis>, Synthetic Route of 3458-28-4, the main research area is microwave extraction antitumor polysaccharide porphyra; Antitumor; Chemical characterization; Microwave assisted extraction; Polysaccharides; Porphyra haitanensis.

Microwave assisted extraction (MAE) technol. was used to extract polysaccharides from Porphyra Haitanensis (PHP) with water. Polysaccharide yield was used as index to evaluate the extraction process. Effects of ratio of water to raw material (X1), microwave power (X2) and extraction time (X3) on polysaccharide yield were investigated. Based on single factor experiment, MAE process of PHP was optimized using response surface methodol. Chem. characterization of PHP was investigated based on anal. of chem. compositions, monosaccharide and thermal gravimetric. The antitumor activities of PHP in vivo and in vitro were evaluated. The results indicated that the optimal conditions for MAE of PHP were ratio of water to raw material 28.98(mL/g), microwave power 77.84 W and extraction time 14.14 min. MAE was a suitable and efficient technique for PHP extraction compared with traditional hot water extraction Anal. of chem. characterization showed that PHP contained 75.36 ± 1.48% of total carbohydrates, 24.63 ± 1.69% of uronic acid residue and no proteins with monosaccharides such as rhamnose, arabinose, xylose, mannose, glucose, and galactose in a molar ratio of 10.25:9.38:1:12.45:9.9:11.55. Thermal gravimetric anal. suggested that PHP was relatively stable below 170°C. PHP had obvious effect on inhibiting proliferation, inducing apoptosis of SGC-7901 tumor cells in vitro and antitumor effect on SGC-7901 tumor-bearing mice in vivo. The results suggested that PHP had the potential for clin. use in cancer prevention and treatment.

Carbohydrate Polymers published new progress about Antitumor agents. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Synthetic Route of 3458-28-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sabogal-Guaqueta, Angelica Maria; Hobbie, Fabian; Keerthi, Akshaya; Oun, Asmaa; Kortholt, Arjan; Boddeke, Erik; Dolga, Amalia published the artcile< Linalool attenuates oxidative stress and mitochondrial dysfunction mediated by glutamate and NMDA toxicity>, HPLC of Formula: 78-70-6, the main research area is linalool oxidative stress mitochondrial dysfunction glutamate NMDA toxicity; Linalool; Mitochondria; Neuroprotection; OHSC; Oxidative stress.

Mitochondrial dysfunction and inflammation contribute to the initiation and development of several brain pathol. conditions, including Alzheimer’s disease and cerebral ischemia. Linalool is an aromatic plant-derived monoterpene alc. with reported anti-inflammatory, and anti-oxidant properties. We investigated the role of linalool on glutamate-induced mitochondrial oxidative stress in immortalized neuronal HT-22 cells. Glutamate induced oxidative stress in neuronal cells, as detected by real-time cell impedance measurements, MTT assay, and anal. of Annexin V/PI. Administration of linalool 100μM reduced cell death mediated by glutamate. Staining of glutamate-stimulated mitochondria by MitoTracker revealed improved morphol. in the presence of linalool. Furthermore, we demonstrated a potential neuroprotective effect of linalool in conditions of oxidative stress by a reduction of mitochondrial ROS and mitochondrial calcium levels, and by preserving mitochondrial membrane potential. Experiments using both high-resolution respirometry and Seahorse Extracellular flux analyzer showed that linalool was able to promote an increase in uncoupled respiration that could contribute to its neuroprotective capacity. Linalool protection was validated using organotypic hippocampal slices as ex vivo model with NMDA as a stimulus to induce excitotoxity cell damage. These results demonstrate that linalool is protective in an in vitro model of glutamate-induced oxidative stress and in an ex-vivo model for excitotoxity, proposing linalool as a potential therapeutic agent against neurodegenerative brain diseases where oxidative stress contributes to the pathol. of the disease.

Biomedicine & Pharmacotherapy published new progress about Alzheimer disease. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, HPLC of Formula: 78-70-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhao, Peng; El-kott, Attalla; Ahmed, Ahmed Ezzat; Khames, Ahmed; Zein, Mohamed Abdellatif published the artcile< Green synthesis of gold nanoparticles (Au NPs) using Tribulus terrestris extract: Investigation of its catalytic activity in the oxidation of sulfides to sulfoxides and study of its anti-acute leukemia activity>, Computed Properties of 699-12-7, the main research area is green preparation gold nanoparticle; XRD particle size distribution gold nanoparticle; sulfide oxidation gold nanoparticle catalyst; sulfoxide preparation catalyst gold nanoparticle; antiacute leukemia activity gold nanoparticle; antioxidant activity gold nanoparticle; cytotoxicity gold nanoparticle.

With regards to applied, facile, green chem. research, a bio-inspired approach is being reported for the synthesis of Au NPs by using Tribulus terrestris extract The innate oxygenated phytochems. facilitated the green reduction of Au3+ ions to corresponding NPs and also stabilized them by encapsulating them. This modification prevented the as-synthesized Au NPs towards agglomeration and tiny NPs were obtained in uniformly spherical in shape and at 10-15 nm dimension. Physicochem. characteristics of the green synthesized Au NPs were evaluated by advanced physicochem. techniques like UV-visible and FTIR spectroscopy, SEM, TEM, EDX and XRD study. Catalytic performance of the biomol. functionalized Au NPs was studied in the controlled and selective oxidation of sulfides to sulfoxides using hydrogen peroxide as green oxidant at room temperature Aromatic, aliphatic and heterocyclic sulfides were oxidized to their corresponding sulfoxides with high yields without formation of over oxidized sulfones. The catalyst was easily recovered and recycled for 8 successive times without noticeable decrease in catalytic activity. In addition, the biosynthesized Au NPs indicated suitable antioxidant and anti-acute leukemia properties against THP-1 cell line. Tribulus terrestris extract and the green synthesized Au NPs exhibited a maximum DPPH scavenging activity of 78% and 29.37%, resp. Again, in the anticancer studies over THP-1 cell line following MTT assay, the Au NP exhibited gradual reduced % cell viability with increase in its concentration At an Au NPs concentration of 2000μg/mL, the % toxicity became maximum suggesting efficient inhibition of cancer invasion. Based on the above results, Au NPs-Tribulus could be administered as a potential anti-leukemia drug for the treatment of acute leukemia following the clin. trial studies in humans.

Inorganic Chemistry Communications published new progress about Cytotoxicity. 699-12-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H10OS, Computed Properties of 699-12-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kumar, Akshay; Kujur, Anupam; Singh, Prem Pratap; Prakash, Bhanu published the artcile< Nanoencapsulated plant-based bioactive formulation against food-borne molds and aflatoxin B1 contamination: Preparation, characterization and stability evaluation in the food system>, Recommanded Product: 3,7-Dimethylocta-1,6-dien-3-ol, the main research area is nanoencapsulation aflatoxin mold; Aflatoxin B(1); Antifungal; Mode of action; Nanoencapsulation; Plant-based formulation.

A novel synergistic formulation (TML) based on the combination of thymol (T), Me cinnamate (M), and linalool (L) has been prepared using the mixture design assay. Nanoencapsulation of developed formulation TML (Ne-TML) was prepared and characterised by SEM, XRD and FTIR. The Ne-TML was assessed for its antifungal and anti-aflatoxin B1 potential in vitro and in the food systems (Pennisetum glaucum L.), and also examined its effects on organoleptic properties. The Ne-TML cause complete inhibition of growth and AFB1 production at 0.3 μl/mL and 0.2 μl/mL. In-situ results revealed that Ne-TML exhibited maximum protection from fungal (75.40%) and aflatoxin B1 contamination (100%) at 0.3 μl/mL during six months of storage. The speculated antifungal mode of action of Ne-TML was related to the decrease in ergosterol content, membrane ions leakage, impairment in carbon-source utilization, mitochondrial functioning, anti-oxidative defense system (SOD, CAT, and GR) and Ver-1 gene of aflatoxin B1 biosynthesis.

Food Chemistry published new progress about Essential oils Role: BUU (Biological Use, Unclassified), BIOL (Biological Study), USES (Uses). 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Recommanded Product: 3,7-Dimethylocta-1,6-dien-3-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Huang, Fei; Hong, Ruiyue; Zhang, Ruifen; Yi, Yang; Dong, Lihong; Liu, Lei; Jia, Xuchao; Ma, Yongxuan; Zhang, Mingwei published the artcile< Physicochemical and biological properties of longan pulp polysaccharides modified by Lactobacillus fermentum fermentation>, COA of Formula: C6H12O6, the main research area is polysaccharides modified by Lactobacillus fermentum fermentation; Biological activity; Fermentation; Longan polysaccharide.

Longan polysaccharides are valuable compounds with many biol. activities. Lactobacillus fermentum was selected to ferment longan pulp and the polysaccharides from unfermented and fermented longan pulp (denoted as LP and LP-F, resp.) were isolated. Their physicochem., immunomodulatory and prebiotic activities were investigated. The results revealed that LP-F, the mol. weight of which was lower than that of LP, contained less neutral sugar, uronic acid and glucose but more arabinose, galactose, rhamnose and mannose. Compared with LP, LP-F had better solubility, lower apparent viscosity and particle size. LP-F exhibited stronger stimulation on macrophages secretion of NO and IL-6, as well as better proliferation of Leuconostoc mesenteroides and Lactobacillus casei. In summary, fermentation treatment could change the physicochem. properties and enhance the bioactivity of polysaccharides from longan pulp.

International Journal of Biological Macromolecules published new progress about Dimocarpus longan (pulp). 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, COA of Formula: C6H12O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Nikoorazm, Mohsen; Ghorbani, Farshid; Ghorbani-Choghamarani, Arash; Erfani, Zahra published the artcile< Nickel Schiff base complex anchored on Fe3O4@MCM-41 as a novel and reusable magnetic nanocatalyst and its application in the oxidation of sulfides and oxidative coupling of thiols using H2O2>, HPLC of Formula: 699-12-7, the main research area is schiff base complex reusable magnetic nanocatalyst; sulfoxide preparation sulfide oxidation disulfide preparation thiol oxidative coupling.

A novel and reusable nanocatalyst was synthesized by anchoring a nickel Schiff base complex onto Fe3O4@MCM-41 (Fe3O4@MCM-41@Ni-P2C) and characterization was accomplished with Fourier transform IR spectroscopy (FT-IR), thermogravimetric anal. (TGA), powder X-ray diffraction (XRD), vibrating sample magnetometry (VSM), transmission electron microscopy (TEM), SEM (SEM) and at. absorption spectroscopy (AAS) techniques. This catalytic system was efficiently used for oxidation of sulfides to sulfoxides and oxidative coupling of thiols to corresponding disulfides using H2O2 as green oxidant at room temperature These reactions were carried out in a green solvent (ethanol) and/or under solvent-free conditions with short reaction time, complete selectivity and very high conversion under mild reaction conditions. More importantly, separation and recycling of this magnetic catalyst can be easily done through a simple and low cost magnetic separation process.

Phosphorus, Sulfur and Silicon and the Related Elements published new progress about Disulfides Role: SPN (Synthetic Preparation), PREP (Preparation). 699-12-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H10OS, HPLC of Formula: 699-12-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Caputo, Lucia; Piccialli, Ilaria; Ciccone, Roselia; de Caprariis, Paolo; Massa, Antonio; De Feo, Vincenzo; Pannaccione, Anna published the artcile< Lavender and coriander essential oils and their main component linalool exert a protective effect against amyloid-β neurotoxicity>, Quality Control of 78-70-6, the main research area is Lavender Coriander essential oil linalool neuroprotective agent neurotoxicity; Alzheimer’s disease; amyloid-β oligomers; coriander essential oil; lavender essential oil; linalool; neuroprotection.

Alzheimer’s disease (AD) is a neurodegenerative disorder leading to cognitive deficits and cognitive decline. Since no cure or preventing therapy is currently available to counteract AD, natural-derived compounds are investigated to find new potential neuroprotective agents for its treatment. In the present study, we tested the neuroprotective effect of lavender and coriander essential oils (EOs) and their main active constituent linalool, against the neurotoxicity elicited by Aβ1-42 oligomers, a key mol. factor in the neurodegeneration of AD. Importantly, our findings on neuronally differentiated PC12 cells exposed to Aβ1-42 oligomers are in accordance with previous in vivo studies reporting the neuroprotective potential of lavender and coriander EOs and linalool. We found that lavender and coriander EOs at the concentration of 10μg/mL as well as linalool at the same concentration were able to improve viability and to reduce nuclear morphol. abnormalities in cells treated with Aβ1-42 oligomers for 24 h. Lavender and coriander EOs and linalool also showed to counteract the increase of intracellular reactive oxygen species production and the activation of the pro-apoptotic enzyme caspase-3 induced by Aβ1-42 oligomers. Our findings provide further evidence that these EOs and their main constituent linalool could be natural agents of therapeutic interest against Aβ1-42-induced neurotoxicity.

Phytotherapy Research published new progress about Alzheimer disease. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Quality Control of 78-70-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Jia, Mengyun; Chen, Jiajun; Liu, Xiaozhen; Xie, Mingyong; Nie, Shaoping; Chen, Yi; Xie, Jianhua; Yu, Qiang published the artcile< Structural characteristics and functional properties of soluble dietary fiber from defatted rice bran obtained through Trichoderma viride fermentation>, Product Details of C6H12O6, the main research area is Trichoderma fermentation soluble dietary fiber defatted rice bran.

Trichoderma viride was utilized to ferment the defatted rice bran (DRB), and soluble dietary fiber was prepared before and after fermentation, named as B-SDF and F-SDF, resp. Optimum fermentation conditions for yield of F-SDF were determined using response surface methodol. (RSM). The yield of F-SDF was significantly increased from 10.5 (weight/weight, %) to 33.4 (weight/weight, %) under the optimal conditions (inoculum size = 10%, pH = 5.8 and time = 41 h). Fourier transform IR spectroscopy (FTIR) demonstrated that both B-SDF and F-SDF had typical characteristics of the IR spectrum of polysaccharides, and X-ray diffraction (XRD) revealed they were mainly substances of amorphous structure. In addition, F-SDF showed looser structure by SEM (SEM) anal., increased mol. weight by high-performance gel permeation chromatog. (HPGPC) anal., and more complex monosaccharide composition by high-performance anion exchange chromatog. (HPAEC) anal. Furthermore, functional properties anal. showed that F-SDF exhibited higher water-holding capacity (WHC), oil-holding capacity (OHC), water solubility (WS) and cholesterol absorption capacity (CAC) than B-SDF. In summary, the present study suggested that SDF from defatted rice bran obtained through Trichoderma viride fermentation has a higher potential to be used as a functional ingredient in foods.

Food Hydrocolloids published new progress about Dietary fiber. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Product Details of C6H12O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Hai-ou; Liu, Si-hong; Zhou, Xue-jie; Yang, Xiao-yue; Gao, Qi; Tanokura, Masaru; Xue, You-lin published the artcile< Treatment with hydrogen peroxide improves the physicochemical properties of dietary fibres from Chinese yam peel>, Computed Properties of 492-62-6, the main research area is hydrogen peroxide Chinese yam peel dietary fiber physicochem property.

Summary : Yam is a common ‘medicine food homol.’ vegetable in Asia, and its peel is often considered a food residue during processing or cooking. In this work, the effects of hydrogen peroxide modification on the dietary fibers (DFs) from Chinese yam peel (CYP) were investigated. The structural characteristics of soluble dietary fiber (SDF), insoluble dietary fiber (IDF), modified soluble dietary fiber (MSDF) and modified insoluble dietary fiber (MIDF) were analyzed using Fourier-transform IR spectroscopy, X-ray diffraction, differential scanning calorimetry, granularity anal., SEM and GC-MS (monosaccharide composition). As results, after modification with hydrogen peroxide, the sizes of the DFs were reduced and MIDF exposed more cellulose. Experiments on the physicochem. and functional properties of DFs showed that MSDF and MIDF obtained a better water holding capacity, oil absorption capacity, swelling capacity and absorption abilities with altered structures, which is of great importance in food processing and development.

International Journal of Food Science and Technology published new progress about Crystallinity. 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Computed Properties of 492-62-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Fu, Yuan; Yuan, Qin; Lin, Shang; Liu, Wen; Du, Gang; Zhao, Li; Zhang, Qing; Lin, De-Rong; Liu, Yun-Tao; Qin, Wen; Li, De-Qiang; Wu, Ding-Tao published the artcile< Physicochemical characteristics and biological activities of polysaccharides from the leaves of different loquat (Eriobotrya japonica) cultivars>, Formula: C6H12O6, the main research area is Eriobotrya leaf physicochem polysaccharide; Binding properties; Enzyme inhibition; Eriobotrya japonica; Loquat; Polysaccharides; Weight-average molecular weights.

In order to explore polysaccharides from loquat leaves (LLPs) as functional food ingredients for prevention and treatment of obesity and type 2 diabetes, the physicochem. characteristics, in vitro binding properties, and inhibitory effects on α-amylase and α-glucosidase of polysaccharides from the leaves of different loquat cultivars, including ‘Baiyu’, ‘Chuannong8’, ‘Yuanbao’, and ‘Dawuxing’, were investigated and compared. Results showed that the contents of total uronic acids and degree of esterification in LLPs ranged from (27.04 ± 1.76)% to (41.46 ± 1.91)%, and from (20.54 ± 0.11)% to (26.90 ± 0.10)%, resp. The weight-average mol. weights of LLPs ranged from 4.307 × 106 Da to 5.101 × 106 Da, and the major constituent monosaccharides of LLPs were rhamnose, galacturonic acid, arabinose, and galactose. Furthermore, LLPs exerted strong in vitro fat binding, cholesterol binding, and bile acid binding capacities, as well as remarkable inhibitory effects on α-amylase and α-glucosidase, which might be attributed to their mol. weights, mol. weight distributions, and degree of esterification. Results are helpful for better understanding of chem. structures and bioactivities of polysaccharides from loquat leaves, and LLPs had good potential to be explored as functional food ingredients for prevention and treatment of obesity and type 2 diabetes.

International Journal of Biological Macromolecules published new progress about Bile acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Formula: C6H12O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts