Tag: M.W=150-200

Shakhmatov, Evgeny G.; Makarova, Elena N.; Belyy, Vladimir A. published the artcile< Structural studies of biologically active pectin-containing polysaccharides of pomegranate Punica granatum>, SDS of cas: 3458-28-4, the main research area is Punica fruit feel membrane pectin polysaccharide structural property; Arabinan; NMR; Pectic polysaccharides; Pomegranate wastes; Punica granatum; Structural analysis.

The polysaccharide PGW was isolated from peels and membranes of fruits of pomegranate P. granatum by hot water extraction The methods of ion exchange chromatog., partial acid hydrolysis, enzymic hydrolysis and NMR spectroscopy were employed to establish the major elements of its structure. It was shown that this polysaccharide contained polymers with different structures, the main components among which were pectic polysaccharides, represented mainly by highly methyl-esterified and lowly acetylated 1,4-α-D-galactopyranosyluronan and a minor amount of partially 2-O- and/or 3-O-acetylated RG-I. The side carbohydrate chains of the branched region of RG-I were mainly represented by terminal, 5-O-, 3-O-, 2,5-di-O-, 3,5-di-O- and 2,3,5-tri-O-substituted α-L-Araf residues indicating the presence of branched 1,5-α-L-arabinan and minor regions of 1,4-β-D-galactan or arabinogalactan type I. The degree of methylation of the isolated pectins varied depending on the method of treatment. As a result, peels and membranes of pomegranate fruits can be recommended as a source of highly and lowly methyl-esterified pectic polysaccharides.

International Journal of Biological Macromolecules published new progress about Carbohydrates Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, SDS of cas: 3458-28-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Iles, Bruno; Ribeiro de Sa Guimaraes Noleto, Isabela; Dourado, Flaviane Franca; de Oliveira Silva Ribeiro, Fabio; de Araujo, Alyne Rodrigues; de Oliveira, Taiane Maria; Souza, Jessica Maria Teles; Barros, Ayslan Batista; Sousa, Gabrielle Costa; de Jesus Oliveira, Antonia Carla; da Silva Martins, Conceicao; de Oliveira Viana Veras, Mariana; de Carvalho Leitao, Renata Ferreira; de Souza de Almeida Leite, Jose Roberto; da Silva, Durcilene Alves; Medeiros, Jand Venes Rolim published the artcile< Alendronate sodium-polymeric nanoparticles display low toxicity in gastric mucosal of rats and Ofcol II cells>, Synthetic Route of 492-62-6, the main research area is alendronate sodium polymeric nanoparticle gastric toxicity osteotoxicity; Alendronate; Cashew gum; Gastric lesion; Polymeric nanoparticle; Red Angico gum.

The use of bisphosphonates constitutes the gold-standard therapy for the control and treatment of bone diseases. However, its long-term use may lead to gastric problems, which limits the treatment. Thus, this study aimed to formulate a nanostructured system with biodegradable polymers for the controlled release of alendronate sodium. The nanoparticles were characterized, and its gastric toxicity was investigated in rats. The synthesis process proved to be effective for encapsulating alendronate sodium, exhibiting nanoparticles with an average size of 51.02 nm and 98.5% of alendronate sodium incorporation. The release tests demonstrated a controlled release of the drug in 420 min, while the morphol. analyzes showed spherical shapes and no apparent roughness. The biol. tests demonstrated that the alendronate sodium nanoformulation reversed the gastric lesions, maintaining the normal levels of malondialdehyde and myeloperoxidase. Also, the encapsulated alendronate sodium showed no toxicity in murine osteoblastic cells, even at high concentrations

NanoImpact published new progress about Anacardium occidentale. 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Synthetic Route of 492-62-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Riley, Nicholas M.; Hebert, Alexander S.; Westphall, Michael S.; Coon, Joshua J. published the artcile< Capturing site-specific heterogeneity with large-scale N-glycoproteome analysis>, Synthetic Route of 3458-28-4, the main research area is glycoproteome glycopeptide IR photon ion electron transfer dissociation.

Protein glycosylation is a highly important, yet poorly understood protein post-translational modification. Thousands of possible glycan structures and compositions create potential for tremendous site heterogeneity. A lack of suitable anal. methods for large-scale analyses of intact glycopeptides has limited our abilities both to address the degree of heterogeneity across the glycoproteome and to understand how this contributes biol. to complex systems. Here we show that N-glycoproteome site-specific microheterogeneity can be captured via large-scale glycopeptide profiling methods enabled by activated ion electron transfer dissociation (AI-ETD), ultimately characterizing 1,545 N-glycosites (>5,600 unique N-glycopeptides) from mouse brain tissue. Our data reveal that N-glycosylation profiles can differ between subcellular regions and structural domains and that N-glycosite heterogeneity manifests in several different forms, including dramatic differences in glycosites on the same protein. Moreover, we use this large-scale glycoproteomic dataset to develop several visualizations that will prove useful for analyzing intact glycopeptides in future studies.

Nature Communications published new progress about Animal gene, Sparc Role: ANT (Analyte), BSU (Biological Study, Unclassified), ANST (Analytical Study), BIOL (Biological Study). 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Synthetic Route of 3458-28-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Shishmarev, Dmitry; Quiquempoix, Lucas; Fontenelle, Clement Q.; Linclau, Bruno; Kuchel, Philip W. published the artcile< Anomerization of Fluorinated Sugars by Mutarotase Studied Using 19F NMR Two-Dimensional Exchange Spectroscopy>, Reference of 492-62-6, the main research area is anomerization fluorinated monosaccharide mutarotase glucose enzyme mol structure NMR.

Five 19F-substituted glucose analogs were used to probe the activity and mechanism of the enzyme mutarotase by using magnetization-exchange NMR spectroscopy. The sugars (2-fluoro-2-deoxy-d-glucose, FDG2; 3-fluoro-3-deoxy-d-glucose, FDG3; 4-fluoro-4-deoxy-d-glucose, FDG4; 2,3-difluoro-2,3-dideoxy-d-glucose, FDG23; and 2,2,3,3-tetrafluoro-2,3-dideoxy-d-glucose (2,3-dideoxy-2,2,3,3-tetrafluoro-d-erythro-hexopyranose), FDG2233) showed sep. 19F NMR spectroscopic resonances from their resp. α- and β-anomers, thus allowing two-dimensional exchange spectroscopy measurements of the anomeric interconversion at equilibrium, on the time scale of a few seconds. Mutarotase catalyzed the rapid exchange between the anomers of FDG4, but not the other four sugars. This finding, combined with previous work identifying the mechanism of the anomerization by mutarotase, suggests that the rotation around the C1-C2 bond of the pyranose ring is the rate-limiting reaction step. In addition to D-glucose itself, it was shown that all other fluorinated sugars inhibited the FDG4 anomerization, with the tetra-fluorinated FDG2233 being the most potent inhibitor. Inhibition of mutarotase by F-sugars paves the way for the development of novel fluorinated compounds that are able to affect the activity of this enzyme in vitro and in vivo.

Australian Journal of Chemistry published new progress about Anomerization. 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Reference of 492-62-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

de Freitas Souza, Carine; Descovi, Sharine; Baldissera, Matheus Dellamea; Bertolin, Kalyne; Bianchini, Adriane Erbice; Mourao, Rosa Helena Veraz; Schmidt, Denise; Heinzmann, Berta Maria; Antoniazzi, Alfredo; Baldisserotto, Bernardo; Martinez-Rodriguez, Gonzalo published the artcile< Involvement of HPI-axis in anesthesia with Lippia alba essential oil citral and linalool chemotypes: gene expression in the secondary responses in silver catfish>, Recommanded Product: 3,7-Dimethylocta-1,6-dien-3-ol, the main research area is hypothalamus pituitary interrenal axis anesthesia Lippia citral linalool Rhamdia; Anesthesia; Fish; Natural products; Stress; mRNA.

In teleost fish, stress initiates a hormone cascade along the hypothalamus-pituitary-interrenal (HPI) axis to provoke several physiol. reactions in order to maintain homeostasis. In aquaculture, a number of factors induce stress in fish, such as handling and transport, and in order to reduce the consequences of this, the use of anesthetics has been an interesting alternative. Essential oil (EO) of Lippia alba is considered to be a good anesthetic; however, its distinct chemotypes have different side effects. Therefore, the present study aimed to investigate, in detail, the expression of genes involved with the HPI axis and the effects of anesthesia with the EOs of two chemotypes of L. alba (citral EO-C and linalool EO-L) on this expression in silver catfish, Rhamdia quelen. Anesthesia with the EO-C is stressful for silver catfish because there was an upregulation of the genes directly related to stress: slc6a2, crh, hsd20b, hspa12a, and hsp90. In this study, it was also possible to observe the importance of the hsd11b2 gene in the response to stress by handling. The use of EO-C as anesthetics for fish is not recommended, but, the use of OE-L is indicated for silver catfish as it does not cause major changes in the HPI axis.

Fish Physiology and Biochemistry published new progress about Anesthesia Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Recommanded Product: 3,7-Dimethylocta-1,6-dien-3-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Jia, Yanan; Gao, Xudong; Xue, Zihan; Wang, Yajie; Lu, Yangpeng; Zhang, Min; Panichayupakaranant, Pharkphoom; Chen, Haixia published the artcile< Characterization, antioxidant activities, and inhibition on α-glucosidase activity of corn silk polysaccharides obtained by different extraction methods>, HPLC of Formula: 3458-28-4, the main research area is review alpha glucosidase antioxidant polysaccharides extraction; Corn silk; Extraction method; Polysaccharide.

A review. The polysaccharides (CSPw, CSPc, CSPa, and CSPu) were prepared by hot water extraction, acid-assisted extraction, alk.-assisted extraction, and ultrasound-assisted extraction from corn silk, resp. High performance gel permeation chromatog. (HPGPC), fourier-transform IR (FT-IR) spectroscopy, and SEM (SEM) results indicated that the extraction methods had an obvious impact on the mol. weight, structure, and morphol. of the CSPs. Among the four polysaccharides, CSPu showed the highest inhibitory α-glucosidase activity, which might be related to its smaller mol. weight Furthermore, kinetics analyses revealed that CSPu had significant inhibition of α-glucosidase in a non-reversible and competitive manner. Fluorescence quenching anal. illustrated that the interaction mechanism of CSPu and α-glucosidase was claimed as a static quenching mechanism. Isothermal titration calorimetry (ITC) anal. showed that the main driving forces for the interaction of CSPu with α-glucosidase was hydrogen bonding and the binding interactions of them occurred spontaneously.

International Journal of Biological Macromolecules published new progress about Antioxidants. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, HPLC of Formula: 3458-28-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ruschhaupt, Peter; Varzi, Alberto; Passerini, Stefano published the artcile< Natural Polymers as Green Binders for High-Loading Supercapacitor Electrodes>, Product Details of C6H12O6, the main research area is natural polymer green binder high loading supercapacitor electrode; binders; carbohydrates; flexible electrodes; high mass loading; supercapacitors.

The state-of-the-art aqueous binder for supercapacitors is CM-cellulose (CMC). However, it limits the mass loading of the coatings owing to shrinkage upon drying. In this work, natural polymers, i.e., guar gum (GG), wheat starch (WS), and potato starch (PS), were studied as alternatives. The flexibility and adhesion of the resulting coatings and electrochem. performance was tested. The combination of 75:25 (weight/weight) ratio PS/GG showed a promising performance. Electrodes were characterized by SEM, thermal, adhesion, and bending tests. Their electrochem. properties were determined by cyclic voltammetry, electrochem. impedance spectroscopy, and cycling experiments The PS/GG mixture conformed well to criteria for industrial production, enabling mass loadings higher than CMC (7.0 mg cm-2) while granting the same specific capacitance (26 F g-1) and power performance (20 F g-1 at 10 A g-1). Including the mass of the current collector, this represents a +45% increase in specific energy at the electrode level.

ChemSusChem published new progress about Binders. 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Product Details of C6H12O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ji, Hai-yu; Chen, Pei; Yu, Juan; Feng, Ying-ying; Liu, An-jun published the artcile< Effects of Heat Treatment on the Structural Characteristics and Antitumor Activity of Polysaccharides from Grifola frondosa>, Recommanded Product: (2S,3S,4R,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is Grifola polysaccharide antitumor agent heat treatment hepatocellular carcinoma; Antitumor; Heat treatment; Polysaccharides from Grifola frondosa; Structure.

This study investigated the effects of heat treatment on structural characteristics and in vitro antitumor activity of polysaccharides from Grifola frondosa. GFP-4 (extracted at 4°C), GFP-4-80 (80°C treatment on GFP-4) and GFP-80 (extracted at 80°C) were prepared, and the chem. composition anal. showed that their total sugar contents were all higher than 90%, high-performance gel-permeation chromatog. (HPGPC), ion chromatog. (IC) and Fourier-transform IR spectroscopy (FTIR) results demonstrated that GFP-4 were degraded and denatured after 80°C heat treatment, MTT and JC-1 results showed that GFP-4 exhibited higher inhibitory effects on HepG2 cells in vitro than GFP-4-80 and GFP-80. Our study suggested that heat treatment at 80°C on polysaccharides from Grifola frondosa would destroy their structure and attenuate their antitumor effects.

Applied Biochemistry and Biotechnology published new progress about Antitumor agents. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Recommanded Product: (2S,3S,4R,5R)-2,3,4,5,6-Pentahydroxyhexanal.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yuan, Yiqiong; Li, Chuan; Zheng, Qianwen; Wu, Jixiang; Zhu, Kexue; Shen, Xuanri; Cao, Jun published the artcile< Effect of simulated gastrointestinal digestion in vitro on the antioxidant activity, molecular weight and microstructure of polysaccharides from a tropical sea cucumber (Holothuria leucospilota)>, Related Products of 3458-28-4, the main research area is Holothuria simulated gastrointestinal digestion polysaccharide antioxidant microstructure.

The physicochem. properties of Holothuria leucospilota polysaccharides (HLP) were measured, and the changes of mol. weight (Mw), antioxidant activity and microstructure in vitro were studied. The Mw of HLP was approx. 52.80 kDa, and the monosaccharide composition was primarily fucose, rhamnose and glucuronic acid. HLP showed good antioxidant activity at high concentration (≥2 mg/mL), and the DPPH (1,1-Diphenyl-2-picryl-hydrazil) free radical scavenging rate reached approx. 84%. It was observed that saliva did not have an effect on the Mw and antioxidant capability of HLP. Gastric and intestinal digestion significantly reduced the Mw of HLP (from 52.80 kDa to 14.67 kDa and 12.01 kDa) and maintained high antioxidant activity. In addition, the structure and surface morphol. were markedly altered. After simulated gastric digestion, the HLP changed from a smooth, irregular, and angular structure to a layered honeycomb with a large volume This result demonstrated that the decrease of Mw after gastric digestion was caused by the destruction of aggregates. Due to the decomposition of glycosidic bonds after digestion in intestine, HLP showed loose, small and blocky structures. Thus, HLP had antioxidant activity, and this activity was improved after gastric and intestinal digestion.

Food Hydrocolloids published new progress about Digestive juice. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Related Products of 3458-28-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Yun; Wang, Shengxuan; Song, Rongzhen; Cai, Jingjing; Xu, Jingjing; Tang, Xiaozhen; Li, Ningyang published the artcile< Ginger polysaccharides induced cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells>, Safety of (2S,3S,4R,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is hepatocellular carcinoma cell cycle arrest apoptosis polysaccharide; Apoptosis; Cell cycle arrest; Ginger polysaccharide.

In this study, ginger polysaccharide (GP) was obtained from ginger by enzymic method, its chem. properties and antitumor activity were investigated. The results indicated that the composition and proportion of GP were L-rhamnose, D-arabinose, D-mannose, D-glucose and D-galactose in a molar ratio of 3.64:5.37:3.04:61.03:26.91, GP had the characteristic absorption peak of polysaccharide. Congo red experiment showed that GP had a triple helix structure, which could have anti-tumor effect. Furthermore, MTT assay, cell morphol. observation, nuclear morphol. observation and reactive oxygen species observation demonstrated that GP had significant antitumor effect. Flow cytometry suggested that GP could promote apoptosis and arrest cells in G0-G1 phase. Real-time fluorescence quantification and Western blot revealed that GP could up-regulate the expression of Bax, Fas, FasL, caspase-3, p21 and p53, and down-regulate the expression of Bcl-2. These studies suggested that GP would be used as an antitumor drug in foods to promote the development of functional foods.

International Journal of Biological Macromolecules published new progress about Absorption. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Safety of (2S,3S,4R,5R)-2,3,4,5,6-Pentahydroxyhexanal.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts