Tag: M.W=150-200

Cinelli, Maris A.; Yang, Jun; Scharmen, Amy; Woodman, Joey; Karchalla, Lalitha M.; Stephen Lee, Kin Sing published the artcile< Enzymatic synthesis and chemical inversion provide both enantiomers of bioactive epoxydocosapentaenoic acids>, Quality Control of 699-12-7, the main research area is Enzymic synthesis epoxydocosapentaenoic acids Bacillus megaterium; chemoenzymatic synthesis; cytochrome P450; docosahexaenoic acid; epoxide inversion; epoxy fatty acids; lipids/chemistry; polyunsaturated fatty acids.

Epoxy PUFAs are endogenous cytochrome P 450 (P 450) metabolites of dietary PUFAs. Although these metabolites exert numerous biol. effects, attempts to study their complex biol. have been hampered by difficulty in obtaining the epoxides as pure regioisomers and enantiomers. To remedy this, we synthesized 19,20- and 16,17-epoxydocosapentaenoic acids (EDPs) (the two most abundant EDPs in vivo) by epoxidation of DHA with WT and the mutant (F87V) P 450 enzyme BM3 from Bacillus megaterium. WT epoxidation yielded a 4:1 mixture of 19,20:16,17-EDP exclusively as (S,R) enantiomers. Epoxidation with the mutant (F87V) yielded a 1.6:1 mixture of 19,20:16,17-EDP; the 19,20-EDP fraction was ∼9:1 (S,R):(R,S), but the 16,17-EDP was exclusively the (S,R) enantiomer. To access the (R,S) enantiomers of these EDPs, we used a short (four-step) chem. inversion sequence, which utilizes 2-(phenylthio)ethanol as the epoxide-opening nucleophile, followed by mesylation of the resulting alc., oxidation of the thioether moiety, and base-catalyzed elimination. This short synthesis cleanly converts the (S,R)-epoxide to the (R,S)-epoxide without loss of enantiopurity. This method, also applicable to eicosapentaenoic acid and arachidonic acid, provides a simple, cost-effective procedure for accessing larger amounts of these metabolites.

Journal of Lipid Research published new progress about Bacillus megaterium. 699-12-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H10OS, Quality Control of 699-12-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Guo, Xiangyang; Ho, Chi-Tang; Wan, Xiaochun; Zhu, Hui; Liu, Qiong; Wen, Zhen published the artcile< Changes of volatile compounds and odor profiles in Wuyi rock tea during processing>, Computed Properties of 78-70-6, the main research area is Wuyi rock tea Odor profile favor Odor activity value; Sensory evaluation Tea processing; Odor activity value (OAV); Odor profile; Rock flavor; Sensory evaluation; Tea processing; Wuyi rock tea.

Wuyi rock tea (WRT), is one kind of oolong tea and widely appreciated for its typical ′rock flavor′. The odor characteristics of WRT during processing were comprehensive investigated by gas chromatog.-mass spectrometry, sensory evaluation and odor activity value (OAV). Alcs., alkenes and esters were the main volatiles formed during tea processes, but the WRT contained more heterocyclic compounds, among which 15 N-containing volatiles were newly identified in this study, accounting for 60.52% of total amounts of volatiles in WRT. In response, the original green and chem. odors converted to roasted and woody odors, and full fire processing was effective to enhance roasted, floral and woody odors, weaken chem. odor. 2-Ethyl-3,5-dimethylpyrazine (OAV 4.71) was confirmed as the aroma-active compound of WRT with roasted odor by aroma recombination experiment In addition, strong roasted, floral and moderate woody odors were perceived as the outline of ′rock flavor′ in WRT aroma. These results provide theor. basis for processing and quality control of WRT.

Food Chemistry published new progress about Lactones Role: ANT (Analyte), PRP (Properties), ANST (Analytical Study). 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Computed Properties of 78-70-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Zichao; Zhao, Xiaoxiao; Liu, Xiaoying; Lu, Wenbo; Jia, Shutong; Hong, Tingting; Li, Ruifang; Zhang, Huiru; Peng, Lin; Zhan, Xiaobei published the artcile< Anti-diabetic activity evaluation of a polysaccharide extracted from Gynostemma pentaphyllum>, Quality Control of 3458-28-4, the main research area is Gynostemma polysaccharide antidiabetic; Anti-diabetic activity; Gynostemma pentaphyllum; Polysaccharide.

In current study, a polysaccharide (GPP) was successfully extracted from Gynostemma pentaphyllum herb. Monosaccharide composition of GPP was rhamnose, arabinose, galactose, glucose, xylose, mannose, galacturonic acid and glucuronic acid in a molar ratio of 4.11: 7.34: 13.31: 20.99: 1.07: 0.91: 4.75: 0.36. Mol. weight and polydispersity (Mw/Mn) of GPP were 4.070 × 104 Da and 1.037, resp. Primary structure features of GPP were determined to be a polysaccharide by FT-IR and NMR. Fasting blood sugar of diabetic mice decreased from 17.56 mmol/L to 7.42 mmol/L by orally administration of 0.5 mL GPP (1 mg/mL) for 30 days. GPP exhibited a dose-dependent inhibition effect on a-glucosidase activity. Moreover, GPP could inhibit the glucose absorption and affect the protein expression of GLUT2, but not the protein expression of SGLT1. These results indicated GPP could be used as an effective ingredient to prevent and cure diabetes.

International Journal of Biological Macromolecules published new progress about Animal gene, SGLT1 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Quality Control of 3458-28-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ahmed, Kabirun; Saikia, Gangutri; Begum, Pakiza; Gogoi, Sandhya Rani; Sharma, Mitu; Talukdar, Hiya; Islam, Nashreen S. published the artcile< Selective and Green Sulfoxidation in Water using a New Chitosan Supported Mo(VI) Complex as Heterogeneous Catalyst>, Application of C8H10OS, the main research area is chitosan molybdenum complex heterogeneous catalyst water selective green sulfoxidation.

Immobilization of oxo-peroxo molybdenum(VI) species on natural biopolymer, chitosan led to the development of a new heterogeneous catalyst which displayed excellent activity, stability and chemoselectivity for the oxidation of a wide variety of sulfides to the resp. sulfoxides by H2O2 in water, at ambient temperature The catalyst has been comprehensively characterized by elemental anal., spectral studies (FTIR, Raman, solid-state 13C NMR and diffuse reflectance UV-Vis), PXRD, Brunauer-Emmett-Teller (BET), SEM, EDX and TGA-DTG anal. The d. functional theory (DFT) method has been employed to study the structure of the synthesized chitosan peroxomolybdenum complex (PMoCh). In addition to water, the catalyst is also highly compatible with a variety of safer organic solvents like methanol and acetonitrile. Apart from being high yielding and operationally simple, the developed catalytic protocol is environmentally clean and safe as it is absolutely free from halogenated organic solvent. Other significant green attributes of the methodol. include its ready scalability, high H2O2 efficiency and easy recyclability of the catalyst for several catalytic cycles with consistent activity/selectivity profile.

ChemistrySelect published new progress about Chemoselectivity. 699-12-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H10OS, Application of C8H10OS.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Matsuo, Koichi; Gekko, Kunihiko published the artcile< Vacuum Ultraviolet Electronic Circular Dichroism Study of D-Glucose in Aqueous Solution>, Application In Synthesis of 492-62-6, the main research area is glucose aqueous solution vacuum UV CD model.

Vacuum UV (VUV) electronic CD (ECD) spectra of D-glucose, α-D-glucopyranose, and β-D-glucopyranose were measured in aqueous solution down to 163 nm using a synchrotron radiation VUV-ECD spectrophotometer and theor. analyzed using mol. dynamics (MD) simulations with explicit water mols. and using time-dependent d. functional theory (TDDFT). The theor. calculated spectra reproduced the exptl. observed spectra well, revealing that VUV-ECD exhibited unique spectra depending on the α-anomer and β-anomer configurations of the hydroxyl group at C-1 and the three gauche (G) and trans (T) rotamer conformations (GT, GG, and TG) of the hydroxymethyl group at C-5. These unique spectra could be ascribed to differences in the patterns of intramol. hydrogen bonds around the hydroxymethyl group at C-5 for the three rotamers and around the hydroxyl group at C-1 for the two anomers. The strengths of these intramol. interactions increased as the degree of hydration around the corresponding chromophores decreased, suggesting that hydration is a key factor for stabilizing rotamer and anomer structures. The rotamerization and anomerization mechanisms are further discussed in terms of differences in the intramol. interactions and the degree of hydration among the rotamer and anomer structures. The findings demonstrate that VUV-ECD spectroscopy is a useful tool for characterizing the equilibrium structures of monosaccharides.

Journal of Physical Chemistry A published new progress about Circular dichroism. 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Application In Synthesis of 492-62-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ren, Cheng; Fang, Runxing; Yu, Xiaochun; Wang, Shun published the artcile< A highly efficient reusable homogeneous copper catalyst for the selective aerobic oxygenation of sulfides to sulfoxides>, Recommanded Product: 2-(Phenylthio)ethanol, the main research area is sulfoxide preparation green chem; sulfide aerobic oxidation copper catalyst.

Readily available copper showed efficient activity and great selectivity for the homogeneous catalysis of oxidation of sulfides to sulfoxides using mol. oxygen as the oxidant. The reaction proceeds under mild conditions in the presence of a catalytic amount of TEMPO. Importantly, the catalysts could be conveniently recovered and reused. And this methodol. was proved to be applicable for the transformation of various aromatic and aliphatic sulfides into the corresponding sulfoxides with high conversion and high selectivity.

Tetrahedron Letters published new progress about Green chemistry. 699-12-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H10OS, Recommanded Product: 2-(Phenylthio)ethanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Abdullayev, Yusif; Ahmadov, Orkhan; Valadova, Gunay; Karimli, Ayan; Autschbach, Jochen published the artcile< Unveiling the catalytic effects of Bronsted acidic ionic liquid on quantitative α-glucose conversion to 5-HMF: Experimental and computational studies>, Synthetic Route of 492-62-6, the main research area is glucose Bronsted acidic ionic liquid dehydration mechanism.

Effective biomass conversion to 5-HMF(5-hydroxymethylfurfural) is still a challenge and needs to be improved because of the 5-HMF importance as building blocks for valuable monomers and fuel precursors. We suggest for the first time utilization of low-cost metal-free Bronsted acidic Ionic liquid (IL) N,N-Diethyl-1,4-phenylenediamine hydrogen sulfate, [DPhDA]HSO4 as a catalyst for the α-glucose dehydration to 5-HMF. Quant. α-glucose conversion is achieved via optimizing the reaction condition: 91.4% 5-HMF yield with 30 mol% [DPhDA]HSO4 in the presence of DMSO as a solvent at 160°C in 30 min (TOF 6.1 h-1). 3-fold increase in reaction time leads to higher (94%) 5-HMF yield at 160°C with lower TOF 1.6 h-1. The IL surprising catalytic performance is scrutinized with its amphiprotic nature (availability of basic and acidic spots in its structure (Fig. 1)). Further computational mechanistic studies revealed the function of the catalytic sites in the α-glucose dehydration. We calculated five-membered ring formation and water extrusion in one concerted transition state (TS2A, ΔG‡ = 38.8 kcal/mol) following the α-glucose ring-opening (TS1, ΔG‡ = 20.4 kcal/mol). Further four steps (sp3-s, C-H bond cleavages (TS3, TS6) and dehydroxylation (TS4A, TS5)) are quite straightforward to reach the product (5-HMF).

Renewable Energy published new progress about Dehydration reaction. 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Synthetic Route of 492-62-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Nuerxiati, Rehebati; Abuduwaili, Aytursun; Mutailifu, Paiheerding; Wubulikasimu, Atikan; Rustamova, Nigora; Cui, Jingxue; Aisa, Haji Akber; Yili, Abulimiti published the artcile< Optimization of ultrasonic-assisted extraction, characterization and biological activities of polysaccharides from Orchis chusua D. Don (Salep)>, SDS of cas: 3458-28-4, the main research area is polysaccharide Orchis chusua biol activity ultrasonic assisted extraction; Biological activity; Characterization; Optimization; Orchis chusua D. Don polysaccharide; Ultrasonic-assisted extraction.

In the present study, ultrasonic-assisted extraction (UAE) of polysaccharides from Orchis chusua D. Don (salep) was optimized by response surface methodol. (RSM) combined with a Box-Behnken design (BBD), the optimum conditions were determined to be: ultrasonic power of 390 W, extraction temperature of 60°C, extraction time of 50 min and water/raw material ratio of 40 mL/g. Based on it, 48.30 ± 0.6% yield of crude polysaccharide was obtained. After purification, the chem. compositions, physicochem. and structural property was investigated based on the GC-MS, TGA, XRD, SEM and Congo red test. The results showed that USP-U and USP-N were hetero-polysaccharides, mainly composed of mannose and glucose, and the average mol. weight was 25.57 kDa and 11.64 kDa, resp. FT-IR spectra and NMR results indicated that the presence of a-linkage glycopyranose via typical peaks. Furthermore, reducing power and antioxidant activities of both purified fractions showed a relatively high ability to scavenge free radicals. Lastly, the cytotoxicity assay showed that purified polysaccharides have no obvious cytotoxicity against RAW267.4 and L6 cells at their effective concentration and had potent anti-inflammatory activity in a concentration-dependent manner. Salep polysaccharide is expected to be developed as a new efficacy factor in the pharmaceutical and food industry.

International Journal of Biological Macromolecules published new progress about Composition. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, SDS of cas: 3458-28-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Han, Yuanji; Wang, Hongyun; Wang, Xiaodan; Li, Ke; Dong, Meifang; Li, Yong; Zhu, Qian; Shang, Fude published the artcile< Mechanism of floral scent production in Osmanthus fragrans and the production and regulation of its key floral constituents, β-ionone and linalool>, Name: 3,7-Dimethylocta-1,6-dien-3-ol, the main research area is transcriptome beta ionone linalool floral scent Osmanthus; Plant morphogenesis; Secondary metabolism; Transcriptional regulatory elements.

Sweet osmanthus (Osmanthus fragrans Lour.) is among the top ten most well-known flowers in China and is recognized as both an aromatic plant and ornamental flower. Here, manual sectioning, SEM, and transmission electron microscopy of sweet osmanthus petals revealed that large amounts of lipids are present inside the petal cells and on the cell surfaces. However, no secretory structures were observed Instead, the petal cells protrude slightly outward, and the surfaces of the cells are adorned with highly regular brush-shaped hairs. The surfaces of the ‘Yingui’ petals possessed mostly curled and more numerous hairs, whereas the ‘Dangui’ petals possessed fewer brush-shaped and more sparsely arranged hairs. In addition, many granular substances were attached to the brush-shaped hairs, and the granules were denser on the hairs of the ‘Yingui’ petals compared to the hairs on the ‘Dangui’ petals. Furthermore, 35 aromatic components in the ‘Yingui’ petals and 30 aromatic components in the ‘Dangui’ petals were detected via GC-MS. The main aromatic component of the ‘Yingui’ petals was β-ionone, whereas that of the ‘Dangui’ petals was linalool and its oxides. Transcriptome sequencing and qRT-PCR indicated that the high β-ionone content in the ‘Yingui’ petals was due to the overexpression of CCD1 and CCD4 and that the high linalool content in the ‘Dangui’ petals was due to the overexpression of MECS, HDR, IDI1, and LIS1, which function upstream of the linalool synthetic pathway. In particular, the expression levels of CCD4 and LIS1 were upregulated by 5.5- and 5.1-fold in the ‘Yingui’ and ‘Dangui’ petals, resp. One transcription factor (ERF61) was cloned and named, and the expression pattern of ERF61 in sweet osmanthus petals was found to be generally consistent with that of CCD4. Tobacco transformation experiments, yeast one-hybrid experiments, and electrophoretic mobility shift assays indicated that ERF61 binds to the CCD4 promoter and stimulates CCD4 expression, thereby regulating the synthesis of β-ionone in sweet osmanthus petals.

Horticulture Research published new progress about Flower petal. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Name: 3,7-Dimethylocta-1,6-dien-3-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Barre, Annick; Bourne, Yves; Van Damme, Els J. M.; Rouge, Pierre published the artcile< Overview of the structure-function relationships of mannose-specific lectins from plants, algae and fungi>, Formula: C6H12O6, the main research area is review Araucaria Phlebodium mannose lectin; function; fungi; lectin; mannose-binding specificity; plant; structure; use as tools.

To date, a number of mannose-binding lectins have been isolated and characterized from plants and fungi. These proteins are composed of different structural scaffold structures which harbor a single or multiple carbohydrate-binding sites involved in the specific recognition of mannose-containing glycans. Generally, the mannose-binding site consists of a small, central, carbohydrate-binding pocket responsible for the “”broadsugar-binding specificity”” toward a single mannose mol., surrounded by a more extended binding area responsible for the specific recognition of larger mannose-containing N-glycan chains. Accordingly, the mannose-binding specificity of the so-called mannose-binding lectins towards complex mannose-containing N-glycans depends largely on the topog. of their mannose-binding site(s). This structure-function relationship introduces a high degree of specificity in the apparently homogeneous group of mannose-binding lectins, with respect to the specific recognition of high-mannose and complex N-glycans. Because of the high specificity towards mannose these lectins are valuable tools for deciphering and characterizing the complex mannose-containing glycans that decorate both normal and transformed cells, e.g., the altered high-mannose N-glycans that often occur at the surface of various cancer cells.

International Journal of Molecular Sciences published new progress about Araucaria brasiliana Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Formula: C6H12O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts