Rubel Mozumder, N H M’s team published research in Applied Biological Chemistry in 2020-12-31 | 492-62-6

Applied Biological Chemistry published new progress about Camellia sinensis. 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Electric Literature of 492-62-6.

Rubel Mozumder, N. H. M.; Lee, Yeong-Ran; Hwang, Kyeong Hwan; Lee, Min-Seuk; Kim, Eun-Hee; Hong, Young-Shick published the artcile< Characterization of tea leaf metabolites dependent on tea (Camellia sinensis) plant age through 1H NMR-based metabolomics>, Electric Literature of 492-62-6, the main research area is Camellia sinensis tea leaf metabolite.

Abstract: The chem. or metabolic compositions of tea (Camellia sinensis) varies according to numerous factors, such as geog. origin, cultivar, climate, plucking position, and horticultural practices. However, how the age of tea plants affects the metabolite compositions of tea leaves has not been reported yet. Therefore, we extended the metabolomic approach to the investigation of the age-related differences of tea leaf metabolites in the fresh leaves collected from tea plants aged 8 and 25 years. Multivariate statistical anal. with comprehensive metabolite profiles analyzed by 1H NMR spectroscopy showed the clear metabolic differentiation between the fresh tea leaves from different ages of the tea plants. Of the various tea leaf metabolites varied according to the age of the tea plants, theanine, glutamine, catechin, and gallocatechin were uniquely dependent on the age of tea plants, demonstrating a difference of theanine metabolism between young and old tea plants. These results suggest that leaves from 25-yr-old tea plants would still be worthy as a functional ingredient for the production in the food or cosmetic industry rather than quality-enhanced tea infusions for human consumption.

Applied Biological Chemistry published new progress about Camellia sinensis. 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Electric Literature of 492-62-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Congqiang’s team published research in Communications Biology in 2021-12-31 | 78-70-6

Communications Biology published new progress about 78-70-6. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Application In Synthesis of 78-70-6.

Zhang, Congqiang; Chen, Xixian; Lee, Raphael Tze Chuen; T, Rehka; Maurer-Stroh, Sebastian; Ruhl, Martin published the artcile< Bioinformatics-aided identification, characterization and applications of mushroom linalool synthases>, Application In Synthesis of 78-70-6, the main research area is .

Abstract: Enzymes empower chem. industries and are the keystone for metabolic engineering. For example, linalool synthases are indispensable for the biosynthesis of linalool, an important fragrance used in 60-80% cosmetic and personal care products. However, plant linalool synthases have low activities while expressed in microbes. Aided by bioinformatics anal., four linalool/nerolidol synthases (LNSs) from various Agaricomycetes were accurately predicted and validated exptl. Furthermore, we discovered a linalool synthase (Ap.LS) with exceptionally high levels of selectivity and activity from Agrocybe pediades, ideal for linalool bioprodn. It effectively converted glucose into enantiopure (R)-linalool in Escherichia coli, 44-fold and 287-fold more efficient than its bacterial and plant counterparts, resp. Phylogenetic anal. indicated the divergent evolution paths for plant, bacterial and fungal linalool synthases. More critically, structural comparison provided catalytic insights into Ap. LS superior specificity and activity, and mutational experiments validated the key residues responsible for the specificity.

Communications Biology published new progress about 78-70-6. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Application In Synthesis of 78-70-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Mashhoori, Mahboobeh-Sadat’s team published research in Polycyclic Aromatic Compounds in 2022 | 699-12-7

Polycyclic Aromatic Compounds published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 699-12-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H10OS, Quality Control of 699-12-7.

Mashhoori, Mahboobeh-Sadat; Sandaroos, Reza; Zeraatkar Moghaddam, Ali published the artcile< Design of a New Poly Imidazolium-Tagged Cobalt (II) Schiff Base Complex for Selective Oxidation of Alcohols and Sulfides in a Water Solvent>, Quality Control of 699-12-7, the main research area is polyimidazolium tagged cobalt Schiff base complex catalyst; alc sulfide selective oxidation.

In this study, a new catalyst including polymeric imidazolium ionic liquid functionalized Cobalt (II) Schiff base complex [PIL-SB-Co (II)] was prepared and characterized using various analyses like FT-IR, H-NMR, FE-SEM, Energy-dispersive X-ray, thermogravimetric anal., and ICP-OES. Then, its catalytic activity was studied in oxidation reaction of sulfides and alcs. This polymeric heterogeneous catalyst can catalyze the oxidation reactions in water as a green solvent, and mild conditions (room temperature) with good to excellent yields of sulfoxides, aldehydes, and ketones as worthwhile and critical products. First preparation and characterization of poly ionic liquid functionalized Co (II) Schiff base catalyst. First oxidation reaction of sulfides and alcs. catalyzed by polymeric ionic liquid Schiff base complex. Oxidation reaction of sulfides and alcs. to sulfoxides and aldehydes and ketones in water as a green solvent and room temperature Reusable catalyst at least for five runs.

Polycyclic Aromatic Compounds published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 699-12-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H10OS, Quality Control of 699-12-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Oner, Z’s team published research in Human & Experimental Toxicology in 2019-07-31 | 78-70-6

Human & Experimental Toxicology published new progress about Apoptosis. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Related Products of 78-70-6.

Oner, Z.; Altinoz, E.; Elbe, H.; Ekinci, N. published the artcile< The protective and therapeutic effects of linalool against doxorubicin-induced cardiotoxicity in Wistar albino rats>, Related Products of 78-70-6, the main research area is linalool doxorubicin cardiotoxicity therapeutics; Doxorubicin; MDA; cardiotoxicity; caspase-3; linalool; oxidative stress.

The aim of the present study was to determine the protective and therapeutic effects of linalool (LIN) against doxorubicin (DOX)-induced cardiotoxicity in rats histol. and biochem. In experiments, 64 male Wistar albino rats were randomly divided into eight groups (n = 8). These groups were control (C) (0.9% saline solution), DOX (20 mg/kg DOX), LIN50 (50 mg/kg LIN), LIN100 (100 mg/kg LIN), DOX + LIN50 (20 mg/kg DOX and 50 mg/kg LIN), DOX + LIN100 (20 mg/kg DOX and 100 mg/kg LIN), LIN50 + DOX (50 mg/kg LIN and 20 mg/kg DOX), and LIN100 + DOX (100 mg/kg LIN and 20 mg/kg DOX). It was determined that histopathol. changes significantly decreased in groups treated with LIN after DOX administration. While the caspase-3 immunostaining was highly evident in DOX group apoptotic cells (p < 0.001, for all), the intensity of caspase-3 immunostaining in the treatment groups decreased (p < 0.05). While DOX administration resulted in a significant increase in malondialdehyde (MDA) levels and plasma Creatine kinase (CK) and lactate dehydrogenase (LDH) levels in cardiac tissue when compared to the C groups, it was observed that DOX + LIN administration led to a significant decrease in MDA, plasma CK and LDH levels and a significant increase in glutathione (GSH), superoxide dismutase, and catalase enzyme levels. Finally, it was concluded that DOX led to heavy cardiotoxicity and DOX + LIN administration could remove cardiomyopathy symptoms. Human & Experimental Toxicology published new progress about Apoptosis. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Related Products of 78-70-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ota, Eisuke’s team published research in Journal of the American Chemical Society in 2019-01-30 | 167938-56-9

Journal of the American Chemical Society published new progress about C-C bond cleavage (photo-). 167938-56-9 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H17NO3, Synthetic Route of 167938-56-9.

Ota, Eisuke; Wang, Huaiju; Frye, Nils Lennart; Knowles, Robert R. published the artcile< A Redox Strategy for Light-Driven, Out-of-Equilibrium Isomerizations and Application to Catalytic C-C Bond Cleavage Reactions>, Synthetic Route of 167938-56-9, the main research area is light driven redox neutral isomerization cyclic aliphatic alc; linear carbonyl compound preparation out of equilibrium isomerization.

We report a general protocol for the light-driven isomerization of cyclic aliphatic alcs. to linear carbonyl compounds These reactions proceed via proton-coupled electron-transfer activation of alc. O-H bonds followed by subsequent C-C β-scission of the resulting alkoxy radical intermediates. In many cases, these redox-neutral isomerizations proceed in opposition to a significant energetic gradient, yielding products that are less thermodynamically stable than the starting materials. A mechanism is presented to rationalize this out-of-equilibrium behavior that may serve as a model for the design of other contrathermodynamic transformations driven by excited-state redox events.

Journal of the American Chemical Society published new progress about C-C bond cleavage (photo-). 167938-56-9 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H17NO3, Synthetic Route of 167938-56-9.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Malerz, Sebastian’s team published research in Journal of Physical Chemistry A in 2021-08-19 | 492-62-6

Journal of Physical Chemistry A published new progress about Acidity (pKa). 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Reference of 492-62-6.

Malerz, Sebastian; Mudryk, Karen; Tomanik, Lukas; Stemer, Dominik; Hergenhahn, Uwe; Buttersack, Tillmann; Trinter, Florian; Seidel, Robert; Quevedo, Wilson; Goy, Claudia; Wilkinson, Iain; Thuermer, Stephan; Slavicek, Petr; Winter, Bernd published the artcile< Following in Emil Fischer's Footsteps: A Site-Selective Probe of Glucose Acid-Base Chemistry>, Reference of 492-62-6, the main research area is site selective probe glucose acid base chem.

Liquid-jet photoelectron spectroscopy was applied to determine the first acid dissociation constant (pKa) of aqueous-phase glucose while simultaneously identifying the spectroscopic signature of the resp. deprotonation site. Valence spectra from solutions at pH values below and above the first pKa reveal a change in glucose’s lowest ionization energy upon the deprotonation of neutral glucose and the subsequent emergence of its anionic counterpart. Site-specific insights into the solution-pH-dependent mol. structure changes are also shown to be accessible via C 1s photoelectron spectroscopy. The spectra reveal a considerably lower C 1s binding energy of the carbon site associated with the deprotonated hydroxyl group. The occurrence of photoelectron spectral fingerprints of cyclic and linear glucose prior to and upon deprotonation are also discussed. The exptl. data are interpreted with the aid of electronic structure calculations Our findings highlight the potential of liquid-jet photoelectron spectroscopy to act as a site-selective probe of the mol. structures that underpin the acid-base chem. of polyprotic systems with relevance to environmental chem. and biochem.

Journal of Physical Chemistry A published new progress about Acidity (pKa). 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Reference of 492-62-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Feng, Zhihui’s team published research in Food Chemistry in 2019-07-01 | 78-70-6

Food Chemistry published new progress about Odor and Odorous substances. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Electric Literature of 78-70-6.

Feng, Zhihui; Li, Yifan; Li, Ming; Wang, Yijun; Zhang, Liang; Wan, Xiaochun; Yang, Xiaogen published the artcile< Tea aroma formation from six model manufacturing processes>, Electric Literature of 78-70-6, the main research area is tea aroma formation processing; Aroma character impact; Precursors; Quantitative SPME; Tea aroma; Tea processing; Tea types; Volatiles.

Tea aroma is determined by the nature of the plant, the production processes, and many other factors influencing its formation and release. The objective of this study was to investigate the impact of manufacturing processes on the aroma composition of tea. Fresh tea leaves from the same cultivar and growing area were selected for producing the six types of tea: green, white, yellow, oolong, black, and dark teas. Comprehensive anal. by gas chromatog. mass spectrometry (GC/MS) was performed for the volatiles of tea infusion, prepared by solid-phase microextraction (SPME), solid-phase extraction (SPE), and solvent assisted flavor evaporation (SAFE). A total of 168 volatile compounds were identified. Black tea has the highest volatile concentration of 710 μg/g, while green tea has the lowest concentration of 20 μg/g. Significantly affected by these processes, tea aroma mols. are formed mainly from four precursor groups: carotenoids, fatty acids, glycosides, and amino acids/sugars.

Food Chemistry published new progress about Odor and Odorous substances. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Electric Literature of 78-70-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Xu, Xiaotong’s team published research in Science of the Total Environment in 2020-08-10 | 492-62-6

Science of the Total Environment published new progress about Biopolymers Role: OCU (Occurrence, Unclassified), RCT (Reactant), OCCU (Occurrence), RACT (Reactant or Reagent) (soluble microbial products and loose- and tightly-bound). 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Quality Control of 492-62-6.

Xu, Xiaotong; Zhang, Hanmin; Gao, Tianyu; Wang, Yuezhu; Teng, Jiaheng; Lu, Mengyang published the artcile< Customized thin and loose cake layer to mitigate membrane fouling in an electro-assisted anaerobic forward osmosis membrane bioreactor (AnOMEBR)>, Quality Control of 492-62-6, the main research area is electro assisted anaerobic forward osmosis membrane bioreactor wastewater treatment; customized thin loose cake layer mitigation membrane fouling; AnOMEBR; Electro-assisted; Electrostatic repulsion; Membrane fouling alleviation; Membrane surface charge.

An anaerobic forward osmosis (FO) membrane bioreactor (AnOMBR) is a potential wastewater treatment technol. with low energy consumption and high effluent quality; however, membrane fouling remains a considerable problem which causes water flux dwindling and shortened membrane lifetime. An electro-assisted, anaerobic forward osmosis membrane bioreactor (AnOMEBR) was developed to treat wastewater and mitigate membrane fouling, where the conductive FO membrane was used as the separation unit and cathode. Formation, development, and alleviation of membrane fouling in AnOMEBR were assessed. Results showed the soluble microbial products content and protein/polysaccharide (PN/PS) value in AnOMEBR were 26 and 15% lower than that in AnOMBR, resp. The sludge mixture absolute zeta value in AnOMEBR was 1.2 times that of AnOMBR. Increased interaction between the membrane surface and neg. charged foulants could inhibit foulant adsorption on the membrane surface in the initial membrane fouling stage. The strong interaction among foulants further affected the composition, structure, and thickness of the FO membrane surface cake layer. AnOMEBR with a shorter hydraulic retention time, higher organic loading rate, and a lower osmotic pressure difference, could still obtain a lower flux decline rate (0.063 LMH/h), 35.7% lower than AnOMBR. The AnOMEBR wastewater treatment capacity was nearly 1.5 times that of AnOMBR. Results provided an efficient strategy to mitigate membrane fouling and improve wastewater treatment capacity.

Science of the Total Environment published new progress about Biopolymers Role: OCU (Occurrence, Unclassified), RCT (Reactant), OCCU (Occurrence), RACT (Reactant or Reagent) (soluble microbial products and loose- and tightly-bound). 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Quality Control of 492-62-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Qiao, Wanjin’s team published research in Microbial Cell Factories in 2020-12-31 | 492-62-6

Microbial Cell Factories published new progress about Carbohydrates Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Electric Literature of 492-62-6.

Qiao, Wanjin; Qiao, Yu; Liu, Fulu; Zhang, Yating; Li, Ran; Wu, Zhenzhou; Xu, Haijin; Saris, Per Erik Joakim; Qiao, Mingqiang published the artcile< Engineering Lactococcus lactis as a multi-stress tolerant biosynthetic chassis by deleting the prophage-related fragment>, Electric Literature of 492-62-6, the main research area is proteomics rpsN rplR lysozyme carbohydrate Lactococcus; Genome editing; Lactococcus lactis; Multi-stress tolerance; Nisin immunity; Nisin yield; Prophage-related fragment; TMT quantitative proteomics.

In bioengineering, growth of microorganisms is limited because of environmental and industrial stresses during fermentation This study aimed to construct a nisin-producing chassis Lactococcus lactis strain with genome-streamlined, low metabolic burden, and multi-stress tolerance characteristics. The Cre-loxP recombination system was applied to reduce the genome and obtain the target chassis strain. A prophage-related fragment (PRF; 19,739 bp) in the L. lactis N8 genome was deleted, and the mutant strain L. lactis N8-1 was chosen for multi-stress tolerance studies. Nisin immunity of L. lactis N8-1 was increased to 6500 IU/mL, which was 44.44% higher than that of the wild-type L. lactis N8 (4500 IU/mL). The survival rates of L. lactis N8-1 treated with lysozyme for 2 h and lactic acid for 1 h were 1000- and 10,000-fold higher than that of the wild-type strain, resp. At 39°C, the L. lactis N8-1 could still maintain its growth, whereas the growth of the wild-type strain dramatically dropped. SEM showed that the cell wall integrity of L. lactis N8-1 was well maintained after lysozyme treatment. Tandem mass tags labeled quant. proteomics revealed that 33 and 9 proteins were significantly upregulated and downregulated, resp., in L. lactis N8-1. These differential proteins were involved in carbohydrate and energy transport/metabolism, biosynthesis of cell wall and cell surface proteins. PRF deletion was proven to be an efficient strategy to achieve multi-stress tolerance and nisin immunity in L. lactis, thereby providing a new perspective for industrially obtaining engineered strains with multi-stress tolerance and expanding the application of lactic acid bacteria in biotechnol. and synthetic biol. Besides, the importance of PRF, which can confer vital phenotypes to bacteria, was established.

Microbial Cell Factories published new progress about Carbohydrates Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Electric Literature of 492-62-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Arora, Sanjay’s team published research in Molecular Pharmaceutics in 2021-02-01 | 3458-28-4

Molecular Pharmaceutics published new progress about Alzheimer disease. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Reference of 3458-28-4.

Arora, Sanjay; Layek, Buddhadev; Singh, Jagdish published the artcile< Design and Validation of Liposomal ApoE2 Gene Delivery System to Evade Blood-Brain Barrier for Effective Treatment of Alzheimer′s Disease>, Reference of 3458-28-4, the main research area is apolipoprotein E2 gene therapy brain Alzheimer disease liposome; Alzheimer’s disease; Apolipoprotein; cell penetrating peptides; glucose transporter; liposomes.

Targeting gene-based therapeutics to the brain is a strategy actively sought to treat Alzheimer′s disease (AD). Recent findings discovered the role of apolipoprotein E (ApoE) isoforms in the clearance of toxic amyloid beta proteins from the brain. ApoE2 isoform is beneficial for preventing AD development, whereas ApoE4 is a major contributing factor to the disease. In this paper, we demonstrated efficient brain-targeted delivery of ApoE2 encoding plasmid DNA (pApoE2) using glucose transporter-1 (glut-1) targeted liposomes. Liposomes were surface-functionalized with a glut-1 targeting ligand mannose (MAN) and a cell-penetrating peptide (CPP) to enhance brain-targeting and cellular internalization, resp. Among various CPPs, rabies virus glycoprotein peptide (RVG) or penetratin (Pen) was selected as a cell-penetration enhancer. Dual (RVGMAN and PenMAN)-functionalized liposomes were cytocompatible at 100 nM phospholipid concentration and demonstrated significantly higher expression of ApoE2 in bEnd.3 cells, primary neurons, and astrocytes compared to monofunctionalized and unmodified (plain) liposomes. Dual-modified liposomes also showed ~2 times higher protein expression than other formulation controls in neurons cultured below the in vitro BBB model. These results translated well to in vivo efficacy study with significantly higher transfection of pApoE2 in the C57BL/6 mice brain following single tail vein administration of RVGMAN and PenMAN functionalized liposomes without any noticeable signs of toxicity. These results illustrate the potential of surface-modified liposomes for safe and brain-targeted delivery of the pApoE2 gene for effective AD therapy.

Molecular Pharmaceutics published new progress about Alzheimer disease. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Reference of 3458-28-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts