Tag: M.W=150-200

Hatzfeld, Jana; Skowaisa, Steffen; Jackel, Elisabeth; Kaufmann, Julia; Haak, Edgar published the artcile< Triaminocyclopentadienyl Ruthenium Complexes - New Catalysts for Cascade Conversions of Propargyl Alcohols>, Related Products of 4396-13-8, the main research area is triaminocyclopentadienyl ruthenium complex preparation catalyst cascade conversion propargyl alc; cycloaddition catalyst triaminocyclopentadienyl ruthenium complex preparation ketolactone phloroglucinol; cyclopentadienyl ligands; heterocycles; homogeneous catalysis; ruthenium; terpenoids.

Various triaminocyclopentadienyl ruthenium complexes have been synthesized from Ru3(CO)12. The new complexes were tested for their ability to catalyze cascade conversions of propargyl alcs. Their associated catalytic activities complement the activities of known diaminocyclopentadienone ruthenium complexes. In particular, the substrate scope of catalytic cycloadditions with 3-ketolactones or phloroglucinol derivatives is extended to terpenoid-derived propargyl alcs. containing an internal alkyne moiety. A wide range of cyclic terpenoid and phloroglucinol adducts are obtained by complementary application of both types of catalysts.

Chemistry – A European Journal published new progress about Alcohols, propargyl Role: RCT (Reactant), RACT (Reactant or Reagent). 4396-13-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H6O5, Related Products of 4396-13-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Mohamed, Maged E.; Abduldaium, Yamen S.; Younis, Nancy S. published the artcile< Ameliorative effect of linalool in cisplatin-induced nephrotoxicity: the role of HMGB1/TLR4/NF-κB and Nrf2/HO1 pathways>, Safety of 3,7-Dimethylocta-1,6-dien-3-ol, the main research area is linalool cisplatin induced nephrotoxicity ameliorative effect; apoptosis; essential oil; human cell line cytotoxicity; monoterpenes; oxidative stress; toll-like receptors.

The monoterpene linalool is a well-known essential oil component produced by several aromatic plants. Cisplatin is a widely used anticancer drug that produces many side effects, particularly nephrotoxicity. Here, we aimed to inspect linalool′s protective activity against cisplatin-induced nephrotoxicity and explore part of the underlying mechanisms. Male Wistar rats were given linalool (50 and 100 mg/kg/day orally) for 15 days; then challenged with cisplatin (8 mg/kg) on the 12th day. Renal function parameters, oxidative stress, inflammatory and apoptotic markers, and toll-like receptor pathway gene, and protein expressions were investigated. Histopathol., immunohistochem., and cell-line mediated cytotoxicity assays were conducted. Linalool ameliorated kidney function after cisplatin challenge and managed all oxidation system parameters including GSH, SOD, CAT, MDA, NADPH, and particularly the Nrf2-mediated pathway markers. Linalool decreased TLR4, MYD88 and TRIF gene and protein expressions; diminished related inflammatory mediators such as TNF-α, IL-1β, IL-6, and NF-κB; and down-regulated HMBG1. Linalool mitigated cisplatin-induced apoptotic markers such as caspase 3, caspase 9, and Bax expression, and boosted the anti-apoptotic Bcl2 expression. Linalool potentiated the cytotoxic effect of cisplatin when investigated on HeLa and PC3 human cancer cell lines. Linalool could protect against cisplatin-induced kidney function and tissue damage.

Biomolecules published new progress about Animal gene Role: BSU (Biological Study, Unclassified), PRP (Properties), BIOL (Biological Study) (Bax). 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Safety of 3,7-Dimethylocta-1,6-dien-3-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Jia, Rui-Bo; Wu, Juan; Li, Zhao-Rong; Ou, Zhi-Rong; Zhu, Qiyuan; Sun, Baoguo; Lin, Lianzhu; Zhao, Mouming published the artcile< Comparison of physicochemical properties and antidiabetic effects of polysaccharides extracted from three seaweed species>, Electric Literature of 3458-28-4, the main research area is Ascophyllum Fucus Undaria diabetes polysaccharide physicochem property antidiabetic; Algal polysaccharides; Antidiabetic effects; Structural characterization.

Three algae polysaccharides (APs) extracted from Ascophyllum nodosum (ANP), Fucus vesiculosus (FVP) and Undaria Pinnatifida (USP) significantly differed in the zeta potential, water and oil holding capacity, monosaccharide composition, organic element composition, mol. weight distribution, microstructure and rheol. properties. Antidiabetic effects of APs were compared by oral intervention at the dose of 400 mg/kg·body weight/day in high sugar and fat diets and streptozotocin injection induced type 2 diabetic rats. The anal. of body weight, water intake, fasting blood glucose, insulin, oral glucose tolerance, blood lipid indicators (including total cholesterol (TC), triglyceride (TG), low d. lipoprotein cholesterol (LDL-C) and free fatty acid (FFA)), liver function indexes (involving alanine aminotransferase (ALT) and aspartate aminotransferase (AST)) and renal function profiles (comprising uric acid (UA) and urea nitrogen (BUN)) showed that APs possessed obvious antidiabetic activities, and FVP showed better effects in controlling the levels of FFA, AST, ALT, UA and BUN. Intervention of FVP reduced the total bile acid (TBA) level and elevated high d. lipoprotein cholesterol (HDL-C) level of diabetic rats. Histomorphol. observation further demonstrated that APs, especially FVP, could attenuate liver and kidney damage caused by diabetes. This study concluded that the antidiabetic effects of ANP, FVP and USP were distinctly different, which might be attributed to their different chem. structures. Therefore, the structure-activity relationship and antidiabetic mechanism of APs will be our future research direction.

International Journal of Biological Macromolecules published new progress about Antidiabetic agents. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Electric Literature of 3458-28-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Xiao, Heng; Chen, Chun; Li, Chao; Huang, Qiang; Fu, Xiong published the artcile< Physicochemical characterization, antioxidant and hypoglycemic activities of selenized polysaccharides from Sargassum pallidum>, Electric Literature of 3458-28-4, the main research area is Sargassum selenium polysaccharide physicochem antioxidant hypoglycemic; Antioxidant; Hypoglycemic; Polysaccharide; Selenylation; Structure.

This study was carried out to study the effects of selenylation on physicochem. and biol. properties of polysaccharide (SPP) extracted from Sargassum pallidum. The selenized derivative of SPP (Se-SPP) with the selenium content of 2419 μg/g was synthesized by sodium selenite/dilute nitric acid method. Physicochem. characterization indicated that selenylation modification resulted in some changes in chem. composition, monosaccharide composition, mol. weight and surface morphol. of polysaccharides. FT-IR spectroscopy showed that a new absorption peak appeared at 675 cm-1 in Se-SPP probably due to the substitution of selenyl groups. Bioactivity assay showed that Se-SPP exhibited higher scavenging radical activities and ferrous ion chelating activities than native SPP. Compared with SPP and acarbose, Se-SPP showed more significantly inhibitory effect on α-glucosidase activity in a noncompetitive inhibition type. The IC50 values of SPP, Se-SPP and acarbose were determined as 1.579, 0.896 and 2.742 mg/mL, resp. These results suggest that Se-SPP can be used to develop a new selenium-complementary ingredient in functional foods.

International Journal of Biological Macromolecules published new progress about Antidiabetic agents. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Electric Literature of 3458-28-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Torretta, Simone; Scagliola, Alessandra; Ricci, Luisa; Mainini, Francesco; Di Marco, Sabrina; Cuccovillo, Ivan; Kajaste-Rudnitski, Anna; Sumpton, David; Ryan, Kevin M.; Cardaci, Simone published the artcile< D-mannose suppresses macrophage IL-1β production>, Formula: C6H12O6, the main research area is mannose macrophage IL1beta production.

D-mannose is a monosaccharide approx. a hundred times less abundant than glucose in human blood. Previous studies demonstrated that supraphysiol. levels of D-mannose inhibit tumor growth and stimulate regulatory T cell differentiation. It is not known whether D-mannose metabolism affects the function of non-proliferative cells, such as inflammatory macrophages. Here, we show that D-mannose suppresses LPS-induced macrophage activation by impairing IL-1β production In vivo, mannose administration improves survival in a mouse model of LPS-induced endotoxemia as well as decreases progression in a mouse model of DSS-induced colitis. Phosphomannose isomerase controls response of LPS-activated macrophages to D-mannose, which impairs glucose metabolism by raising intracellular mannose-6-phosphate levels. Such alterations result in the suppression of succinate-mediated HIF-1α activation, imposing a consequent reduction of LPS-induced Il1b expression. Disclosing an unrecognized metabolic hijack of macrophage activation, our study points towards safe D-mannose utilization as an effective intervention against inflammatory conditions.

Nature Communications published new progress about Animal gene, IL1B Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Formula: C6H12O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Shengnan; Zhao, Lingling; Li, Qinghua; Liu, Chang; Han, Jinlian; Zhu, Lijie; Zhu, Danshi; He, Yutang; Liu, He published the artcile< Rheological properties and chain conformation of soy hull water-soluble polysaccharide fractions obtained by gradient alcohol precipitation>, Synthetic Route of 3458-28-4, the main research area is soy hull water soluble polysaccharide rheol gradient alc precipitation.

In this study, we aim to reveal the properties of different fractions of soy hull soluble polysaccharide (SHSP) derived by alc. precipitation and the related mechanism. Three fractions were obtained, designated as SHSP20, SHSP40 and SHSP60; every fraction has its advantage(s). The mol. weight, monosaccharide composition, functional groups, morphol., and other rheol. properties of all SHSP fractions were investigated. The results showed that SHSP20 and SHSP40 accounted for 74.3% of soy hull soluble polysaccharide. FTIR spectrum confirmed the presence of uronic acid and protein in SHSP fractions. Also, the mol. weight of the polysaccharide fractions varied from 124.21 to 381.83 kDa. GC anal. indicated that mannose, galacturonic acid, and galactose were the main monosaccharide components of all the SHSP fractions. However, the monosaccharide types and ratios of the three SHSP fractions are significantly different. Furthermore, shear thinning behavior of SHSPs solution was observed SHSP40 exhibited the highest viscosity among samples tested. Atomic force microscopy further confirmed the various morphologies of SHSP fractions. The results suggest that SHSPs obtained by gradient alc. precipitation have different molar masses and chain conformations.

Food Hydrocolloids published new progress about Cell morphology. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Synthetic Route of 3458-28-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Qiu, Lin; Xiao, Chao-Jiang; Shen, Yi; Xu, Wei; Liu, Xiao-Bo; Dong, Xiang; Jiang, Bei published the artcile< Bioactive hydroxypropionylated glucose derivatives from Astragalus bhotanensis>, Reference of 492-62-6, the main research area is hydroxypropionylated glucose derivative isolation Astragalus bhotanensis pharmacodynamics; Astragalus bhotanensis; Leguminosae; analgesic; antioxidant; cytotoxicity; hydroxypropionylated glucose derivatives.

Four previously undescribed hydroxypropionylated D-glucose derivatives, astrabhotins A-D, along with ten known compounds α-D-glucose, β-D-glucose, quebrachitol, 3-hydroxypropionic acid, oleic acid, isoliquiritigenin, liquiritigenin, odoratin, 7β-hydroxysitosterol and daucosterol, were isolated from the roots of Astragalus bhotanensis. Their structures were elucidated based on the analyses of extensive spectroscopic data and physicochem. properties. Astrabhotin A reduced the writhing response remarkably with 52.5% inhibition by acetic acid induced writhing test. The analgesic effect of was stronger than the standard drug aspirin. In addition, compounds and showed significant antioxidant activities with IC50 values of 9.9 ± 0.2 and 7.9 ± 0.4 μg/mL, and exhibited weak or moderate cytotoxicity against HepG2 cells with IC50 values of 106.6 ± 2.7 and 42.0 ± 0.9 μg/mL, resp.

Natural Product Research published new progress about Analgesics. 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Reference of 492-62-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Becker, Vivien; Hui, Xin; Nalbach, Lisa; Ampofo, Emmanuel; Lipp, Peter; Menger, Michael D.; Laschke, Matthias W.; Gu, Yuan published the artcile< Linalool inhibits the angiogenic activity of endothelial cells by downregulating intracellular ATP levels and activating TRPM8>, Application of C10H18O, the main research area is linalool TRPM8 antiangiogenic agent angiogenesis; ATP; Angiogenesis; Endothelial cells; Linalool; TRPM8; Vascularization.

Angiogenesis crucially contributes to various diseases, such as cancer and diabetic retinopathy. Hence, anti-angiogenic therapy is considered as a powerful strategy against these diseases. Previous studies reported that the acyclic monoterpene linalool exhibits anticancer, anti-inflammatory and anti-oxidative activity. However, the effects of linalool on angiogenesis still remain elusive. Therefore, we investigated the action of (3R)-(-)-linalool, a main enantiomer of linalool, on the angiogenic activity of human dermal microvascular endothelial cells (HDMECs) by a panel of angiogenesis assays. Non-cytotoxic doses of linalool significantly inhibited HDMEC proliferation, migration, tube formation and spheroid sprouting. Linalool also suppressed the vascular sprouting from rat aortic rings. In addition, Matrigel plugs containing linalool exhibited a significantly reduced microvessel d. 7 days after implantation into BALB/c mice. Mechanistic analyses revealed that linalool promotes the phosphorylation of extracellular signal-regulated kinase (ERK), downregulates the intracellular level of ATP (ATP) and activates the transient receptor potential cation channel subfamily M (melastatin) member (TRPM)8 in HDMECs. Inhibition of ERK signaling, supplementation of ATP and blockade of TRPM8 significantly counteracted linalool-suppressed HDMEC spheroid sprouting. Moreover, ATP supplementation completely reversed linalool-induced ERK phosphorylation. In addition, linalool-induced ERK phosphorylation inhibited the expression of bone morphogenetic protein (BMP)-2 and linalool-induced TRPM8 activation caused the inhibition of β1 integrin/focal adhesion kinase (FAK) signaling. These findings indicate an anti-angiogenic effect of linalool, which is mediated by downregulating intracellular ATP levels and activating TRPM8.

Angiogenesis published new progress about Angiogenesis. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Application of C10H18O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yuan, Qin; He, Yuan; Xiang, Pan-Yin; Huang, Yue-Jia; Cao, Zheng-Wen; Shen, Si-Wei; Zhao, Li; Zhang, Qing; Qin, Wen; Wu, Ding-Tao published the artcile< Influences of different drying methods on the structural characteristics and multiple bioactivities of polysaccharides from okra (Abelmoschus esculentus)>, Reference of 3458-28-4, the main research area is Abelmoschus polysaccharide bioactivity drying; Antioxidant activity; Binding capacity; Drying method; Enzyme inhibition; Okra polysaccharide; Structural characteristic.

In this study, in order to evaluate the influences of drying methods on the chem. structures and bioactivities of polysaccharides from okra (OPPs), four drying methods, including microwave drying at 400 W, 600 W, and 800 W, freezing drying, hot air drying, and vacuum drying, were applied to dry okra fruits. Six different OPPs were extracted from okra dried by different drying methods. Results showed that physicochem. characteristics and bioactivities of OPPs varied by different drying methods. Noticeable variations in extraction yields, mol. weights, rheol. properties, molar ratios of constituent monosaccharides, contents of uronic acids, degrees of esterification, and contents of total phenolics were observed in OPPs obtained by different drying methods. In addition, results showed that OPPs, especially OPP-H and OPP-V obtained by hot air drying and vacuum drying, resp., exhibited remarkable antioxidant activities (ABTS, DPPH, and nitric oxide radical scavenging activities, and ferric reducing antioxidant powers), strong in vitro binding capacities (fat, cholesterol, and bile acids binding capacities), and obvious inhibitory activities on α-amylase and α-glucosidase. Results suggested that the hot air and vacuum drying techniques could be appropriate drying methods before extraction of OPPs with high bioactivities for applications in the functional food and medicine industries.

International Journal of Biological Macromolecules published new progress about Abelmoschus esculentus. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Reference of 3458-28-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kundu, Bidyut Kumar; Das, Mriganka; Ganguly, Rakesh; Bhobe, Preeti A.; Mukhopadhyay, Suman published the artcile< Role of zeolite encapsulated Cu(II) complexes in electron transfer as well as peroxy radical intermediates formation during oxidation of thioanisole>, Name: 2-(Phenylthio)ethanol, the main research area is copper complex encapsulated zeolite sulfoxidation catalyst; electron transfer copper complex encapsulated zeolite sulfoxidation catalyst; peroxy radical copper complex encapsulated zeolite sulfoxidation catalyst.

Zeolite encapsulated host-guest complexes [CuL(NO3)@Y], and [CuL2@Y] (where, HL is 1-[(3-dimethylamino-2,2-dimethyl-propylimino)-methyl]-naphthalen-2-ol, I) have been synthesized and characterized by XRD, FTIR, Raman, TEM, XPS, UV-DRS, BET, EXAFS, and EPR spectroscopy. These complexes were used as heterogeneous catalysts for the oxidation of thioanisole, di-Ph sulfide, and 2-phenylthioanisole to produce sulfoxides analogs. H2O2 shows superior conversion efficiency and product selectivity over other common oxidants, viz tert-Bu hydroperoxide (TBHP), urea hydrogen peroxide (UHP) and di-tert-Bu hydroperoxide (DTBP). Formation of thermally stable copper hydroperoxo intermediate, which is to be believed as rate determining step in past few years, has been well proven. Besides that, for the first time, we have established that the oxidation process is not only going through by the generation of Cu(II)-OOH species but there is a considerable role of electron transfer (ET) mechanism also. Further, better TON value and recyclability make the encapsuled heterogeneous complexes more useful than that of homogeneous analogs.

Journal of Catalysis published new progress about Crystal structure (of CuL(NO3) and CuL2 complexes). 699-12-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H10OS, Name: 2-(Phenylthio)ethanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts