Tag: M.W=150-200

Liu, Lili published the artcileCopper-catalysed N-arylation of pyrrole with aryl iodides under ligand-free conditions, COA of Formula: C10H9NO, the publication is Journal of Chemical Research (2014), 38(3), 180-182, database is CAplus.

A simple, inexpensive and ligand-free copper-catalyzed N-arylation of nitrogen containing heterocycles such as pyrrole, imidazole, indole, and benzimidazole with aryl iodides has been developed, giving N-arylated products in moderate to excellent yields. The catalyst loading is relative low (5 mol%) and the catalyst system was stable in air.

Journal of Chemical Research published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, COA of Formula: C10H9NO.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

He, Zhen published the artcileMicrobiota in mesenteric adipose tissue from Crohns disease promote colitis in mice, Application of 3-Hydroxyphenylacetic acid, the publication is Microbiome (2021), 9(1), 228, database is CAplus and MEDLINE.

Mesenteric adipose tissue (mAT) hyperplasia, known as creeping fat is a pathol. characteristic of Crohns disease (CD). The reserve of creeping fat in surgery is associated with poor prognosis of CD patients, but the mechanism remains unknown. Mesenteric microbiome, metabolome, and host transcriptome were characterized using a cohort of 48 patients with CD and 16 non-CD controls. Multidimensional data including 16S rRNA gene sequencing (16S rRNA), host RNA sequencing, and metabolome were integrated to reveal network interaction. Mesenteric resident bacteria were isolated from mAT and functionally investigated both in the dextran sulfate sodium (DSS) model and in the Il10 gene-deficient (Il10-/-) mouse colitis model to validate their pro-inflammatory roles. Mesenteric microbiota contributed to aberrant metabolites production and transcripts in mATs from patients with CD. The presence of mAT resident microbiota was associated with the development of CD. Achromobacter pulmonis (A. pulmonis) isolated from CD mAT could translocate to mAT and exacerbate both DSS-induced and Il10 gene-deficient (Il10-/-) spontaneous colitis in mice. The levels of A. pulmonis in both mAT and mucous layer from CD patients were higher compared to those from the non-CD group. This study suggests that the mesenteric microbiota from patients with CD sculpt a detrimental microenvironment and promote intestinal inflammation.

Microbiome published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C8H8O3, Application of 3-Hydroxyphenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kang, Yuxuan published the artcilePreparation of Kushui Rose (Rosa setate x Rosa rugosa) essential oil fractions by double molecular distillation: Aroma and biological activities, Safety of cis-3,7-Dimethyl-2,6-Octadien-1-Ol, the publication is Industrial Crops and Products (2022), 114230, database is CAplus.

Kushui Rose (Rosa setate x Rosa rugosa, KR) is a distinctive Chinese rose variety. Its extracts, especially essential oil (EO), showed various biol. activities. In this study, double mol. distillation was used to sep. different fractions from KREO. GC-MS was used to detect the composition of volatile components in different fractions. The aroma anal. of different fractions was carried out by a professional sensory evaluation team. D1 (the light phase in the first stage) and R2 (the heavy phase in the second stage) showed better biol. activities, with a lower IC50 value on antioxidant ability and a higher capacity for antimicrobial. Furthermore, D1 and R2 also effectively prevented the oxidation of sunflower oil. The antimicrobial mechanism was explored by relative conductivity, the content of protein and reducing sugar, and SEM on Escherichia coli. In all, mol. distillation could be considered an effective way to improve the aroma and biol. activity for KREO.

Industrial Crops and Products published new progress about 106-25-2. 106-25-2 belongs to alcohols-buliding-blocks, auxiliary class Natural product, name is cis-3,7-Dimethyl-2,6-Octadien-1-Ol, and the molecular formula is C10H18O, Safety of cis-3,7-Dimethyl-2,6-Octadien-1-Ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Miao, Hua published the artcile1-Hydroxypyrene mediates renal fibrosis through aryl hydrocarbon receptor signalling pathway, Recommanded Product: 3-Hydroxyphenylacetic acid, the publication is British Journal of Pharmacology (2022), 179(1), 103-124, database is CAplus and MEDLINE.

In chronic kidney disease (CKD), patients inevitably reach end-stage renal disease and require renal transplant. Evidence suggests that CKD is associated with metabolite disorders. However, the mol. pathways targeted by metabolites remain enigmatic. Here, we describe roles of 1-hydroxypyrene in mediating renal fibrosis. We analyzed 5406 urine and serum samples from patients with Stage 1-5 CKD using metabolomics, and 1-hydroxypyrene was identified and validated using longitudinal and drug intervention cohorts as well as 5/6 nephrectomized and adenine-induced rats. We identified correlations between the urine and serum levels of 1-hydroxypyrene and the estimated GFR in patients with CKD onset and progression. Moreover, increased 1-hydroxypyrene levels in serum and kidney tissues correlated with decreased renal function in two rat models. Up-regulated mRNA expression of aryl hydrocarbon receptor and its target genes, including CYP1A1, CYP1A2 and CYP1B1, were observed in patients and rats with progressive CKD. Further we showed up-regulated mRNA expression of aryl hydrocarbon receptor and its three target genes, plus up-regulated nuclear aryl hydrocarbon receptor protein levels in mice and HK-2 cells treated with 1-hydroxypyrene, which caused accumulation of extracellular matrix components. Treatment with aryl hydrocarbon receptor short hairpin RNA or flavonoids inhibited mRNA expression of aryl hydrocarbon receptor and its target genes in 1-hydroxypyrene-induced HK-2 cells and mice. Metabolite 1-hydroxypyrene was demonstrated to mediate renal fibrosis through activation of the aryl hydrocarbon receptor signalling pathway. Targeting aryl hydrocarbon receptor may be an alternative therapeutic strategy for CKD progression.

British Journal of Pharmacology published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C8H8O3, Recommanded Product: 3-Hydroxyphenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Bremner, John B. published the artcileAnnulation of Eight- to Ten-Membered Oxaza Rings to the Benzo[b]thiophene System by Intramolecular Nucleophilic Displacement, COA of Formula: C8H19NO2, the publication is Australian Journal of Chemistry (2014), 67(8 & 9), 1217-1221, database is CAplus.

Concise synthetic routes to 2H-benzo[b]thieno[3,2-b][1,5]oxazocin-6(3H)-one, and the new benzo[b]thieno[3,2-b][1,5]oxazonin-7(2H)-one and 2H-benzo[b]thieno[3,2-b][1,5]oxazecin-8(3H)-one systems, have been developed based on intramol. nucleophilic displacement in the key ring forming step.

Australian Journal of Chemistry published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H19NO2, COA of Formula: C8H19NO2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chen, Yiding published the artcileAn Aryne-Based Route to Substituted Benzoisothiazoles, Product Details of C6H9N3O2S, the publication is Organic Letters (2015), 17(19), 4786-4789, database is CAplus and MEDLINE.

The combination of arynes, generated using fluoride from the corresponding 2-(trimethylsilyl)aryl triflates, and 3-hydroxy-4-aminothiadiazoles leads to the selective formation of 3-amino-substituted benzo[d]isothiazoles. Variation of the substitution pattern of the aryne precursor, and of the thiadiazole, is possible, with the target heterocycles being obtained in good to excellent yields. In all cases, use of 3-hydroxy-4-aminothiadiazoles leads to incorporation of the amino-substituent in the product heterocycle.

Organic Letters published new progress about 30165-97-0. 30165-97-0 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Thiadiazole,Alcohol, name is 4-Morpholino-1,2,5-thiadiazol-3-ol, and the molecular formula is C6H9N3O2S, Product Details of C6H9N3O2S.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Grimster, Neil P. published the artcileAlkynes to (E)-enolates using tandem catalysis: stereoselective anti-aldol and syn-[3,3]-rearrangement reactions, Computed Properties of 17877-23-5, the publication is Tetrahedron (2010), 66(33), 6429-6436, database is CAplus.

A new tandem catalysis strategy that transformed alkyne derivatives to (E)-enol-equivalent followed by either stereoselective anti-selective aldol coupling or syn-selective [3,3]-rearrangement transformations was reported. The mechanism was thought to proceed through an interchanging series of Lewis acid and Bronsted acid catalyzed reactions via the intermediacy of a ketiminum ion species. For example, the scandium(III) triflate-catalyzed reaction of alkyne I with Me₂CHCHO and triphenylsilanol afforded adduct II in 73% yield and dr >95:5, while zinc triflate-catalyzed reaction of (E)-PhCH:CHCH₂OH with I gave III in 88% yield and dr >95:5.

Tetrahedron published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C9H22OSi, Computed Properties of 17877-23-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chan, Daniel G. published the artcileEnol Silyl Ethers via Copper(II)-Catalyzed C-O Bond Formation, Recommanded Product: Triisopropylsilanol, the publication is Organic Letters (2011), 13(10), 2778-2781, database is CAplus and MEDLINE.

Cu(II) acetate catalyzes the coupling of pinacol vinylboronates with silanols producing enol silyl ethers. This represents a novel enol silyl ether synthesis via formation of the C-O bond instead of the conventional Si-O bond. This also constitutes the 1st transition-metal-catalyzed oxidative cross-coupling with silanols. Thirteen enol silyl ethers were prepared by reaction of tert-butyldimethylsilanol with pinacol vinylboronates in the presence of Cu(II) acetate, 3-hexyne, triethylamine, pyridine N-oxide and oxygen in 28% to 72% yield. E.g., reaction of E-PhCH₂OCH₂CH₂CH:CHBpin (HBpin = pinacolborane) with tert-butyldimethylsilanol gave E-PhCH₂OCH₂CH₂CH:CHOSiBu^tMe₂ in 72% yield. Direct silylation of a hydroxyketoaldehyde would not be feasible using conventional methods, but reaction of the hydroxy ketoboronate ester E-MeC(O)CH₂CH(OH)(CH₂)₃CH:CHBpin with tert-butyldimethylsilanol afforded E-MeC(O)CH₂CH(OH)(CH₂)₃CH:CHOSiBu^tMe₂ in 42% yield.

Organic Letters published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C9H22OSi, Recommanded Product: Triisopropylsilanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Luzzio, Frederick A. published the artcilePreparation of β-phenylnitroethanes having electron-donating aryl substitution, Synthetic Route of 528594-30-1, the publication is Tetrahedron Letters (2007), 48(38), 6704-6708, database is CAplus.

β-Phenyl-β-hydroxynitroethanes having activating aryl substituents are treated with Et₃SiH/F₃CCO₂H under solventless conditions to give the corresponding phenylnitroethanes. Substrates having no aryl substituents or substituents that are only mildly activating or deactivating do not result in appreciable conversion to the title compounds

Tetrahedron Letters published new progress about 528594-30-1. 528594-30-1 belongs to alcohols-buliding-blocks, auxiliary class Nitro Compound,Benzene,Phenol,Ether, name is 2-Methoxy-4-(2-nitroethyl)phenol, and the molecular formula is C9H11NO4, Synthetic Route of 528594-30-1.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Maciag, Monika published the artcileEvaluation of β-adrenergic ligands for development of pharmacological heart failure and transparency models in zebrafish, Computed Properties of 86-48-6, the publication is Toxicology and Applied Pharmacology (2022), 115812, database is CAplus and MEDLINE.

Cardiovascular toxicity represents one of the most common reasons for clin. trial failure. Consequently, early identification of novel cardioprotective strategies could prevent the later-stage drug-induced cardiac side effects. The use of zebrafish (Danio rerio) in preclin. studies has greatly increased. High-throughput and low-cost of assays make zebrafish model ideal for initial drug discovery. A common strategy to induce heart failure is a chronic β-adrenergic (βAR) stimulation. Herein, we set out to test a panel of βAR agonists to develop a pharmacol. heart failure model in zebrafish. We assessed βAR agonists with respect to the elicited mortality, changes in heart rate, and morphol. alterations in zebrafish larvae according to Fish Embryo Acute Toxicity Test. Among the tested βAR agonists, epinephrine elicited the most potent onset of heart stimulation (EC50 = 0.05 mM), which corresponds with its physiol. role as catecholamine. However, when used at ten-fold higher dose (0.5 mM), the same compound caused severe heart rate inhibition (-28.70 beats/min), which can be attributed to its cardiotoxicity. Further studies revealed that isoetharine abolished body pigmentation at the sublethal dose of 7.50 mM. Addnl., as a proof of concept that zebrafish can mimic human cardiac physiol., we tested βAR antagonists (propranolol, carvedilol, metoprolol, and labetalol) and verified that they inhibited fish heart rate in a similar fashion as in humans. In conclusion, we proposed two novel pharmacol. models in zebrafish; i.e., epinephrine-dependent heart failure and isoetharine-dependent transparent zebrafish. We provided strong evidence that the zebrafish model constitutes a valuable tool for cardiovascular research.

Toxicology and Applied Pharmacology published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, Computed Properties of 86-48-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts