Tag: M.W=150-200

Zhao, Hongyi published the artcileEfficient and stereoselective one-pot synthesis of benzo[b]oxazolo[3,4-d][1,4]oxazin-1-ones, Recommanded Product: 4,5-Difluoro-2-nitrophenol, the publication is RSC Advances (2020), 10(40), 24037-24044, database is CAplus and MEDLINE.

An efficient and mild one-pot convergent synthesis protocol has been developed for benzo[b]oxazolo[3,4-d][1,4]oxazin-1-one derivatives through the Mitsunobu reaction and sequential cyclization. Various tricyclic fused benzoxazinyl-oxazolidinones (20 examples) were obtained in good to excellent yields and high enantioselectivities with facile operation. Furthermore, four stereoisomers were afforded resp. in high ee values (>97.8%) via using different chiral 2,3-epoxy-4-trityloxybutanol. This methodol. has been applied to the synthesis of key intermediates of drug candidates.

RSC Advances published new progress about 55346-97-9. 55346-97-9 belongs to alcohols-buliding-blocks, auxiliary class Fluoride,Nitro Compound,Benzene,Phenol, name is 4,5-Difluoro-2-nitrophenol, and the molecular formula is C24H29N5O3, Recommanded Product: 4,5-Difluoro-2-nitrophenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Xiang-mei published the artcileIdentification of vitamin C precursor 2-keto-L-gulonic acid, Formula: C6H10O7, the publication is Zhongguo Weisheng Jianyan Zazhi (2014), 24(10), 1399-1400, database is CAplus.

The objective of this paper was to establish the method system for identification of 2-keto-L-gulonic acid (2-KLG) in fermentation broth, and to distinguish 2-KLG from its byproducts (5-DKG and 2-DKG). The standard substance and fermentation product samples were analyzed by thin layer chromatog.(TLC), HPLC and m.p. determination, then the results were compared to confirm the consistency of the three methods in identification of 2-KLG. The TLC results indicated that the Rf value, color and size of chromatogram were concordant between fermentation product and the standard substance of 2-KLG. HPLC results showed that the fermentation product exhibited concordant retention time (8 min), m.p.(170 °C or so) and pH value with standard substance of 2-KLG, but different from 2-DKG and 5-DKG. This method system could identify the existence of 2-KLG in unknown fermentation products, with great significance in screening of new strains of 2-KLG from further fermentation of D-glucose.

Zhongguo Weisheng Jianyan Zazhi published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C5H7NO, Formula: C6H10O7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Huang, M. published the artcileAntioxidant effect of glutathione on promoting 2-keto-L-gulonic acid production in vitamin C fermentation system, HPLC of Formula: 526-98-7, the publication is Journal of Applied Microbiology (2018), 125(5), 1383-1395, database is CAplus and MEDLINE.

The study aims to investigate the antioxidant effect of glutathione on promoting 2-KGA in Vc fermentation system using Ketogulonicigenium vulgare 25B-1 and Bacillus endophyticus ST-1 as the co-culturing microbes. Methods and Results : The activities of antioxidant-related enzymes and qPCR were used to study the antioxidant effect of glutathione addition in Vc fermentation system. The addition of GSH and GSH/GSSG increased 2-KGA production and decreased fermentation time, and the highest 2-KGA production increased by 40·63% and the lowest fermentation time shortened to 60 h when the addition of optimal concentration ratio of GSH/GSSG was 50 : 1. Moreover, the increased production of 2-KGA was accompanied by up-regulated the activities of total antioxidant capacity (T-AOC), total superoxide dismutase (T-SOD), catalase (CAT) and over-expressed oxidative stress-related genes sod,gst,gr,zwf,gp, which resulted in scavenging reactive oxygen species to reduce oxidative stress in Vc fermentation system. Conclusions : Glutathione showed a significant effect on increasing 2-KGA production and decreasing fermentation time in Vc fermentation system. GSH/GSSG could maintain a dynamic balance with two forms of glutathione and the optimal concentration ratio of GSH/GSSG was 50 : 1. Significance and Impact of the Study : Glutathione is proved to be effective to relieve oxidative stress. The promotion effects of GSSG and GSH on 2-KGA production could help to further explore the optimization of co-culture fermentation process for Vc industrial production

Journal of Applied Microbiology published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C6H10O7, HPLC of Formula: 526-98-7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhao, Xin-qi published the artcileNon targeted metabonomics analysis of small molecular substances in fermented cereal drinks, Computed Properties of 86-48-6, the publication is Xiandai Shipin Keji (2021), 37(10), 96-102, 18, database is CAplus.

Millet, glutinous rice and other cereals were used as main raw materials. Two probiotics, L. paracasei L1 and L. casei YQ336, isolated from naturally fermented sweet potato sour liquid and tofu sour liquid were used as fermentation bacteria. Non targeted metabonomics technol. was used to analyze the differences of small mol. substances in cereal drinks before and after fermentation Through principal component anal. (PCA) and orthogonal partial least squares discriminant anal. (OPLS-DA), it was found that there were 25 categories and 145 differential metabolites with significant changes (VIP>1 and p<0.05) in beverages before and after fermentation, mainly including 34 organic acids and their derivatives, 21 flavonoids, 20 sugars and their derivatives, 16 alkaloids, 10 nucleotides and their derivatives 10 amino acids and their derivatives The bioactive substances with significantly increased content after fermentation include 36668 times of 1-hydroxy-2-naphthoic acid, 1000 times of dihydroresveratrol, 800 times of 2-hydroxyvaleric acid, 517 times of daidzein, 488 times of vitexin, 238 times of apigenin, 148 times of isoerucic acid, 130 times of genistein, etc. The anal. of KEGG metabolic pathway showed that there were 19 metabolic pathways with significant differences. It is speculated that grain substrate may have certain effects on the synthesis and accumulation of secondary metabolism of L. paracasei L1 and L. casei YQ336. This study will lay a theor. foundation for the fermentation of plant matrix food by lactic acid bacteria and the metabolic mechanism of plant matrix.

Xiandai Shipin Keji published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C6H8N2, Computed Properties of 86-48-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Lu, Shu-xia published the artcileNew progress on two-step mixed cultures fermentation for 2-KGA production of vitamin C precursor, Safety of (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, the publication is Weishengwuxue Zazhi (2015), 35(3), 1-8, database is CAplus.

A review. Two-step mixed cultures fermentation initiatively established with independent intellectual property rights is a microbial transformation method used in vitamin C industrial production in China. 2-Keto-L-gulonic acid (2-KGA), the precursor of vitamin C, is transformed from L-sorbose through the mixed culture fermentation that has the advantages of simple operation, less pollution and lower energy consumption. In this paper, the latest new progresses of mixed cultures fermentation producing 2-KGA are reviewed from the aspects of key enzymes of Ketogulonicigenium vulgare, extracellular substances of co-helper, Omics and exogenous additives. Meanwhile, the prospective research fields are also mentioned in order to provide some references for the researchers.

Weishengwuxue Zazhi published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C6H10O7, Safety of (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Li, Dandan published the artcileAminoalcohol-induced activation of organophosphorus hydrolase (OPH) towards diisopropylfluorophosphate (DFP), Name: Triisopropanolamine, the publication is PLoS One (2017), 12(1), e0169937/1-e0169937/23, database is CAplus and MEDLINE.

Aminoalcs. have been addressed as activating buffers for alk. phosphatase. However, there is no record on the buffer activation regarding organophosphorus hydrolase (OPH). Here we reported the activating effects of aminoalcs. on OPH-catalyzed hydrolysis of diisopropylfluorophosphate (DFP), an analog mol. of G-type warfare agents. The kinetic parametors kcat, Vmax and kcat/Km in the OPH reaction were remarkably increased in the buffers (pH 8.0, 25 °C) containing aminoalcs. with C2 between nitrogen (N) and oxygen (O) in their structures, including triethanolamine (TEA), diethanolamine, monoethanolamine, 1-amino-2-propanol, 2-amino-2-methyl-1-propanol, and triisopropanolamine. In contrast, much lower or no rate-enhancing effects were observed in the adding of amines, alcs., amine/alc. mixtures, or 3-amino-1-propanol (C3 between N and O). The 300 mM TEA further increased DFP-degrading activities of OPH mutants F132Y and L140Y, the previously reported OPH mutants with desirable activities towards DFP. However, the treatment of ethylenediaminetetraacetate (EDTA) markedly abolished the TEA-induced activation of OPH. The product fluoride effectively inhibited OPH-catalyzed hydrolysis of DFP by a linear mixed inhibition (inhibition constant Ki ∼ 3.21 mM), which was partially released by TEA adding at initial or later reaction stage. The obtained results indicate the activation of OPH by aminoalc. buffers could be attributed to the reduction of fluoride inhibition, which would be beneficial to the hydrolase-based detoxification of organophosphofluoridate.

PLoS One published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C9H21NO3, Name: Triisopropanolamine.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Fan, Shicun published the artcileDevelopment of a minimal chemically defined medium for Ketogulonicigenium vulgare WSH001 based on its genome-scale metabolic model, COA of Formula: C6H10O7, the publication is Journal of Biotechnology (2014), 15-22, database is CAplus and MEDLINE.

Com. production of 2-keto-L-gulonic acid (2-KLG), the immediate precursor of L-ascorbic acid, is by Ketogulonicigenium vulgare in co-culture with Bacillus megaterium. We used flux balance anal. (FBA) to study a genome-scale metabolic model (GSMM) of K. vulgare, iWZ663, and found that K. vulgare is deficient in nutrient biosynthetic pathways. Individually omitting L-glycine, L-cysteine, L-methionine, L-tryptophan, adenine, thymine, thiamine and pantothenate from complete chem. defined medium (CDM), caused biomass formation of K. vulgare to decrease to 1%, 21%, 16%, 1%, 26%, 57%, 73% and 24%, resp. Based on these results and FBA, a minimal chem. defined medium (MCDM) was developed that supported monoculture of K. vulgare (0.28 OD₆₀₀) and 2-KLG production (3.59 g/L), which were similar to those in complete CDM or corn steep liquor powder (CSLP) medium. This study demonstrated the potential of using GSMM and FBA to characterize nutrient requirements, optimize CDM, and study interactions in co-culture.

Journal of Biotechnology published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C6H10O7, COA of Formula: C6H10O7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Jun published the artcileProphylactic effect of flavanol rich preparation metabolites in promoting resilience to a mouse model of social stress, Related Products of alcohols-buliding-blocks, the publication is Translational Psychiatry (2020), 10(1), 183, database is CAplus and MEDLINE.

Major depressive disorder (MDD) is a leading cause of disability, and there is an urgent need for new therapeutics. Stress-mediated induction of pro-inflammation in the periphery contributes to depression-like behaviors both in humans and in exptl. models. Inflammatory cytokine interleukin-6 (IL-6) has emerged as a potential therapeutic target. Our studies demonstrated that metabolism of flavanol rich cocoa preparation (FRP) led to the accumulation of select phenolic acids that may contribute to its anti-inflammatory activity. Using a repeated social defeat stress (RSDS) model of depression, we showed that oral administration of FRP attenuates susceptibility to RSDS-mediated depression, supporting the further development of FRP as a novel therapeutic for the treatment of stress disorders and anxiety in humans.

Translational Psychiatry published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C9H8BNO2, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yuan, Bo published the artcileUHPLC-QqQ-MS/MS method development and validation with statistical analysis: Determination of raspberry ketone metabolites in mice plasma and brain, SDS of cas: 621-37-4, the publication is Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences (2020), 122146, database is CAplus and MEDLINE.

Raspberry ketone (RK) (4-(4-hydroxyphenyl)-2-butanone) is the major compound responsible for the characteristic aroma of red raspberries, and has long been used com. as a flavoring agent and recently as a weight loss supplement. A targeted UHPLC-QqQ-MS/MS method was developed and validated for anal. of RK and 25 associated metabolites in mouse plasma and brain. Dispersion and projection anal. and central composite design were used for method optimization. Random effect anal. of variance was applied for validation inference and variation partition. Within this framework, repeatability, a broader sense of precision, was calculated as fraction of accuracy variance, reflecting instrumental imprecision, compound degradation and carry-over effects. Multivariate correlation anal. and principle component anal. were conducted, revealing underlying association among the manifold of method traits. R programming was engaged in streamlined statistical anal. and data visualization. Two particular phenomena, the analytes’ background existence in the enzyme solution used for phase II metabolites deconjugation, and the noted lability of analytes in pure solvent at 4° vs. elevated stability in biomatrices, were found critical to method development and validation. The approach for the method development and validation provided a foundation for experiments that examine RK metabolism and bioavailability.

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C11H15BO4, SDS of cas: 621-37-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yuan, Bo published the artcileDevelopment and validation of a micro-QuEChERS method with high-throughput enhanced matrix removal followed with UHPLC-QqQ-MS/MS for analysis of raspberry ketone-related phenolic compounds in adipose tissues, SDS of cas: 621-37-4, the publication is Talanta (2021), 122716, database is CAplus and MEDLINE.

Raspberry ketone (RK) is a major flavor compound in red raspberries, and it has been marketed as a popular weight-loss dietary supplement with high potential in accumulating in fatty tissues. However, challenges in extracting and characterizing RK and its associated phenolic compounds in fatty tissues persist due to the complex matrix effect. In this work, we reported a high-throughput sample preparation method for RK and 25 related phenolic compounds in white adipose tissues using an improved micro-scale QuEChERS (quick, efficient, cheap, easy, rugged and safe) approach with enhanced matrix removal (EMR)-lipid cleanup in 96-well plates, followed by UHPLC-QqQ-MS/MS anal. The absolute recovery was 73-105% at the extraction step, and achieved 71-96% at the EMR cleanup step. The EMR cleanup removed around 66% of total lipids in the acetonitrile extract as profiled by UHPLC-QTOF-MS/MS. The innovative introduction of a reversed-phase C18 sorbent into the extract significantly improved the analytes′ recovery during SpeedVac drying. The final accuracy achieved 80-120% for most analytes. Overall, this newly developed and validated method could serve as a powerful tool for analyzing RK and related phenolic compounds in fatty tissues.

Talanta published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C10H11N3O3S, SDS of cas: 621-37-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts