Tag: M.W=1000-2000

Safety of 1159408-65-7. Today I’d like to introduce a new chemical compound, CAS is 1159408-65-7, Name is 4,8-Dioxa-12,16-diazaheneicosanamide, 6-amino-11,17-dioxo-6-[[3-oxo-3-[[3-[[1-oxo-5-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]pentyl]amino]propyl]amino]propoxy]methyl]-N-[3-[[1-oxo-5-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]pentyl]amino]propyl]-21-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-, 2,2,2-trifluoroacetate, Formula is C81H129F3N10O38, Molecular Weight is 1907.93g/mol. Because of its complex structure and huge molecular weight, this compound is rarely understood. Now let me introduce some knowledge about its synthesis.

The general reactant of this compound is 5-Hexen-1-ol；5H-Pyrano[3,2-d]oxazole-6,7-diol, 5-[(acetyloxy)methyl]-3a,6,7,7a-tetrahydro-2-methyl-, (3aR,5R,6R,7R,7aR)-6,7-diacetate, , Reagents is Trimethylsilyl triflate；Sodium bicarbonate, Catalyst(), Solvent is Dichloromethane,Water, Products β-D-Galactopyranoside, 5-hexen-1-yl 2-(acetylamino)-2-deoxy-, 3,4,6-triacetate, Yield: 82%, Synthetic Methods procedure :1. Stir the reactant ( 642.7 g, 1.95 mol ) in anhydrous 1, 2-dichloroethane ( 4500 mL ) with 4 Å molecular sieves ( 650 g ) for 5 minutes at room temperature., 2. Add 5-Hexen-1-ol ( 215 g, 2.15 mol ) and continue stirring for 30 minutes., 3. Add TMS-triflate ( 180.7 mL, 0.98 mol ) dropwise under constant stirring over 10 minutes and continue stirring for 2 hours at room temperature., 4. Quench the reaction mixture with cold saturated NaHCO3 solution ( 2 L ) and separate the organic layer., 5. Extract the product into dichloromethane ( DCM, 4L ) ; wash the combined organic layers with water, dry over anhydrous Na2SO4 and evaporate to dryness under reduced pressure., Transfornation (Alkylation or Silylation of Alcohol with Inorganic/ Organic Esters. Characterization Data include ‘s Proton NMR Spectrum : ( 400 MHz, DMSO-d 6 ) : δ 7.80 ( d, J = 9.2 Hz, 1H, NHCOCH3 ) , 5.83-5.72 ( m, 1H, -CH=CH2 ) ; 5.20 ( d, J = 3.4 Hz, 1H, H4 ) ; 5.02-4.91 ( m, 3H, -CH=CH2, H3 ) , 4.47 ( d, J = 8.5 Hz, 1H, H1 ) , 4.06-3.97 ( m, 3H, H5, H6, H6′ ) ; 3.86 ( dt, J = 8.8, 11.1 Hz, 1H, H2 ) ; 3.70 ( dt, J = 6.0, 9.9 Hz, 1H, -OCH2-CH2 ) ; 3.41 ( dt, J = 6.4, 9.9 Hz, 1H, -OCH2-CH2 ) ; 2.09 ( s, 3H, -COCH3 ) ; 2.03-1.96 ( m, 2H, -CH2- ) ; 1.99 ( s, 3H, -COCH3 ) ; 1.88 ( s, 3H, -COCH3 ) ; 1.75 ( s, 3H, -COCH3 ) ; 1.51-1.42 ( m, 2H, -CH2- ) ; 1.39-1.30 ( m, 2H, -CH2- ) ., Carbon-13 NMR : ( 101 MHz, DMSO-d 6 ) : δ 170.0, 169.9, 169.6, 169.1, 138.7, 114.7, 101.0, 70.4, 69.8, 68.6, 66.7, 61.5, 49.3, 39.9 32.8, 28.4, 24.5, 22.8, 20.5, 20.5., HRMS: calc. for C20H31NO9: 429.1999; found 429.1997., State is pale brown solid

Safety of 1159408-65-7. I’m so glad you had the patience to read the whole article, if you want know more about 1159408-65-7, you can browse my other blog.

Reference:
CAS Method Number 3-353-CAS-9716164,
,CAS Method Number 3-367-CAS-11845945

Today I’d like to introduce a new chemical compound, CAS is 1953146-81-0, Name is 36-(((2R,3R,4R,5R,6R)-3-Acetamido-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-21,21-bis((3-((3-(5-(((2R,3R,4R,5R,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)pentanamido)propyl)amino)-3-oxopropoxy)methyl)-19,26,32-trioxo-4,7,10,13,16,23-hexaoxa-20,27,31-triazahexatriacontan-1-oic acid, Formula is C75H134N10O35, Molecular Weight is 1735.91g/mol. Because of its complex structure and huge molecular weight, this compound is rarely understood. Now let me introduce some knowledge about its synthesis.. Product Details of 1953146-81-0

The general reactant of this compound is 1-[(3R,5S)-5-[[Bis(4-methoxyphenyl)phenylmethoxy]methyl]-1-[1,12,19,25-tetraoxo-14,14-bis[[3-oxo-3-[[3-[[1-oxo-5-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]pentyl]amino]propyl]amino]propoxy]methyl]-29-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-16-oxa-13,20,24-triazanonacos-1-yl]-3-pyrrolidinyl] butanedioate;Cytidine, N-acetyl-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxy-, 3′-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]；Guanosine, 5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxy-N-(2-methyl-1-oxopropyl)-, 3′-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]；Uridine, 5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-O-methyl-, 3′-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite], Reagents is Methylamine, Triethylamine trihydrofluoride, Catalyst(), Solvent is Pyridine；Water, Products RNA, (G-G-A-A-U-C-Um-Um-A-Um-A-Um-Um-Um-G-A-U-C-Cm-A-A), 3′-[O-[[(2S,4R)-1-[29-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-14,14-bis[[3-[[3-[[5-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-1-oxopentyl]amino]propyl]amino]-3-oxopropoxy]methyl]-1,12,19,25-tetraoxo-16-oxa-13,20,24-triazanonacos-1-yl]-4-hydroxy-2-pyrrolidinyl]methyl] hydrogen phosphorothioate], complex with RNA (Um-Um-G-G-A-U-Cm-A-A-A-Um-A-Um-A-A-G-A-Um-U-C-Cm-sp-Cm-sp-U) 3′-[O-[6-[2-[5-[1,3-dihydro-3,3-dimethyl-5-sulfo-1-(3-sulfopropyl)-2H-indol-2-ylidene]-1,3-pentadien-1-yl]-3-methyl-5-sulfo-1-(3-sulfopropyl)-3H-indolium-3-yl]-1-oxohexyl] hydrogen phosphorothioate], inner salt (1:1), Synthetic Methods procedure :1. Synthesize sense and antisense strands on an ABI synthesizer using commercially available 5′-O- ( 4, 4′-dimethoxytrityl ) -2′-deoxy-2′-fluoro-, 5′-O- ( 4, 4′-dimethoxytrityl ) -2′-O- ( tert-butyldimethylsilyl ) -, and 5′-O- ( 4, 4′-dimethoxytrityl ) -2′-O-methyl- 3′-O- ( 2-cyanoethyl-N, N-diisopropyl ) phosphoramidite monomers of uridine, 4-N-acetylcytidine, 6-N-benzoyladenosine, and 2-N-isobutyrylguanosine using standard solid-phase oligonucleotide synthesis and deprotection protocols., 2. Add phosphorothioate linkages by oxidation of phosphite utilizing 0.1 M DDTT in pyridine., 3. Treat the support with 40% aqueous methylamine at 45 °C for 1.5 hour., 4. Filter the suspension through a 0.2-μm filter to remove solid residues., 5. Vortex the combined filtrate with Et3N·3HF at 40 °C for 1 hour to remove tert-butyldimethylsilyl ( TBDMS ) protecting groups from the oligonucleotide., 6. Purify the ligand-conjugated and unconjugated oligonucleotides by anion-exchange high-performance liquid chromatography ( IEX-HPLC ) with TSK-Gel Super Q-5PW support using a linear gradient of 22-42% buffer B over 130 min with 50 ml/min flow rate., 7. Use buffer A as 0.02 M Na2HPO4 in 10% CH3CN ( pH 8.5 ) and buffer B as buffer A plus 1 M NaBr., 8. Combine the pure fractions, concentrate and desalt on a sartorius ultrafiltration station., 9. Confirm the integrities of the purified oligonucleotides by LC-MS and by analytical IEX HPLC., 10. Mix equimolar amounts of complementary sense and antisense strands, anneal by heating to 90 °C and cool slowly., Transfornation (.

I’m so glad you had the patience to read the whole article, if you want know more about 1953146-81-0, you can browse my other blog.. Product Details of 1953146-81-0

Reference:
CAS Reaction Number: 31-355-CAS-9994399,
,CAS Method Number: 3-614-CAS-3165786

Today I’d like to introduce a new chemical compound, CAS is 1159408-65-7, Name is 4,8-Dioxa-12,16-diazaheneicosanamide, 6-amino-11,17-dioxo-6-[[3-oxo-3-[[3-[[1-oxo-5-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]pentyl]amino]propyl]amino]propoxy]methyl]-N-[3-[[1-oxo-5-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]pentyl]amino]propyl]-21-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-, 2,2,2-trifluoroacetate, Formula is C81H129F3N10O38, Molecular Weight is 1907.93g/mol. Because of its complex structure and huge molecular weight, this compound is rarely understood. Now let me introduce some knowledge about its synthesis.. Recommanded Product: 1159408-65-7

The general reactant of this compound is N-(Benzyloxycarbonyl)-6-aminohexanoic acid；4,8-Dioxa-12,16-diazaheneicosanamide, 6-amino-11,17-dioxo-6-[[3-oxo-3-[[3-[[1-oxo-5-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]pentyl]amino]propyl]amino]propoxy]methyl]-N-[3-[[1-oxo-5-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]pentyl]amino]propyl]-21-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-, 2,2,2-trifluoroacetate (1:1), Reagents is Diisopropylethylamine，1-[Bis(dimethylamino)methylene]-1H-benzotriazolium hexafluorophosphate(1-) 3-oxide, Catalyst(), Solvent is Dimethylformamide, Products 12-Oxa-2,9,16,20-tetraazapentacosanoic acid, 8,15,21-trioxo-10,10-bis[[3-oxo-3-[[3-[[1-oxo-5-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]pentyl]amino]propyl]amino]propoxy]methyl]-25-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-, phenylmethyl ester, Yield: 58%, Synthetic Methods procedure :1. Mix the reactant ( 0.333 g, 1.257 mmol ) in DMF ( 30 mL ) with HBTU ( 0.524 g, 1.38 mmol ) and DIEA ( 0.450 mL, 2.5 mmol ) , stir for 5 minutes., 2. Add a solution of the amine ( 1.60 g, 0.838 mmol ) in DMF ( 5 mL ) and stir the mixture overnight at room temperature., 3. Remove the solvents and volatiles under reduced pressure, dissolve the residue in DCM., 4. Purify the crude product by silica gel chromatography using EtOAc and 5-20% MeOH in DCM as eluents., , Transfornation (Acylation of Nitrogen Nucleophiles by Carboxylic Acids. Characterization Data include ‘s Proton NMR Spectrum : ( 500 MHz, DMSO-d 6 ) : δ 7.90-7.79 ( m, 6H, NH ) ; 7.74 ( t, J = 5.5 Hz, 3H, NH ) ; 7.37-7.26 ( m, 5H ) ; 7.20 ( t, J = 5.6 Hz, 1H, NH ) ; 6.98 ( s, 1H, NH ) , 5.20 ( d, J = 3.4 Hz, 3H, sugar H4 ) ; 4.98 ( s, 2H ) ; 4.95 ( dd, J = 3.4, 11.2 Hz, 3H, sugar H3 ) ; 4.48 ( d, J = 8.4 Hz, 3H, sugar H1 ) ; 4.07-3.95 ( m, 9H, sugar H5, H6, H6′ ) ; 3.86 ( dt, J = 8.8, 11.0 Hz, 3H, sugar H2 ) ; 3.69 ( dt, J = 6.0, 9.9 Hz, 3H ) ; 3.55-3.47 ( m, 12H ) ; 3.43-3.33 ( m, 3H ) ; 3.06-2.98 ( m, 12H ) ; 2.95 ( q, J = 6.8 Hz, 2H ) ; 2.27 ( t, J = 6.4 Hz, 6H ) ; 2.09 ( s, 9H ) ; 2.03 ( t, J = 7.1 Hz, 8H ) ; 1.98 ( s, 9H ) ; 1.89 ( s, 9H ) ; 1.76 ( s, 9H ) ; 1.54-1.33 ( m, 20H ) ; 1.28-1.16 ( m, 4H ) ., Carbon-13 NMR : ( 126 MHz, DMSO-d 6 ) : δ 172.4, 172.0, 170.1, 170.0, 169.9, 169.6, 169.4, 156.1, 137.3, 128.3, 127.8, 127.7, 101.0, 70.5, 69.8, 68.7, 68.3, 67.3, 66.7, 65.1, 61.4, 59.5, 53.2, 49.4, 41.6, 40.2, 36.4, 36.3, 36.0, 35.8, 35.0, 29.3, 29.2, 28.6, 25.9, 25.0, 22.8, 21.8, 20.5, 20.4., Mass Spectrum: Mass calc. for C93H145N11O39: 2039.97; found: 2062.90 ( M+Na, MALDI-TOF, matrix: HABA ) ., State is white foamy solid

I’m so glad you had the patience to read the whole article, if you want know more about 1159408-65-7, you can browse my other blog.. Recommanded Product: 1159408-65-7

Reference:
CAS Method Number 3-353-CAS-9716164,
,CAS Method Number 3-367-CAS-11845945

Today I’d like to introduce a new chemical compound, CAS is 1159408-65-7, Name is 4,8-Dioxa-12,16-diazaheneicosanamide, 6-amino-11,17-dioxo-6-[[3-oxo-3-[[3-[[1-oxo-5-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]pentyl]amino]propyl]amino]propoxy]methyl]-N-[3-[[1-oxo-5-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]pentyl]amino]propyl]-21-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-, 2,2,2-trifluoroacetate, Formula is C81H129F3N10O38, Molecular Weight is 1907.93g/mol. Because of its complex structure and huge molecular weight, this compound is rarely understood. Now let me introduce some knowledge about its synthesis.. Electric Literature of 1159408-65-7

The general reactant of this compound is Phenylmethyl 8,14-dioxo-3,3-bis[[3-oxo-3-[[3-[[1-oxo-5-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]pentyl]amino]propyl]amino]propoxy]methyl]-18-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-5-oxa-2,9,13-triazaoctadecanoate；Trifluoroacetic acid, Reagents is Acetic acid；Hydrogen, Catalyst(Palladium), Solvent is Methanol,Dichloromethane,Toluene, Products 4,8-Dioxa-12,16-diazaheneicosanamide, 6-amino-11,17-dioxo-6-[[3-oxo-3-[[3-[[1-oxo-5-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]pentyl]amino]propyl]amino]propoxy]methyl]-N-[3-[[1-oxo-5-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]pentyl]amino]propyl]-21-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-, 2,2,2-trifluoroacetate (1:1), Yield: 98%, Synthetic Methods procedure :1. Dissolve the reactant ( 56 g, 29 mmol ) in MeOH ( 300 mL ) and purge with argon., 2. Add 10 wt% Pd-C ( 5 g, wet Degussa type E101 NE/W ) and acetic acid ( 2.3 mL ) , and hydrogenate the reaction under normal pressure overnight., 3. Filter the reaction mixture through celite and evaporate the filtrate under reduced pressure., 4. Dissolve the residue in DCM/toluene ( 5:1, v/v ) , add trifluoroacetic acid ( TFA, 2.3 mL ) and stir the mixture for 30 minutes at room temperature., 5. Remove the solvents under reduced pressure., Transfornation (Hydrolysis or Hydrogenolysis of Amides/ Imides/ Carbamates. Characterization Data include ‘s Proton NMR Spectrum : ( 400 MHz, DMSO-d 6 ) : δ 8.06 ( brs, 3H, -NH3 + ) ; 7.88 ( t, J = 5.5 Hz, 3H, NH ) ; 7.82 ( d, J = 9.2 Hz, 3H, NH ) ; 7.76 ( t, J = 5.6 Hz, 3H, NH ) ; 5.20 ( d, J = 3.4 Hz, 3H, sugar H4 ) ; 4.95 ( dd, J = 3.4, 11.2 Hz, 3H, sugar H3 ) ; 4.47 ( d, J = 8.5 Hz, 3H, sugar H1 ) ; 4.07 – 3.97 ( m, 9H, sugar H5, H6, H6′ ) ; 3.86 ( dt, J = 8.9, 11.0 Hz, 3H, sugar H 2 ) ; 3.69 ( dt, J = 5.9, 9.8 Hz, 3H ) ; 3.63 ( t, J = 6.3 Hz, 6H ) ; 3.48-3.34 ( m, 9H ) ; 3.03 ( quintet, J = 6.6 Hz, 12H ) ; 2.33 ( t, J = 6.2 Hz, 6H ) ; 2.09 ( s, 9H ) ; 2.03 ( t, J = 7.1 Hz, 6H ) ; 1.99 ( s, 9H ) ; 1.89 ( s, 9H ) ; 1.76 ( s, 9H ) ; 1.56-1.38 ( m, 18H ) ., Carbon-13 NMR : ( 101 MHz, DMSO-d 6 ) : δ 172.0, 170.0, 169.9, 169.5, 169.3, 158.4, 158.1, 116.9, 114.0, 100.9, 70.4, 69.8, 68.6, 68.1, 67.6, 66.6, 61.3, 59.1, 49.3, 36.3, 36.2, 35.7, 35.0, 29.2, 28.5, 22.6, 21.8, 20.4, 20.3., Mass Spectrum: Mass calc. for free base C79H128N10O36: 1792.84; found: 1815.83 ( M+Na+, MALDI-TOF, matrix: HABA ) ., State is offwhite solid

I’m so glad you had the patience to read the whole article, if you want know more about 1159408-65-7, you can browse my other blog.. Electric Literature of 1159408-65-7

Reference:
CAS Method Number 3-353-CAS-9716164,
,CAS Method Number 3-367-CAS-11845945