Tag: M.W=100-200

Application of 68327-04-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 68327-04-8, name is (1S,2S)-2-Aminocyclopentanol hydrochloride, molecular formula is C5H12ClNO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Example 119Synthesis of (1S,2S)-2-(3-flupsilonorophenethylamino)cyclopentanol (XIII-I) trans-(1S, 2S)-2-Aminocyclopentanol hydrochloride (1.51 g, 0.011 mol) and triethylamine (Et3N, 1.32 g, 1.81 g, 0.013 mol), 3 A molecular sieves (3 g) were dissolved in dry DCE (30 mL). The mixture was stirred at room temperature under a N2 atmosphere for 10 min. NaBH(OAc)3 (2.76 g, 0.013 mol) and 1-4 (1.38 g, 0.01 mol) was then added, and the reaction mixture was stirred at room temperature under a N2 atmosphere overnight. NaOH (1 M, 20 mL) was then added, and the organic layer was separated. The aqueous layer was extracted with CH2Cl2 (20 mL x 2). The combined organic layers were washed with 1 M NaOH (20 mL) and H2O (20 mL), and then dried over Na2SO4. The solvent was concentrated in vacuo. The residue was purified by column chromatography (silica gel, CH2Cl2 : MeOH = 9.5 : 0.5) to afford a pale-yellow oil (1.38 g, 62%)

According to the analysis of related databases, 68327-04-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; NORTHWESTERN UNIVERSITY; SILVERMAN, Richard, B.; JI, Haitao; LAWTON, Graham, R.; WO2008/42353; (2008); A1;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 28539-02-8, name is 1-(Hydroxymethyl)benzotriazole, the common compound, a new synthetic route is introduced below. category: alcohols-buliding-blocks

Example 439; 1-({trans-4-[({4-[2-(Difluoromethyl)-1H-benzimidazol-1-yl]-6-[(3S)-3-methylmorpholin-4-yl]pyrimidin-2-yl} amino)methyl]cyclohexyl}amino)-2-methylpropan-2-ol (100 mg) was dissolved in ethanol (2 mL), and triethylamine (31 mul) and 1H-benzotriazal-1-ylmethanol (82 mg) were added thereto, followed by stirring at room temperature for 2 hours. To the reaction mixture was added lithium borohydride (4.8 mg), followed by further stirring at room temperature for 1 hour. Water (10mL) was added thereto, followed by extraction with ethyl acetate (15 mL) and washing with saturated brine. The organic layer was dried over anhydrous magnesium sulfate, and then the solvent was evaporated under reduced pressure. The residue was purified by amino silica gel column chromatography (hexane:ethyl acetate=70:30) to obtain 4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-N-{[trans-4-(5,5-dimethyl-1,3-oxazolidin-3-yl)cyclohexyl]methyl}-6-[(3S)-3-methylmorpholin-4-yl]pyrimidin-2-amine (68 mg) as a white powder.

The synthetic route of 28539-02-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Astellas Pharma Inc.; EP2397479; (2011); A1;,
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Synthetic Route of 15852-73-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 15852-73-0, name is (3-Bromophenyl)methanol, molecular formula is C7H7BrO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: In a typical reaction procedure, bromobenzene (0.4 mmol),4-methylbenzeneboronic acid (0.1 mmol), Pd1Ni4/ZrO2 alloy catalyst and Na2CO3 (1 equiv.) were added into a reactor (10 mL) equipped with a magnetic stirrer and EtOH (2 mL) was added as the solvent. The reaction mixture was stirred at 80 °C under an N2 atmosphere for 4 h. After reaction, the catalyst was separated by simple filtration and the solution was analysed by GC and GC?MS. For isolation of the products, the solvent was removed under reduced pressure. The residue was purified by flash chromatography on a silica column, using ethylacetate and n-hexane as the eluent. The NMR data for the products agreed with the literature

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 15852-73-0, (3-Bromophenyl)methanol.

Reference:
Article; Zhang, Li-Jie; Yao, Xian; Sun, Ying-xin; Zhang, Jia-wei; Cai, Chun; Journal of Chemical Research; vol. 42; 8; (2018); p. 419 – 423;,
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Reference of 29055-08-1, Adding some certain compound to certain chemical reactions, such as: 29055-08-1, name is (2-(Methylamino)phenyl)methanol,molecular formula is C8H11NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 29055-08-1.

To a solution (50 [ML)] of [2- (methylamino) phenyl] methanol (1.37 g: synthesized according to the method described in WO 01/32652) in tetrahydrofuran were added pyridine (1.05 [ML),] acetic anhydride (1.23 [ML)] and 4-dimethylaminopyridine (0.18 g), and the mixture was stirred at room temperature for 8 hrs. Water (100 mL) was added to the reaction mixture, and the mixture was extracted with ethyl acetate (100 mL). The organic layer was washed successively with a 5percent aqueous copper (II) sulfate solution (50 mL), a saturated aqueous sodium hydrogen carbonate solution (50 mL) and saturated brine (50 mL), and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure and the obtained residue was purified by flash silica gel column chromatography (eluted with ethyl acetate: hexane=1 : 5, then 1: 3) to give the title compound (0.38 g) as a white solid. [H-NMR] [(CDCL3)] [: 2.] 08 (3H, s), 2.87 (3H, s), 4.40 [(LH,] br), 5.08 (2H, s), 6.64-6. 74 (2H, m), 7.17-7. 32 (2H, m).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 29055-08-1, (2-(Methylamino)phenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; TAKEDA CHEMICAL INDUSTRIES, LTD.; WO2003/105845; (2003); A1;,
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Application of 39590-81-3, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 39590-81-3 as follows.

To a solution of (1-hydroxymethylcyclopropyl)methanol (1.02 g, 10 mmol) in DMF (20 mL),Add imidazole (1.36g, 20mmol) and cool to 0C.Add TBDPSCl (2.75 g, 10 mmol),The crude product was purified by column chromatography after 12 h of reaction to give compound 1-26 (2.046 g, yield 60%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,39590-81-3, its application will become more common.

Reference:
Patent; Sichuan Kelun Botai Bio-pharmaceutical Co., Ltd.; Liu Gang; Yu Hua; Dong Zhenwen; Du Jing; Wang Runjiang; Liu Wei; Zeng Hong; Song Hongmei; Ge Yong; Wang Lichun; Wang Jingyi; (44 pag.)CN107814798; (2018); A;,
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Related Products of 768-95-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.768-95-6, name is Adamantan-1-ol, molecular formula is C10H16O, molecular weight is 152.23, as common compound, the synthetic route is as follows.

1-adamantanol (2 mmol) and catalytic amounts of the ionic liquid were charged into an oven-dried Schlenk tube under nitrogen, and the reaction mass was stirred for 15-20 minutes at r.t. To the resulting mixture the corresponding nitrile (1 mmol) was added, and the reaction mixture was stirred at the indicated temperature for the specified time (see Table 2). Progress of the reaction was monitored by TLC and GC-MS, after completion of reaction, the reaction mass was quenched with distilled water followed by neutralization with dilute NaHCO3 solution. The product was extracted in diethyl ether and dried over anhydrous MgSO4, the ether layer was evaporated in vacuum and the crude compound so obtained was chromatographed with hexane-ethyl acetate mixture(80:20) to afford pure colorless solids.

Statistics shows that 768-95-6 is playing an increasingly important role. we look forward to future research findings about Adamantan-1-ol.

Reference:
Article; Kalkhambkar, Rajesh G.; Waters, Sarah N.; Laali, Kenneth K.; Tetrahedron Letters; vol. 52; 8; (2011); p. 867 – 871;,
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Adding a certain compound to certain chemical reactions, such as: 558-42-9, 1-Chloro-2-methyl-2-propanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 558-42-9, blongs to alcohols-buliding-blocks compound. Recommanded Product: 558-42-9

A solution of 5 -fluoro-3 -nitropyridin-2( 1 H)-one (0.7058 g, 4.46 mmol), 1 -chloro2-methylpropan-2-ol (1.454 g, 13.39 mmol), potassium carbonate (1.234 g, 8.93 mmol) and sodium iodide (2.008 g, 13.39 mmol) in DMF (22.32 ml) in a pressure tube was heated to 125 °C and stirred overnight. LCMS showed ?1 :1 starting material:desiredproduct. The reaction was cooled to room temperature. EtOAc (150 mL) was added, and the solution was filtered through Celite®. The filtrate was washed with brine (40 mL), and the organic layer was dried over Na2SO4, filtered and concentrated in vacuo to give a residue which was purified by flash chromatography using an ISCO 80g column (solid loading) eluting with 20-100percent EtOAc/hexane. Appropriate fractions were collected andconcentrated in vacuo to give 5-fluoro-1-(2-hydroxy-2-methylpropyl)-3-nitropyridin-2(1H)-one (0.127 g, 0.497 mmol, 11.12 percentyield).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,558-42-9, its application will become more common.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; LIU, Chunjian; LIN, James; MOSLIN, Ryan M.; WEINSTEIN, David S.; TOKARSKI, John S.; WO2015/89143; (2015); A1;,
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Adding a certain compound to certain chemical reactions, such as: 4845-50-5, 1,4-Dioxane-2,3-diol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 4845-50-5, blongs to alcohols-buliding-blocks compound. Computed Properties of C4H8O4

5-bromo-3-chloro-1 ,2-diaminobenzene (4.6 g; 20 mmol; 1.0 eq.) is dissolved in EtOH (200 ml_) and then 2,3-dihydroxy-1 ,4-dioxane (2.5 g, 20 mmol; 1.0 eq.) is added. The mixture is stirred for 4 h at rt and a second portion of 2,3- dihydroxy-1 ,4-dioxane (1.3 g; 10 mmol; 0.5 eq.) is added. After stirring for 24 h at rt, RM is concentrated in a rotary evaporator and the residue is purified by FCC to provide 7-bromo-5-chloroquinoxaline (Intermediate 3) as a beige solid (4.7 g; yield 92 %; 98 % by UPLC).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,4845-50-5, its application will become more common.

Reference:
Patent; SELVITA S.A.; FABRITIUS, Charles-Henry Robert Yves; NOWAK, Mateusz Oktawian; WIKLIK, Katarzyna Anna; SABINIARZ, Aleksandra Barbara; BIE?, Marcin Dominik; BUDA, Anna Ma?gorzata; GUZIK, Pawel Szczepan; JAKUBIEC, Krzysztof Roman; MACIUSZEK, Monika; KWIECI?SKA, Katarzyna; TOMCZYK, Mateusz Micha?; GA??ZOWSKI, Micha? Miko?aj; GONDELA, Andrzej; DUDEK, ?ukasz Piotr; (681 pag.)WO2016/180536; (2016); A1;,
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Adding a certain compound to certain chemical reactions, such as: 27489-62-9, trans-4-Aminocyclohexanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 27489-62-9, blongs to alcohols-buliding-blocks compound. Recommanded Product: 27489-62-9

tert-butyl (trans-4-hydroxycyclohexyl)carbamate To a solution of (1R,4R)-4-aminocyclohexanol (15 g, 0.13 mol) in acetonitrile (240 mL) was added in portions di-tert-butyl dicarbonate (31.2 g, 0.14 mol). The mixture was stirred overnight at room temperature. The precipitate obtained was washed with hexane/ethyl acetate (3:1) and hexane giving the title compound as a white solid (83%). 1H NMR (300 MHz, CHLOROFORM-d) delta ppm 1.17 (br. s., 2 H) 1.44 (br. s., 9 H) 1.32 – 1.40 (m, 2 H) 1.99 (br. s., 4 H) 3.44 (br. s., 1 H) 3.61 (br. s., 1 H) 4.38 (br. s., 1 H)

At the same time, in my other blogs, there are other synthetic methods of this type of compound,27489-62-9, trans-4-Aminocyclohexanol, and friends who are interested can also refer to it.

Reference:
Patent; Almirall, S.A.; Prat Quinones, Maria; Fonquerna Pou, Silvia; Puig Duran, Carlos; Lumeras Amador, Wenceslao; Aiguade Bosch, Jose; Caturla Javaloyes, Juan Francisco; EP2386555; (2011); A1;,
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Electric Literature of 558-42-9 , The common heterocyclic compound, 558-42-9, name is 1-Chloro-2-methyl-2-propanol, molecular formula is C4H9ClO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Compound 10-a (77 mg, 0.177 mmol) was dissolved in a mixed liquid of methanol and water (1/1, v/v, 5 mE), and to the solution were added sodium carbonate (28 mg, 0.266 mmol) and 1 -chloro-2-methyl-propan-2-ol (28 mg, 0.266 mmol). The reaction solution was stirred at 80° C. overnight. The reaction mixture was diluted with saturated brine, and the aqueous layer was extracted with ethyl acetate. The separated organic phase was dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The residue was purified by Prep -HPEC to obtain compound 13 (35 mg, 39percent). EC-MS (ESI): mlz=507.3 (M+H). ?H NMR (400 MHz, CDC13): oe 8.32 (1H, s), 7.74 (1H, s), 7.68 (1H, s), 7.49 (1H, d, J=8.0 Hz), 7.26-7.29 (2H, m), 6.98 (1H, s), 3.91 (4H, d, J=4.8 Hz), 3.77-3.90 (6H, m), 2.58-2.64 (8H, m), 2.27 (2H, s), 1.09 (6H, s).

The synthetic route of 558-42-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SHANGHAI YINGLI PHARMACEUTICAL CO., LTD; XU, Zusheng; (174 pag.)US2016/214994; (2016); A1;,
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