Tag: M.W=100-200

Application of 624-95-3 ,Some common heterocyclic compound, 624-95-3, molecular formula is C6H14O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Typically, the dehydrogenation reactions were performedin a stainless steel autoclave equipped with an automatictemperature controller, a thermocouple, a magnetic stirrerand a pressure gauge. Taking catalytic dehydrogenationof 3,3-dimethyl-1-butanol as an example: 3,3-dimethyl-1-butanol (2 mmol), 6.6Cu-2Ni/gamma-Al2O3 (0.4 g), styrene(8 mmol) and mesitylene (2 mL) were added to the autoclave.After the autoclave was sealed, N2 was charged toreplace the air. Then, the autoclave was heated to 150 Cunder magnetic stirring within 20 min. After 24 h, the reactorwas cooled down to room temperature. The liquid reactionmixture was diluted and analyzed.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,624-95-3, its application will become more common.

Reference:
Article; Yang, Xiaomei; Fu, Xiaomin; Bu, Ningning; Han, Li; Wang, Jianfeng; Song, Chengying; Su, Yunlai; Zhou, Lipeng; Lu, Tianliang; Journal of the Iranian Chemical Society; vol. 14; 1; (2017); p. 111 – 119;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 2240-88-2, 3,3,3-Trifluoropropan-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: alcohols-buliding-blocks, blongs to alcohols-buliding-blocks compound. category: alcohols-buliding-blocks

Example 114 2-[3-(2-Fluorobenzyl)-1H-pyrazolo[4,3-b]pyridin-1-yl]-5,5-dimethyl-4-(3,3,3-trifluoropropoxy)-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one Under argon, 57 mg (0.22 mmol) of triphenyl phosphine was dissolved in 1.5 ml THF, 43 mul (0.22 mmol) of diisopropyl azodicarboxylate and 25 mg (0.22 mmol) of 3,3,3-trifluoropropan-1-ol were added and it was stirred for 10 min. Then a suspension of 80 mg of example 109 in 0.5 ml DMF, which had been treated for 3 min in the ultrasonic bath, was added and the reaction mixture was stirred overnight at RT (solution). A further 57 mg (0.22 mmol) of triphenyl phosphine was added, the mixture was treated for 10 min in the ultrasonic bath, then a further 43 mul (0.22 mmol) of diisopropyl azodicarboxylate was added and it was stirred overnight. Then a further 25 mg (0.22 mmol) of 3,3,3-trifluoropropan-1-ol and 57 mg (0.22 mmol) of triphenyl phosphine were added, the reaction mixture was treated for 10 min in the ultrasonic bath, then 43 mul (0.22 mmol) of diisopropyl azodicarboxylate was added and it was stirred for another night at RT. The reaction mixture was purified by preparative HPLC (Reprosil C18, gradient of acetonitrile/0.01percent aq. formic acid). Yield: 37 mg (37percent of theor.) LC-MS (method 1): Rt=1.21 min; MS (ESIpos): m/z=501 [M+H]+ 1H-NMR (400 MHz, DMSO-d6): delta [ppm]=1.35 (s, 6H), 2.92 (qt, 2H), 4.79 (t, 2H), 5.87 (s, 2H), 7.11-7.27 (m, 3H), 7.32-7.41 (m, 1H), 7.45 (dd, 1H), 8.68 (dd, 1H), 8.86 (dd, 1H), 11.45 (s, 1H).

The synthetic route of 2240-88-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BAYER INTELLECTUAL PROPERTY GMBH; FOLLMANN, Markus; STASCH, Johannes-Peter; REDLICH, Gorden; GRIEBENOW, Nils; LANG, Dieter; WUNDER, Frank; HUeBSCH, Walter; LINDNER, Niels; VAKALOPOULOS, Alexandros; TERSTEEGEN, Adrian; US2013/338137; (2013); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 612-16-8 , The common heterocyclic compound, 612-16-8, name is (2-Methoxyphenyl)methanol, molecular formula is C8H10O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: Reactions were performed in a magnetically stirred round bottomed flask fitted with acondenser and placed in a temperature controlled oil bath. 1,2-Diamine (2 mmol)was added to alcohol (3 mmol) and the reaction mixture was allowed to stir at 135C in an open (air) atmosphere. After disappearance of the diamine (reaction was monitored by TLC)or after the appropriate time, the reaction mixture was cooled to roomtemperature. The crude residue was further purified by column chromatography using silica gel (100-200 mesh) to afford pure products. All the products wereidentified on the basis of NMR and mass spectral data

The synthetic route of 612-16-8 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Marri, Mahender Reddy; Peraka, Swamy; Macharla, Arun Kumar; Mameda, Naresh; Kodumuri, Srujana; Nama, Narender; Tetrahedron Letters; vol. 55; 48; (2014); p. 6520 – 6525;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 346-06-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 346-06-5, name is (2-(Trifluoromethyl)phenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows.

Example 99; 5-(2-Trifluoromethylbenzyloxy)-quinazoline-2,4-diamine; [00297] Step 1; 2- (Trifluoromethyl)benzyl alcohol(1.15 g; 6.3 mmol) was added to a cooled (0 °C) slurry of sodium hydride (243.7 mg; 6 mmol) in dimethylformamide under nitrogen atmosphere. The reaction mixture was slowly warmed to room temperature, stirred for 45 min.. The reaction mixture was then added to a cooled (0 °C) solution of 2,6-difluorobenzonitrile in dimethylformamide , stirred for 3 hours at room temperature. The reaction mixture was poured on crushed ice-water, stirred, filtered, washed with water and dried to afford 1.39 grams of 2-fluoro-6-(2-trifluoro- methylphenyl-methoxy) benzonitrile as a white solid.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 346-06-5, (2-(Trifluoromethyl)phenyl)methanol.

Reference:
Patent; DECODE CHEMISTRY, INC.; SINGH, Jasbir; GURNEY, Mark E.; WO2005/123724; (2005); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 14002-80-3, Adding some certain compound to certain chemical reactions, such as: 14002-80-3, name is Methyl 3-hydroxy-2,2-dimethylpropanoate,molecular formula is C6H12O3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 14002-80-3.

[0417] Synthesis of methyl 2,2-dimethyl-3-oxopropanoate (91A): To a suspension of methyl 2,2-dimethyl-3-hydroxypropionate (1.93 ml, 15.1 mmol) and trichloroisocyanuric acid (3.52 g, 15.1 mmol) in dichloromethane (30 ml) was added TEMPO (50 mg, 0.3 mmol) at 0 C. The reaction was warmed to room temperature and stirred for 3 hours. The mixture was filtered and the filtrate was washed with 1M sodium bicarbonate (30mL), followed by 1M HC1 (30 mL), and brine (30 mL). The organic layer was dried with sodium sulfate, filtered, and concentrated under vacuum. The crude product was taken to the next step without further purification.

According to the analysis of related databases, 14002-80-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; GILEAD SCIENCES, INC.; BRIZGYS, Gediminas; CANALES, Eda; HALCOMB, Randall, L.; HU, Yunfeng, Eric; KATO, Darryl; LINK, John, O.; LIU, Qi; SAITO, Roland, D.; TSE, Winston, C.; ZHANG, Jennifer, R.; (253 pag.)WO2016/33243; (2016); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 111-46-6, 2,2′-Oxybis(ethan-1-ol), can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C4H10O3, blongs to alcohols-buliding-blocks compound. Computed Properties of C4H10O3

2,2-oxydiethanol (168 mmol) in THF (100 ml) was added dropwise to a solution of sodium hydride (42mmol) in THF (80 ml) at 0C during 30 minutes. The solution was stirred for 2 hours at room temperature. 3-bromoprop-1-yne (42 mmol) was added and the solution was refluxed overnight, followed by addition of water (80 ml). Solvent was evaporated and extracted with EtOAc (4x lOOmI). The combined organic layers were washed with brine, dried over anhydrous Na2504, filtered and concentrated in vacuo. The obtained mixture was purified with flash chromatography (100% Heptaneto 40% EtOAc in Heptane)Yield: 58.3 %, MS (ESI) m/z 167 [M+Na] +1H-NMR (ODd3, 400 MHz) 6 2.44 (t, J=2.4 Hz, 1H), 3.62 (t, J=4.4 Hz, 2H), 3.69-3.77 (m, 6H), 4.22 (d, J=2.4Hz, 2H)

The synthetic route of 111-46-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; UNIVERSITEIT ANTWERPEN; JOOSSENS, Jurgen; AUGUSTYNS, Koen; LAMBEIR, Anne-Marie; VAN DER VEKEN, Pieter; VAN SOOM, Jeroen; MAGDOLEN, Viktor; (66 pag.)WO2015/144933; (2015); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 44565-27-7, name is 4-Amino-2-methylbutan-1-ol. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 44565-27-7

Reference Example 17 (+/-)-N-[3,5-Bis(trifluoromethyl)benzyl]-7,8-dihydro-7-(4-hydroxy-3-methylbutyl)-5-(4-methylphenyl)-8-oxo-6-pyrido[3,4-b]pyridinecarboxamide The compound as obtained in Reference Example 3 was reacted with 4-amino-2-methyl-1-butanol and treated in the same manner as in Reference Example 13, to obtain the entitled compound as colorless crystals. m.p. 129-130 C. (after once melted, this again solidified), 188-190 C. (re-melted) (recrystallized from ethyl acetate-isopropyl ether) NMR(200 MHz, CDCl3) ppm: 0.79(3H,d,J=6.6 Hz), 1.4-1.8(3H,m), 2.28(3H,s), 3.03(1H,t,J=6.6 Hz,-OH), 3.2-3.7(4H,m), 4.49(2H,d,J=5.8 Hz), 7.0-7.3(4H,m), 7.30(1H,dd,J=8.4,4.4 Hz), 7.53(1H,dd,J=8.4,1.4 Hz), 7.68(2H,s), 7.78(1H,s), 8.48(1H,t,J=6.0 Hz), 8.61(1H,dd,J=4.4,1.4 Hz).

With the rapid development of chemical substances, we look forward to future research findings about 44565-27-7.

Reference:
Patent; Natsugari, Hideaki; Doi, Takayuki; Ikeura, Yoshinori; US2002/132817; (2002); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 403-41-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 403-41-8, name is 1-(4-Fluorophenyl)ethyl Alcohol. A new synthetic method of this compound is introduced below.

0039] H Equipped with a magnetic stirrer in round bottom flask methyl benzyl alcohol (12. 22g, 100. Ommol, namely formula The R1 is 4-methyl, R2 is hydrogen, X is carbon, eta is 1, m is 0), ferric chloride (0. 81g, 5mmol), L- isoleucineAcid (1.31g, 10mmol), TEMP0 (1.56g, 10mmol), toluene 300. OmL was added , then the reaction with oxygen in the air bottleReplacement, stirred and reflux for 6h. After completion of reaction, the reaction mixture was cooled to room temperature, filtered, the filtrate evaporated to give the crude product,The resultant crude product was purified by column chromatography, with n-hexane: Elution: (10 1 volume ratio) mixed liquid of ethyl acetate containing the desired collectionLabeled compound of the eluent, evaporation of the solvent and dried to give the product p-tolualdehyde 10. 93g, 91% yield. 1- (4-fluorophenyl) ethanol (1 · 40g, 10. Ommol, i.e., of formula (I), R1 is 4-fluoro,R2 is methyl, X is carbon, [eta] is l, m is 0) is used, experimental methods and procedures were the same as in Example 1, except that: trifluoromethanesulfonate Iron(0 · 50g, 1. Ommol), L- isoleucine (0 · 26g, 2 · Ommol), TEMPO (0 · 16g, 1 · Ommol), xylene 30. OmL,After stirring at reflux with oxygen reaction bottle of air displacement 48h. To give the final product 1.23g, 88% yield.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,403-41-8, 1-(4-Fluorophenyl)ethyl Alcohol, and friends who are interested can also refer to it.

Reference:
Patent; Zhejiang University; Zhang, Guofu; Li, Shasha; Ding, Chengrong; Zhang, Guihua; Xie, Xiaoqiang; Lei, Jie; (12 pag.)CN105294413; (2016); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 1737-26-4 ,Some common heterocyclic compound, 1737-26-4, molecular formula is C9H9F3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Under nitrogen atmosphere, to a 15-mL Pyrex glass screw-cap tube were added 1-phenylethanol (1a: 0.613 g, 5 mmol), benzyl alcohol (2a: 0.543 g, 5 mmol), K3PO4 (531 mg, 2.5 mmol), and Pt-Sn/gamma-Al2O3 (catalyst III: 147 mg, 0.075 mol % Pt). The resultant mixture was stirred in the sealed tube at 155 C for 48 h. After cooled to ambient temperature, the catalyst and base were removed by centrifugation and washed with Et2O (2×5 mL). The combined supernatant was condensed under reduced pressure and subject to purification by silica gel column chromatography (eluent: petroleum ether (60-90 C)/EtOAc = 20:1, v/v), affording product 3a as a white solid (1.018 g, 96%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1737-26-4, 1-[4-(Trifluoromethyl)phenyl]ethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Wu, Kaikai; He, Wei; Sun, Chenglin; Yu, Zhengkun; Tetrahedron Letters; vol. 57; 36; (2016); p. 4017 – 4020;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 4254-29-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 4254-29-9, name is 2,3-Dihydro-1H-inden-2-ol, molecular formula is C9H10O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Example 94 yV7,/V7-Dimethyl-7,8-dihydro-6W-indeno[5,6-e][1,2,4]triazine-3,7-diamine 1 -Oxide (111). /V,/V-Dimethyl-2-indanamine (107). Methanesulfonyl chloride (11.5 mL, 149 mmol) was added dropwise to a stirred solution of 2-indanol (106) (20 g, 149 mmol) and JPr2NEt (28.6 mL, 164 mmol) in DCM (300 mL) at 0 0C, and the solution stirred at 20 0C for 16 h. The solution was washed with 1 M HCI (80 mL), aqueous saturated NaHCO3 solution (80 mL) and brine (100 mL), dried and the solvent evaporated. The residue was recrystallised from EtOH to give 2,3-dihydro-1/V-inden-2-yl methanesulfonate (31.14 g, 98%) as a white solid. Aqueous HNMe2 (40%, 180 mL, 1.42 mol) was added slowly to a stirred solution of mesylate (30.25 g, 143 mmol) in DMF (200 mL) and the solution stirred at 20 0C for 16 h. The solution was partitioned between EtOAc (400 mL) and water (800 mL) and the organic fraction washed with water (3 x 80 mL), brine (100 mL), dried and the solvent evaporated. The residue was suspended in 1 M HCI (400 mL) and washed with DCM (3 x 80 mL). The pH of the aqueous fraction was adjusted to 14 with NaOH, the mixture chilled at 5 0C for 8 h and the precipitate filtered. The precipitate was washed with water (50 mL) and dried to give amine 107 (21.54 g, 93%) as a light gray solid: 1H NMR delta 7.10-7.17 (m, 4 H, Harom), 3.01-3.08 (m, 3 H, H-2, CH2), 2.82-2.91 (m, 2 H1 CH2), 2.31 [s, 6 H, N(CHa)2].

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 4254-29-9, 2,3-Dihydro-1H-inden-2-ol.

Reference:
Patent; AUCKLAND UNISERVICES LIMITED; WO2006/104406; (2006); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts