Sep 2021 News New learning discoveries about 178312-48-6

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 178312-48-6, (4,4-Difluorocyclohexyl)methanol, other downstream synthetic routes, hurry up and to see.

Related Products of 178312-48-6 ,Some common heterocyclic compound, 178312-48-6, molecular formula is C7H12F2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

The above (4, 4-difluorocyclohexyl) methanol was dissolved in 5 ml of pyridine. Thereto 2.2 g of p- toluenesulfonyl chloride was added at 0C and the mixture was stirred at room temperature overnight. Thereafter, the reaction mixture was concentrated under reduced pressure. The residue was dissolved in ethyl acetate, washed successively with water, dilute hydrochloric acid and aqueous saturated sodium chloride, dried over anhydrous magnesium sulfate, and then concentrated under reduced pressure. The residue was subjected to silica gel column chromatography to obtain 3.1 g of 4, 4- difluorocyclohexylmethyl p-toluenesulfonate. 4, 4-Difluorocyclohexylmethyl p-toluenesulfonate: lH-NMR (CDC13, TMS) 5 (ppm): 1.18-1. 37 (2H, m), 1.56-1. 86 (5H, m), 2.00-2. 17 (2H, br), 2.46 (3H, s), 3. 86 (2H, d), 7. 35 (2H, d), 7.78 (2H, d).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 178312-48-6, (4,4-Difluorocyclohexyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; SUMITOMO CHEMICAL COMPANY, LIMITED; WO2005/63694; (2005); A1;,
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Sep 2021 News Analyzing the synthesis route of 932-01-4

Statistics shows that 932-01-4 is playing an increasingly important role. we look forward to future research findings about 4,4-Dimethylcyclohexanol.

Electric Literature of 932-01-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.932-01-4, name is 4,4-Dimethylcyclohexanol, molecular formula is C8H16O, molecular weight is 128.21, as common compound, the synthetic route is as follows.

N,N’-carbonyldiimidazole (118 mg) was added to a mixture of 4,4-dimethylcyclohexanol (72 mg) and acetonitrile (7 ml). The reaction mixture was stirred at 45C for 1 hour, added with water and chloroform and washed with water. The organic layer was dried over sodium sulfate and the solvent was evaporated under reduced pressure. The product (190 mg) of the above (2), triethylamine (0.21 ml), 4-dimethylaminopyridine (10 mg) and DMF (5 ml) were added to the residue and the reaction mixture was heated at 80C for 1 hour. The reaction mixture was evaporated under reduced pressure, and water and chloroform were added thereto. The organic layer was dried over sodium sulfate and the solvent was evaporated under reduced pressure. The residue was purified by silica gel chromatography (elution solvent: hexane/ethyl acetate = 100/0 to 0/100 gradient) to obtain 135 mg of 4,4-dimethylcyclohexyl (S)-3-(4-benzyloxy-3-methoxybenzylcarbamoyl)-piperidine-1-carboxylate.

Statistics shows that 932-01-4 is playing an increasingly important role. we look forward to future research findings about 4,4-Dimethylcyclohexanol.

Reference:
Patent; Dainippon Sumitomo Pharma Co., Ltd.; EP2277861; (2011); A1;,
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13 Sep 2021 News Introduction of a new synthetic route about 402-63-1

At the same time, in my other blogs, there are other synthetic methods of this type of compound,402-63-1, 1-(3-Fluorophenyl)ethanol, and friends who are interested can also refer to it.

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.402-63-1, name is 1-(3-Fluorophenyl)ethanol, molecular formula is C8H9FO, molecular weight is 140.1549, as common compound, the synthetic route is as follows.Quality Control of 1-(3-Fluorophenyl)ethanol

Example 93 5-(2-(4-Hydroxy-piperidino)-ethyl)-2-methyl-1H-indole-3-carboxylic Acid-1-(3-fluorophenyl)-ethyl Ester The procedure for Example 65 was followed, substituting 1-(3-fluorophenyl)-ethanol for (S)-phenylethanol, and substituting 4-hydroxypiperidine for diethylamine. ESI+MS m/z 425 (M+1).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,402-63-1, 1-(3-Fluorophenyl)ethanol, and friends who are interested can also refer to it.

Reference:
Patent; Millennium Pharmaceuticals, Inc.; US2003/64991; (2003); A1;,
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13 Sep 2021 News Sources of common compounds: 558-42-9

According to the analysis of related databases, 558-42-9, the application of this compound in the production field has become more and more popular.

Synthetic Route of 558-42-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 558-42-9, name is 1-Chloro-2-methyl-2-propanol, molecular formula is C4H9ClO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

[00296j Step 1: methyl 6-chloro-5-(2-hydroxy-2-methyl-propoxy)pyridine-2-carboxylate [00297j A solution of methyl 6-chloro-5 -hydroxy-pyridine-2- carboxylate (1.6 g, 8.3 mmol) in methanol (1.5 mL) was treated with finely ground potassium carbonate (4.6 g, 33.0 mmol). The reaction mixture was heated to 80 °C and1-chloro-2-methyl-propan-2-ol (1.7 mL, 16.5 mmol) was added. The reaction mixture was heated at 80 °C overnight. The reaction mixture was concentrated under reduced pressure. The remaining residue was suspended in water (75 mL) and extracted with ethyl acetate (2 x 75 mL). Organic layers were combined, dried over sodium sulfate, filtered and concentrated under reduced pressure. The resulting oil was purified bysilica gel colunm chromatography: 40 gram silica gel column, 0-30percent ethyl acetate/hexane gradient over 25 mm to afford methyl 6-chloro-5-(2-hydroxy-2-methyl- propoxy)pyridine-2-carboxylate (1.2 g, 54percent) was obtained as a colorless solid. ?H NMR (400 MHz, CDC13) oe 8.09 (d, J = 8.4 Hz, 1H), 7.27 (d, J = 8.4 Hz, 1H), 3.98 (s, 3H), 3.94 (s, 2H), 1.41 (s, 6H). ESI-MS mlz calc. 259.1, found 260.2 (M+1)+;Retention time: 0.99 mm (3 mm run).

According to the analysis of related databases, 558-42-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; VERTEX PHARMACEUTICALS INCORPORATED; DENINNO, Michael, Paul; ANDERSON, Corey; CONROY, Erica, Lynn; FRIEMAN, Bryan, A.; GROOTHENHUIS, Peter, Diederik Jan; HADIDA-RUAH, Sara, Sabina; HURLEY, Dennis, James; PIERRE, Fabrice Jean, Denis; SILINA, Alina; UY, Johnny; ZHOU, Jinglan; WO2015/6280; (2015); A1;,
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13 Sep 2021 News New learning discoveries about 41175-50-2

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,41175-50-2, its application will become more common.

Adding a certain compound to certain chemical reactions, such as: 41175-50-2, 1,2,3,5,6,7-Hexahydropyrido[3,2,1-ij]quinolin-8-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 41175-50-2, blongs to alcohols-buliding-blocks compound. Recommanded Product: 1,2,3,5,6,7-Hexahydropyrido[3,2,1-ij]quinolin-8-ol

General procedure: Fast Black K Salt hemi(zinc chloride) salt (dye content ~30%) (1.5 g, 1.08 mmol, 1.2equiv.) was dissolved in a mixture of NaOAc buffer (0.1 M, pH 4.0) and MeCN (1 : 1,v/v, 8 mL). The resulting mixture was stirred at rt for 10 min, then sonicated to get near complete solubilization. In another round-bottom flask, the functionalized N,Ndisubstituted aniline (0.9 mmol, 1.0 equiv.) was dissolved in MeCN (2 mL) and cooled to 0 C. The diazonium salt solution was directly filtrated and added to this tertiary aniline and the resulting mixture was stirred at rt for 2 h. The fine precipitate newly formed was recovered by filtration and washed twice with a mixture of deionized water and MeCN (1: 1, v/v). The resulting solid was then dried by lyophilization to afford the BHQ-2 derivative as an amorphous dark purple solid.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,41175-50-2, its application will become more common.

Reference:
Article; Chevalier, Arnaud; Renard, Pierre-Yves; Romieu, Anthony; Tetrahedron Letters; vol. 55; 50; (2014); p. 6764 – 6768;,
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Sep 2021 News A new synthetic route of 10602-04-7

According to the analysis of related databases, 10602-04-7, the application of this compound in the production field has become more and more popular.

Synthetic Route of 10602-04-7, Adding some certain compound to certain chemical reactions, such as: 10602-04-7, name is (4-Ethynylphenyl)methanol,molecular formula is C9H8O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 10602-04-7.

To a 40 mL glass vial with rubber septum was added 3 (1.00 g, 2.04 mmol), 4-ethynylbenzyl alcohol 4 (0.405 g, 3.06 mmol), PdCI2(PPh3)2 (86 mg, 0.123 mmol), Cul (39 mg, 0.204 mmol), /’Pr2EtN (1.06 g, 8.17 mmol) and THF (7 mL). The contents were briefly placed under vacuum, and then placed under a nitrogen atmosphere. The vial was sealed and heated at 70 °C for 16 h. After cooling to rt, the mixture was filtered through celite, washing with EtOAc, and the filtrated was concentrated under vacuum. The residue was purified by silica gel chromatography (heptane / ethyl acetate / NEt3) to give 5 (0.680 g, 62percent) as a foamy solid. 1H NMR (400 MHz, CDCI3): 3.74 (s, 6 H), 4.12 (s, 2 H), 4.53 (d, J = 4.0 Hz, 2 H), 5.29 (t, J = 4.0 Hz, 1 H), 6.93 (dd, J = 8.0 Hz, 4 H), 7.19 – 7.58 (m, 17 H).

According to the analysis of related databases, 10602-04-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; NOVARTIS AG; BARYZA, Jeremy Lee; BLOMMERS, Marcel; FERNANDEZ, Cesar; GENO, Erin; GOSSERT, Alvar; GREENIDGE, Paulette; HUESKEN, Dieter; HUNZIKER, Juerg; NATT, Francois Jean-Charles; PATNAIK, Anup; PATTERSON, Andrew; RONDEAU, Jean-Michel Rene; WEILER, Jan; ZHU, Meicheng; WO2015/51045; (2015); A2;,
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13/9/2021 News Some scientific research about 929-06-6

With the rapid development of chemical substances, we look forward to future research findings about 929-06-6.

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 929-06-6, name is 2-(2-Aminoethoxy)ethanol, molecular formula is C4H11NO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Safety of 2-(2-Aminoethoxy)ethanol

Example 1 Tert-butyl 2-(2-hydroxyethoxy)ethylcarbamate In a three-necked flask (1000 mL) equipped with a mechanical stirrer, 52.5 g (500 mmol) of diglycolamine and 200 mL of chloroform were dissolved and cooled to 20C on an ice-water bath. To the flask, a mixture prepared by dissolving 109 g (500 mmol) of (Boc)2O in 200 mL of chloroform was added with stirring. The resultant solution was stirred overnight at room temperature. After reaction completion, 400 mL of water were added, and the organic and aqueous phases were allowed to separate. The resultant organic phase was removed, washed with water twice, saturated brine twice, dried over anhydrous MgSO4, filtered, and vacuum dried to yield 99.607 g of the title compound 1.

With the rapid development of chemical substances, we look forward to future research findings about 929-06-6.

Reference:
Patent; Tianjin Hemey Bio-Tech Co., Ltd.; EP2123283; (2009); A1;,
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13/9/2021 News New downstream synthetic route of 115652-52-3

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,115652-52-3, its application will become more common.

Adding a certain compound to certain chemical reactions, such as: 115652-52-3, (1-Aminocyclopropyl)methanol hydrochloride, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 115652-52-3, blongs to alcohols-buliding-blocks compound. HPLC of Formula: C4H10ClNO

[l-[(5-Bromo-4-chloro-3-pyridyl)methylamino]cyclopropyl]methanol:

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,115652-52-3, its application will become more common.

Reference:
Patent; DENALI THERAPEUTICS INC.; DE VICENTE FIDALGO, Javier; ESTRADA, Anthony A.; FENG, Jianwen A.; FOX, Brian; FRANCINI, Cinzia Maria; HALE, Christopher R.H.; HU, Cheng; LESLIE, Colin Philip; OSIPOV, Maksim; SERRA, Elena; SWEENEY, Zachary K.; THOTTUMKARA, Arun; (226 pag.)WO2018/213632; (2018); A1;,
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Sep 2021 News Simple exploration of 1875-88-3

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1875-88-3, its application will become more common.

Adding a certain compound to certain chemical reactions, such as: 1875-88-3, 2-(4-Chlorophenyl)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 1875-88-3, blongs to alcohols-buliding-blocks compound. name: 2-(4-Chlorophenyl)ethanol

Example 8A: To a solution of 2-(4-chlorophenyl)ethanol (250 mg, 1.60 mmol, 215 mu, 1 eq) and Et3N (243 mg, 2.40 mmol, 333 mu, 1.50 eq) in DCM (5 mL) at 0 C was added methanesulfonyl chloride (340 mg, 2.97 mmol, 230 mu, 1.86 eq). The solution was stirred at 0 C for 2 hours. Water (30 mL) was added to the solution. The organic layer was separated, dried over anhydrous sodium sulfate, and concentrated to afford the target compound (350 mg, 93% yield). The product can be used directly for the next step without further purification. MR (400 MHz, METHANOLS) delta 7.35 – 7.21 (m, 4H), 4.43 (t, J= 6.6 Hz, 2H), 3.04 (t, J= 6.6 Hz, 2H), 2.98 (s, 3H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1875-88-3, its application will become more common.

Reference:
Patent; CHRYSALIS, INC.; GWALTNEY, Stephen; (167 pag.)WO2017/143011; (2017); A1;,
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13/9/2021 News New learning discoveries about 100-37-8

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,100-37-8, its application will become more common.

Related Products of 100-37-8 ,Some common heterocyclic compound, 100-37-8, molecular formula is C6H15NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

41 g of ibuprofen was dissolved in 200 ml of ethyl acetate. 16 mL of thionyl chloride was added into the mixture. The mixture was refluxed for 2 h. The mixture was evaporated todryness completely. 500 mL of ethyl acetate was added intothe residue and evaporated off. 500 mL of ethyl acetate wasadded into the reaction mixture. The solution was cooled to 5C. with ice-water bath. 23 g of N,N-diethylaminoethanolwas added into the reaction mixture drop by drop. 40 g ofNaCO was added into the reaction mixture slowly. Themixture was stirred for overnight at RT. 200 mL of water wasadded into the mixture. The ethyl acetate solution was collected and washed with water (3×200 mL) and dried overanhydrous NaSO4. Sodium sulfate was removed by filtration and washed with ethyl acetate (3×100 mL). Anhydrous HCl gas (10 g) was bubbled into the mixture. The solid was collected and washed with ethyl acetate.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,100-37-8, its application will become more common.

Reference:
Patent; TECHFIELDS PHARMA COMPANY LIMITED; YU, CHONGXI; XU, LINA; (113 pag.)JP2018/65866; (2018); A;,
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