Tag: M.W=100-200

Related Products of 161446-90-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 161446-90-8, name is 3-Chloro-4-fluorobenzyl Alcohol. This compound has unique chemical properties. The synthetic route is as follows.

Example 222 4- ( (3-Chloro-4-fluorobenzyl) oxy) -1- (2- ( (1RS,2SR) -2- (2- hydroxypropan-2-yl ) cyclopropyl) -l-methyl-lH-benzimidazol-6- yl) pyridin-2 (1H) -one To a mixture of. 4-hydroxy-l- (2- ( ( IRS, 2SR) -2- (2- hydroxypropan-2-yl ) cyclopropyl) -l-methyl-lH-benzimidazol-6- yl) pyridin-2 (1H) -one (100 mg) , (3-chloro-4- fluorophenyl) methanol (95 mg) , tributylphosphine (0.219 ml) and THF (10 ml) was added 1, 1′ – (azodicarbonyl) dipiperidine (223 mg) , and the mixture was stirred at 60C for 2 h. The reaction mixture was diluted with EtOAc, washed with water and brine successively, dried over MgS04, filtered through a plug of NH silica gel, and concentrated in vacuo. The residue was purified by silica gel column chromatography (hexane/EtOAc then EtOAc/MeOH) , followed by NH silica gel column chromatography (hexane/EtOAc) . Then the resulting solid was recrystallized from IPA-EtOAc to give the title compound (58.4 mg) as an off-white solid. MS (ESI+) : [M+H] + 482.2. XH NMR (400 MHz, DMSO-d6) : delta 1.09 (6H, s) , 1.23-1.32 (1H, m) , 1.36-1.44 (1H, m) , 1.56-1.66 (1H, m) , 2.22-2.31 (1H, m) , 3.86 (3H, s), 5.18 (2H, s) , 5.86 (1H, s) , 5.98 (1H, d, J = 2.3 Hz), 6.13 (1H, dd, J = 2.3, 7.8 Hz), 7.09 (1H, d, J = 8.4 Hz), 7.35 (1H, d, J = 7.9 Hz), 7.51-7.59 (3H, m) , 7.60-7.70 (2H, m) .

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 161446-90-8, 3-Chloro-4-fluorobenzyl Alcohol.

Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; KASAI, Shizuo; IGAWA, Hideyuki; TAKAHASHI, Masashi; MAEKAWA, Tsuyoshi; KAKEGAWA, Keiko; YASUMA, Tsuneo; KINA, Asato; AIDA, Jumpei; KHAMRAI, Uttam; KUNDU, Mrinalkanti; WO2013/105676; (2013); A1;,
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Synthetic Route of 136-80-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 136-80-1, name is N-(2-Hydroxyethyl)-2-methylaniline, molecular formula is C9H13NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

This embodiment provides a quinone compound, and its reaction formula is:In a reaction flask, 5 mmol of N-hydroxyethyl-2-methylaniline and 7.5 mmol of 2-methylaniline provided in Example 2 were weighed out and dissolved in 200 ml of acetonitrile, and Sn/activated carbon loaded catalyst was added, and TLC was used to detect N. The reaction was stopped after the reaction of hydroxyethyl-2-methylaniline was completed.After isolation and purification, 7-methylindole was obtained (yield 64.3%).

According to the analysis of related databases, 136-80-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Chongqing Huage Biochemical Co., Ltd.; He Xiaoqiang; Chen Zhizhong; Wu Chengli; (8 pag.)CN107445881; (2017); A;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 100-37-8, name is 2-(Diethylamino)ethanol. A new synthetic method of this compound is introduced below., Application In Synthesis of 2-(Diethylamino)ethanol

165 g of ibuprofen and 160 mL of isopropyl acetate were placed in a pre-dried 500 mL three-necked flask and equipped with a reflux and agitation device; 64 mL of thionyl chloride was slowly added to the three-necked flask with stirring, and the mixture was stirred at room temperature for 30 minutes and then heated to reflux. Keep refluxed for 2-3 hours; The reaction mixture was rotary evaporated until No fraction dropout, and evaporated to dryness by adding 120 mL of n-hexane, and 120 mL of isopropyl acetate was added thereto, and the distillation was continued until no fraction was dropped, and the distillation was repeated once with isopropyl acetate. The evaporated mixture was dissolved in 600 mL of isopropyl acetate and transferred to a pre-dried 2 L three-necked flask, stirred and cooled to below 10 C; 93.6g of 2-(diethylamino)ethanol was slowly added dropwise to the above three necked flask through a constant pressure dropping funnel, and the temperature was controlled within 10 C, after the completion of the dropwise addition, stirring was continued at 0-10 C for 0.5 hours; 88 g of anhydrous potassium carbonate solid was added to the above three-necked bottle in portions, stirred at 5-10 C for 30 minutes, then slowly warmed to 15-25 C, and stirred at this temperature for 8-10 hours; 320 mL of deionized water was added to the above reaction solution, stirred for 15-30 minutes, and the organic phase was separated. The organic phase was washed four times with deionized water (320 mL X 4) and dried over anhydrous sodium sulfate. Filtration, then washed solid sodium sulfate with a small amount of isopropyl acetate; The above organic phase was transferred to a 2L three-necked flask, and the temperature was lowered to below 10 C, and about 32 g of hydrogen chloride gas was introduced at 0-10 C and maintained it for 1- 2 hours, then Concentrated a part of the solution, added 120 mL of n-hexane under stirring, added 1 g of seed crystals, and sealed and placed in refrigerator for crystallization; Filtration, washing with ethyl acetate / n-hexane (V / V = 1:1, 200 ml X 2); The obtained solid was dried under vacuum at 40-50 C until the water (moisture content )is qualified, to obtain 178.56 g of a crystalline crystal, a molar yield of 65.2%, and a purity of 99.76 %.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 100-37-8, 2-(Diethylamino)ethanol.

Reference:
Patent; Tianjin Xinchen Taifeier Pharmaceutical Technology Co., Ltd.; Yao Chen; (25 pag.)CN108727206; (2018); A;,
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Related Products of 5182-44-5 ,Some common heterocyclic compound, 5182-44-5, molecular formula is C8H9ClO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

2-(3-chlorophenyl)acetaldehyde[115] The mixture of Example 86A (5.73 g, 36.5 mmol) and Dess-Martin periodinane (18.6 g, 43.8 mmol) in 200 mL of dichloromethane was stirred under 2 atmosphere for 4 hours at room temperature. Then saturated aHC03 (500 mL) and a2S2C>3 (100 mL) was added with stirring for another 30 minutes. The mixture was extracted with dichloromethane (3 x 300 mL). The organic layers were combined, dried over Na2S04, filtered, and concentrated. The crude product was purified by distillation under reduced pressure.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,5182-44-5, its application will become more common.

Reference:
Patent; ABBVIE INC.; BAYBURT, Erol K.; CLAPHAM, Bruce; COX, Phil B.; DAANEN, Jerome F.; GOMTSYAN, Arthur; KORT, Michael E.; KYM, Philip R.; VOIGHT, Eric A.; SCHMIDT, Robert G.; DART, Michael J.; GFESSER, Gregory; WO2013/62966; (2013); A2;,
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Related Products of 1875-88-3 ,Some common heterocyclic compound, 1875-88-3, molecular formula is C8H9ClO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

(9A) Ethyl 3-{4-[2-(4-chlorophenyl)ethoxy]phenyl}-3-ethoxypropionate Ethyl 3-ethoxy-3-(4-hydroxyphenyl)propionate (100 mg, 0.420 mmol) produced in Example 1 (1C) and 2-(4-chlorophenyl)ethanol (99 mg, 0.630 mmol) were dissolved in tetrahydrofuran (10 mL), and triphenylphosphine (178 mg, 0.680 mmol) and a 40percent diethyl azodicarboxylate toluene solution (309 muL, 0.680 mmol) were added thereto at room temperature, and then, the resulting mixture was stirred under a nitrogen atmosphere at 50° C. for 4 hours. After the reaction solution was cooled to room temperature, the solvent was distilled off under reduced pressure, and the resulting residue was purified by silica gel column chromatography (hexane:ethyl acetate=100:0 to 95:5 (v/v)), whereby the objective title compound was obtained as a yellow oily substance (151 mg, yield: 95percent). 1H NMR (CDCl3, 400 MHz): delta1.13 (3H, t, J=7.0 Hz), 1.23 (3H, t, J=7.0 Hz), 2.55 (1H, dd, J=5.0, 15.2 Hz), 2.79 (1H, dd, J=9.0, 15.2 Hz), 3.06 (2H, t, J=7.0 Hz), 3.30-3.38 (2H, m), 4.14 (4H, t, J=7.3 Hz), 4.68 (1H, dd, J=5.0, 8.9 Hz), 6.86 (2H, d, J=8.6 Hz), 7.22 (2H, d, J=8.3 Hz), 7.24 (2H, d, J=8.6 Hz), 7.28 (2H, d, J=8.6 Hz)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1875-88-3, its application will become more common.

Reference:
Patent; DAIICHI SANKYO COMPANY, LIMITED; US2011/53974; (2011); A1;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 7287-81-2, name is 1-(m-Tolyl)ethanol, molecular formula is C9H12O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Computed Properties of C9H12O

General procedure: Firstly, GO (0.01 g) was added into water (3 mL) and the mixturecould generate the stable colloidal suspensions under a mild ultrasonictreatment. Afterwards, the alcohol (2 mmol) and (NH4)5H5[H2(WO4)6](0.03 mmol, M=1602) were added. The mixture was stirred for 15 min atroom temperature. Subsequently, hydrogen peroxide (30 wt%, 8 mmol)was added dropwise and the mixture was heated to 70C until thereaction was fully completed (monitored by TLC). After the reactioncompleted, GO could be readily separated from the mixtures bycentrifugation, and then ethyl acetate was added to the mixture to extract organic constituents. Finally, the organic extracts were concentratedunder reduced pressure and purified by column chromatography.

With the rapid development of chemical substances, we look forward to future research findings about 7287-81-2.

Reference:
Article; Fu, Huihui; Hu, Chuanfeng; Huang, Zhida; Zhou, Jianhao; Peng, Xinhua; Synlett; vol. 29; 4; (2018); p. 447 – 451;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.60211-57-6, name is 3,5-Dichlorobenzyl alcohol, molecular formula is C7H6Cl2O, molecular weight is 177.0279, as common compound, the synthetic route is as follows.Application In Synthesis of 3,5-Dichlorobenzyl alcohol

Step 1.Preparation of {7-[4-(3,5-Dichloro-benzyloxy)-benzylsulfanyl]-indan-4-yloxy}-acetic Acid Methyl Ester (Compound 77A) The product from Example 75C (0.42 g, 1 mmoles), (3,5-dichlorophenyl)-methanol (0.24 g, 1.3 mmoles), triphenyl phosphine (0.38 g, 1.5 mmoles), and 0.23 ML of diethyl azodicarboxylate (0.25 g, 1.5 mmoles) were dissolved in 9 ML of tetrahydrofuran.The reaction mixture was stirred at room temperature under nitrogen for 18 hrs.The reaction mixture was evaporated to give a residue, which was flash chromatographed (silica gel, 20% ethyl acetate in hexane) to afford the title compound in good purity. MS m/z 265

At the same time, in my other blogs, there are other synthetic methods of this type of compound,60211-57-6, 3,5-Dichlorobenzyl alcohol, and friends who are interested can also refer to it.

Reference:
Patent; Auerbach, Bruce J.; Bratton, Larry D.; Filzen, Gary F.; Geyer, Andrew G.; Trivedi, Bharat K.; Unangst, Paul C.; US2003/225158; (2003); A1;,
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Adding a certain compound to certain chemical reactions, such as: 41175-50-2, 1,2,3,5,6,7-Hexahydropyrido[3,2,1-ij]quinolin-8-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: 1,2,3,5,6,7-Hexahydropyrido[3,2,1-ij]quinolin-8-ol, blongs to alcohols-buliding-blocks compound. name: 1,2,3,5,6,7-Hexahydropyrido[3,2,1-ij]quinolin-8-ol

Method A – From US 3,932,415 7,7′-Methylenebis(2,3,6,7-tetrahydrobenzo[i,j]quinolizine-8,8′-diol)Hydrochloric acid (0.8 cm3, 32%) was added drop wise to a solution of 8-hydroxyjulolidine (3.00 g, 15.9 mmol) in methanol (16 cm3) at 5C. Formalin (0.593 cm3, 40% in water) was then added to the reaction and the resulting mixture was allowed to stand overnight at 5C. The mixture was then poured into water (50 cm3) before being neutralised with a saturated solution of sodium bicarbonate. The mixture was extracted with chloroform (3 x 40 cm3), the combined extracts were dried over sodium sulphate, filtered and the solvent removed under reduced pressure. Column chromatography (3:7 ethyl acetate/hexane) gave the target material as a colourless solid (2.11 g, 68%).deltaH (250 MHz, CDCI3): 6.68 (2H, s, CH), 3.64 (2H, s, CH2), 3.00 (8H, t, J1 = 6 Hz, CH2), 2.67 (4H, J1 = 6 Hz, CH2), 2.60 (4H1 1, J2 = 7 Hz1 CH2), 1.97 – 1.90 (8H, m, CH2); deltac (100 MHz, CDCI3): 149.3, 142.7, 127.6, 114.6, 114.5, 108.5, 50.2, 49.4, 30.9, 27.0, 22.5, 21.7, 21.2; vmax (KBr)/cm 1: 3431 , 2927, 2853, 2842, 1618, 1494, 1450, 1350, 1332, 1310, 1281 , 1270, 1153, 1132; m/z (ESI): 389.3 (100%, [M-H]+).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,41175-50-2, 1,2,3,5,6,7-Hexahydropyrido[3,2,1-ij]quinolin-8-ol, and friends who are interested can also refer to it.

Reference:
Patent; WISTA LABORATORIES LTD.; CLUNAS, Scott; STRORY, John, Mervyn, David; RICKARD, Janet, Elizabeth; HORSLEY, David; HARRINGTON, Charles, Robert; WISCHIK, Claude, Michel; WO2010/67078; (2010); A2;,
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Electric Literature of 5020-41-7 ,Some common heterocyclic compound, 5020-41-7, molecular formula is C9H12O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: Alcohol S1 (2.0 mmol, 1.0 equiv) and H2SO4 (0.2 equiv) were added successively to a solution of aldehyde S2 (1.2 equiv) intoluene (5.0 mL). The reaction mixture was stirred at room temperature for 2 h. Then the reaction mixture was quenched withwater (2.0 mL) and extracted with ethyl acetate. The combined organic extract was washed with saturated brine and dried withanhydrous MgSO4. After filtration and concentration, the residue was purified by flash chromatography to give substrate 1.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 5020-41-7, 2-(3-Methoxyphenyl)ethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Wang, Zehua; Mao, Ying; Guan, Honghao; Cao, Min; Hua, Jing; Feng, Lei; Liu, Lei; Chinese Chemical Letters; vol. 30; 6; (2019); p. 1241 – 1243;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 623-50-7, name is Ethyl 2-hydroxyacetate, the common compound, a new synthetic route is introduced below. Safety of Ethyl 2-hydroxyacetate

Step 1; Benzyloxy-acetic acid ethyl ether; 1 1 5 g of ethyl glycolate is dissolved in 120 ml of dry THF under an atmosphere of nitrogen and cooled to 0 4 9 g of sodium hydride is added portionwise over 40 minutes and the reaction mixture stirred at 0 for 15 minutes and then 4 3 g of tetrabutylammonium iodide is added followed by 13 3 ml of benzyl bromide The mixture allowed to warm to RT and stirred for 3 hours The reaction then quenched with 20 ml of a saturated aqueous ammonium chloride solution and the THF then removed in vacuo The residue is partitioned between EtOAc (100 ml) and H2O (150 ml) The aqueous then extracted twice with EtOAc and the combined EtOAc extracts washed with 50 ml brine then dried over magnesium sulfate, filtered and the solvent evaporated The residue is purified by flash chromatography on silica eluting with a 19 1 /so-hexane/diethyl ether to 4 1 /so-hexane/diethyl ether mixture to yield the title compound

The synthetic route of 623-50-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; NOVARTIS AG; WO2009/106539; (2009); A1;,
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