Tag: M.W=100-200

Related Products of 13726-17-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.13726-17-5, name is (4-Chloro-3-methoxyphenyl)methanol, molecular formula is C8H9ClO2, molecular weight is 172.61, as common compound, the synthetic route is as follows.

[00154] Step 2. A suspension of pyridinium chlorochromate (1.37 g, 6.34 mmol) in dichloromethane (35 mL) was treated with Celite (2.0 g) and stirred at rt. A solution of (4-chloro-3-methoxyphenyl)methanol (730 mg, 4.23 mmol) in dichloromethane (5 mL) was added in one portion, and the resulting mixture was stirred at rt for 3 h. After this time, the mixture was diluted with diethyl ether, and stirred vigorously. The mixture was then filtered through a pad of silica gel and the collected solids were rinsed with additional diethyl ether. The combined filtrates were concentrated under vacuum to provide 4-chloro-3-methoxybenzaldehyde as a pale tan-yellow solid (630 mg, 87%). 1H NMR (400 MHz, CDCl3) delta ppm 3.98 (s, 3 H) 7.41 (dd, J=I.9, 1.8 Hz, 1 H) 7.45 (d, J=2.0 Hz, 1 H) 7.55 (d, J=7.6 Hz, 1 H) 9.95 (s, I H).

The chemical industry reduces the impact on the environment during synthesis 13726-17-5, I believe this compound will play a more active role in future production and life.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; BATT, Douglas, G.; WO2010/9069; (2010); A1;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 30379-58-9, name is Benzyl 2-hydroxyacetate. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: Benzyl 2-hydroxyacetate

General procedure: The suitable acid (1.1 equiv), DCC (1.1 equiv) and a catalytic amount of DMAP (0.1-0.2 equiv.) were added to a solution of the alcohol in anhydrous DCM, and stirred at room temperature for several hours. The solid was removed by filtration, and the filtrate was washed successively with a 1N aqueous acetic acid solution and water, dried over MgSO4, filtered, and concentrated under vacuum.The resulting residue was purified by silica gel chromatography to yield the expected compound.

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Reference:
Article; El Hilali, Mostafa; Reux, Bastien; Debiton, Eric; Leal, Fernand; Galmier, Marie-Josephe; Vivier, Magali; Chezal, Jean-Michel; Miot-Noirault, Elisabeth; Coudert, Pascal; Weber, Valerie; Bioorganic and Medicinal Chemistry; vol. 25; 20; (2017); p. 5692 – 5708;,
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Related Products of 4358-87-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 4358-87-6, name is Methyl 2-hydroxy-2-phenylacetate. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: Entry 5: According to general procedure II (chapter 2.1.2) racemic methyl mandelate (rac-132, 336 mg, 2.00 mmol, 1.0 equiv), DMF (30.9 ilL, 29.2 mg, 0.40 mmol, 20 molpercent), dioxane (1 mL, 2 M)and 2-fluoro benzoyl chloride (372 ilL, 490 mg, 3.00 mmol, 1.5 equiv) were combined and allowed to react for 36 h at 80 C. Chromatographic purification of the crude material (540 mg, 232/332 86:14) on silica gel (mass of crude material/Si02 1:9) with Et20/nPen 5:95 gave rise of the chloride rac-232 ascolorless oil (227 mg, 1.23 mmol, 62percent).M (C9H9C102) = 184.62 g/mol; rf (Si02, Et20/nPen 5:95) = 0.37; [aID2° = +134.1 (c = 1.48 g/100 mL,CHCI3).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 4358-87-6, Methyl 2-hydroxy-2-phenylacetate.

Reference:
Patent; UNIVERSITAET DES SAARLANDES; HUY, Peter Helmut; (208 pag.)WO2016/202894; (2016); A1;,
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Reference of 115-20-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.115-20-8, name is Trichloroethanol, molecular formula is C2H3Cl3O, molecular weight is 149.4, as common compound, the synthetic route is as follows.

A solution of 3-tert-butyl-5-methylsulfamoyl-benzoic acid (WO 2008/021388, which is incorporated herein by reference in its entirety, 400 mg, 1.47 mmol) in THF (10 ml) was treated with TEA (270 mu1, 1.91 mmol) and DPPA (412 mul, 1.91 mmol). The reaction mixture was stirred at RT for 1 hour and then 2,2,2-trichloro-ethanol (225 mul, 2.35 mmol) was added. The reaction mixture was heated at 70 C. for 18 hours and cooled at RT. The volatiles were removed under reduced pressure and the residue was partitioned between EtOAc and an aqueous 5% citric acid solution. The two phases were separated and the aqueous phase was extracted with EtOAc. The combined organic phases were washed with a saturated aqueous NaHCO3 solution and brine, dried with Na2SO4 and the solvent was removed under reduced pressure. Purification by FCC, eluting with 0-70% EtOAc/cyclohexane gave the title compound (429 mg, 70%). 1H NMR (300 MHz, CDCl3): 1.35 (9H, s), 2.69 (3H, d, J=5.4 Hz), 4.45 (1H, q, J=5.4 Hz), 4.84 (2H, s), 7.18 (1H, br s), 7.62 (1Ht, J=1.7 Hz), 7.66 (1H, br s), 7.81 (1H, br s).

Statistics shows that 115-20-8 is playing an increasingly important role. we look forward to future research findings about Trichloroethanol.

Reference:
Patent; CHIESI FARMACEUTICI S.P.A.; CAPALDI, Carmelida; ARMANI, Elisabetta; JENNINGS, Andrew Steven Robert; HURLEY, Christopher; (82 pag.)US2017/183345; (2017); A1;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 117284-59-0, name is 2-(2,2-Difluorocyclopropyl)ethanol. This compound has unique chemical properties. The synthetic route is as follows. SDS of cas: 117284-59-0

Methanesulfonyl chloride (1.35 mL) was added to a solution of 2- (2 , 2-difluorocyclopropyl) ethanol (1.42 g) and triethylamine (3.24 mL) in THF (20 mL) dropwise at 0 C. The mixture was stirred at room temperature overnight. Water was added, and the mixture was extracted with ethyl acetate. The organic layer was washed with brine, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography(hexane/ethyl acetate) to give the title compound (1.31 g) as a pale yellow oil.XH NMR (300 MHz, DMSO-d6) delta 1.17-1.30 (1H, m) , 1.44-1.98 (4H, m) , 3.19 (3H,. s) , 4.16-4.36 (2H, m)

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 117284-59-0, 2-(2,2-Difluorocyclopropyl)ethanol.

Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; YASUMA, Tsuneo; KAMATA, Makoto; YAMASHITA, Tohru; HIROSE, Hideki; MURAKAMI, Masataka; KINA, Asato; YONEMORI, Kazuko; MIZOJIRI, Ryo; FUJIMORI, Ikuo; FUJIMOTO, Takuya; IKEDA, Zenichi; WO2012/74126; (2012); A1;,
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Related Products of 30379-58-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.30379-58-9, name is Benzyl 2-hydroxyacetate, molecular formula is C9H10O3, molecular weight is 166.17, as common compound, the synthetic route is as follows.

To a solution of 4-(methylsulfonamidomethyl)benzoic acid (0.4 g, 1.745 mmol) and benzyl 2-hydroxyacetate (0.290 g, 1.745 mmol) in a mixture of DCM and THF 1/1 (50 ml), EDC (0.334 g, 1.745 mmol) and DMAP (0.256 g, 2.094 mmol) were added in one portion. The reaction was stirred at RT for 3h. The solvent was removed under vacuum and the resulting crude was portioned between EtOAc and HC1 2N. The organic phase was separated, washed with brine and dried over Na2S04. The solvent was removed under vacuum affording 2-(benzyloxy)-2- oxoethyl 4-(methylsulfonamidomethyl) benzoate (0.4 g, 1.060 mmol, 60.7% yield, MS/ESr 377.9 [MH] +). This product was employed in the following step without any further purification.

The chemical industry reduces the impact on the environment during synthesis 30379-58-9, I believe this compound will play a more active role in future production and life.

Reference:
Patent; CHIESI FARMACEUTICI S.P.A.; ARMANI, Elisabetta; AMARI, Gabriele; CAPALDI, Carmelida; ESPOSITO, Oriana; PERETTO, Ilaria; WO2013/45280; (2013); A1;,
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Reference of 100-86-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 100-86-7, name is 2-Methyl-1-phenyl-2-propanol, molecular formula is C10H14O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

2.5.1 (1,1-Dimethyl-2-phenyl-ethoxy)-trimethylsilyl ether IR (neat): nu = 2950, 1450, 1255, 1095, 838, 740, 693 cm-1; 1H NMR (400 MHz, CDCl3): delta = 0.148 (s, 9H), 1.292 (s, 6H), 2.802 (s, 2H), 7.272-7.356 (m, 5H) ppm; MS (EI, 70 eV) m/z: 222 [M+], 207 [M+-CH3], 133 [M+-OTMS]; Anal. calcd for C13H22OSi: C, 70.27; H, 9.90. Found: C, 70.25; H, 9.87.

According to the analysis of related databases, 100-86-7, the application of this compound in the production field has become more and more popular.

Reference:
Article; Shirini, Farhad; Khaligh, Nader Ghaffari; Akbari-Dadamahaleh, Somayeh; Journal of Molecular Catalysis A: Chemical; vol. 365; (2012); p. 15 – 23;,
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Related Products of 5182-44-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 5182-44-5, name is 2-(3-Chlorophenyl)ethanol, molecular formula is C8H9ClO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Example 63-Chloro-7-[2-(3-chloro-phenyl)-ethoxymethyl]-6H-pyrimido[4,5-c]pyridazin-5-one6.1 [2-(3-Chloro-phenyl)-ethoxy]-acetic acid methyl ester; To a solution of 2-(3-chloro-phenyl)-ethanol (1.96 g, 12.51 mmol) in THF (55 ml) was added n-BuLi (8.8 ml, 1.6 M solution in hexane, 13.77 mmol) at -78 C. Then sodium iodoacetate (2.6 g, 12.51 mmol) was added and the mixture was allowed to warm to ambient temperature and was stirred overnight. The THF was then removed and 1 N HCl was added to the remaining residue to adjust the pH to 1. This mixture was extracted two times with dichloromethane and the combined extracts were dried (Na2SO4) and evaporated. The remaining red liquid was dissolved in MeOH (60 ml) and thionylchloride (1.56 ml, 21.5 mmol) was added dropwise at -15 C. The reaction mixture was then stirred for 1.5 h at ambient temperature. Then water was added and the mixture was extracted three times with ether. The combined extracts were washed with brine, dried (Na2SO4) and evaporated. The remaining residue was then purified by column chromatography (silica gel, heptane/ethyl acetate 95:5 to 88:12) to give the title compound (2.161 g, 9.45 mmol; 76%) as orange liquid. MS: m/e=229.2 [M+H+].

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 5182-44-5, 2-(3-Chlorophenyl)ethanol.

Reference:
Patent; Conte, Aurelia; Dehmlow, Henrietta; Grether, Uwe; Kratochwil, Nicole A.; Kuehne, Holger; Narquizian, Robert; Panousis, Constantinos G.; Peters, Jens-Uwe; Ricklin, Fabienne; US2008/234277; (2008); A1;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 112-27-6, name is 2,2′-(Ethane-1,2-diylbis(oxy))diethanol. This compound has unique chemical properties. The synthetic route is as follows. Product Details of 112-27-6

j00524j A solution of triethylene glycol (30 g, 199.7 mmol) in THF (300 mL) wascooled to 0C and charged with NaOH (11.98 g, 299.7 mmol) and stirred for 15 mm. Thissolution was charged with tosyl chloride (38.07 g, 199.7 mmol) and stirred at room temperature for 2 h. The reaction mixture was concentrated in vacuo and the residue obtained was dilutedwith water (100 mL) and extracted with ethyl acetate (3 X 200 mL). The combined organic layers were dried over anhydrous Na2SO4, filtered and concentrated in vacuo resulting in acrude compound which was purified by chromatography on silica gel, eluting with 2%methanol in DCM to give 18.5 g, 30% yield of the title compound as a colorless oil. ?H NMR(400 MHz, CDC13): oe = 7.78 (d, J= 8.3 Hz, 2H), 7.33 (d, J= 8.1 Hz, 2H), 4.25 -4.10 (m, 2H),3.75 – 3.60 (m, 6H), 3.63 – 3.52 (m, 4H), 2.43 (s, 3H).

With the rapid development of chemical substances, we look forward to future research findings about 112-27-6.

Reference:
Patent; COFERON, INC.; FOREMAN, Kenneth, W.; JIN, Meizhong; WANNER, Jutta; WERNER, Douglas, S.; WO2015/106292; (2015); A1;,
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Related Products of 928-51-8 ,Some common heterocyclic compound, 928-51-8, molecular formula is C4H9ClO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of2b(6.52 g, 50.90 mmol) in pyridine (20 mL) was successively added toluene-4-sulfonylchloride (TsCl, 9.72 g, 50.90 mmol) under nitrogen atmosphere, the mixture was stirred at 0 C for 2 h. The resulting mixture was poured into water (110 mL), extracted with ethyl acetate (EA, 2 × 70 mL), The combined organic layers were washed with hydrochloric acid (2 M, 50 mL) and brine, dried over anhydrous Na2SO4and concentrated under vacuum to give3b(10.54 g, 79%) as a colorless oil, Rf(PE /EA, 5:1) = 0.21.1H NMR (CDCl3, 400 MHz) delta = 7.79 (d, J=8.2 Hz, 2H), 7.36 (d, J=8.2 Hz, 2H), 4.07 (t, J=5.6 Hz, 2H), 3.50 (t, J=5.7 Hz, 2H), 2.46 (s, 3H), 1.86-1.79(m, 2H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,928-51-8, its application will become more common.

Reference:
Article; Wei, Zhao; Liu, Yan-Qin; Zhou, Xin-Bo; Luo, Yuan; Huang, Chun-Qian; Wang, Yong-An; Zheng, Zhi-Bing; Li, Song; Bioorganic and Medicinal Chemistry Letters; vol. 24; 24; (2014); p. 5743 – 5748;,
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