Tag: M.W=100-200

Electric Literature of 34626-51-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.34626-51-2, name is 5-Bromopentan-1-ol, molecular formula is C5H11BrO, molecular weight is 167.0442, as common compound, the synthetic route is as follows.

5-bromopentanol (8 g) was dissolved in DICHLOROMETHANE (100 mL) and was chilled in an ice bath. Dihydropyran (9 g) was added dropwise followed by P-TOLUENE SULFONIC acid monohydrate (1 g). The mixture was allowed to slowly warm to room temperature and stirred for 18 HOURS. The mixture was diluted with 200 mL ether, washed with 10% INA (: H (100 mL) and dried over MgSO4 to give the title compound. DZ (CDC13, 62.9 MHz): 19.7, 25.0, 25.5, 28. 9,30. 7,32. 6,33. 7,62. 4,67. 2 and 89. 9.

Statistics shows that 34626-51-2 is playing an increasingly important role. we look forward to future research findings about 5-Bromopentan-1-ol.

Reference:
Patent; THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN; WO2004/98582; (2004); A2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2568-33-4, name is 3-Methylbutane-1,3-diol, molecular formula is C5H12O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. COA of Formula: C5H12O2

5t (1.0 mmol), carbodiimide (CDI, 1.1 mmol), and DMAP(0.1 mmol) were sequentially added under air to a reaction tubeequipped with a stir bar and a septum. Et3N (1.5 mmol) and CH2Cl2(2 mL) was added by syringe and the resulting mixture vigorouslystirred for 3 h at ambient temperature. After this time, 8i(2.0 mmol) was sequentially added to this solution and the result-ing mixture again stirred for 14 h at ambient temperature. After thistime, the resulting solution was quenched with sat. NH4Claq andextracted with EtOAc. The solution obtained was ltered throughthe plug of silica gel and anhydrous MgSO4, and then concentratedby rotary evaporation. The pure product 9i was obtained byrecrystallization (65%, X mg, X mmol). IR(neat): 3484, 3341, 2970,1684, 1594, 1515, 1272, 1102 cm1.1H NMR (500 MHz, CDCl3) d: 8.59(brs, 1H), 8.02 (d, J 8.7 Hz, 2H), 7.63 (d, J 8.7 Hz, 2H), 4.49 (t,J 6.8 Hz, 2H), 2.05 (s, 6H), 1.98 (t, J 6.8 Hz, 2H), 1.32 (s, 6H);13CNMR (125 MHz, CDCl3) d: 170.30, 166.13, 141.66, 130.81, 126.32,119.23, 70.05, 62.49, 62.07, 41.80, 32.42, 29.81. HRESIMS calcd. forC16H23O4NBr (MH): 372.0810; found 372.0811.

With the rapid development of chemical substances, we look forward to future research findings about 2568-33-4.

Reference:
Article; Murata, Yumi; Takeuchi, Kentaro; Nishikata, Takashi; Tetrahedron; vol. 75; 18; (2019); p. 2726 – 2736;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 41175-50-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 41175-50-2, name is 1,2,3,5,6,7-Hexahydropyrido[3,2,1-ij]quinolin-8-ol. A new synthetic method of this compound is introduced below.

Under Argon, fresh distilled DMF (2.8 mL) was added dropwise toPOCl3 (2.8 mL) at room temperature and stirred for 30 min to yield ared solution. Then a portion of 2,3,6,7-tetrahydro-1H,5H-pyrido[3,2,1-ij]quinolin-8-ol (3.15 g, 16.64 mmol, dissolved in 10 mL DMF) wasadded dropwise to the above solution and a scarlet suspension wasyielded. The mixture was stirred at room temperature for 30 min and80 C for 30 min until the reaction was completed, then the reactionmixture was poured into 150 mL of ice water. NaOH solution (20%)was added to adjust the pH to 6 and continue stirred for 2 h, and alarge amount of precipitate was obtained. The crude product was purifiedby flash column chromatography (PE:EA = 20:1, v/v) to give theproduct as a brown solid (2.50 g, yield: 69.1%). 1H NMR (500 MHz,CDCl3) delta 11.80 (s, 1H), 9.36 (s, 1H), 6.82 (s, 1H), 3.27 (m, 4H), 2.66 (t,J = 6.4, 6.4 Hz, 4H), 1.92 (q, J = 6.0, 6.0, 5.9 Hz, 4H). 13C NMR(126 MHz, CDCl3) delta 191.66, 159.41, 149.58, 131.25, 113.68, 110.75,105.35, 50.40, 50.04, 27.32, 21.77, 20.68, 19.75.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,41175-50-2, its application will become more common.

Reference:
Article; Gan, Yabing; Li, Haitao; Liu, Meiling; Yao, Shouzhuo; Yin, Guoxing; Yin, Peng; Yu, Ting; Zhang, Youyu; Zhou, Li; Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy; vol. 241; (2020);,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 18776-12-0, name is 3-Chloro-1-phenylpropan-1-ol, the common compound, a new synthetic route is introduced below. Application In Synthesis of 3-Chloro-1-phenylpropan-1-ol

A. (1 -Bromo-3-chloropropyl)benzene; 3-Chloro-1 -phenyl-1 -propanol (1.71 g, 10 mmol) was dissolved in dry Et20 (27 ml_) and purged with N2. A solution of PBr3 (0.63 ml_, 6.6 mmol) in dry Et20 (27 mL) was added dropwise very slowly. The reaction was stirred for 2 h at room temperature, followed by washing with 5% aqueous sodium acetate (x2) and brine (x1 ). The organic fraction was dried (MgS04), filtered, and the solvent evaporated to dryness. The resulting crude mixture was purified by column chromatography (S1O2, hexane/EtOAc) to obtain the desired compound as a yellow oil in 45% yield (1 .06 g, 4.54 mmol).

The synthetic route of 18776-12-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PROUS INSTITUTE FOR BIOMEDICAL RESEARCH, S.A.; MUNOZ, Rosa; GARCIA-DELGADO, Noemi; FLORES, Ramon; SERRADELL, Neus; PROUS, Josep, R.; WO2012/13691; (2012); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of 50595-15-8, Adding some certain compound to certain chemical reactions, such as: 50595-15-8, name is tert-Butyl 2-hydroxyacetate,molecular formula is C6H12O3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 50595-15-8.

To a 20 mL reaction vial with magnetic stir bar was massed 4- chlorosulfonylbenzoyl chloride (See procedure above; SI-3, limiting reagent, 0.501 g, 2.10 mmol), and the vial was capped with a septum and positive pressure nitrogen line. Through the septum was added tetrahydrofuran (20 mL/g, 10 mL), and the vial was cooled in a dry ice/acetone bath. Upon equilibrating to temperature, triethylamine (2.0 eq, 0.58 mL, 4.2 mmol) was added in one portion, followed by 3-azidopropan-1-ol (1.0 eq, 0.219 grams, 0.20 mL, 2.09 mmol). The vial was allowed to react in the cooling bath. After one hour, complete conversion was observed (reaction progress monitored by HPLC), and tert-butyl glycolate (1.5 eq, 0.415 g, 3.14 mmol), and the cooling bath was removed and the vial was allowed to warm to room temperature. After one hour, conversion was observed to be 24percent, and the reaction was allowed to stir overnight at room temperature to reach completion. The crude reaction was diluted in ethyl acetate (40 mL/g, 20 mL), washed twice with water (20 mL/g each, 10 mL each), and finally brine (10 mL/g, 5 mL). The rich organic layer was dried over magnesium sulfate, filtered, and concentrated in vacuo. The oil thus obtained was purified by column chromatography (silica, heptane/ethyl acetate). SI-5 was obtained after concentration as a solid with a yield of 63percent (526 mg). The structure was confirmed with HSQC and HMBC spectroscopy; correlation was observed between the azidopropyl methylene and the carboxylate carbon, confirming connectivity. SI-5: 1H NMR (500 MHz, CDCl3) delta 8.22 (d, J = 7.9 Hz, 2H), 8.04 (d, J = 8.2 Hz, 2H), 4.55 (s, 2H), 4.48 (t, J = 6.1 Hz, 2H), 3.50 (t, J = 6.4 Hz, 2H), 2.08 (quintet, J = 6.3 Hz, 2H), 1.43 (s, 9H) ppm; 13C NMR (126 MHz, CDCl3) delta 164.7, 164.6, 140.0, 134.9, 130.3, 128.1, 83.6, 65.5, 62.8, 48.2, 28.1, 27.9 ppm; HRMS (ESI-TOF): calc?d for

According to the analysis of related databases, 50595-15-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; CREECH, Gardner, S.; KHEIRABADI, Mahboubeh; EASTGATE, Martin, D.; NIRSCHL, David, S.; CARTER, Percy, H.; (82 pag.)WO2018/227053; (2018); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 13401-56-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 13401-56-4, name is 3-Chloro-2,2-dimethylpropan-1-ol. This compound has unique chemical properties. The synthetic route is as follows.

7-Hydroxyindole (5.00 g, 37.55 mmol), 3-chloro-2,2-dimethyl-propan-1-ol (6.91 g, 56.33 mmol), triphenyl (1.57 g, 6.00 mmol) were dissolved in THF (150 mL), and after replacing with nitrogen, DIAD (15.19 g, 75.10 mmol) was added dropwise to the mixture. The mixture was stirred at 70 C for 12 hours. TLC showed the reaction was complete, the reaction solution was concentrated to dryness. The crude product was purified by column chromatography (PE: EA = 50: 1, 20: 1) to deliver the title compound (white solid, 3.5 g, yield 39.21%). 1H NMR (400MHz, CDCl3): delta 7.29 (s, 1H), 7.21 (t, J=4.0 Hz, 1H), 7.03 (t, J=8.0 Hz, 1H), 6.68 (d, J=8.0 Hz, 1H), 6.58 – 6.53 (m, 1H), 3.96 (s, 2H), 3.65 (s, 2H), 1.20 (s, 6H). LCMS (ESI) (5-95AB): m/z: 238.1 [M+1].

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 13401-56-4, 3-Chloro-2,2-dimethylpropan-1-ol.

Reference:
Patent; GUANGDONG ZHONGSHENG PHARMACEUTICAL CO., LTD; DING, Charles Z.; CHEN, Shuhui; ZHAO, Baoping; LIU, Xile; XIAO, Linxia; DING, Chao; WANG, Fei; LI, Jian; (153 pag.)EP3290419; (2018); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 2568-33-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2568-33-4, name is 3-Methylbutane-1,3-diol, molecular formula is C5H12O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of 3-methylbutan-l,3-diol (10.0 g, 96.1 mmol) in DCM (100 mL) was added 4- methylbenzene- l-sulfonyl chloride (20.1 g, 106 mmol) and TEA (24.3 g, 240 mmol). The reaction mixture was stirred at room temperature for 12 h. Then the mixture was extracted with DCM (150 mLx3). The combined organic layers were washed with water and brine, dried over MgSC”4, and filtered. The filtrate was concentrated under reduced pressure. The resulting residue was purified by chromatography over silica gel (eluting with PE_EA=5: 1) to give the title compound.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 2568-33-4, 3-Methylbutane-1,3-diol.

Reference:
Patent; MERCK SHARP & DOHME CORP.; BIFTU, Tesfaye; COLLETTI, Steven L.; HAGMANN, William K.; KAR, Nam Fung; JOSIEN, Hubert; NAIR, Anilkumar; NARGUND, Ravi; BIJU, Purakkattle; ZHU, Cheng; HU, Bin; WO2015/51496; (2015); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 6006-82-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 6006-82-2, name is 2-(Benzo[d][1,3]dioxol-5-yl)ethanol, molecular formula is C9H10O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

B. 1-acetoxy-2-[(3,4-methylenedioxy)phenyl]ethane To a stirred solution of 2-(3,4-methylenedioxy)phenyl-1-ethanol (1.68 g, 10 mmol) in dry pyridine was added acetic anhydride and the resultant reaction mixture was stirred at 80 C. for 1 h. The reaction mixture was poured into ice-water and was extracted with ether (2*75 ml). The combined ether extract was washed with water (2*50 ml), 5% HCl (2*50 ml) and then with 5% NaHCO3 (2*50 ml). The organic layer was dried over magnesium sulfate and the solvent was removed under reduced pressure to give 1-acetoxy-2-[(3,4-methylenedioxy)phenyl]ethane as a solid (1.7 g, 81% yield).

According to the analysis of related databases, 6006-82-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Texas Biotechnology Corporation; US6432994; (2002); B1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 7287-81-2, name is 1-(m-Tolyl)ethanol, the common compound, a new synthetic route is introduced below. Application In Synthesis of 1-(m-Tolyl)ethanol

General procedure: The catalyst solutionwas prepared by dissolving complex 3(36.1 mg,0.05mmol) in methanol (5.0 mL).Under a nitrogen atmosphere, the mixture of an alcohol substrate (2.0 mmol) and1.0 mL of the catalyst solution (0.01mmol) in 20mL acetone was stirred at 56 Cfor 10 minutes. tBuOK(22.4mg, 0.2 mmol)was then added to initiate the reaction.At the stated time, 0.1 mL of the reaction mixture was sampled and immediately diluted with 0.5 mL acetone pre-cooled-to-0 C for GC or NMR analysis. After the reaction was complete, the reaction mixture was condensed under reduced pressure and subject to purification by flash silica gel column chromatography to afford the corresponding ketone product, which was identified by comparison with the authentic sample through NMR and GC analysis.

The synthetic route of 7287-81-2 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Wang, Qingfu; Du, Wangming; Liu, Tingting; Chai, Huining; Yu, Zhengkun; Tetrahedron Letters; vol. 55; 9; (2014); p. 1585 – 1588;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of 3840-31-1 ,Some common heterocyclic compound, 3840-31-1, molecular formula is C10H14O4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: To 3.5 g (53 mmol) of 85% potassiumhydroxide was added a solution of 10 g (50.5 mmol) ofalcohol 8 in 40 mL of DMSO, and the mixture washeated at 50-70 while stirring till the dissolution ofK, then the heating was switched off. On coolingthe mixture to room temperature a solution of 7 g(56.9 mmol) of allyl bromide in 10 mL of DMSO wasadded, and the mixture was stirred for 16 h. Then themixture was heated (5060) at stirring till thecompletion of the reaction (5 h). The mixture wasdiluted with 200 mL of water, the reaction product wasextracted into ethyl acetate (4 × 50 mL). The organicphase was washed with water, dried with Na2SO4, thesolvent was distilled off, the residue was dried in avacuum.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 3840-31-1, (3,4,5-Trimethoxyphenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Potapov; Panov; Musalov; Zhivet?eva; Musalova; Khabibulina; Amosova; Russian Journal of Organic Chemistry; vol. 52; 11; (2016); p. 1571 – 1575; Zh. Org. Khim.; vol. 52; 11; (2016); p. 1579 – 1583,5;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts