Tag: M.W=100-200

Related Products of 52059-53-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.52059-53-7, name is 2-(3-Fluorophenyl)ethanol, molecular formula is C8H9FO, molecular weight is 140.1549, as common compound, the synthetic route is as follows.

To a solution of (S)-isopropyl 2-(2-amino-4-(4,4-dimethylpiperidin- 1 -yl)-5 ?,6?-difluoro-6-methyl- [3,3 ?-bipyridinj -5 -yl)-2-(tert-butoxy)acetate (0.042 g, 0.059 mmol, 1 equiv) and 2-(3-fluorophenyl)ethanol (0.042 g, 0.297 mmol, 5 equiv) in THF (1.5 mL)was added 60% NaH (0.012 g, 0.297 mmol, 5 equiv). The reaction was heated at 60 C for 1 h. EtOH (0.9 mL) and 10 N NaOH (0.1 mL) were added and the temperature was raised to 80 C for 4 h. After cooling to ambient temperature, the reaction was filtered. The cmde mixture was purified by preparative LC/MS to provide the product (9 mg, 26%). ?H NMR (500 MHz, DMSO-d6) 7.89 – 7.44 (m, 2H), 7.38 – 7.32 (m, 1H), 7.17 -7.10 (m, 2H), 7.07 -7.00 (m, 1H), 5.70 (s, 1H), 5.09 (br s, 1H), 4.75 -4.53 (m, 2H), 3.18- 3.02 (m, 2H), 2.91 – 2.64 (m, 1H), 2.32 (s, 3H), 1.60 – 1.43 (m, 1H), 1.26 (s, 2H), 1.16 (s, 9H), 1.09 – 0.98 (m, 1H), 0.86 (br s, 3H), 0.62 (br s, 3H) [note: appears to be a 60:40 mixture ofrotamers around pyridine pyridine biaryl bond, piperidine protons are broad and not all visiblej. LCMS (M+1) = 583.3.

Statistics shows that 52059-53-7 is playing an increasingly important role. we look forward to future research findings about 2-(3-Fluorophenyl)ethanol.

Reference:
Patent; VIIV HEALTHCARE UK (NO.5) LIMITED; BELEMA, Makonen; BOWSHER, Michael S.; DESKUS, Jeffrey A; EASTMAN, Kyle J.; GILLIS, Eric P; FRENNESSON, David B; IWUAGWU, Christiana; KADOW, John F.; NAIDU, B. Narasimhulu; PARCELLA, Kyle E.; PEESE, Kevin M; SAULNIER, Mark G; SIVAPRAKASAM, Prasanna; (463 pag.)WO2018/127800; (2018); A1;,
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Reference of 13330-96-6, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 13330-96-6 as follows.

To a suspension of hexane prewashed sodium hydride (11.0 mmol, 440 mg of a 60% dispersion in mineral oil) in THF (20 mL) was cannulated a solution of 4-(N,N-dimethylamino)butan-1-ol (8.80 mmol, 1.03 g) in THF (30 mL). The resulting suspension was stirred at 20 C. under N2 for 2 hours and then cannulated into a solution of 4-[(3-bromophenyl)amino]-7-fluoro-6-nitroquinazoline (J Med Chem, 1996;39:918-928) (0.80 g, 2.20 mmol) in THF (30 mL) under N2. The dark red solution was then heated at reflux overnight.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,13330-96-6, its application will become more common.

Reference:
Patent; Warner-Lambert Company; US6344459; (2002); B1;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 27129-87-9, name is (3,5-Dimethylphenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows. Quality Control of (3,5-Dimethylphenyl)methanol

General procedure: A dried round bottomed flask equipped with a magnetic stir bar was charged with 15 mg Polymer anchored-Pd(II) C catalyst (PS-8-AQ-Pd), 2-phenyl pyridine (0.5 mmol), benzyl alcohol (1.0 mmol)and TBHP (2.0 mmol) were added to a reaction vessel. The mixture was stirred at 110 C for 8 h, then cooled to room temperature and catalyst was filtered, the filtrate was extracted with ethyl acetate(3 10 mL). The combined organic layers were extracted with water, and dried over anhydrous Na2SO4. The organic layers were evaporated under reduced pressure and the resulting crude product was purified by column chromatography by using ethylacetate/hexane (1:4) as eluent to give the corresponding ortho acylation products. The products were characterized by 1H NMR,13C NMR and HRMS.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 27129-87-9, (3,5-Dimethylphenyl)methanol.

Reference:
Article; Perumgani, C. Pullaiah; Parvathaneni, Sai Prathima; Kodicherla, Balaswamy; Keesara, Srinivas; Mandapati, Mohan Rao; Inorganica Chimica Acta; vol. 455; (2017); p. 105 – 111;,
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Electric Literature of 623-69-8 ,Some common heterocyclic compound, 623-69-8, molecular formula is C5H12O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To NaH (0.366 g, 9.16 mmol) in THF (12 mL) at 0 °C was added 1 ,3- dimethoxy-2-propanol (1 g, 8.32 mmol) in THF (8 mL) solution. The mixture was warmed to room temperature and stirred for 0.5 hour. To this was added tosyl chloride (1.587 g, 8.32 mmol) in one portion. The white cloudy mixture was stirred at room temperature for 16 hours. LC/MS showed complete conversion. The reaction mixture was poured into water and extracted with EtOAc. The organic extracts were combined, washed with brine, dried with sodium sulfate and concentrated in vacuo to give 2 g of colorless oil. The crude mixture was purified by Analogix system (silica gel column 80 g, gradient: 0 min, 100percentn-heptane; 5-12 min, 20percent EtOAc in Heptane; 12-15 min. 30percent EtOAc in Heptane and hold until 30 min). The pure fractions were combined and concentrated in vacuo to give 1.25 g of product as colorless oil which solidified upon standing.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,623-69-8, its application will become more common.

Reference:
Patent; NOVARTIS AG; ANTONIOS-MCCREA, William, R.; BARSANTI, Paul, A.; HU, Cheng; JIN, Xianming; MARTIN, Eric, J.; PAN, Yue; PFISTER, Keith, B.; SENDZIK, Martin; SUTTON, James; WAN, Lifeng; WO2012/66070; (2012); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 671802-00-9, name is tert-Butyl 3-(2-hydroxyethoxy)propanoate. A new synthetic method of this compound is introduced below., name: tert-Butyl 3-(2-hydroxyethoxy)propanoate

Step 1: Synthesis of tert-butyl 3-{2-[(5-bromopyridin-2-yl)oxy]ethoxy}propanoate:[0692] To a stirred solution of 5-bromopyridin-2-ol (3.0 g, 17.24 mmol), tert-butyl 3-(2- hydroxyethoxy)propanoate (3.3 g, 17.19 mmol) and triphenylphosphine (6.8 g, 25.81 mmol) in tetrahydrofuran (120.0 mL) was added diethyl diazene-l,2-dicarboxylate (4.49 g, 25.78 mmol) dropwise at 0 C under an atmosphere of nitrogen. The resulting solution was stirred overnight at rt. The reaction mixture was concentrated under reduced pressure to give a crude residue, which was purified by silica gel flash chromatography (eluent: ethyl acetate/petroleum ether, v/v =1/3) to provide the titled product (yield: 50%) as colorless oil.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 671802-00-9, tert-Butyl 3-(2-hydroxyethoxy)propanoate.

Reference:
Patent; ARVINAS, INC.; JIN, Meizhong; CREW, Andrew, P.; DONG, Hanqing; WANG, Jing; SIU, Kam; FERRARO, Caterina; CHEN, Xin; QIAN, Yimin; (351 pag.)WO2016/118666; (2016); A1;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 42514-50-1, name is 3-Amino-3-methylbutan-1-ol. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C5H13NO

3-Amino-3-methyl-butan-1-ol (5.0 g, 0.04 mol) was dissolved in 150 mL CH2Cl2 and treated with di-tert-butyl dicarbonate (11.12 g, 0.05 mol). The resulting mixture was stirred for 18 h at 25 C. The mixture was concentrated to the desired material as an amber oil (9.8 g, 100%): 1H NMR (DMSO-d6) delta 3.55 (s, 1H), 4.43 (t, 1H, J = 5 Hz), 3.46 (m, 2H), 1.71 (t, 2H, J = 7 Hz), 1.37 (s, 9H), 1.12 (s, 6H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 42514-50-1, 3-Amino-3-methylbutan-1-ol.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; WO2003/99286; (2003); A1;,
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Application of 4720-29-0 , The common heterocyclic compound, 4720-29-0, name is 3-(Benzylamino)-1-propanol, molecular formula is C10H15NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

1,1-bis(methylthio)-2-nitroethylene 9 (1.00 g, 6.06 mmol) was added to asolution of N-benzylamino-3-propan-1-ol 8a (1.00 g, 6.06 mmol) and DMAP (0.74 g, 6.06mmol) in t-butanol (20 mL). The resulting solution was heated to reflux for 24 h under nitrogenatmosphere. The reaction was monitored by TLC (CH2Cl2/MeOH, 97/3). After cooling to roomtemperature, the solvent was removed in vacuo to afford an oily residue which was purified byflash chromatography on silica gel (CH2Cl2/MeOH, 98/2) to give nitroacetamide 11a (oil, 0.42 g,28%), a mixture of (Z)- and (E)-isomers in a ratio close to 1/1.

The synthetic route of 4720-29-0 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Fante, Bamba; Soro, Yaya; Siaka, Sorho; Marrot, Jerome; Coustard, Jean-Marie; Synlett; vol. 25; 7; (2014); p. 969 – 974;,
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Synthetic Route of 928-92-7 ,Some common heterocyclic compound, 928-92-7, molecular formula is C6H12O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a stirred solution of oxalyl chloride (5.23 mL 60 mmol) in 50 mL dry CH2Cl2 at -78°C under Argon, dimethyl sulfoxide ( 8.51 mL, 120 mmol) in 5 mL dry CH2Cl2 was added slowly. The reaction mixture was allowed to stirr for next 15 min. 4-Hexen-1-ol (4.7 mL, 40 mmol) in 10 mLCH2Cl2 was added dropwise to the reaction mixture and stirring was continued for next 45 min at -78°C. Further, Et3N (33.38 mL, 240 mmol) was added dropwise at 0°C and the reaction mixture was allowed to stirr for next 1 h (Foul smell of dimethyl sulfide). This was further treated with benzyl(triphenylphosphoranylidene)acetate (19.7 g, 48 mmol) in 70 mL dry CH2Cl2 and wasallowed to stirr for next 12 h at room temperature. Then, the reaction mixture was quenched withwater and extracted with excess CH2Cl2 and brine. The organic phase was separated, dried over MgSO4 and evaporated under reduced pressure. The crude brownish oil was subjected to column chromatography. The product (8) was separated as light yellow oil (95:5, E:Z) at gradient(hexane/ethyl acetate, 95:5) (7.73 g, 84percent).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 928-92-7, 4-Hexen-1-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Holla, Harish; Labaied, Mehdi; Pham, Ngoc; Jenkins, Ian D.; Stuart, Kenneth; Quinn, Ronald J.; Bioorganic and Medicinal Chemistry Letters; vol. 21; 16; (2011); p. 4793 – 4797;,
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Related Products of 3637-61-4, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 3637-61-4, name is Cyclopentanemethanol. A new synthetic method of this compound is introduced below.

A solution of triphenylphosphine (28.80 g, 109.8 mmol) and imidazole (14.9 g, 219.6 mmol) in methylene chloride (160 mL) was cooled to 0 C. and then slowly treated with iodine (27.87 g, 109.8 mmol). The reaction mixture was then treated dropwise with a solution of cyclopentylmethanol (10.00 g, 99.8 mmol) in methylene chloride (10 mL). The resulting reaction mixture was allowed to warm to 25 C. where it was stirred for for 4 h. The reaction mixture was then diluted with water (50 mL), and the reaction mixture was further extracted with methylene chloride (3*20 mL). The combined organic layers were dried over sodium sulfate, filtered, and concentrated in vacuo at 25 C. The resulting solid was washed with pentane (4*50 mL) and filtered through a silica gel plug. The filtrate was concentrated in vacuo at 25 C. to afford iodomethylcyclopentane (18.48 g, 88%) as a clear colorless liquid: EI-HRMS m/e calcd for C6H11I (M+) 209.9906, found 209.9911.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,3637-61-4, Cyclopentanemethanol, and friends who are interested can also refer to it.

Reference:
Patent; Hoffman-La Roche Inc.; US6610846; (2003); B1;,
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Reference of 4720-29-0, Adding some certain compound to certain chemical reactions, such as: 4720-29-0, name is 3-(Benzylamino)-1-propanol,molecular formula is C10H15NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 4720-29-0.

A solution of N-benzylpropanolamine (3.3 g) and benzyl(S)-(+)-glycidyl ether (3.6 g) in ethanol (40 mL) was heated at 40 C. for 18 h. The solvent was evaporated under reduced pressure to give the subtitled compound as a colourless oil (6.8 g, 100%), which was used without further purification. 1H NMR (400 MHz, DMSO-d6): delta 7.29 (m, 10H), 4.54 (m, 1H), 4.45 (s, 2H), 4.36 (t, 2H), 3.76 (m, 1H), 3.44 (m, 5H), 2.47 (m, 4H), 1.57 (m, 2H).

According to the analysis of related databases, 4720-29-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; AstraZeneca AB; Lonn, Hans Roland; Connolly, Stephen; Swallow, Steven; Karlsson, Staffan PO; Aurell, Carl-Johan; Ponten, John Fritiof; Doyle, Kevin James; Van de Poel, Amanda Jane; Jones, Graham Peter; Watson, David Wyn; MacRitchie, Jaqueline Anne; Palmer, Nicholas John; (50 pag.)US9522894; (2016); B2;,
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