Tag: M.W=100-200

Synthetic Route of 18776-12-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.18776-12-0, name is 3-Chloro-1-phenylpropan-1-ol, molecular formula is C9H11ClO, molecular weight is 170.64, as common compound, the synthetic route is as follows.

To a solution of the 3-chloro-1-phenyl-propan-1-ol (1.5 g, 8.79 mmol) in DCM at 0 C. (50 mL) was added TEA (1.6 mL, 11.4 mmol) followed by MsCl (0.75 mL, 9.7 mmol). The reaction mixture was stirred 1.5 hours at 0 C., quenched with ice, and partitioned between a saturated solution of NaHCO3 and DCM. The organic layer was separated, washed with brine, dried over MgSO4, filtered, and concentrated at 0 C. The methanesulfonic acid 3-chloro-1-phenyl-propyl ester (95% crude yield, 2.08 g) thus prepared was used in the next step without purification.

The chemical industry reduces the impact on the environment during synthesis 18776-12-0, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Roche Palo Alto LLC; US2007/123535; (2007); A1;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 558-42-9, name is 1-Chloro-2-methyl-2-propanol, the common compound, a new synthetic route is introduced below. Quality Control of 1-Chloro-2-methyl-2-propanol

EXAMPLE 1 Preparation of 2-(2-hydroxy-2-methylpropoxy)phenol from 1-chloro-2-methyl-2-propanol Catechol (11.0 g, 0.10 mole), sodium carbonate (10.6 g, 0.10 mole) and 100 g methanol were combined in a 250 ml 3-necked round bottom flask equipped with an air stirrer, heating mantle, condenser and thermometer, and heated to reflux (approximately 65° C.). 1-Chloro-2-methyl-2-propanol (10.9 g, 0.10 mole) was added by syringe. The mixture was refluxed for 3 hours, then left standing overnight. Water (40 ml) was added and the mixture was refluxed for 2 hours. After cooling, the water was extracted three times with 100 ml of dichloromethane. The combined dichloromethane layers were washed twice with 100 ml of water, then concentrated to afford 4.40 g (24percent) of waxy yellow solid. Recrystallization from ethyl acetate (10 g) and hexane (50 g) gave a white solid. 1 Hnmr analysis was consistent with the structural formula of 2-(2-hydroxy-2-methylpropoxy)phenol. Analysis: Cald., C 65.91percent, H, 7.74percent; found, C 65.85, 66.05, H 7.66, 7.66.

The synthetic route of 558-42-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Union Carbide Corporation; US4639536; (1987); A;,
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Electric Literature of 23147-58-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 23147-58-2, name is Glycerol aldehyde dimer. A new synthetic method of this compound is introduced below.

Compound I-ee was prepared using the method of Example 7. To a solution of compound I-ee (0.1 mmol) in methanol (1 mL) was added the aldehyde or ketone (0.2 mmol) and acetic acid (0.4 mmol), followed by sodium cyanoborohydride (0.2 mmol). The solution was stirred at 20 to 25 C (for reactive aldehydes) or 50 to 60 C (for less reactive aldehydes and ketones) until all of Compound I-ee was consumed. The reaction mixture was concentrated on a rotary evaporator, re-dissolved in a mixture of water-acetonitrile, filtered through a one-gram plug of C-18 silica gel, and purified by reversed-phase HPLC, eluted using a gradient of acetonitrile in water containing 0.1% acetic acid. The product was obtained as a white solid after lyophilization of desired fractions. EPO [00182] Compound I-nn (5S,6R)-5-[N-(2-hydroxyethyl)methylamino]polyangi-l ,6- diol) was synthesized using glycolaldehyde dimer at room temperature. ESI-TOF-MS m/z 518.3839, calcd for C31H52NO5 ([M + H]+) 518.3840.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,23147-58-2, Glycerol aldehyde dimer, and friends who are interested can also refer to it.

Reference:
Patent; KOSAN BIOSCIENCES INCORPORATED; WO2006/66147; (2006); A2;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 3068-00-6, name is 1,2,4-Butanetriol, molecular formula is C4H10O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. name: 1,2,4-Butanetriol

Example 1; Instead of PEG-400 and the para-toluenesulfonic acid catalyst used in ComparativeExample 1, dioxane and a strong acid ion exchange resin (Amberlyst 15, H+ form) containing a sulfonic acid group were used in equal amounts. Then, the reaction was conducted using a batch type reactor under conditions of atmospheric pressure and 1000C for 20 hours. The reaction yield was 96 mol%.

With the rapid development of chemical substances, we look forward to future research findings about 3068-00-6.

Reference:
Patent; SK CORPORATION; WO2007/81065; (2007); A1;,
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Adding a certain compound to certain chemical reactions, such as: 1036260-25-9, 3-Aminocyclobutanol hydrochloride, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 1036260-25-9, blongs to alcohols-buliding-blocks compound. Recommanded Product: 1036260-25-9

step 1: A mixture of 3-aminocyclobutanol hydrochloride (1.91 g, 15.47 mmol), isobenzofuran-1,3-dione (2.52 g, 17.01 mmol) and DIPEA (6.0 g, 46.40 mmol) in PhMe (100 mL) was stirred at 110 C. for 18 h. The reaction mixture was concentrated and purified by SiO2 chromatography eluting with PE/EA (3:1) to afford 2-(3-hydroxycyclobutyl)isoindoline-1,3-dione as white solid (2.1 g, 62.6%). LCMS (ESI): m/z=218.1 [M+1]+

The synthetic route of 1036260-25-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GENENTECH, INC.; Rudolph, Joachim; Gazzard, Lewis J.; Crawford, James J.; Ndubaku, Chudi; Drobnick, Joy; Lee, Wendy; US2015/31674; (2015); A1;,
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Related Products of 769-30-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.769-30-2, name is Benzo[d][1,3]dioxol-4-ylmethanol, molecular formula is C8H8O3, molecular weight is 152.15, as common compound, the synthetic route is as follows.

A solution of (benzo[d][l,3]dioxol-7-yl)methanol (2.0 g, 13.1 mmol) and 6i(lH-imidazol-l-yl)methanone (4.26 g, 26.2 mmol) in 20 mL CH2CI2 was heated overnight at 50 C The reaction was quenched with water and extracted with CH2CI2, and the combined layers were dried over MgS04, filtered, and concentrated. Purification via silica gel chromatography using 10-70% EtOAc in CH2C12 gave (benzo[d][l,3]dioxol-7-yl)methyl lNo.-imidazole-l-carboxylate (2.8 g, 86%). ltt NMR (400 MHz, CDC13) 8 8.15 (t, /= 0.9 Hz, 1H), 7.44 (t, J= 1.4 Hz, 1H), 7.07 (dd, J= 1.6, 0.8 Hz, 1H), 6.95 (m, 2H), 6.84 (m, 1H), 6.01 (s, 2H), 5.33 (s, 2H).

Statistics shows that 769-30-2 is playing an increasingly important role. we look forward to future research findings about Benzo[d][1,3]dioxol-4-ylmethanol.

Reference:
Patent; VERTEX PHARMACEUTICALS INCORPORATED; WO2006/28904; (2006); A1;,
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Adding a certain compound to certain chemical reactions, such as: 15852-73-0, (3-Bromophenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: alcohols-buliding-blocks, blongs to alcohols-buliding-blocks compound. category: alcohols-buliding-blocks

General procedure: To a solution of alcohol(1 mmol) in a mixture of MeCN and MeOH (5:1, 2.4 mL) was added TsNBr2(2.5 mmol) and K2CO3 (5 mmol) and stirred at room temperature. Aftercompletion of the reaction (TLC) sodium thiosulfate was added and thereaction mixture was stirred for 10 min. The reaction mixture was extracted indiethyl ether and hexane (1:1), dried, (Na2SO4) and concentrated. Purificationof the crude product by flash chromatography on silica gel (230?400 mesh)with petroleum ether?EtOAc as eluent gave the pure product

The synthetic route of 15852-73-0 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Rajbongshi, Kamal Krishna; Sarma, Manas Jyoti; Phukan, Prodeep; Tetrahedron Letters; vol. 55; 39; (2014); p. 5358 – 5360;,
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Adding a certain compound to certain chemical reactions, such as: 117087-18-0, 2-((Benzyloxy)methyl)propane-1,3-diol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Product Details of 117087-18-0, blongs to alcohols-buliding-blocks compound. Product Details of 117087-18-0

White powder obtained in the step (3) (75 g, 0.38 mol)Soluble in N,N-dimethylformamide (1L), ice bath,Nitrogen partial protection,One copy Sodium hydrogen(15.2g, 0.38mol, 60% in mineral oil),After stirring for 1 hour, methanesulfonyl chloride (43 g, 0.375 mol) was added dropwise.The system was allowed to warm to room temperature and stirring was continued for 2 hours.Then the system is cooled to 0 C,Add one part of sodium hydrogen (15.2g, 0.38mol),The system was slowly warmed to room temperature again and stirring was continued for 3 hours.In the ice bath, adding 1M means adjusting the pH to neutral.Add 2L of water, extract ethyl acetate 300mL 5 times,The organic phases were combined, washed 3 times with water, dried and concentrated.The residue was dissolved in methanol 500 mL.Add 100 mL to the methanol phase and stir for 20 minutes.Layered,Then the lower layer was continuously added with 100 mL of petroleum ether, stirred for another 20 min, layered, and the lower layer was concentrated, and ethyl acetate and petroleum ether were crystallized 1:10.Obtained 53 g of a white solid. Yield 78%

At the same time, in my other blogs, there are other synthetic methods of this type of compound,117087-18-0, 2-((Benzyloxy)methyl)propane-1,3-diol, and friends who are interested can also refer to it.

Reference:
Patent; Shanghai Xinyuan Pharmaceutical Technology Co., Ltd.; Chai Teng; Lin Zengming; (12 pag.)CN108314665; (2018); A;,
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Synthetic Route of 1124-63-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1124-63-6, name is 3-Cyclohexylpropan-1-ol, molecular formula is C9H18O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Example 125 5-(3-Cyclohexyl-propoxy)-1-(4-nitro-phenyl)-1H-tetrazole Cyclohexylpropyl alcohol (237 mL, 1.58 mol) was added to a suspension of NaH (66.0 g, 1.65 mol) in tetrahydrofuran (1.40 L). A solution of 5-Chloro-1-(4-nitro-phenyl)-1 H-tetrazole (320 g, 1.42 mol) in tetrahydrofuran (900 mL) was added dropwise over 1.5 hours. The reaction was allowed to cool to room temperature and stirred overnight. The mixture was concentrated in vacuo to a solid. The solid was dissolved in ethyl acetate, washed with saturated aqueous sodium chloride solution (2x), dried (Na2SO4), and filtered through silica gel (700 g). The red filtrate was concentrated in vacuo until product began to precipitate from solution. Hexane was added and the slurry filtered to provide a tan solid (320 g, 64 %). Mp 82-88C (dec); 1H NMR (CDCl3, 300 MHz) delta 8.43 (d, 9.2 Hz, 2 H), 8.04 (d, 9.2 Hz, 2 H), 4.70 (t, 7.0 Hz, 2 H), 1.96 (m, 2 H), 1.75-1.64 (m, 5 H), 1.39-1.13 (m, 6 H), 0.97-0.87 (m, 2 H); MS (CI) mlz 332 (MH+); Anal. calcd for C16H21N5O3: C, 57.99; H, 6.39; N, 21.13. Found: C, 57.80; H, 6.35; N, 21.02; Rf = 0.43 (N).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1124-63-6, 3-Cyclohexylpropan-1-ol.

Reference:
Patent; BAYER CORPORATION; EP1054881; (2008); B1;,
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Related Products of 42514-50-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 42514-50-1, name is 3-Amino-3-methylbutan-1-ol. This compound has unique chemical properties. The synthetic route is as follows.

Step 4: (3-Hydroxy-1,1-dimethyl-propyl)-carbamic acid tert-butyl ester. 3-Amino-3-methyl-butan-1-ol(5.0 g, 0.04 mol) was dissolved in 150 mL CH2Cl2 and treated with di-tert-butyl dicarbonate(11.12 g, 0.05 mol). The resulting mixture was stirred for 18 h at 25 C. The mixture was concentrated to the desired material as an amber oil(9.8 g, 100%); 1H NMR (DMSO-d6) delta 3.55 (s,1H), delta 4.43 (t, J=5 Hz, 1H), delta 3.46 (m, 2H), delta 1.71 (t, J=7 Hz, 2H), delta 1.37(s, 9H), delta 1.12(s, 6H).

According to the analysis of related databases, 42514-50-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Kim, Kyoung S.; Lu, Songfeng; Sheng, X. Christopher; Crews JR., Alvin Donald; US2004/242596; (2004); A1;,
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