Tag: M.W=100-200

Related Products of 127-66-2, Adding some certain compound to certain chemical reactions, such as: 127-66-2, name is 2-Phenylbut-3-yn-2-ol,molecular formula is C10H10O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 127-66-2.

General procedure: A 50-mL stainless steel autoclave equipped with a magnetic stir bar was charged with ZnCl2 (27.2 mg, 20 molpercent), DBU (76 mg, 50 molpercent), 2b (154.1 mg, 1 mmol), H2O (27 mg, 1.5 mmol) and CH3CN (2.0 mL) successively and sealed at r.t. Then, the pressure was adjusted to 1 MPa with CO2 at the preset temperature (80 °C) and the autoclave was heated at this temperature for 48 h. After the reaction was complete, the reactor was cooled in ice-water bath, and then excess CO2 was carefully vented. Then, the residue was obtained by removing the solvent under vacuum and further purified by column chromatography (petroleum ether/EtOAc 100:1-5:1) to obtain 6b.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 127-66-2, 2-Phenylbut-3-yn-2-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Song, Qing-Wen; Zhao, Qing-Ning; Li, Jing-Yuan; Zhang, Kan; Liu, Ping; Synthesis; vol. 51; 3; (2019); p. 739 – 746;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 623-50-7, name is Ethyl 2-hydroxyacetate, molecular formula is C4H8O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. SDS of cas: 623-50-7

A solution of ethyl glycolate (500 mg, 4.8 mmol) and tosyl chloride (915 mg, 4.8 mmol) in anhydrous diethyl ether (2 ml) at 0 0C was treated dropwise with triethylamine (1.34 ml, 9.6 mmol). The temperature was maintained at 0 0C with stirring for a further 2 h. After this time, water was added and the phases separated. The aqueous phase was extracted with fresh diethyl ether. The combined organic extracts were dried (MgSO4), filtered and the solvent removed in vacuo. The crude product was purified by column chromatography over silica gel (Rf=0.29, 25% ethyl acetate in hexane) affording the tosylate 2 as a colorless oil which solidified on standing as a white solid (868 mg, 70%). [This procedure was repeated on 2 x scale (1.8 g, 73%)]. deltaH (400 MHz, CDCl3) 1.22-1.27 (3H, m, CH3), 2.46 (3H, s, ArCH3), 4.16-4.22 (2H, m, CH2CH3), 4.58-4.59 (2H, m, OCH2), 7.36 (2H, d, J=8.2 Hz, ArH), 7.84 (2H, d, J=8.2 Hz, ArH); deltac (100.6 MHz, CDCl3) 14.2, 21.9, 62.1, 64.9, 128.3,130.1, 132.9, 145.5, 166.2; MS (ES+) 276.0 (100%, [M+H20]+) (ion not detected in ES’).

With the rapid development of chemical substances, we look forward to future research findings about 623-50-7.

Reference:
Patent; H. LEE MOFFITT CANCER CENTER & RESEARCH INSTITUTE; UNIVERSITY OF SOUTH FLORIDA; UNIVERSITY OF CENTRAL FLORIDA; WO2007/136858; (2007); A2;,
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Adding a certain compound to certain chemical reactions, such as: 27489-62-9, trans-4-Aminocyclohexanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 27489-62-9, blongs to alcohols-buliding-blocks compound. Recommanded Product: 27489-62-9

Step -I: trans-4-(Dibenzylamino)cyclohexanol (intermediate B8-1) [00288] Benzyl bromide (11.36 mL, 96 mmol) was subsequently added dropwise to a stirring solution of trans -4-aminocyclohexanol (5 g, 43.4 mmol) and potassium carbonate (21g, 152 mmol) in acetonitrile (100 mL). The reaction mixture was stirred at 90 C for 16 h, cooled to ambient temperature, filtered through a Celite pad, and washed with ethyl acetate. The filtrate was concentrated in vacuo. The residue was purified using CombiFlash (40.0 g silica gel column; 2% methanol in DCM), to obtain the title product (6 g, 20.31 mmol, 46.8% yield), as an off-white solid. lU NMR (400 MHz, chloroform-d) delta 7.34 – 7.38 (m, 4H), 7.26 – 7.31 (m, 4H), 7.15 – 7.24 (m, 2H), 3.61 (s, 5H), 2.52 (s, 1.96 – 2.06 (m, 2H), 1.88 (br. s., 2H), 1.43 (d, J= 15.31 Hz, 2H), 1.21 (br. s., 2H); MS(ES): m/z 296.2 [M+H]+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,27489-62-9, trans-4-Aminocyclohexanol, and friends who are interested can also refer to it.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; WASHBURN, William N.; MURUGAIAH SUBBAIAH, Murugaiah Andappan; AHMAD, Saleem; WO2014/39412; (2014); A1;,
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Related Products of 2568-33-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.2568-33-4, name is 3-Methylbutane-1,3-diol, molecular formula is C5H12O2, molecular weight is 104.1476, as common compound, the synthetic route is as follows.

Under argon 3-methylbutane-1 ,3-diol (650 muIota_) is added at 0C to a suspension of NaH (ca. 60% in mineral oil; 400 mg). The mixture is stirred for 1 hour and then treated with 5-bromo-2-chloro-4,6-dimethylpyrimidine (1 .2 g). After stirring for 2 hours at room temperature the mixture is diluted with ethyl acetate and washed with ice- water and brine. After drying (MgSO4) the solvents are evaporated and the residue is chromatographed on silica gel (cyclohexane/ethyl acetate 70:39?50:50) to give the title compound. Yield: 1 .1 g; LC (method 3): tR = 0.79 min; Mass spectrum (EST): m/z = 289 [M+H]+.

Statistics shows that 2568-33-4 is playing an increasingly important role. we look forward to future research findings about 3-Methylbutane-1,3-diol.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; ECKHARDT, Matthias; FRATTINI, Sara; HAMPRECHT, Dieter; HIMMELSBACH, Frank; LANGKOPF, Elke; LINGARD, Iain; PETERS, Stefan; WAGNER, Holger; WO2013/144098; (2013); A1;,
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Synthetic Route of 13330-96-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 13330-96-6, name is 4-(Dimethylamino)butan-1-ol, molecular formula is C6H15NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a mixture of sodium hydride (72%, 232 mg, 7.0 mmol) and tetrahydrofuran (20 ml) was added 4-(dimethylamino)-1-butanol (0.82 g, 7.0 mmol) at 0C (external temperature), and the reaction mixture was stirred at 45C for 20 minutes. Then, the reaction mixture was cooled at 0C (external temperature). To the reaction mixture was added dropwise a mixture of tributyl-iodomethyl-tin (2.0 g, 4.6 mmol) and N,N-dimethylformamide (20ml) at the same temperature. Then, the reaction mixture was stirred at 45C for 30 minutes. The reaction mixture was brought to room temperature, water and ethyl acetate were added to the reaction mixture, and the organic layer was separated. The organic layer was washed with water and an aqueous saturated sodium chloride solution, and the solvent was distilled off under reduced pressure. The residue was purified by silica gel column chromatography (heptane: ethyl acetate=20:1, NH silica gel) to obtain the title compound (1.4 g, 3.3 mmol, 70%). 1H-NMR Spectrum (CDCl3) delta (ppm) : 0.81-0.97 (15H, m), 1.26-1.35(6H, m), 1.47-1.55(10H, m), 2.21(6H, s), 2.24-2.28(2H, m), 3.30-3.33(2H, m), 3.71(2H, t, J=6.8Hz).

According to the analysis of related databases, 13330-96-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Eisai R&D Management Co., Ltd.; EP1867650; (2007); A1;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 37585-25-4, name is (2-Amino-5-chlorophenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows. Formula: C7H8ClNO

General procedure: To an oven-dried 15 mL sealed tube were added 2-aminophenylmethanol 1 (0.425 mmol), benzonitrile 2(0.25 mmol), Ru cat. b (1.94 mg, 1 mol%), and KOtBu (14.02 mg, 0.5equiv) intamyl alcohol (1 mL) under an air atmosphere. The sealedtube was capped and heated at 130C for 2 h. The reaction mixturewas cooled down to room temperature and directly concentratedunder vacuum. The crude mixture was puried by preparative thin-layer-chromatography (petroleum ether/ethyl acetate 20/1) togive the desired product 3 or 4.

With the rapid development of chemical substances, we look forward to future research findings about 37585-25-4.

Reference:
Article; Wan, Xiao-Min; Liu, Zi-Lin; Liu, Wan-Qing; Cao, Xiao-Niu; Zhu, Xinju; Zhao, Xue-Mei; Song, Bing; Hao, Xin-Qi; Liu, Guoji; Tetrahedron; vol. 75; 18; (2019); p. 2697 – 2705;,
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Application of 13330-96-6 ,Some common heterocyclic compound, 13330-96-6, molecular formula is C6H15NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: To a solution of 8 (1.00 mmol) in iPrOH (30 mL) was addedB2Pin2 (1.01 g, 4.00 mmol) and KOtBu (0.028 g, 2.50 mmol). Thereaction was stirred at 110 C. After 12 h, the mixture was cooled toroom temperature and was concentrated in vacuo. Then themixture was diluted with water and extracted with ethyl acetate.The combined organic layer was washed by saturated sodiumchloride solution for three times, dried over anhydrous Na2SO4 andconcentrated under reduced pressure. The residue was purified bysilica gel chromatography to give 9.To a stirred solution of 9 (0.29 mmol) and triphosgene (0.086 g,0.33 mmol) in anhydrous dichloromethane (5 mL) at 0 C wasadded triethylamine (0.12 mL, 0.87 mmol) under nitrogen atmosphere.Then a solution of 4-(dimethylamino)butan-1-ol(0.87 mmol) in dichloromethane (5 mL) was added. The mixturewas stirred at room temperature overnight, diluted withdichloromethane (15 mL) and washed with water (3 20 mL). Theorganic phases were separated, combined, dried over anhydrousNa2SO4 and concentrated in vacuo. The residue was purified byusing column chromatography to afford the corresponding product10a-10e.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 13330-96-6, 4-(Dimethylamino)butan-1-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Lu, Dong; Liu, Jianan; Zhang, Yunzhe; Liu, Feifei; Zeng, Limin; Peng, Runze; Yang, Li; Ying, Huazhou; Tang, Wei; Chen, Wuhong; Zuo, Jianping; Tong, Xiankun; Liu, Tao; Hu, Youhong; European Journal of Medicinal Chemistry; vol. 145; (2018); p. 328 – 337;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 148043-73-6, name is 4,4,5,5,5-Pentafluoropentan-1-ol. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of 4,4,5,5,5-Pentafluoropentan-1-ol

4,4,5,5,5-pentafluoropentanol (10 g) and methylene chloride (100 ml) is added to the reaction flask. Add triethylamine (11.3 g). Under ice bath, drop methanesulfonyl chloride (6.72 g). The completion of the dropping. Restoration to room temperature react for 2 hours. Water to wash the excess triethylamine and methyl chloride, dried with anhydrous sodium sulfate, turns on lathe does, get 14.14 g 4,4,5,5,5-pentafluoropentyl methanesulfonate.

With the rapid development of chemical substances, we look forward to future research findings about 148043-73-6.

Reference:
Patent; Tianjin Fuyin Biotechnology Development Co., Ltd.; Liu, Wenjuan; Mo, Lan; (9 pag.)CN104447447; (2017); B;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 5259-98-3, name is 5-Chloropentan-1-ol. A new synthetic method of this compound is introduced below., Application In Synthesis of 5-Chloropentan-1-ol

A solution of 5-chloro-l-pentanol (10 g, 80 mmol) in DMF (100 mL) at 0 0C was treated with imidazole (19 g, 185 mmol) and TBDPS-Cl (26 g, 95 mmol), and the mixture was stirred and allowed to warm to room temperature over 2 hours before being quenched with the addition of water and extracted with EtOAc. The organic extract was washed with aqueous IN HCl, saturated aqueous NaHCOs, saturated aqueous NaCl, dried (Na2SO4), concentrated under reduced pressure, and subjected to flash chromatography to give 5 -(t-butyldimethylsilyloxy)-l -chloropentane as a colorless liquid (11 g, 38percent).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 5259-98-3, 5-Chloropentan-1-ol.

Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; VITAE PHARMACEUTICALS, INC.; WO2008/124575; (2008); A1;,
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Electric Literature of 4541-14-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 4541-14-4, name is 4-(Benzyloxy)butan-1-ol. This compound has unique chemical properties. The synthetic route is as follows.

General Procedure P. A solution of the alcohol (1 equiv) in anhydrous CH2Cl2 (0.2 M) at 0 0C was treated with PCC (1.5 equiv) and the mixture was stirred for 45 min. The reaction mixture was allowed to warm at 25 C and stirred for 3 h. The suspension was filtered through Celite and concentrated. Column chromatography (SiO2) afforded the aldehyde.; 4-(Benzyloxy)butan-l-ol was oxidized to 4-(benzyloxy)butanal (7.35 g, 79%) following general procedure P

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 4541-14-4, 4-(Benzyloxy)butan-1-ol.

Reference:
Patent; BOGER, Dale, L.; WO2008/150492; (2008); A1;,
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