Tag: M.W=100-200

Reference of 81156-68-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.81156-68-5, name is 2,4-Dichlorophenethyl alcohol, molecular formula is C8H8Cl2O, molecular weight is 191.06, as common compound, the synthetic route is as follows.

Example 4 Preparation of methyl 2- [3- (2- (2, 4-dichlorophenyl) ETHOXY) PHENYL- THIOJISOBUTYRATE (ST2534) The title product was prepared according to the procedure described in Method B starting from methyl 2- (3- hydroxyphenylthio) iso-butyrate (prepared as described in example 1) (0.280 g, 1.24 mmol) and DIAD (0.325 g, 1.61 mmol) dissolved in 3 mL of anhydrous THF and added dropwise to a solution of 2,4- dichlorophenetylalcohol (0.260 G, 1.36 mmol), and triphenylphosphine (0.422 g, 1.61 mmol) in 4 mL of anhydrous THF at 0C. The reaction was left overnight under magnetic stirring at room temperature. After this period, the solvent was evaporated and the residue purified by silica gel chromatography using hexane/AcOEt 9.6/0. 4 as eluent. 0.327 g of oily product were obtained (yield: 66 %); TLC: silica gel, eluent hexane/AcOEt 9/1, Fr: 0.34 ; IH NMR (CDC13, 300 MHz) B : 7.40 (d, 1H), 7.20 (m, 3H), 7.00 (m, 2H), 6.90 (dd, 1H), 4.15 (t, 2H), 3.65 (s, 3H), 3.20 (t, 2H), 1.45 (s, 6H); HPLC: Column: Inertisil ODS-3 (5 ZM) 4.6 x 250 mm, T: room temperature, mobile phase CH3CN/H20 90/10 (v/v), pH: as is, flow rate: 0.8 mL/min, 205 nm UV detector, retention time 12.40 min; KF: 0.2 % H20; E. A. conforming for CL9H20CL203S.

The chemical industry reduces the impact on the environment during synthesis 81156-68-5, I believe this compound will play a more active role in future production and life.

Reference:
Patent; SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.p.A.; WO2004/56355; (2004); A1;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 155310-11-5, name is 3-Amino-2,2-difluoropropan-1-ol, the common compound, a new synthetic route is introduced below. HPLC of Formula: C3H7F2NO

To a solution of 3-amino-2,2-difluoro-propan-1-ol (2.00 g, 18.0 mmol, CAS155310-11-5) in a mixed solvents of THF (75 mL) and H2O (75 mL) was added Boc2O (3.93 g, 18.0 mmol) slowly at 0 C. The reaction mixture was stirred at 25 C. for 16 hours. On completion, the reaction mixture was diluted with 1.0 M aq.HCl (100 mL) and extracted with EA (2×150 mL). The combined organic phase was washed with brine (50 mL), dried over Na2SO4, filtered and concentrated in vacuo to give the title compound (3.76 g, 98% yield) as white solid. 1H NMR (400 MHz, CDCl3) delta 5.04 (s, 1H), 4.10-3.87 (m, 1H), 3.76-3.63 (m, 2H), 3.60-3.54 (m, 2H), 1.48 (s, 9H).

The synthetic route of 155310-11-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Kymera Therapeutics, Inc.; Mainolfi, Nello; Ji, Nan; Kluge, Arthur F.; Weiss, Matthew M.; Zhang, Yi; (1443 pag.)US2019/192668; (2019); A1;,
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Synthetic Route of 431-23-2 ,Some common heterocyclic compound, 431-23-2, molecular formula is C4H7F3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of 3,3,3-trifluoro-2-methylpropan-1-ol (800 mg, 6.25 mmol) in DCM (20mL) was added triethylamine (950 mg, 9.39 mmol). The mixture was cooled to -20 oc andtrifluoromethanesulfonic anhydride (2.20 g, 7.70 mmol) was added. The mixture was stirred at0 oc overnight. The mixture was diluted with DCM (50 mL), washed with 1 M HCl aqueoussolution (50 mLx 2). The separated organic layer was dried over anhydrous Na2S04, and thenconcentrated in vacuo to give the title compound as yellow oil (1.1 g, yield 68% ).1HNMR (400 MHz, CDCh) 8 (ppm): 4.64-4.46 (m, 2H), 2.79-2.67 (m, 1H), 1.29 (d, J= 7.1 Hz,3H).19F NMR (376 MHz, CDCh) 8 (ppm): -71.6, -74.5.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 431-23-2, 3,3,3-Trifluoro-2-methylpropan-1-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; SUNSHINE LAKE PHARMA CO., LTD.; CALITOR SCIENCES, LLC; DAI, Weilong; XI, Ning; LI, Minxiong; ZHANG, Tao; LI, Xiaobo; HU, Haiyang; CHEN, Wuhong; WANG, Tingjin; LIU, Jun; (188 pag.)WO2017/48675; (2017); A1;,
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Synthetic Route of 6214-45-5, Adding some certain compound to certain chemical reactions, such as: 6214-45-5, name is (4-Butoxyphenyl)methanol,molecular formula is C11H16O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6214-45-5.

To a solution of different benzyl alcohols (7.82 mmol) in acetonitrile (27 mL), chlorotrimethylsilane (8.73 mmol) was added and then sodium iodide (8.05 mmol) was slowly added. This mixture was allowed to reflux with constant stirring at 90 C for 2 h, under nitrogen.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 6214-45-5, (4-Butoxyphenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Lopez, Jhon J.; Perez, Edwin G.; Synthetic Communications; vol. 49; 5; (2019); p. 715 – 723;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1875-89-4, name is 2-(m-Tolyl)ethanol. This compound has unique chemical properties. The synthetic route is as follows. Computed Properties of C9H12O

3-methyl phenethyl alcohol (5 g, 36.7 MMOL) was diluted in 30 mL of chloroform and ammonium nitrate (3.12 g, 38.9 MMOL) was added. The reaction mixture was cooled to 0 °C and trifluor acetic acid anhydride (16.02 mL, 113 MMOL) was added dropwise. The reaction stirred at 0 °C for 3 hours before water was added to slowly quench the reaction. The chloroform layer was washed with water then collected and dried over NA2SO4 then concentrated. The desired isomer crystallized out of the crude solution in ethyl acetate and was then triturated with acetonitrile to afford 5.25 g of the desired isomer as a brown solid. Yield 87percent; MS (APCI) : 199 [M-H]-.

With the rapid development of chemical substances, we look forward to future research findings about 1875-89-4.

Reference:
Patent; WARNER-LAMBERT COMPANY LLC; WO2004/41793; (2004); A1;,
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Related Products of 6214-45-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.6214-45-5, name is (4-Butoxyphenyl)methanol, molecular formula is C11H16O2, molecular weight is 180.24, as common compound, the synthetic route is as follows.

Was synthesized following the same general procedure as that for the preparation of 4-ethoxybenzyl chloride; thionyl chloride (7.42 g, 69.2 mmol), 4-butoxybenzyl alcohol (9.45 g, 52.4 mmol), CH2Cl2 (145 mL). Oil, 10.4 g (99%). 1H NMR (300 MHz, CDCl3) delta=7.28 (d, 2H, J=6.6 Hz), 6.86 (d, 2H, J=6.6 Hz), 4.56 (s, 2H), 3.95 (t, 2H, J=6.6 Hz), 1.76 (m, 2H), 1.48 (m, 2H), 0.97 (t, 3H, J=7.5 Hz). 13C NMR (75 MHz, CDCl3) delta=159.5, 130.2, 129.7, 114.9, 67.9, 46.6, 31.5, 19.4, 14.0.

Statistics shows that 6214-45-5 is playing an increasingly important role. we look forward to future research findings about (4-Butoxyphenyl)methanol.

Reference:
Patent; Percec, Virgil; US2006/88499; (2006); A1;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.54410-90-1, name is 4-Pentylcyclohexanol, molecular formula is C11H22O, molecular weight is 170.2918, as common compound, the synthetic route is as follows.SDS of cas: 54410-90-1

EXAMPLE 11 Preparation of 6-ethyl-trans-decalin-2-carboxylic acid trans-4-pentyl-1-cyclohexyl ester 2.10 g of 6-ethyl-trans-decalin-2-carboxylic acid, prepared according to Example 5, are dissolved in 30 ml of absolute methylene chloride and treated with a solution 1.87 g of 4-pentyl-trans-cyclohexanol in 20 ml of absolute methylene chloride. Subsequently, there are added 0.20 g of 4-(dimethylamino)pyridine and, after cooling to 5 C., while stirring 2.48 g of solid dicyclohexylcarbodiimide. Dicyclohexylurea begins to separate out after a short time. After 1 hour at 2 C. and 1.25 hours at room temperature, the precipitate is removed by filtration under suction and back-washed with methylene chloride and hexane. By evaporating the filtrate in vacuo, there are obtained 4.80 g of crude 6-ethyl-trans-decalin-2-carboxylic acid trans-4-pentyl-1-cyclohexyl ester which, for purification, is chromatographed on 90 g of silica gel. Elution with hexane/toluene (1:1) yields 3.22 g of substance which is recrystallized from hexane up to constant melting point and clearing point and dried up to constant weight in a high vacuum (0.01 mbar). There is obtained 6-ethyl-trans-decalin-2-carboxylic acid trans-4-pentyl-1-cyclohexyl ester as colorless crystals; m.p. 50.4 C., cl.p. 86.3 C. The following compound can be prepared in an analogous manner: 6-Butyl-trans-decalin-2-carboxylic acid trans-4-pentyl-1-cyclohexyl ester; m.p. 62.2-65.4 C.; cl.p. 109.3 C.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,54410-90-1, 4-Pentylcyclohexanol, and friends who are interested can also refer to it.

Reference:
Patent; Hoffmann-La Roche Inc.; US4391731; (1983); A;,
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Related Products of 2576-29-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2576-29-6, name is 2-((2-Chloroethyl)amino)ethanol hydrochloride, molecular formula is C4H11Cl2NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Similarly, a suspension of 2-[(2-chloroethyl)amino]ethanol hydrochloride (2.0 g, 8.4 mmol) in 1,4-dioxane (150 mL) was treated with Et3N (1.8 g), cooled with ice bath and then 15 (2.0 g,5.4 mmol) was added. The reaction was kept at 20 0C overnight, then water (100 mL) was added and the mixture was extracted with EtOAc (3×150 mL). The combined organic phases were washed with pre-cooled dilute HCl, water, aqueous NaHCO3, and brine, dried and concentrated under pressure, and then passed through a short column of silica gel, eluting with heptane/EtOAc (1:1), to give 16a (4.1 g, 37%).

According to the analysis of related databases, 2576-29-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; AUCKLAND UNISERVICES LIMITED; WO2008/30112; (2008); A1;,
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Related Products of 54410-90-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 54410-90-1, name is 4-Pentylcyclohexanol. This compound has unique chemical properties. The synthetic route is as follows.

(R)-4-(6-Hydroxnaphthalen-2-yl)-4-methyl-oxazolidin-2-one (Example 4, 0.3303 g, 0.001358 mol) was added to a capped 40 mL vial equipped with a magnetic stir bar. 4-o Pentyl-cyclohexanol (0.277 g, 0.00163 mol) was added, followed by tetrahydrofuran (6.00 mL, 0.0740 mol). Triphenylphosphine polymer-bound (1.17 g, 0.00217 mol) was then added and the mixture was stirred for 5 minutes. Diisopropyl azodicarboxylate (0.428 mL, 0.00217 mol) was then added and the mixture was stirred for 48 hours at room temperature. The mixture was diluted in ethyl acetate, filtered through CELITE, concentrated unders vacuum and purified by flash chromatography (0-5% MeOH in dichloromethane) to give 0.3672 g of the title compound (68% yield).

According to the analysis of related databases, 54410-90-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BIOGEN IDEC MA INC.; GUCKIAN, Kevin, M.; CALDWELL, Richard, D.; KUMARAVEL, Gnanasambandam; LEE, Wen-cherng; LIN, Edward, Yin-shiang; LIU, Xiaogao; MA, Bin; SCOTT, Daniel, M.; SHI, Zhan; ZHENG, Guo, Zhu; TAVERAS, Arthur, G.; THOMAS, Jermaine; WO2010/51030; (2010); A1;,
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Adding a certain compound to certain chemical reactions, such as: 103694-68-4, 2,2-Dimethyl-3-(m-tolyl)propan-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: 2,2-Dimethyl-3-(m-tolyl)propan-1-ol, blongs to alcohols-buliding-blocks compound. name: 2,2-Dimethyl-3-(m-tolyl)propan-1-ol

EXAMPLE 6 Manufacture of 1-methoxy-2,2-dimethyl-3-(3-methylphenyl)-propane In a 250 ml three-necked flask flushed with argon, 4.5 g of 2,2-dimethyl-3-(3-methylphenyl)-propan-1-ol (according to Example 5) in 50 ml of dry tetrahydrofuran were boiled for 11/2 hours under reflux with 0.7 g of sodium hydride. 3.2 g of dimethyl sulfate in 30 ml of tetrahydrofuran were then added dropwise thereto and the mixture was boiled under reflux for a further hour. After leaving the reaction mixture to stand for 24 hours, it was extracted by shaking with 20 ml of 10% by weight sodium hydroxide solution. Finally, the organic phase was dried with potassium carbonate and subjected to fractional distillation. 3.6 g of end product were obtained at 52 C./0.12 mbar.

The synthetic route of 103694-68-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Consortium fur Elektrochemische Industrie GmbH; US4710316; (1987); A;,
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