Tag: M.W=100-200

Synthetic Route of 13588-28-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.13588-28-8, name is 2-(2-Methoxypropoxy)propan-1-ol, molecular formula is C7H16O3, molecular weight is 148.2001, as common compound, the synthetic route is as follows.

In a 500 mL flask, flake-like sodium hydroxide (manufactured by Tosoh Corporation) (hereinafter also referred to as”NaOH tablets”) 51.5 g (relative to the following DPMI moles,Equivalent to 1. 4 moles)And 1-bromopropane (manufactured by Wako Pure Chemical Industries, Ltd.) (hereinafter also referred to as “PrBr”) 144.2 g(Relative to the following DPMI moles,Equivalent to 1. 3 moles)Start stirring.After raising the liquid temperature to 35 C,While keeping the temperature inside the system at 35 C,(Hereinafter referred to as “DPM”) was added dropwise over 6 hours to a solution of 133.7 g of dipropylene glycol monomethyl ether (isomer mixture) (manufactured by Wako Pure Chemical Industries, Ltd.).Thereafter,The overnight stirring was carried out while maintaining the temperature of 35 C.In addition,The amount of propylene gas as a low boiling compound produced in the above reaction was measured using a gas flow meter.The reaction solution was added with water 118. After 5 g, extraction /The resulting organic phase 194. 6 g was analyzed by gas chromatography,As a result, it was found that dipropylene glycol methyl n-propyl ether (isomer mixture) (hereinafter also referred to as “DPMNP”) 136.3 g (DPM basis yield: 79.4%, PrBr basis yield: 61 . 1% ).

Statistics shows that 13588-28-8 is playing an increasingly important role. we look forward to future research findings about 2-(2-Methoxypropoxy)propan-1-ol.

Reference:
Patent; Daicel Corporation; Mori, Atsushi; (9 pag.)CN105503545; (2016); A;,
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Reference of 81335-87-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 81335-87-7, name is (2-Amino-4-methylphenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: Benzyl alcohol derivative 11 (1 eq.) was dissolved in CH2Cl2 (0.4 M). Manganese (IV) oxide (2.1 eq.)was added under argon and the solution was left to stir at room temperature for 48 h. The progress ofthe reaction was monitored by TLC analysis. After completion, manganese oxide was filtered off andthe resulting filtrate was concentrated under reduced pressure. The crude product was purified by silicacolumn chromatography employing mixtures of n-hexane and ethyl acetate as eluents to obtain thedesired product 10.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 81335-87-7, (2-Amino-4-methylphenyl)methanol.

Reference:
Article; Jarrige, Lucie; Merad, Jeremy; Zaied, Siwar; Blanchard, Florent; Masson, Geraldine; Synlett; vol. 28; 14; (2017); p. 1724 – 1728;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 81335-87-7, name is (2-Amino-4-methylphenyl)methanol. A new synthetic method of this compound is introduced below., SDS of cas: 81335-87-7

General procedure: A test tube (25 mL) wascharged with 2-aminobenzyl alcohol 1 (0.5 mmol, 1equiv), alkynes 2 (0.75 mmol, 1.5 equiv), AgOTf (0.025 mmol, 5 mol %), HOTf (0.05mmol, 10 mol%), LiBr (0.05 mmol, 10mol%), H2O (0.2 mL), and toluene (3 mL) were added. Themixture was stirred at 40 oC in air for 8 hours, the reaction wascooled down to room temperature, the mixture was quenched by sat. aq. NaHCO3,and diluted with 10 mL dichloromethane and washed with 10 mL H2O.The aqueous layer was extracted twice with dichloromethane (10 mL) and thecombined organic phase was dried over Na2SO4. Afterevaporation of the solvents, the residue was purified by silica gelchromatography (hexane/AcOEt = 30:1).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 81335-87-7, (2-Amino-4-methylphenyl)methanol.

Reference:
Article; Xu, Xuefeng; Zhang, Xu; Liu, Wenming; Zhao, Qiang; Wang, Zhiqiang; Yu, Lintao; Shi, Fu; Tetrahedron Letters; vol. 56; 24; (2015); p. 3790 – 3792;,
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Application of 144284-25-3, Adding some certain compound to certain chemical reactions, such as: 144284-25-3, name is 2,4,5-Trifluorobenzyl alcohol,molecular formula is C7H5F3O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 144284-25-3.

To 25mL sealed tube were added norcantharidin 4 (1.0mmol, 168mg), 4-DMAP (1.0mmol, 244mg), after argon replacement three times, then added DCM 2.5mL, 2,4,5-trifluoro Benzyl alcohol 5 (2.0mmol, 232muL) was reacted at 60 for 14h. After the reaction was completed, it was cooled to room temperature, washed three times with HCl (1 mol/L) and saturated brine, and the organic phases were combined. After the organic phases were dried over anhydrous sodium sulfate, flash column chromatography gave a white solid product 6-3, yield 37.9%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 144284-25-3, 2,4,5-Trifluorobenzyl alcohol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Zunyi Medical University; Jia Jia; He Chunyang; Zhu Erlin; Wang Le; Li Xiaofei; Zhang Jianyong; (9 pag.)CN111253415; (2020); A;,
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Synthetic Route of 81156-68-5 ,Some common heterocyclic compound, 81156-68-5, molecular formula is C8H8Cl2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

5-[2-(2,4-Dichloro-phenyl)-ethoxy]-isophthalic acid dimethyl ester 1.75 g of triphenylphosphine and 1 g of 5-Hydroxy-isophthalic acid dimethyl ester were dissolved in 17 ml of anhydrous THF. The solution was cooled to 0-10 C. and a solution of 1 ml DEAD in 1 ml anhydrous THF was added dropwise over 20 min. The reaction was warmed to RT and stirred for 45 min. A solution of 11.3 ml 2-(2,4-Dichlorophenyl)-ethanol in 1 ml anhydrous THF was added with cooling. The reaction was stirred at RT for 16 h, then the solvents were removed under reduced pressure. The residue was treated with n-hepane:ethyl acetate/1:1. The filtrate was dried under reduced pressure and the product was purified by silica gel chromatography, eluding with n-heptane:ethyl acetate/4:1 to n-heptane:ethyl acetate/3:1.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,81156-68-5, its application will become more common.

Reference:
Patent; Nazare, Marc; Will, David William; Peyman, Anuschirwan; Matter, Hans; Zoller, Gerhard; Gerlach, Uwe; US2002/198195; (2002); A1;,
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Application of 1051899-73-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1051899-73-0, name is (3-Amino-2-fluorophenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows.

A solution of 2,4-dichloropyrimidine (300 mg, 2.01 mmol), (3-amino-2- fluorophenyl)methanol (256 mg, 1.81 mmol) and triethylamine (309 mul, 2.22 mmol) in 2- propanol (5 ml) was stirred over a period of 15 hrs at 90C as described in Method 1. Work-up and purification gave (3-(2-chloropyrimidin-4-ylamino)-2 -fluorophenyl) methanol (206 mg, 40.3 %) as a white solid. Mass Spectrum: M+H+ 254. NMR Spectrum (DMSOdbeta): 4.44 (s, 2H), 5.39 (bs, IH), 6.51 (bs, IH), 7.13 (ddd, IH), 7.30 (dd, IH), 7.36 (dd, IH), 8.09 (d, IH), 9.41 (bs, IH)

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1051899-73-0, (3-Amino-2-fluorophenyl)methanol.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2008/104754; (2008); A1;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 155310-11-5, name is 3-Amino-2,2-difluoropropan-1-ol, the common compound, a new synthetic route is introduced below. Quality Control of 3-Amino-2,2-difluoropropan-1-ol

EXAMPLE 28; Preparation of Compound 79; Step 1 & Step 2; Into the solution of 2,2-difluoro-3-aminopropionic acid (2 g, 14.4 mmol) in 40 mL of THF, was added 2N LAH solution in THF at 0 C. The mixture was heated to reflux for 3 h. After cooling to 0 C., 1.75 mL of 5N KOH water solution was added and the mixture was filtered. The solid was washed with 40 ml of THF. The combined filtrates were dried with MgSO4. After removal of the solvent in vacuo, 525 mg of the desired compound 73 was obtained.To the crude compound 73 in 100 mL of toluene, was added TEA (552 mg, 5.46 mmol) and phthalic anhydrite (740 mg, 5 mmol). After azeotroping for 3 h, the toluene was removed in vacuo and the residue was purified by preparative flash chromatography (silica gel, ethyl acetate/hexane, 1:4) to afford the desired product 74 (358 mg): 1H NMR (CDCl3); 7.92 (2H, m), 7.8 (2H, m), 4.21(2H, t), 3.74 (2H, m) 3.23(1H, br; OH) MS [M+H]=241.89

The synthetic route of 155310-11-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Gilead Sciences, Inc.; US2010/22508; (2010); A1;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 79944-63-1, name is (3-Amino-5-chlorophenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 79944-63-1

Example A24; a) Preparation of intermediate 83; [Show Image] 3-Amino-5-chloro-benzenemethanol (0.0194 mol) was added in one portion to a solution of intermediate 77 (0.0162 mol) in 1,4-dioxane (80 ml). DIPEA (0.0194 mol) was added. The resultant reaction mixture was stirred for 8 hours at room temperature. CH2Cl2 (50 ml) and brine (50 ml) were added. The layers were separated. The organic layer was washed with brine (2 x 20 ml). The organic layers were combined, dried (MgSO4), filtered and the solvent was evaporated, yielding 6 g (90%) of intermediate 83.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 79944-63-1, (3-Amino-5-chlorophenyl)methanol.

Reference:
Patent; Janssen Pharmaceutica NV; EP1904461; (2008); A2;,
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Adding a certain compound to certain chemical reactions, such as: 18684-63-4, Bicyclo[2.2.2]octan-2-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 18684-63-4, blongs to alcohols-buliding-blocks compound. SDS of cas: 18684-63-4

3-(bicyclo-[2.2.2]oct-2-yloxy)-4-Methoxybenzaldehyde Bicyclo[2.2.2]-2-octanol (5.00 g, 40 mmol), isovanillin (6.09 g, 40 mmol) and triphenylphosphine (13.1 g, 50 mmol) are dissolved in dry tetrahydrofuran. To this reaction mixture is added dropwise diethylazodicarboxylate (8.71 g, 50 mmol). The reaction is stirred for 1 hour at room temperature and is refluxed for 80 hours. The reaction mixture was cooled and concentrated in vacuo and the residue is mashed 3*150 ml of ether to remove the desired material from the triphenylphosphine oxide. The combined ethereal layers are washed with 2*100 ml H2 O, 2*100 ml 2N NaOH solution, 2*100 ml H2 O and 2*100 ml brine. The organics are dried, filtered and concentrated in vacuo. The compound is purified by flash silica gel (32-80 mesh) chromatography with 20% ethyl acetate/hexane. The appropriate fractions are concentrated in vacuo to yield 3.32 g (32%) of product as a viscous oil. 1 H NMR (250 MHz, CDCl3): delta 7.4 (dd, 1H, J=8.5 Hz, J=1.5 Hz), 7.35 (d, 1H, J=1.5 Hz), 6.95 (d, 1H, J=8.5 Hz), 4.52 (m, 1H), 3.91 (s, 3H), 2.2-1.3 (m, 12H). 13 C NMR (63 MHz, CDCl3): delta 190.9, 155.7, 147.9, 129.97, 126.2, 112.6, 110.9, 77.5, 56.1, 34.74, 28.18, 25.25, 24.55, 23.29, 22.78, 19.09 (16 lines).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,18684-63-4, Bicyclo[2.2.2]octan-2-ol, and friends who are interested can also refer to it.

Reference:
Patent; Pfizer Inc.; US5128358; (1992); A;,
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Reference of 1875-89-4, Adding some certain compound to certain chemical reactions, such as: 1875-89-4, name is 2-(m-Tolyl)ethanol,molecular formula is C9H12O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1875-89-4.

General procedure: The alcohol (1.0 eq) was added to a suspension of Dess-Martin periodinane (1.2 eq) in CH2Cl2(100 mM) under an argon atmosphere at room temperature. The mixture was allowed to stir for0.5 – 20 hours, while consumption of starting material was monitored by TLC. After the reactionwas complete, 1M Na2S2O3 (equal volume to CH2Cl2) was added. After stirring for 15 minutes,the phases were separated and the aqueous phase was extracted with CH2Cl2 twice. Thecombined organic layers were washed with 5% NaHCO3 and brine, and dried over Na2SO4. Thesolvent was evaporated under reduced pressure and the residue was purified by columnchromatography to afford analytically pure aldehydes.b) alcohol precursors for aldehydes 13, 14, 20 (solid alcohols)The alcohol (1.0 eq) was dissolved in CH2Cl2 (200 mM) and the solution was added to asuspension of Dess-Martin periodinane (1.2 eq) in CH2Cl2 (200 mM) under an argon atmosphereat room temperature. The mixture was allowed to stir for 0.5 – 20 hours (TLC monitoring). Then,Et2O (equal volume to CH2Cl2), 1M Na2S2O3 and saturated NaHCO3 (both equal volume toCH2Cl2) were added. After stirring for 15 minutes, the phases were separated and the aqueousphase was extracted with Et2O twice. The combined organic layers were washed with sat.NaHCO3 and brine, and dried over Na2SO4. The solvent was evaporated under reduced pressureand the residue was purified by column chromatography to afford analytically pure aldehydes.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1875-89-4, 2-(m-Tolyl)ethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Ruff, Bettina M.; Bra?se; O’Connor, Sarah E.; Tetrahedron Letters; vol. 53; 9; (2012); p. 1071 – 1074;,
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