Tag: M.W=100-200

623-04-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 623-04-1, name is (4-Aminophenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows.

4-aminobenzyl alcohol (1 g, 8.12 mmol) was dissolved in 5 mL of 5M hydrochloric acid solution,A solution of sodium nitrite (840 mg, 12.18 mmol, dissolved in 20 mL of deionized water) was added dropwise to the solution. The mixture was added dropwise within 30 minutes. The reaction mixture was vigorously stirred in an ice-water bath.Sodium azide (2.1 g, 32.3 mmol) was added portionwise to the reaction system, and the resulting mixture was stirred at room temperature overnight. After the reaction is complete,The residue was poured into saturated NaHCO3 solution and extracted with ethyl acetate. The organic layer was washed with saturated NaCl solution, dried over anhydrous Na2SO4, filtered and concentrated.The crude product was isolated and purified by silica gel column chromatography (EA:PE=1:3, volume ratio) to give 950 mg of a yellow oily liquid in a yield of 78.0%.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 623-04-1, (4-Aminophenyl)methanol.

Reference:
Patent; Peking University; Tang Xinjing; Jin Qingqing; (36 pag.)CN107365254; (2017); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

3360-41-6, Adding a certain compound to certain chemical reactions, such as: 3360-41-6, 4-Phenylbutan-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 3360-41-6, blongs to alcohols-buliding-blocks compound.

General procedure: To 16 (0.6 g, 0.6 mmol) was added dichloromethane (5 mL) in a round-bottom flask. After 10 min, oxalyl chlorideor oxalyl bromide was added (0.6 mmol). The reaction mixture was magnetically stirred at room temperature. Uponcessation of gas evolution, 4 was added (0.5 mmol), and the reaction mixture was heated to reflux. After thereaction was complete according to TLC analysis, the mixture was cooled to room temperature and filtered. Thesolid on the funnel was washed with dichloromethane (3 ¡Á 10 mL), and the filtrate was concentrated under reducedpressure to afford the desired product 5 in an essentially pure state based on 1H and 13C NMR spectroscopicanalyses.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,3360-41-6, its application will become more common.

Reference:
Article; Xia, Xuanshu; Toy, Patrick H.; Beilstein Journal of Organic Chemistry; vol. 10; (2014); p. 1397 – 1405;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

440-60-8, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 440-60-8 as follows.

In a 10 mL round bottom flask, 0.99 g of pentafluorobenzyl alcohol and 2 g of diethylene glycol dimethyl ether were sequentially added.The resulting mixture was subjected to ultrasonic irradiation at 40 kHz/30 W/70 C for 30 minutes in an ultrasonic reaction apparatus. The diethylene glycol dimethyl ether was removed under reduced pressure, and recrystallized to obtain 0.89 g of pentafluorobenzoic acid in a yield of 95%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,440-60-8, its application will become more common.

Reference:
Patent; Central South University; Xiao Fang; Xiao Yuanyuan; Zeng Ming; Li Na; Yin Lirong; (15 pag.)CN108467342; (2018); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

78-69-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 78-69-3, name is 3,7-Dimethyloctan-3-ol, molecular formula is C10H22O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Add 2g to the reaction flaskTetraacetyl substituted glucose bromine (chemical formula:), 0.38 g of tetrahydrolinalol (chemical formula:),0.73g of silver carbonate and 10mL of dichloromethane,Reacting at room temperature for 24 hours;The solvent was removed under reduced pressure.Separated by column chromatography,The eluent (a mixture of petroleum ether and ethyl acetate in a mass ratio of 5:1) was washed down with 0.80 g of a white solid.That is, tetrahydrolinalol tetraacetyl glucoside (chemical formula:).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 78-69-3, 3,7-Dimethyloctan-3-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Shanghai Institute of Technology; Li Hongyi; Pan Xianhua; Chen Yu; Huo Jiyou; Yuan Hongshun; (9 pag.)CN109970826; (2019); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 6214-44-4, name is (4-Ethoxyphenyl)methanol. A new synthetic method of this compound is introduced below., 6214-44-4

A mixture of benzyl alcohol (1 mmol), phenylacetonitrile (3 mmol), 0.0998 g of metal-MgO (Pd: 0.0075 mmol; Au: 0.0075 mmol; Pt: 0.0075 mmol), trifluorotoluene (1 ml) and n-dodecane (20 mul) as internal standard were placed into an autoclave. The resulting mixtures were vigorously stirred at 180 C under nitrogen, being monitored by GC.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,6214-44-4, (4-Ethoxyphenyl)methanol, and friends who are interested can also refer to it.

Reference:
Article; Corma, Avelino; Rodenas, Tania; Sabater, Maria J.; Journal of Catalysis; vol. 279; 2; (2011); p. 319 – 327;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

2050-25-1 , The common heterocyclic compound, 2050-25-1, name is 2-(2-(Benzyloxy)ethoxy)ethanol, molecular formula is C11H16O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Under a nitrogen atmosphere, silver trifluoromethane sulfonate (19.64 g, 76.44 mmol), lithium trifluoromethane sulfonate (3.97 g, 25.48 mmol), 1-(chloromethyl)-4-fluoro- 1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate) (18.05 g, 50.96 mmol) and potassium fluoride (5.92 g, 101.92 mmol) were mixed.2-(2-benzyloxyethoxy)ethanol (5 g, 25.48 mmol), trimethyl(1,1,2,2,2-pentafluoroethyl)silane (14.69 g, 76.44 mmol), EtOAc (20 mL), trifluoromethylbenzene (20 mL), and 2-fluoropyridine (7.42 g, 76.44 mmol) were then added under N2 atmosphere in this order. The reaction mixture was stirred under N2 atmosphere for 60 h at 30 C then filtered through a plug of silica (eluting with EtOAc). The filtrate was collected and concentrated. The residue was purified via silica gel chromatography (PE:EtOAc = 25:1) to obtain 2-[2-(1,1,2,2,2-pentafluoroethoxy)ethoxy]ethoxymethylbenzene (2.5 g, 31% yield) as a light yellow liquid. 1H NMR (400 MHz, CDCl3) d 7.36- 7.24 (m, 5H), 4.56 (s, 2H), 4.17- 4.11 (m, 2H), 3.76- 3.72 (m, 2H), 3.71- 3.65 (m, 2H), 3.65- 3.60 (m, 2H). 19F NMR (376 MHz, CDCl3) d -90.77 (s), -86.02 (s).

According to the analysis of related databases, 2050-25-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; NAVITOR PHARMACEUTICALS, INC.; SAIAH, Eddine; O’NEILL, David, John; KANG, Seong Woo Anthony; (366 pag.)WO2019/241789; (2019); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

617-94-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 617-94-7, name is 2-Phenyl-2-propanol, molecular formula is C9H12O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of NaH (60 % dispersion in mineral oil, 105 mg, 9.61 mmol) in diethylether (9.5 ml)was added alpha,alpha-dimethyl benzenemethanol (3.04 g, 22.3 mmol) at 0 C. After stirring for 40 min atr oom temperature, trichloroacetonitrile (2.0 ml, 20.0 mmol) was added at 0 C. The reaction mixture was stirred for 3 h at room temperature and concentrated in vacuo. Hexane (2.5 ml) and MeOH (0.1ml) were added to the resulting residue. The mixture was filtered through Celite and concentrated invacuo to give S11 (4.85 g, 78%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 617-94-7, 2-Phenyl-2-propanol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Ota, Eisuke; Mikame, Yu; Hirai, Go; Nishiyama, Shigeru; Sodeoka, Mikiko; Synlett; vol. 27; 7; (2016); p. 1128 – 1132;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

3973-18-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 3973-18-0, name is Propynol ethoxylate. This compound has unique chemical properties. The synthetic route is as follows.

4-((2-azidoethyl)amino)-N-(4-fluorophenyl)-N’-hydroxy-1,2,5-oxadiazole-3-carboxamidine (III-4, 0.75g, 2.45mmol) into a 50mL eggplant-shaped bottle,Add 3mL of water and 18mL of acetonitrile solution respectively. Under ice bath, add ethoxylated propynol (290 muL, 2.94 mmol) and cuprous iodide (93 mg, 0.49 mmol),Keep warm and stir for 0.5h, then transfer to room temperature and continue stirring for about 8h.TLC monitored the reaction until the reaction was complete (developing agent: dichloromethane: methanol = 15:1 v/v); the solvent was distilled off under reduced pressure, methanol (20 mL) was added and stirred for 30 min, filtered with suction, and the solvent was distilled off under reduced pressure to obtain a light brown solid , Column chromatography purification (eluent: petroleum ether: ethyl acetate = 2:1 ~ 1:4v/v), to obtain 165mg white solid I-8, the yield was 17.3%,

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 3973-18-0, Propynol ethoxylate.

Reference:
Patent; China Pharmaceutical University; Zhu Qihua; Zhang Shan; He Guangchao; Shen Hui; Wang Yiwei; Gu Shuhui; Sun Zeren; Xu Yungen; (24 pag.)CN111138425; (2020); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 42142-52-9 as follows., 42142-52-9

To a solution of 25 g N-methyl-3-phenyl-3-hydroxyphenyl propylamine in hexamethylphosphorous triamide and 19 g potassium f-butoxide at 50-600C was charged 50 g of 2-flourotoluene and the mixture was heated to 105-1100C. The reaction was maintained for 19-20 hours. After the completion of the reaction (monitored by TLC) there were charged 250 ml of water followed by 250 ml toluene and the mixture was stirred for 10-15 minutes. The aqueous and organic layers were separated, then the aqueous layer was extracted with (2*75 ml) toluene. The combined organic layer was washed with (3×75 ml) water and then subjected to distillation to obtain a thick residue. The residue was dissolved in 150 ml of acetone followed by adding of 12.5 g oxalic acid and 200 ml of isopropyl ether and the mixture was stirred for 1-1.5 hours at 0-50C, then the obtained solid was separated by filtration and washed with isopropyl ether (100 ml) resulting in the (+/-)-atomoxetine oxalate with yield 62.4% and a purity of 95.4 area-% by HPLC.

The chemical industry reduces the impact on the environment during synthesis 42142-52-9, I believe this compound will play a more active role in future production and life.

Reference:
Patent; DR. REDDY’S LABORATORIES LTD.; DR. REDDY’S LABORATORIES, INC.; WO2006/37055; (2006); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 349-75-7, name is (3-(Trifluoromethyl)phenyl)methanol. A new synthetic method of this compound is introduced below., 349-75-7

A solution of (3-Trifluoromethyl-phenyl)-methanol (180 g, 1.0 mol, 1.0 eqiv.) in dichloromethane (1000 mL) was cooled below 10 C. and phosphorus tribromide (360 g, 1.30 mol, 1.3 eqiv.) was added dropwise in 30 minutes. The mixture was stirred overnight and water was added dropwise until no gas was produced. The solution was washed with saturated sodium hydrogen carbonate (2¡Á500 mL) and water (200 mL). The organic layer dried over anhydrous sodium sulfate and concentrated in vacuo to give the title compound as an brown-red liquid (163 g, 67%).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,349-75-7, (3-(Trifluoromethyl)phenyl)methanol, and friends who are interested can also refer to it.

Reference:
Patent; Kalypsys, Inc.; US2005/234046; (2005); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts