Tag: M.W=100-200

403-41-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 403-41-8, name is 1-(4-Fluorophenyl)ethyl Alcohol. A new synthetic method of this compound is introduced below.

General procedure: The catalyst solutionwas prepared by dissolving complex 3(36.1 mg,0.05mmol) in methanol (5.0 mL).Under a nitrogen atmosphere, the mixture of an alcohol substrate (2.0 mmol) and1.0 mL of the catalyst solution (0.01mmol) in 20mL acetone was stirred at 56 Cfor 10 minutes. tBuOK(22.4mg, 0.2 mmol)was then added to initiate the reaction.At the stated time, 0.1 mL of the reaction mixture was sampled and immediately diluted with 0.5 mL acetone pre-cooled-to-0 C for GC or NMR analysis. After the reaction was complete, the reaction mixture was condensed under reduced pressure and subject to purification by flash silica gel column chromatography to afford the corresponding ketone product, which was identified by comparison with the authentic sample through NMR and GC analysis.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 403-41-8, 1-(4-Fluorophenyl)ethyl Alcohol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Wang, Qingfu; Du, Wangming; Liu, Tingting; Chai, Huining; Yu, Zhengkun; Tetrahedron Letters; vol. 55; 9; (2014); p. 1585 – 1588;,
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105-30-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 105-30-6, name is 2-Methylpentan-1-ol, molecular formula is C6H14O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

2-Methyl-1-iodopentane Triphenylphosphine (1.93 g, 7.358 mmol) and imidazole (0.5 g, 7.344 mmol) were dissolved in dichloromethane (5.0 ml), and the solution was stirred for 5 minutes. Then, iodine (1.86 g, 7.328 mmol) was added thereto, and the mixture was stirred for 10 minutes. A dichloromethane (2.0 ml) solution of 2-methyl-1-pentanol (0.5 g, 5.672 mmol) was added dropwise thereto, and the mixture was stirred at room temperature for 1.5 hours. After the reaction was confirmed by TLC to be complete, the reaction solution was filtered through celite, and a 5% aqueous sodium thiosulfate solution was added to the filtrate to remove iodine. The organic layer was washed twice with brine and dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure, and then, the residue was purified by silica gel column chromatography (hexane) to obtain 2-methyl-1-iodopentane (0.56 g, yield: 54%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 105-30-6, 2-Methylpentan-1-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; TOHOKU UNIVERSITY; KAKE EDUCATIONAL INSTITUTION; KANAGAWA PREFECTURAL HOSPITAL ORGANIZATION KANAGAWA CHILRDEN’S MEDICAL CENTER; ABE, Takaaki; TOMINAGA, Teiji; HAYASHI, Kenichiro; OSAKA, Hitoshi; US2015/353489; (2015); A1;,
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Adding some certain compound to certain chemical reactions, such as: 928-92-7, name is 4-Hexen-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 928-92-7. 928-92-7

[199] To a vial charged with a stir bar were added tm -T-nonenoic acid (143.7 mg,0.9198 mmol), DMAP (23.0 mg, 0.184 mmol), EDC hydrochloride (352.1 rag, 1.840 mmol), and 7.5 mL dry’ dichloromethane under argon atmosphere. Trans-4-hexen-l-oi (216 pL, 1.840 mmol) was added, and the reaction ws stirred for 3 h. The reaction mixture was quenched with a solution of 1 M aq. HC1 (15 mL) after which, the product was extracted with DCM (4 x 15 mL). This organic phase was dried over MgSCL, filtered, and concentrated in vacuo. The product w’as purified by column chromatography (5:95 EtjO: pentane) to yield the product as a colorless oil (201.7 mg, 92% yield). 5H NMR (400 MHz, Chloroform-d)) d 5.52 – 5.36 (m, 4H), 4.08 (t, J~ 6.7 Hz, 2H), 2.31 (t, J- 7.5 Hz, 2H), 2.1 1 – 2.03 (m, 2H), 1.99 (dddd, J= 8.7, 6.5, 3.0, 1.3 Hz, 2H), 1.74 – 1.59 (m,1 OH), 1.42 – 1.26 (m, 4H).,3C NMR (101 MHz, CDCb) d 173.95, 131.28, 129.97, 125.81, 124.86, 63.78, 34.37, 32.39, 29.21, 28.88, 28.66, 28.47, 24.91, 17.94, 17.93.HRMS (EH-): [M] _ CisEbcCb Calculated – 238.1933, Found – 238.1935.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 928-92-7.

Reference:
Patent; CALIFORNIA INSTITUTE OF TECHNOLOGY; AHMED, Tonia, S.; MONTGOMERY, Patrick, T.; GRUBBS, Robert, H.; (104 pag.)WO2019/113019; (2019); A2;,
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626-18-6, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 626-18-6, name is 1,3-Benzenedimethanol. This compound has unique chemical properties. The synthetic route is as follows.

To a solution of 1,3-phenylenedimethanol (2) (3.51?g, 25.4?mmol) in tetrahydrofuran (THF; 84.4?mL) at 0?C was added 55% sodium hydride (dispersion in paraffin liquid, 1.11?g, 25.4?mmol). After dropping 4-methoxybenzyl chloride (3.43?mL, 25.4?mmol), tetrabutylammonium iodide (1.00?g, 2.71?mmol) was added. The reaction mixture was stirred for 1?h?at room temperature and for 3?h?at 60?C, and then saturated aqueous ammonium chloride was added at 0?C. The mixture was extracted with ethyl acetate, and the organic layer was dried over sodium sulfate. After filtration of the mixture and evaporation of the solvent, the crude product was purified by column chromatography on silica (eluant: hexane/ethyl acetate?=?6/1) to afford 3 (2.15?g, 33%). 1H NMR (CDCl3, 300?MHz): delta 7.37-7.28 (6H, m, Ar), 6.92-6.88 (2H, m, Ar), 4.71 (2H, s, 1-H), 4.53 (2H, s, Bn), 4.51 (2H, s, Bn), 3.81 (3H, s, OCH3); 13C NMR (CDCl3, 300?MHz): delta 159.17 (4′), 141.09, 138.58, 130.17, 129.39, 128.53, 126.95, 126.27, 126.14, 113.77 (3′), 71.85 (PMPCH2 or PMBOCH2), 71.66 (PMPCH2 or PMBOCH2), 65.04 (CH2OH), 55.21 (CH3O); HR MS: calcd for C16H18O3Na [M+Na]+ 281.1148, found 281.1160.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 626-18-6, 1,3-Benzenedimethanol.

Reference:
Article; Tanaka, Makoto; Zhu, Yunhao; Shionyu, Masafumi; Ota, Nozomi; Shibata, Natsumi; Watanabe, Chihiro; Mizusawa, Akihito; Sasaki, Ryuzo; Mizukami, Tamio; Shiina, Isamu; Hasegawa, Makoto; European Journal of Medicinal Chemistry; vol. 146; (2018); p. 636 – 650;,
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100-86-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 100-86-7, name is 2-Methyl-1-phenyl-2-propanol. This compound has unique chemical properties. The synthetic route is as follows.

For the tetrahydropyanylation or trimethylsilylation of alcohols, to solution of the DHP(1 mmol) or HMDS(1 mmol) in CH3CN (5ml) were added {K*18-crown-6]Br3}n (0.001 mmol). The solution was stirred at room temperature for 1 min. Then alcohol(1 mmol for THP and 2 mmolf for TMS) was stirred at room temperature for an appropriate time (Table 2). After completion of the reaction, CH3CN was removed by water bath distillation. To the residue was added n-hexane or ethyl acetate(5 ml) and the mixture was filtered (the catalyst is insoluble in n-hexane and ethyl acetate). The filtrate was wahed with n-hexane or ethyl acetate (10 ml*2). The solvent was removed by distillation to yield pure products.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 100-86-7, 2-Methyl-1-phenyl-2-propanol.

Reference:
Article; Chehardoli, Gholamabbas; Zolfigol, Mohammad Ali; Derakhshanpanah, Fateme; Cuihua Xuebao/Chinese Journal of Catalysis; vol. 34; 9; (2013); p. 1730 – 1733;,
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108-82-7, Adding a certain compound to certain chemical reactions, such as: 108-82-7, 2,6-Dimethylheptan-4-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 108-82-7, blongs to alcohols-buliding-blocks compound.

General procedure: NaOCl5H2O crystals (12.0e18.0 mmol) wereadded in one portion to a mixture of Bu4NHSO4 (0.170 g,0.50 mmol), TEMPO (15.6 mg, 0.10 mmol), and alcohols (10.0 mmol)in dichloromethane (10 mL or 30 mL) at several temperature. Afterstirring for an appropriate time, 0.5 mL of the organic layer and0.03 g weighed of PCBTF as an internal standard were added to1e2 mL of CH2Cl2 for GC analysis. GCeMS analyses of the productswere identical with authentic samples.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,108-82-7, its application will become more common.

Reference:
Article; Okada, Tomohide; Asawa, Tomotake; Sugiyama, Yukihiro; Iwai, Toshiaki; Kirihara, Masayuki; Kimura, Yoshikazu; Tetrahedron; vol. 72; 22; (2016); p. 2818 – 2827;,
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112-60-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 112-60-7, name is 2,2′-((Oxybis(ethane-2,1-diyl))bis(oxy))diethanol. This compound has unique chemical properties. The synthetic route is as follows.

To a cold (0 C) stirred solution of tert-butyl 2-bromoacetate (5.4 mL, 36.6 mmol) and 2,2′-((oxybis(ethane-2,l-diyl))bis(oxy))diethanol (35.0 mL, 203 mmol) in DMSO (50 mL) was added NaH (1.6217 g, 40.6 mmol, 60% in oil) in two portions. The reaction mixture was slowly warmed up to rt, stirred for 23 h, diluted with water (50 mL), saturated with NaCl (50 g), stirred for 5 min, extracted with Et20 (3 x 100 mL), and concentrated. The residue was taken in DCM (50 mL) and water (25 mL), stirred for 5 min. The organic solution was passed through a phase separator, concentrated and purified on a 80 g Si02 cartridge using a gradient of ethyl acetate in hexanes (50- 100%) to afford the title compound (8.2 g, 72.7% yield) as a pale yellow oil. Rf = 0.08 (EtOAc). NMR (400 MHz, CDCb) delta 4.02 (d, J = 1.0 Hz, 2H), 3.75 – 3.60 (m, 12H), 1.47 (s, 9H) ppm.LRMS (ESI) m/z: calculated for Ci4H2807 308.3679; found 330.95 (M+Na)+; Found 347.01 (M+K)+.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 112-60-7, 2,2′-((Oxybis(ethane-2,1-diyl))bis(oxy))diethanol.

Reference:
Patent; QUARTZ THERAPEUTICS, INC.; ZAMBONI, Robert; HENNING, Ryan; JI, Alan; SMITH, Tyler; HELLER, Bradley; REDDY, Thumkunta Jagadeeswar; ROCHELEAU, Sylvain; BEAULIEU, Marc Andre; (266 pag.)WO2018/200981; (2018); A1;,
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928-92-7, Adding a certain compound to certain chemical reactions, such as: 928-92-7, 4-Hexen-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 928-92-7, blongs to alcohols-buliding-blocks compound.

202] To a vial charged with a stir bar were added tram- 9 -¡¤ u n d e e e no i e acid (51.4 g,0,280 mmol), DMAP (6.8 mg, 0.0560 mmol), EDC hydrochloride (106.9 mg, 0.560 mmol), and 2.2 mL dry dich.oromethane under argon atmosphere. 7ram’-4~hexen-l-ol (65.6 pL, 0.560 mmol) was added, and the reaction was stirred for 3 h. The reaction mixture was quenched with a solution of 1M aq. HC1 (5 mL) after which, the product was extracted with DCM (4 x 5 mL). This organic phase was dried over MgS04, filtered, and concentrated in vacuo. The product was purified by column chromatography (5:95 Et20: pentane) to yield the product as a colorless oil (68.3 g, 92% yield).*H NMR (400 MHz, Chlorofomw/i) d 5.46 – 5.25 (m, 4H), 3.99 (t, 6.7 Hz, 2H), 2.27 – 2.15(m, 2H), 1.97 (tdd, J= 7.6, 5.9, 1.5 Hz, 2H), 1.92 – 1.85 (m, 2H), 1.65 – 1.49 (m, 10H), 1.32 – 1.13 (m, 8H).C NMR (101 MHz, CDCb) 6 174.12, 131.69, 130.10, 125.93, 124.76, 63.90, 34.53, 32.70, 29.66, 29.27, 29.26, 29.11, 29.02, 28.60, 25.15, 18.08, 18.06.HRMS (Hi -): [M]+ 7H30O2 Calculated – 266.2237, Found – 266.2246.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,928-92-7, its application will become more common.

Reference:
Patent; CALIFORNIA INSTITUTE OF TECHNOLOGY; AHMED, Tonia, S.; MONTGOMERY, Patrick, T.; GRUBBS, Robert, H.; (104 pag.)WO2019/113019; (2019); A2;,
Alcohol – Wikipedia,
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111-90-0 , The common heterocyclic compound, 111-90-0, name is Diethylene Glycol Monoethyl Ether, molecular formula is C6H14O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A. 3-(4-(2-(2-ethoxyethoxy)ethoxy)-1,2,5-thiadiazol-3-yl)pyridine To a solution of 2-(2-ethoxyethoxy)ethanol (1.21 g, 9 mmol) and sodium hydride (310 mg, 9 mmol) in dry tetrahydrofuran was added a solution of 3-(4-chloro-1,2,5-thiadiazol-3-yl)pyridine (590 mg, 3 mmol) in dry tetrahydrofuran. The reaction mixture was stirred at room temperature for 2 h. water was added and the mixture was extracted with ether. The ether phase was dried and evaporated to give the title compound.

The synthetic route of 111-90-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; NOVO NORDISK A/S; EP384288; (1995); B1;,
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Adding a certain compound to certain chemical reactions, such as: 4254-29-9, 2,3-Dihydro-1H-inden-2-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 4254-29-9, blongs to alcohols-buliding-blocks compound. 4254-29-9

(41D) Methyl (3S)-3-[4-(2,3-dihydro-1H-inden-2-yloxy)phenyl]-3-ethoxypropionate Methyl (3S)-3-ethoxy-3-(4-hydroxyphenyl)propionate (100 mg, 0.446 mmol) produced in (41C) and indan-2-ol (90 mg, 0.669 mmol) were dissolved in tetrahydrofuran (10 mL), and triphenylphosphine (178 mg, 0.680 mmol) and a 40% diethyl azodicarboxylate toluene solution (309 muL, 0.680 mmol) were added thereto at room temperature, and then, the resulting mixture was stirred under a nitrogen atmosphere at 50 C. for 4 hours. After the reaction solution was cooled to room temperature, the solvent was distilled off under reduced pressure, and the resulting residue was purified by silica gel column chromatography (hexane:ethyl acetate=100:0 to 95:5 (v/v)), whereby the objective title compound was obtained as a yellow oily substance (103 mg, yield: 68%). 1H NMR (CDCl3, 400 MHz): delta1.14 (3H, t, J=7.0 Hz), 2.58 (1H, dd, J=4.7, 15.3 Hz), 2.82 (1H, dd, J=8.9, 15.2 Hz), 3.20 (2H, dd, J=2.7, 16.4 Hz), 3.31-3.41 (4H, m), 3.68 (3H, s), 4.70 (1H, dd, J=5.1, 9.0 Hz), 5.14-5.19 (1H, m), 6.88 (2H, d, J=8.6 Hz), 7.19 (1H, d, J=5.9 Hz), 7.20 (1H, t, J=5.5 Hz), 7.24-7.26 (4H, m)

With the rapid development of chemical substances, we look forward to future research findings about 4254-29-9.

Reference:
Patent; DAIICHI SANKYO COMPANY, LIMITED; US2011/53974; (2011); A1;,
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