Tag: M.W=100-200

1777-82-8, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 1777-82-8 as follows.

General procedure: To a mixture of alcohol (1mmol) and electrospun PVA/Fe2O3/MoSB nanocomposite (0.005g), 0.6mmol t-BuOOH (57muL) was added under solvent free conditions and the reaction mixture was stirred at 80C for 6h.

The chemical industry reduces the impact on the environment during synthesis 1777-82-8, I believe this compound will play a more active role in future production and life.

Reference:
Article; Noghi, Sedighe Abbaspour; Naeimi, Atena; Hamidian, Hooshang; Polymer; vol. 149; (2018); p. 229 – 237;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 558-42-9, 1-Chloro-2-methyl-2-propanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 558-42-9, blongs to alcohols-buliding-blocks compound. 558-42-9

EXAMPLE 121 4-[2-tert-Butyl-1-(tetrahydropyran-4-ylmethyl)-1H-imidazol-4-yl]-N-(2-hydroxy-2-methylpropyl)-N-methylthiophene-2-carboxamide (Compound 121) Step 1; 1-Chloro-2-methyl-2-propanol (103 muL, 1.00 mmol) was dissolved in a 40percent methylamine methanol solution (0.5 mL), and the mixture was stirred at 100¡ãC for 15 minutes at 100 W in a microwave-assisted chemical synthesis instrument (CEM Discover). After the mixture was left to cool to room temperature, the solvent was evaporated under reduced pressure. Then, acetonitrile (3 mL) was added to the residue, and the precipitated solid was removed by filtration. After an aqueous sodium hydrogen carbonate solution (10 drops) was added to the filtrate, the solvent was evaporated under reduced pressure to give a roughly purified product of 2-methyl-1-(methylamino)propan-2-ol. The roughly purified product was used in the subsequent step as such without purification.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,558-42-9, its application will become more common.

Reference:
Patent; Kyowa Hakko Kirin Co., Ltd.; EP2090570; (2009); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The common heterocyclic compound, 2050-25-1, name is 2-(2-(Benzyloxy)ethoxy)ethanol, molecular formula is C11H16O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route. 2050-25-1

Step 1. 2-(2-(2-(Benzyloxy)ethoxy)ethoxy)acetonitrile. To a stirring solution of diethylene glycol benzyl ether (1.0 g, 5.1 mmol) in THF (10 mL) at 0 C, was added in small portions NaH (408 mg, 10.2 mmol), then the reaction mixture was warmed to rt and stirred for 30 mins. The reaction mixture was cooled to 0 C, and bromoacetonitrile (0.39 mL, 5.6 mmol) was added dropwise and stirred for 3h. The reaction was quenched with saturated ammonium chloride, and extracted with EtOAc (3 x 50 mL). The combined organic phase was washed with brine, dried over magnesium sulfate, filtered and concentrated. The crude residue was further purified by silica gel chromatography using 25% acetone/hexanes eluent to afford 2-(2-(2-(benzyloxy)ethoxy)ethoxy)acetonitrile as a colorless oil (437 mg, 37%): XH NMR (500MHz, CDC13) delta ppm 7.35 (d, J= 4.9 Hz, 4H), 7.27 – 7.32 (m, 1H), 4.57 (s, 2H), 4.33 (s, 2H), 3.76 – 3.80 (m, 2H), 3.67 – 3.74 (m, 4H), 3.62 – 3.66 (m, 2H).

The synthetic route of 2050-25-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; NORTHEASTERN UNIVERSITY; MALAMAS, Michael; MAKRIYANNIS, Alexandros; SUBRAMANIAN, Kumara Vadivel; WHITTEN, Kyle M.; ZVONOK, Nikolai M.; WEST, Jay Matthew; MCCORMACK, Michael; PAVLOPOULOS, Spiro; WO2015/179190; (2015); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

440-60-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.440-60-8, name is (Perfluorophenyl)methanol, molecular formula is C7H3F5O, molecular weight is 198.09, as common compound, the synthetic route is as follows.

General procedure: Liquid-phaseoxidation of 1-phenylethanol was performed in glass flaskequipped with a magnetic stirrer, reflux condenser, andthermometer. In a typical experiment, a mixture of the1-phenylethanol (2mmol), toluene (10 mL), and the catalyst(0.3 g) was transferred in a glass three-necked roundbottomedflask (100 mL); the resulting mixture was thenheated to desired temperature with vigorous stirring. Theoxidation experiment was started by bubbling oxygen gas ata flow rate of 20 mL/min into the reaction mixture. After thereaction, the solid catalyst was filtered off by centrifugationand the liquid productswere analyzed by gas chromatographyto determine the conversion of the alcohol and productselectivity by GC, 7890A,Agilent Technologies Inc., equippedwith a flame ionization detector (FID) and a 19019S-001 HPPONAcolumn.

Statistics shows that 440-60-8 is playing an increasingly important role. we look forward to future research findings about (Perfluorophenyl)methanol.

Reference:
Article; Assal, Mohamed E.; Kuniyil, Mufsir; Shaik, Mohammed Rafi; Khan, Mujeeb; Al-Warthan, Abdulrahman; Siddiqui, Mohammed Rafiq H.; Adil, Syed Farooq; Journal of Chemistry; vol. 2017; (2017);,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

3973-18-0 ,Some common heterocyclic compound, 3973-18-0, molecular formula is C5H8O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

In 175 mL of dichloromethane, 1,2-bis(diphenylphosphino)ethane (1.73 g, 4.40 mmol), cobalt bromide (0.865 g, 4.00 mmol), and zinc iodide (4.2 g, 13.15 mmol) were dissolved, followed by stirring at 30 C. for 30 minutes. Then, 2-(propynyloxy)ethanol (8.94 g, 91.0 mmol) and butadiene (20% by weight toluene solution) (36.8 ml, 136.5 mmol) were added thereto, and then Bu4NBH4 (1.1 g, 4.3 mmol) was added. After stirring at 45 C. for 1 hour, the solvent was evaporated under reduced pressure, and the obtained residue was purified by silica gel column chromatography (hexane/ethyl acetate=5/1). Thus, 11.7 g of the title compound, an alcohol, was obtained as a colorless oily substance. Yield: 85.0%. [0149] 1H NMR (CDCl3, 300 MHz): delta 5.80-5.60 (m, 3H), 3.92 (s, 1H), 3.72 (t, 2H), 3.48 (t, 2H), 2.75-2.60 (m, 4H), 2.22 (brs, 1H)

According to the analysis of related databases, 3973-18-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; TAKASAGO INTERNATIONAL CORPORATION; Touge, Taichiro; Hakamata, Tomohiko; Nara, Hideki; US2014/39220; (2014); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

2807-30-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2807-30-9, name is 2-Propoxyethanol. This compound has unique chemical properties. The synthetic route is as follows.

Compound 170: 2-((S)-1-[1,4]Dioxan-2-ylmethoxy)-9-(2-propoxy-ethoxy)-6,7-dihydro-pyrimido[6,1-a]isoquinolin-4-one Intermediate 6 (0.15 g, 0.45 mmol, 1 eq.), 2-Propoxy-ethanol (63 muL, 0.55 mmol, 1.2 eq.) and PPh3 (144 mg, 0.55 mmol, 1.2 eq.) were suspended in 1,4-dioxane (5 mL) and the mixture was degassed with N2. DIAD (0.108 mL, 0.55 mmol, 1.2 eq.) was added and the reaction was stirred at RT overnight. 0.5 eq. of DIAD and PPh3 were added, and the reaction mixture was stirred at room temperature for an extra 2 h. Reaction mixture was diluted with brine, extracted with EtOAc, dried over MgSO4 and concentrated. Crude product was purified on silicagel column to give compound 170.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 2807-30-9, 2-Propoxyethanol.

Reference:
Patent; GALAPAGOS NV; LABEGUERE, Frederic Gilbert; NEWSOME, Gregory John Robert; ALVEY, Luke Jonathan; SANIERE, Laurent Raymond Maurice; FLETCHER, Stephen Robert; US2013/165437; (2013); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

627-18-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 627-18-9, name is 3-Bromopropan-1-ol, molecular formula is C3H7BrO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Synthesis of Compound (1b):At less than 0 C,Dihydroartemisinin (840 mg, 3.0 mmol) and 3-bromo-1-propanol (0.42 mL, 4.6 mmol)Dissolved in CH2Cl2 (20 mL), BF3¡¤Et2O (0.63 mL, 5.0 mmol) was added dropwise.After the dropwise addition, stirring was continued for 5 min at the same temperature, and then transferred to an ice water bath.Stirring was continued for about 50 minutes. After the reaction is over,Wash with saturated NaHCO3 solution, water and saturated brine.The organic layer was collected and dried over anhydrous sodium sulfate.Concentrate to a pale yellow oily crude product.The crude product was chromatographed on silica gel (ethyl acetate: petroleum ether = 3:97)A colorless solid (471 mg, 39%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 627-18-9, 3-Bromopropan-1-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Guangzhou University Of Traditional Chinese Medicine (Guangzhou Traditional Chinese Medicine Institute); He Xixin; Pi Rongbiao; Li Mingtao; Zhong Xiaolin; Luo Huijuan; Wang Jiamin; (12 pag.)CN108586480; (2018); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

558-42-9, Adding a certain compound to certain chemical reactions, such as: 558-42-9, 1-Chloro-2-methyl-2-propanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 558-42-9, blongs to alcohols-buliding-blocks compound.

To a stirred solution of 177 (3.4 g, 12.0 mmol) in dry DMF (20 mL), Cs2CO3 (7.7 g, 24.0 mmol) and l-chloro-2-methylpropan-2-ol 179 (1.6 g, 14.0 mmol) were added and heated at 90¡ãC for 16 h. The progress of the reaction was monitored by TLC. After completion of the reaction, the reaction mixture was quenched with water and extracted with EtOAc. The combined organic layer were washed with brine, dried over anhydrous Na2S04 and concentrated under reduced pressure to afford 180. Yield: 1.7 g, 40percent. 1H NMR (400 MHz, DMSO-d6) delta 1.06 – 1.11 (m, 4H), 1.21 (s, 6H), 2.13 – 2.22 (m, 2H), 2.55 – 2.60 (m, 1H), 3.01 (1920) – 3.07 (m, 1H), 3.76 (s, 2H), 4.84 – 4.94 (m, 2H), 5.00 – 5.19 (m, 1H), 5.53-5.60 (m, 1H), 6.91 (1921) – 6.98 (m, 1H), 7.10 – 7.18 (m, 1H), 7.24 – 7.31 (m, 1H), 8.26 (s, 1H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,558-42-9, its application will become more common.

Reference:
Patent; CV6 THERAPEUTICS (NI) LIMITED; SPYVEE, Mark; (500 pag.)WO2018/98206; (2018); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 597-31-9, 3-Hydroxy-2,2-dimethylpropanal, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 597-31-9, blongs to alcohols-buliding-blocks compound. 597-31-9

COMPARATIVE EXAMPLE 4 A suspension of 50 parts of PE in a mixture of 180 parts of water and 18 parts of xylene was heated to 60C, to which 124 parts of the crude HPA obtained in Reference Example 1 and 9 parts of a 50 wt % sulfuric acid were simultaneously added over 2 h. After stirring for 12 h while keeping the temperature at 60C, the mixture was neutralized with a 48 wt % sodium hydroxide aqueous solution. The resultant slurry mixture was filtered under reduced pressure and the separated solid was washed with water and dried, to obtain 99.5 parts of SPG. The yield was 89 mol%, the purity was 98% by weight, and the particle size after exposed to ultrasonic wave was 9 um. During the solid-liquid separation by filtration through a glass filter under reduced pressure, the crack of cake occurred. However, the filtration, washing with water and drying were made as in Example 1 to obtain SPG crystals. The liquid content of SPG cake immediately after the filtration was 60% by weight.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,597-31-9, its application will become more common.

Reference:
Patent; MITSUBISHI GAS CHEMICAL COMPANY, INC.; EP1598357; (2005); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 932-01-4, name is 4,4-Dimethylcyclohexanol. This compound has unique chemical properties. The synthetic route is as follows. 932-01-4

To a mixture of 4,4-Dimethylcyclohexanol (63.2 mg, 0.000493 mol), (R)-4-(6- hydroxynaphthalen-2-yl)-4-methyl-oxazolidin-2-one (100 mg, 0.0004 mol), 5 triphenylphosphine (129 mg, 0.000493 mol), and tetrahydrofuran (4 mL, 0.05 mol), diisopropyl azodicarboxylate (0.0971 mL, 0.000493 mol ) was added dropwise and was stirred at room temperature overnight. The mixture was diluted with EA and washed with 5% citric acid and brine then dried with magnesium sulfate and concentrated. The crude was taken up into DCM and subjected to ISCO combiflash purification with EtOAc/hexane (0- I0 70) to give product.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 932-01-4, 4,4-Dimethylcyclohexanol.

Reference:
Patent; BIOGEN IDEC MA INC.; GUCKIAN, Kevin, M.; CALDWELL, Richard, D.; KUMARAVEL, Gnanasambandam; LEE, Wen-cherng; LIN, Edward, Yin-shiang; LIU, Xiaogao; MA, Bin; SCOTT, Daniel, M.; SHI, Zhan; ZHENG, Guo, Zhu; TAVERAS, Arthur, G.; THOMAS, Jermaine; WO2010/51030; (2010); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts