Tag: M.W=100-200

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 39590-81-3, name is 1,1-Bis(Hydroxymethyl)cyclopropane. This compound has unique chemical properties. The synthetic route is as follows. 39590-81-3

A. Iodination of Diol 6 to Prepare 7a [0228] Triphenylphospine (257.2 g) and imidazole (66.7 g) were charged to a reactor. DCM (490 mL) was charged, agitation was initiated and the solution was cooled to 0 C. Iodine (249.2 g) was added as a solid portion-wise over 1 h while maintaining the internal temperature below 10 C. Upon completion of the addition, a solution of 6 (50 g) in DCM (113 mL) was slowly charged to the reactor over 0.5 h while maintaining the internal temperature below 10 C. After stirring for 2.5 h, an aqueous solution of NaCl (25 g) in water (225 mL) was charged to the reactor. Following phase separation, the bottom organic layer was diluted with n-heptane (550 mL). The organic phase was washed with an aqueous solution of sodium sulfite (21 g) in water (190 mL). Following layer separation, the organic phase was concentrated to 600 mL via vacuum distillation. Additional n-heptane (550 mL) was charged, and the mixture was again concentrated to 600 mL via vacuum distillation. The resulting slurry was filtered over a silica gel plug (85 g) that had been slurry packed with n-heptane. The silica gel plug was rinsed with additional n-heptane (1 L), and the filtrate was then concentrated via vacuum distillation to provide the desired product 7a as a colorless liquid (114 g, 70%). 1H NMR (400 MHz, CDCl3) delta 3.33 (s, 2H), 0.95 (s, 2H). 13C NMR (75 MHz, CDCl3): 19.1, 22.7, 26.0.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 39590-81-3, 1,1-Bis(Hydroxymethyl)cyclopropane.

Reference:
Patent; Scott, Robert William; Wang, Fang; Shi, Bing; Mogalian, Erik; US2013/324496; (2013); A1;,
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404-91-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 404-91-1, name is 2-(3-Fluoro-4-methoxyphenyl)ethanol. This compound has unique chemical properties. The synthetic route is as follows.

A mixture of resin bound triphenyl phosphine (polystyrene 2% cross linking, loading = 3 mmol/g, 3 g, 9 mmol) and imidazole (0.48 g, 7.1 mmol) in DCM (30 ml.) cooled on an ice bath was drop wise added Br2 (1.13 g, 7.1 mmol), whereupon a solution of 4-(2-hydroxy- ethyl)-2-fluoro-1-methoxy-benzene (1.0g, 5.88 mmol) in DCM (5 ml.) was added. The cooling bath was removed and the reaction mixture was stirred for 16 hs before the resin was filtered off. The resin was washed with DCM and the filtrate was concentrated in vacuo. The residue was purified using column chromatography (SiO2, heptane-EtAOc 95:5) to give 0.82 g of 4- (2-bromo-ethyl)-2-fluoro-1-methoxy-benzene

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 404-91-1, 2-(3-Fluoro-4-methoxyphenyl)ethanol.

Reference:
Patent; NOVO NORDISK A/S; WO2008/84044; (2008); A1;,
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617-94-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 617-94-7, name is 2-Phenyl-2-propanol. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: Bi(OTf)3 (1.0 mol%) was added to a solution of the appropriate secbenzylalcohol (1.0 equiv) and TMSN3 (1.2 equiv) in CH2Cl2 (4.0mL/mmol) at r.t. When the reaction was complete (TLC), the solventwas removed and the crude material was purified by column chromatography.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 617-94-7, 2-Phenyl-2-propanol.

Reference:
Article; Tummatorn, Jumreang; Thongsornkleeb, Charnsak; Ruchirawat, Somsak; Thongaram, Phanida; Kaewmee, Benyapa; Synthesis; vol. 46; 11; (2015);,
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3360-41-6, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 3360-41-6, name is 4-Phenylbutan-1-ol. This compound has unique chemical properties. The synthetic route is as follows.

Triphenylphosphine (2.72 g, 10.4 mmol) was added to the 4-phenyl-1-butanol (1.2 g, 8.0 mmol) in CCl4 (10 mL) at room temperature under atmosphere of argon, and the mixture was refluxed for 1 h. The reaction quenched with water and extracted with hexane. The extracts were washed with brine, dried over MgSO4, and concentrated under reduced pressure. The residue was purified by column chromatography with hexane/AcOEt (100:1) to give (4-chlorobutyl)benzene (5d) as a colorless oil in 85% yield. The analytical data were identical with those of a literature compound.10 IR (neat): nu = 2940 (CH2), 699 (Alkyl-Cl); 1H NMR (500 MHz, CDCl3): delta = 1.72-1.86 (4H, m), 2.64 (2H, t, J = 7.2 Hz), 3.54 (2H, t, J = 6.3 Hz), 7.15-7.21 (3H, m), 7.25-7.31 (2H, m); 13C NMR (125 MHz, CDCl3): delta = 28.5, 32.1, 35.1, 44.9, 125.9, 128.4, 141.8; MS (EI) m/z 168 ([M]+).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 3360-41-6, 4-Phenylbutan-1-ol.

Reference:
Article; Hatae, Noriyuki; Kujime, Eiko; Yano, Keigo; Kizuka, Mami; Ashida, Rina; Choshi, Tominari; Nishiyama, Takashi; Okada, Chiaki; Iwamura, Tatsunori; Yoshimura, Teruki; Heterocycles; vol. 97; 1; (2018); p. 560 – 568;,
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111-90-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 111-90-0, name is Diethylene Glycol Monoethyl Ether. This compound has unique chemical properties. The synthetic route is as follows.

The 4,7-dichloroquinazoline used as a starting material was obtained as follows:- A mixture of 4-chloroanthranilic acid (17.2 g) and formamide (10 ml) was stirred and heated to 130C for 45 minutes and to 175C for 75 minutes. The mixture was allowed to cool to approximately 100C and 2-(2-ethoxyethoxy)ethanol (50 ml) was added. The solution so formed was poured into a mixture (250 ml) of ice and water. The precipitate was isolated, washed with water and dried. There was thus obtained 7-chloroquinazolin-4-one (15.3 g, 85%).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 111-90-0, Diethylene Glycol Monoethyl Ether.

Reference:
Patent; ZENECA LIMITED; EP520722; (1992); A1;,
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Adding a certain compound to certain chemical reactions, such as: 6338-55-2, 2-(2-(2-Aminoethoxy)ethoxy)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 6338-55-2, blongs to alcohols-buliding-blocks compound. 6338-55-2

To a 250-mL round-bottom flask was added 2-[2-(2- aminoethoxy )ethoxy ] ethan- 1 -ol (5.3 g, 35.53 mmol, 2 equiv), CH2CI2 (50 mL), triemylamine (5.37 g, 53.07 mmol, 3 equiv), and INT-L3 (R1 = H, 5 g, 17.7 mmol, 1 equiv). The resulting solution was stirred overnight. The reaction was then quenched by the addition of 50 mL of water and extracted with 3 x 50 mL of ethyl acetate. The organic layers were combined, dried over anhydrous sodium sulfate, filtered, and concentrated under vacuum The residue was applied onto a silica gel column with CftCh/methanol (0-55%) providing 6.4 g (92%) of 2-[2-(2-[[4-(benzyloxy)benzene]sulfonamido]ethoxy)emoxy]ethan-l-ol (I T-T1) as a white solid.

With the rapid development of chemical substances, we look forward to future research findings about 6338-55-2.

Reference:
Patent; ARDELYX, INC.; DRAGOLI, Dean; DOTSENKO, Irina; LEWIS, Jason; (439 pag.)WO2018/129552; (2018); A1;,
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6338-55-2, Adding a certain compound to certain chemical reactions, such as: 6338-55-2, 2-(2-(2-Aminoethoxy)ethoxy)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 6338-55-2, blongs to alcohols-buliding-blocks compound.

2-(2-(2-aminoethoxy)ethoxy)ethanol (0.6 g, 4.062 mmol) was dissolved in acetonitrile (25 ml). The solution was cooled to 0C and Et3N (1.13 ml, 8.12 mmol, 2 eq.) was added followed by Boc2O (0.268 g, 1.23 mmol). The reaction was followed by TLC and stirred overnight at room temperature. Water (15 ml) was added and the solution was extracted with EtOAc (3×30 ml), brine was used to help separating the two layers (5 ml) and also (30 ml) for washing. The combined organic layers were dried over Na2SO4, filtered and concentrated under reduced pressure. The crude product was purified by flash chromatography on silica gel (CH2Cl2/MeOH, 96:4) to give the title compound as a yellow oil (0.670 g, 66 % yield)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,6338-55-2, its application will become more common.

Reference:
Article; Simonin, Jonathan; Vernekar, Sanjeev Kumar V.; Thompson, Andrew J.; Hothersall, J. Daniel; Connolly, Christopher N.; Lummis, Sarah C.R.; Lochner, Martin; Bioorganic and Medicinal Chemistry Letters; vol. 22; 2; (2012); p. 1151 – 1155;,
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108-82-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 108-82-7, name is 2,6-Dimethylheptan-4-ol. This compound has unique chemical properties. The synthetic route is as follows.

A solution of Intermediate 16 (13-oxo-pentacosane-l,25-dioic acid) (1.01 g), 4-dimethylaminopyridine (0.86 g), N-(3-dimethylaminopropyl)-N-ethylcarbodiimide hydrochloride (0.95 g) and 2,6- dimethylheptan-4-ol (1.92 g) in dichloromethane (20 mL) was stirred at room temperature overnight. The solution was washed with diluted hydrochloric acid, dried over anhydrous magnesium sulfate, filtered and the solvent removed. The residue was passed down a silica gel (20 g) column using dichloromethane as the eluent, yielding 0.40 g of product.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 108-82-7, 2,6-Dimethylheptan-4-ol.

Reference:
Patent; ALNYLAM PHARMACEUTICALS, INC.; ANSELL, Steven, Michial; DU, Xinyao; WO2013/86322; (2013); A1;,
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623-50-7, Adding a certain compound to certain chemical reactions, such as: 623-50-7, Ethyl 2-hydroxyacetate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 623-50-7, blongs to alcohols-buliding-blocks compound.

Step 1-Synthesis of ethyl 4-oxotetrahydrofuran-3-carboxylate (ge). NaH (60%, 4.6 g, 116 mmol) was suspended in ether (200 mL) and cooled in ice-bath. To this suspension was added ethyl glycolate (10 mL, 100 mmol) dropwise under N2. The resulting white slurry was stirred at rt for 45 min. Ether was removed in vacuo to give white solid. It was suspended in DMSO (130 mL), cooled in ice-bath, and ethyl arcylate (13.7 mL, 127 mmol) was added dropwise. The resulting yellow mixture was stirred at rt overnight. The reaction solution was poured into 10% aq. HCl (500 mL) slowly. It was extracted with ether (3¡Á). The combined ether extract was washed with brine, dried over MgSO4, filtered, concentrated in vacuo to give 14 g (80%) of (ge) as clear yellow liquid. It was carried on without further purification.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,623-50-7, its application will become more common.

Reference:
Patent; Genentech, Inc.; US2010/331305; (2010); A1;,
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100-37-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 100-37-8, name is 2-(Diethylamino)ethanol, molecular formula is C6H15NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: Under air atmosphere, a reaction tube was charged with disulfide (0.2 mmol), Tertiary amine (0.4 mmol), I2 (0.4 mmol) Na2CO3 (0.4 mmol) and DMSO (2 mL). The vessel was sealed and heated at 100 C (oil bath temperature) for 24 h and then cooled to room temperature. The reaction mixture was washed with saturated Na2S2O3(2 x 15 mL) and then brine (1 x 15 mL). After the aqueous layer was extracted with ethyl acetate, the combined organic layers were dried over anhydrous Na2SO4 and evaporated under vacuum. The residue was purified by flash column chromatography (hexane/ethyl acetate) to afford the desired products.

The chemical industry reduces the impact on the environment during synthesis 100-37-8, I believe this compound will play a more active role in future production and life.

Reference:
Letter; Gao, Xu-Hong; Xu, Wei; Zhang, Xing-Guo; Deng, Chen-Liang; Synlett; vol. 28; 7; (2017); p. 841 – 846;,
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