Tag: M.W=100-200

Application of 770-71-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.770-71-8, name is Adamantan-1-ylmethanol, molecular formula is C11H18O, molecular weight is 166.26, as common compound, the synthetic route is as follows.

General procedure: To the solution of starting alcohol 2 (6 mmol) in dichloromethane(8 mL) was added Et3N (0.84 mL, 606 mg, 6 mmol) inatmosphere of Ar. The mixture was cooled to 0 to 5 C and theacryloyl chloride (0.49 mL, 543 mg, 6 mmol) in dichloromethane(2 mL) was added dropwise. The resulting mixture was stirred atthis temperature for 3 h and then at room temperature for 24 h.The reaction mixture was poured into water (15 mL) and extractedwith dichloromethane (4 20 mL). The combined organic layer waswashed with brine solution (3 20 mL) and was dried over anhydrousMg2SO4. The solvent was evaporated in vacuo; the residuewas purified by preparative column chromatography on silica gel.

Statistics shows that 770-71-8 is playing an increasingly important role. we look forward to future research findings about Adamantan-1-ylmethanol.

Reference:
Article; Averina, Elena B.; Vasilenko, Dmitry A.; Gracheva, Yulia A.; Grishin, Yuri K.; Radchenko, Eugene V.; Burmistrov, Vladimir V.; Butov, Gennady M.; Neganova, Margarita E.; Serkova, Tatyana P.; Redkozubova, Olga M.; Shevtsova, Elena F.; Milaeva, Elena R.; Kuznetsova, Tamara S.; Zefirov, Nikolay S.; Bioorganic and Medicinal Chemistry; vol. 24; 4; (2016); p. 712 – 720;,
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Synthetic Route of 702-98-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 702-98-7, name is 2-Methyladamantan-2-ol. This compound has unique chemical properties. The synthetic route is as follows.

b. Synthesis of 2-methyl-2-adamantyl acrylate 2-methyl-2-adamantanol (33 g, 0.2 mol) and triethylamine (0.22 mol) were dissolved in 300 ml of THF and then acryloyl chloride (19 g, 0.21 mol) was added slowly thereto using a dropping funnel. Then, the reaction was stirred at room temperature for about 12 hours. After completion of the reaction, excess THF was removed using a rotary evaporator and then the resultant product was poured into water. Then, the resultant product was neutralized with dilute sulfuric acid and extracted using diethyl ether and was then dried over magnesium sulfate. The diethyl ether removed crude product was vacuum-distilled to yield the desired product (yield: 80%). 1H-NMR (CDCl3; ppm): 6.3 (doublet), 6.1 (1H, dd), 5.7 (1H, d), 2.3 (2H, s), 1.5-2.1 (m) FT-IR (NaCl; cm-1): 2911, 2861, 1718, 1635, 1618, 1401, 1201

According to the analysis of related databases, 702-98-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Chem Search Corp.; US6222061; (2001); B1;,
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6240-11-5, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 6240-11-5 as follows.

In a 1 L round bottom flask equipped with a reflux condenser, 126.20 g (0.70 mol) of 2- (1-adamantyl) ethanol was added while 164 g of concentrated sulfuric acid and 200 g (48% aqueous solution) of hydrobromic acid were cooled in an ice bath, . The mixture was refluxed for 6 hours, cooled to room temperature and then added to 400 g of ice. The aqueous phase was extracted with 400 ml of pentane. The organic phase was washed with 2 M NaOH solution and water, dried over magnesium sulfate and the solvent was removed in vacuo. The product was distilled in vacuo to give 153.2 g (90%) of (1- (2-bromo-ethyl) -adamantane as a colorless oil.

The chemical industry reduces the impact on the environment during synthesis 6240-11-5, I believe this compound will play a more active role in future production and life.

Reference:
Patent; LUMMUS NOVOLEN TECHNOLOGY GMBH; (91 pag.)JP6196581; (2017); B2;,
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440-60-8, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 440-60-8, name is (Perfluorophenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows.

(a) Pentafluorobenzyl Fluoride A mixture of pentafluorobenzyl alcohol (3.0 g) and dry methylene dichloride (50 ml) was cooled to a temperature of 0 C. in an ice-bath and 2-chloro-1-diethylamino-1,1,2-trifluoroethane (4.3 g) was slowly added to the cooled, stirred mixture over a period of ten minutes. After standing for a period of 18 hr. at 0 C. the reaction mixture was poured into ice and the organic layer was separated and washed with IM aqueous sodium carbonate solution. The organic layer was dried over anhydrous sodium sulfate, the solvent was removed by distillation and the product was distilled under reduced pressure to give pentafluorobenzyl fluoride, b.p. 51 C. at 30 mm Hg.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 440-60-8, (Perfluorophenyl)methanol.

Reference:
Patent; ICI Australia Limited; US4283414; (1981); A;,
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445-26-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 445-26-1, name is 1-(2-Fluorophenyl)ethanol, the common compound, a new synthetic route is introduced below.

Intermediate 1-17-1 Preparation of 1 -(1 -bromoethyl)-2-fluorobenzene 500 mg 1 -(2-Fluorophenyl)ethanol (3.6 mmol, 1 .0 eq.) was dissolved in 1 .6 mL hydrobromicacid (33% solution in acetic acid, 9.8 mmol, 2.8 eq.) and stirred at room temperature over night. The reaction mixture was poured into diethylether and stirred for 5 min. The solution was added portionwise into 30 mL of saturated sodium hydrogen carbonate solution and stirred for 15 min. The layers were separated and the aqueous layer was extracted with diethylether twice. The collected organic layers were rinsed with brine, dried over a silicon filter and concentrated in vacuo. The crude product was used without further purification: 554 mg, 2.73 mmol, 77%. 1 H NMR (300 MHz, DMSO-d6) delta [ppm] = 1 .98 (d, 3H), 5.57 (q, 1 H), 7.13 – 7.24 (m, 2H), 7.31 – 7.41 (m, 1 H), 7.56 – 7.65 (m, 1 H).

Statistics shows that 445-26-1 is playing an increasingly important role. we look forward to future research findings about 1-(2-Fluorophenyl)ethanol.

Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; HITCHCOCK, Marion; MENGEL, Anne; MUeLLER, Thomas; BAeRFACKER, Lars; CLEVE, Arwed; BRIEM, Hans; SIEMEISTER, Gerhard; BONE, Wilhelm; FERNANDEZ-MONTALVAN, Amaury, Ernesto; SCHROeDER, Jens; MOeNNING, Ursula; HOLTON, Simon; PREUSSE, Cornelia; (165 pag.)WO2017/157991; (2017); A1;,
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7287-81-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 7287-81-2, name is 1-(m-Tolyl)ethanol, molecular formula is C9H12O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Example 37. Synthesis of (¡À)(1 hromoethyfl-3-methylbenzene,Phosphorus tribromide (4.28 g, 15.9 mmoi) was added drop-wise to a stirred neat solution of 1- (m-toiyi)ethanoi (0.9 g, 6.6 mmoi) at 0C. After being stirred to room temperature over 12 h, the reaction was carefully? quenched with sat?d saturated aqueous NaHCO3 solution an( the mixture was extracted with EtOAc, The organic extract was washed with water, dried with MgSO, and cone, in vacuo to afford the title compound (i.2 g. 91%) as a colorless oil, that was used directly in the next step without tiirther purification. LCMS 200 (M + Kj.

The chemical industry reduces the impact on the environment during synthesis 7287-81-2, I believe this compound will play a more active role in future production and life.

Reference:
Patent; CONSTELLATION PHARMACEUTICALS; ALBRECHT, Brian, K.; AUDIA, James, Edmund; COOK, Andrew, S.; DAKIN, Les, A.; DUPLESSIS, Martin; GEHLING, Victor, S.; HARMANGE, Jean-Christophe; NAVESCHUK, Christopher, G.; VASWANI, Rishi, G.; WO2013/120104; (2013); A2;,
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37585-16-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 37585-16-3, name is (2-Amino-4-chlorophenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: To an oven-dried 15 mL sealed tube were added 2-aminophenylmethanol 1 (0.425 mmol), benzonitrile 2(0.25 mmol), Ru cat. b (1.94 mg, 1 mol%), and KOtBu (14.02 mg, 0.5equiv) intamyl alcohol (1 mL) under an air atmosphere. The sealedtube was capped and heated at 130C for 2 h. The reaction mixturewas cooled down to room temperature and directly concentratedunder vacuum. The crude mixture was puried by preparative thin-layer-chromatography (petroleum ether/ethyl acetate 20/1) togive the desired product 3 or 4.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 37585-16-3, (2-Amino-4-chlorophenyl)methanol.

Reference:
Article; Wan, Xiao-Min; Liu, Zi-Lin; Liu, Wan-Qing; Cao, Xiao-Niu; Zhu, Xinju; Zhao, Xue-Mei; Song, Bing; Hao, Xin-Qi; Liu, Guoji; Tetrahedron; vol. 75; 18; (2019); p. 2697 – 2705;,
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623-50-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 623-50-7, name is Ethyl 2-hydroxyacetate, molecular formula is C4H8O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

ethyl glycolate (10g, 96.1mmol) and a imidazole (13g, 0.19mol) was dissolved in dichloromethane (100 mL)placed in three round bottom flask, was added at 0C tert-butyldimethylsilyl chloride (15.8g, 0.1mol), the mixture was stirred for 8hours at room temperature, washed with water (100mL * 3), dried over sodium sulfate and concentrated to give the titlecompound as a yellow oil (18g, 85.8%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 623-50-7, Ethyl 2-hydroxyacetate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; MEDSHINEDISCOVERY INC.; CHENXIN PHARMACEUTICAL LTD; Zheng, Huiping; Wu, Chengde; Yu, Tao; Huang, Lei; Hao, Dongling; Gao, Bo; Sun, Jikui; Shi, Nengyang; Chen, Shuhui; (151 pag.)TW2016/2107; (2016); A;,
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Adding a certain compound to certain chemical reactions, such as: 100-37-8, 2-(Diethylamino)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 100-37-8, blongs to alcohols-buliding-blocks compound. 100-37-8

0 C, under Ar protection,To NaH (60%, 1.1g, 27.01mmol, 2.5eq)Compound 2 (1.52 g, 12.97 mmol, 1.2 eq) was added dropwise to a solution of THF (15 mL)Of THF (5 mL).Stir at 0 C for 15 min.Compound 1 (2.0 g, 10.80 mmol, 1.0 eq) was added.Stir overnight at room temperature. The reaction was quenched with saturated NH4Cl.The reaction solution was concentrated under reduced pressure, diluted with water (40 mL), washed with PE: EtOAc = 10: 1 (40 mL), and adjusted to pH = 4 with 5M aq.Filtration gave compound 3 (3.0 g, 82%) as a white solid.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,100-37-8, its application will become more common.

Reference:
Patent; Longtaishen Pharmaceutical (Nanjing) Co., Ltd.; Yang Lei; (55 pag.)CN110698460; (2020); A;,
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111-90-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 111-90-0, name is Diethylene Glycol Monoethyl Ether. This compound has unique chemical properties. The synthetic route is as follows.

EXAMPLE 10 43 g (0.32 mole) of diethylene glycol monoethyl ether was added dropwise to a mixture consisting of 6 g (0.16 mole) of sodium borohydride, 25 ml of xylene and 10 g (0.097 mole) of benznitrile at 110 C. over two hours while agitating the mixture. Subsequently, the mixture was agitated at the same temperature for 16 hours. After cooling to room temperature, the mixture was neutralized with dilute sulfuric acid. As a result, benzylamine was obtained in 74% yield and the benzynitriles remained unreactive in the proportion of 25%.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 111-90-0, Diethylene Glycol Monoethyl Ether.

Reference:
Patent; Kao Corporation; US5196601; (1993); A;,
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