Tag: M.W=100-200

Electric Literature of 18729-48-1, Adding some certain compound to certain chemical reactions, such as: 18729-48-1, name is 3-Methylcyclopentanol,molecular formula is C6H12O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 18729-48-1.

A solution of 3-methylcyclopentanol (0.3g, 3.0mmol), triethylamine (2eq) and methanesulfonyl chloride (1.5eq) in dichloromethane (lOmL) was stirred at rt for 18h. The resultant mixture was then diluted with dichloromethane and washed with H20 and then brine. The organic phase was collected, dried (MgS04) and concentrated in vacuo to give 3- methylcyclopentyl methanesulfonate

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 18729-48-1, 3-Methylcyclopentanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; CELLZOME LIMITED; HARRISON, Richard, John; OXENFORD, Sally; HOBSON, Andrew; RAMSDEN, Nigel; MILLER, Warren; WO2011/134831; (2011); A1;,
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Reference of 2050-25-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2050-25-1, name is 2-(2-(Benzyloxy)ethoxy)ethanol, molecular formula is C11H16O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: Methanesulfonyl chloride (1.5 equiv.) was added drop-wise to astirred solution of alcohol (1 equiv.) and Et3N (1.5 equiv.) in anhydrousDCM (30 mL) at 0 C under nitrogen. The reaction wasallowed to warm to room temperature, and stirred for 2 h. Thereaction mixture was poured into methanol (10 mL), and concentratedin vacuo. The reaction mixture was then diluted with diethylether (20 mL), washed with water (3 20 mL) and brine(3 20 mL). The combined organic extracts were then dried overanhydrous MgSO4, filtered, and concentrated in vacuo. The residuewas dissolved in DMF (25 mL), sodium azide (3 equiv.) was added, and the mixture was stirred at 60 C for 16 h. The reaction mixturewas concentrated in vacuo, and The reaction mixture was thendiluted with diethyl ether (50 mL), washed with water (3 20 mL)and brine (3 30 mL), dried over anhydrous MgSO4, filtered, andconcentrated in vacuo, to give a residue which was purified by flashchromatography.

According to the analysis of related databases, 2050-25-1, the application of this compound in the production field has become more and more popular.

Reference:
Article; Suthagar, Kajitha; Watson, Andrew J.A.; Wilkinson, Brendan L.; Fairbanks, Antony J.; European Journal of Medicinal Chemistry; vol. 102; (2015); p. 153 – 166;,
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Reference of 10029-04-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.10029-04-6, name is Ethyl 2-(hydroxymethyl)acrylate, molecular formula is C6H10O3, molecular weight is 130.14, as common compound, the synthetic route is as follows.

Lithium hydroxide monohydrate (145 mg, 3.46 mmol, 5.0 eq.) was added to a solution of ethyl 2-(hydroxymethyl)acrylate (90 mg, 0.69 mmol, 1.0 eq.) in tetrahydrofuran/methanol/water (3 mL, 1/1/1, v/v/v). The reaction was stirred at room temperature for 14 hours, and concentrated. The residue was dissolved in water (10 mL), adjusted with 2 N HCl to pH=5, and then extracted with ethyl acetate (20 mL*3). The combined organic phases were dried over anhydrous sodium sulfate, and concentrated to give the title compound (70 mg, yield: 100%).

Statistics shows that 10029-04-6 is playing an increasingly important role. we look forward to future research findings about Ethyl 2-(hydroxymethyl)acrylate.

Reference:
Patent; Zhejiang DTRM Biopharma Co. Ltd.; He, Wei; (167 pag.)US2016/200730; (2016); A1;,
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Reference of 7287-81-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 7287-81-2, name is 1-(m-Tolyl)ethanol. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: A mixture of alcohol 1 (0.50 mmol), immobilized lipase (200 mg, 0.5%(w/w) enzyme/Toyonite-200M), and molecular sieves 3A (three pieces) in dry i-Pr2O (5.0mL) in a test tube with a rubber septum was stirred at 30 C for 30 min. The reaction wasstarted by addition of vinyl acetate (93 muL, 1.0 mmol) via a syringe. The progress of thereaction was monitored by TLC. The reaction was stopped by filtration at an appropriateconversion, and the filtrate was concentrated under reduced pressure. Alcohol 1 and ester 2were separated by silica gel column chromatography.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 7287-81-2, 1-(m-Tolyl)ethanol.

Reference:
Article; Ema, Tadashi; Inoue, Hiroki; Chemistry Letters; vol. 44; 10; (2015); p. 1374 – 1376;,
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Adding a certain compound to certain chemical reactions, such as: 671802-00-9, tert-Butyl 3-(2-hydroxyethoxy)propanoate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C9H18O4, blongs to alcohols-buliding-blocks compound. COA of Formula: C9H18O4

To a solution of Compound (g-2) (0.15 g, 0.79 mmol) and triethylamine (0.16 g, 1.6 mmol) in THF (10 mL) was added methanesulfonyl chloride (0.13 g, 1.2 mmol) at 0 C., and then the reaction mixture was stirred at room temperature for 16 hours. The solvent was removed under reduced pressure, and the residue was dissolved in ethyl acetate (30 mL). The solution was washed with saturated aqueous sodium hydrogencarbonate, dried with sodium sulfate, and concentrated in vacuo to give Compound (g-3) (0.21 g, 100% yield). (1089) 1H-NMR (CDCl3, 400 MHz) delta: 3.68-3.64 (m, 4H), 3.03-2.99 (m, 2H), 2.98 (s, 3H), 2.44-2.41 (m, 2H), 1.38 (s, 9H).

The synthetic route of 671802-00-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SUMITOMO DAINIPPON PHARMA CO., LTD.; WATANABE, Hitoshi; ISOBE, Yoshiaki; KIMURA, Hidenori; FUJIWARA, Yuji; US2019/16711; (2019); A1;,
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Related Products of 111-45-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 111-45-5, name is 2-(Allyloxy)ethanol. This compound has unique chemical properties. The synthetic route is as follows.

To a solution of sodium hydroxide (4.6 g, 115 mmol) in water (25 mL) was added a solution of ethyleneglycol monoallyl ether (10.0 g, 98 mmol) in THF (50 mL) at 0 C (ice/water bath). A solution of p-toluene sulfonyl chloride (17.9 g, 93 mmol) in THF (40 mL) was added dropwise to the alkaline solution at 0 oC. After completion of addition, the reaction mixture was stirred for 1 h at room temperature and poured into ice/water. The organic materials were extracted with hexane and hexane layer was washed with brine, dried with MgSO4 , and evaporated to leave a residue which was distilled under vacuum to give 22.4 g of 2-(p-tolylsulfonyloxy)ethyl propenyl ether (1b) as a colorless oil in 93% yield (22.4 g).

According to the analysis of related databases, 111-45-5, the application of this compound in the production field has become more and more popular.

Reference:
Article; Kultyshev, Roman G.; Kawanishi, Yuji; Nishioka, Masateru; Miyazawa, Akira; Synthetic Communications; vol. 44; 4; (2014); p. 556 – 563;,
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Electric Literature of 2612-28-4 ,Some common heterocyclic compound, 2612-28-4, molecular formula is C6H14O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

EXAMPLE B A mixture of 2.3 g of trans-4-(4-cyano-3-fluorophenyl)-cyclohexanecarbaldehyde, 1.2 g of 2-propylpropane-1,3-diol, 0.01 g of p-toluenesulfonic acid and 15 ml of toluene is boiled for 3 hours under a water separator and is cooled. Working up in the customary manner gives 2-[trans-4-(4-cyano-3-fluorophenyl)-cyclohexyl]-5-propyl-1,3-dioxane.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 2612-28-4, 2-Propylpropane-1,3-diol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Merck Patent Gesellschaft Mit Beschrankter Haftung; US4784471; (1988); A;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 33524-31-1, name is (2,5-Dimethoxyphenyl)methanol, the common compound, a new synthetic route is introduced below. Computed Properties of C9H12O3

EXAMPLE 1 Preparation of 2,5-dimethoxybenzyl bromide: 2,5-Dimethoxybenzyl bromide was prepared by a modified method described by A. L. Shulgin and E. M. Gal in J. Chem. Soc. (London), 1316 (1953). A solution of 4.35 ml (46.3 mmol) PBr3 in 60 ml CCl4 was added dropwise over a period of 1 hour while cooling with ice to a solution of 20 ml (138.9 mmol) 2,5-dimethoxybenzyl alcohol in 200 ml dry CCl4 and the resulting mixture stirred for 15 h at 20 C. in the absence of moisture. After decantation of the CCl4 phase and washing of the inorganic phase (phosphorous acid) with CCl4, the combined organic phases were chromatographed on neutral aluminium oxide (Alumina Woelm N-Super I) and concentrated. The crude product was purified by sublimation in a high vacuum (T=80-100 C.; 0.1 mbar); white needles (melting point 74.5 C., as measured with a Perkin Elmer DSC 7) (lit. 75-76 C.). Yield 20.2 g=45% of the theoretical.

The synthetic route of 33524-31-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Bayer Aktiengesellschaft; US4859731; (1989); A;,
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Related Products of 454-91-1, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 454-91-1, name is 1-[3-(Trifluoromethyl)phenyl]ethanol. A new synthetic method of this compound is introduced below.

Example 88 1-[3-(Trifluoromethyl)phenyl]ethyl N-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}carbamate 4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2,3-dimethylaniline (72 mg) was added to toluene/triethylamine = 10/1 (7 ml), and the mixture was heated under reflux to prepare a solution. A solution of triphosgene (110 mg) in methylene chloride was then added to the solution, and the mixture was heated under reflux for 15 min. Subsequently, 3-trifluoromethyl-alpha-methylbenzyl alcohol (70 mg) was added thereto, and the mixture was further stirred with heating under reflux for 2 hr. After the completion of the reaction, the reaction solution was allowed to cool to room temperature before distilled water was added thereto. The mixture was subjected to separatory extraction with chloroform, followed by washing with a 1 N aqueous hydrochloric acid solution and saturated brine. The washed solution was dried over sodium sulfate and was concentrated. The residue waspurified on a column using chloroform/methanol to give the title compound (90 mg, yield 68%). 1H-NMR (CDCl3, 400 MHz): 8.39 – 8.45 (1H, m), 8.13 (1H, s), 7.40 – 7.72 (6H, m), 6.99 (1H, d, J = 9.0 Hz), 6.48 – 6.55 (2H, m), 5.93 (1H, 1, J = 6.6 Hz), 4.15 (3H, s), 4.09 (3H, s), 2.24 (3H, s), 2.07 (3H, s), 1.63 (3H, d, J = 6.6 Hz) Mass spectrometry value (ESI-MS, m/z): 542 (M++1)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,454-91-1, its application will become more common.

Reference:
Patent; KIRIN BEER KABUSHIKI KAISHA; EP1243582; (2002); A1;,
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Electric Literature of 15852-73-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 15852-73-0, name is (3-Bromophenyl)methanol, molecular formula is C7H7BrO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a cold (0 C) solution of 3-bromophenylethanol (39) (50 g, 267 mmol) and imidazole (27 g, 401 mmol) in DMF (500 mL) was added tert-butylchlorodiphenylsilane (83 mL, 320 mmol) and the mixture was warmed up to rt then stirred at rt for 8 h. To the reaction mixture was added saturated aqueous ammonium chloride solution and EtOAc. The organic layer was separated and washed with brine then dried over MgSO4, filtered and evaporated in vacuo. The resulting residue was purified by column chromatography on silica gel (EtOAc-hexane) to give the title compound (40) (117 g, quant.) as a white solid.1H NMR (CDCl3) delta: 1.10 (9H, s), 4.72 (2H, s), 7.16-7.27 (2H, m), 7.35-7.48 (8H, m), 7.66-7.69 (4H, m). MS (FAB) m/z: 425 (M+), calcd for C23H25BrOSi: 425.

According to the analysis of related databases, 15852-73-0, the application of this compound in the production field has become more and more popular.

Reference:
Article; Imamura, Masakazu; Nakanishi, Keita; Suzuki, Takayuki; Ikegai, Kazuhiro; Shiraki, Ryota; Ogiyama, Takashi; Murakami, Takeshi; Kurosaki, Eiji; Noda, Atsushi; Kobayashi, Yoshinori; Yokota, Masayuki; Koide, Tomokazu; Kosakai, Kazuhiro; Ohkura, Yasufumi; Takeuchi, Makoto; Tomiyama, Hiroshi; Ohta, Mitsuaki; Bioorganic and Medicinal Chemistry; vol. 20; 10; (2012); p. 3263 – 3279;,
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