Tag: M.W=100-200

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 81156-68-5, name is 2,4-Dichlorophenethyl alcohol. A new synthetic method of this compound is introduced below., name: 2,4-Dichlorophenethyl alcohol

(i) Toluene-4-sulfonic acid 2-(2,4-dichloro-phenyl)-ethyl ester This compound was prepared using a procedure analogous to that described for the preparation of Example 169 (i), using 2-(2,4-dichloro-phenyl)-ethanol as the starting material. The compound was recrystallized from n-heptane/ethyl acetate. Yield: 7.12 g MS (Cl+): m/e=345, chloro pattern.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 81156-68-5, 2,4-Dichlorophenethyl alcohol.

Reference:
Patent; Nazare, Marc; Essrich, Melanie; Will, David William; Matter, Hans; Ritter, Kurt; Wehner, Volkmar; US2003/199689; (2003); A1;,
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Adding a certain compound to certain chemical reactions, such as: 626-95-9, 1,4-Pentanediol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 626-95-9, blongs to alcohols-buliding-blocks compound. SDS of cas: 626-95-9

General procedure: An aqueous solution containing 1,4-butanediol (0.5 mmol),cyclohexene (5 mmol, 0.506 mL, 10 equiv), KOH (25 mol%,0.007 g, 0.125 mmol), and 1 or 2 (10 mol%, 0.0506 g or 0.051 g,0.05 mmol) was heated to 100 C for 48 h in a sealed vessel. Oncompletion of the reaction, the products were extracted withDCM and injected into gas chromatography. gamma-Butyrolactonewith 73% and 84% yields was observed with the formation ofcyclohexane with 22% and 24% yields.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,626-95-9, 1,4-Pentanediol, and friends who are interested can also refer to it.

Reference:
Article; Bhatia, Anita; Kannan, Muthukumar; Muthaiah, Senthilkumar; Synlett; vol. 30; 6; (2019); p. 721 – 725;,
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Adding a certain compound to certain chemical reactions, such as: 54410-90-1, 4-Pentylcyclohexanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C11H22O, blongs to alcohols-buliding-blocks compound. Computed Properties of C11H22O

Step 2:2L four bottles of the first step to add 200.8g (1179.0mmol, 1.0eq), 800.0 g of dichloroethane, 131.2 g (1279.0 mmol, 1.1 eq) of triethylamine, 14.4 g (117.8 mmol, 0.1 eq) of 4-dimethylaminopyridine,Into the ice machine cooling to -5 ~ 0 stand.A solution of 148.6 g (1297.0 mmol, 1.1 eq) of methanesulfonyl chloride and 200.8 g of dichloroethane was added dropwise over 1.5 h, and the dropping temperature was controlled at -5 to 5 C,Followed by 0 ~ 5 insulation stirring 1.0h.Add water 600g quenching reaction, then stop the cooling, the kettle temperature to room temperature, stirring 0.5h, standing for 0.5h, divided into an oil layer 1268.0g, the water back to the kettle by adding dichloroethane 200.0g secondary extraction, stirring 0.5 h, standing for 0.5h, separate the secondary reservoir 188.7g.Combined with a secondary oil layer, add water 400.0g washing, stirring 0.5h, standing for 0.5h, separated from the oil layer, desolvation, the use of ethanol to get 260.0g two-step product, the content of> 98%, yield 88% Cis – trans isomer ratio 56/44.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,54410-90-1, 4-Pentylcyclohexanol, and friends who are interested can also refer to it.

Reference:
Patent; Dalian Jiu Xin Fine Chemical Co., Ltd.; Dai Yao; Liang Quande; Zhao Danyang; Liu Lingling; Wang Weixin; Wang Rongliang; (5 pag.)CN106916089; (2017); A;,
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Synthetic Route of 6214-45-5 ,Some common heterocyclic compound, 6214-45-5, molecular formula is C11H16O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: In a 5 mL sealed tube, TBPB(30 mol%, 0.041 g), and TBHP (70 wt% in H2O, 1.0 mmol, 0.131 g) was added to a solution ofbenzyl alcohol 1a (0.4 mmol, 0.043 g) in chlorobenzene (1 mL). The resultant mixture washeated at 80 C for 2.5 h. After completion of the reaction as was indicated by TLC monitoring,the reaction mixture was cooled to ambient temperature and saturated NaHCO3 (2 mL) wasadded. The product was extracted with ethyl acetate (2 × 3 mL). The combined organic phasewas dried over Na2SO4. The solvent was removed under the reduced pressure. The residue waspurified by column chromatography using n-hexane-EtOAc (15:1) as eluent to afford pureproduct 2a as a white solid.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,6214-45-5, its application will become more common.

Reference:
Article; Adib, Mehdi; Pashazadeh, Rahim; Synlett; vol. 29; 1; (2018); p. 136 – 140;,
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Related Products of 13588-28-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 13588-28-8, name is 2-(2-Methoxypropoxy)propan-1-ol. This compound has unique chemical properties. The synthetic route is as follows.

Jimroth type reflux condenser, Dean-Stark trap tube,In a 100 mL two-necked flask equipped with a nitrogen inlet tube,Dipropylene glycol monomethyl ether represented by the following formula (20) (with isomer) (7.41 g, 50 mmol), vinylacetic acid synthesized in Example 1 (formula (1-0),4.74 g, 55 mmol),p-Toluenesulfonic acid monohydrate (0.48 g, 2.5 mmol)And toluene (35 mL) was added.Immerse the two-necked flask in an oil bath,The temperature of the oil bath was raised to 130 C.While maintaining the same temperature, the mixture was stirred for 4 hours under a nitrogen stream to distill off the by-produced water.Cool the two-necked flask to room temperature (25 C),Wash twice with 5 wt% aqueous sodium bicarbonate (10 mL),Further, after washing twice with distilled water (10 mL), it was dried over magnesium sulfate. After removing the magnesium sulfate, the solution was concentrated under reduced pressure in the same manner as in Example 2. The obtained concentrated residue was purified by distillation under reduced pressure to isolate the compound (1-1b) (10.57 g, yield 98%)

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 13588-28-8, 2-(2-Methoxypropoxy)propan-1-ol.

Reference:
Patent; JNC Corporation; Masayuki, Sato; Urata, Yasuo; Yatsuda, Shinichi; Masuhara, Shigeo; Hashimoto, Kazuki; (20 pag.)JP5803424; (2015); B2;,
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Synthetic Route of 15963-47-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.15963-47-0, name is (3-Chlorocyclobutyl)methanol, molecular formula is C5H9ClO, molecular weight is 120.58, as common compound, the synthetic route is as follows.

(A) [[(3-Chlorocyclobutyl)methoxy]methyl]benzene A mixture of 3-chlorocyclobutanemethanol (17.3 g, 0.143 mole) and benzylbromide (26.96 g, 0.158 mole) in dry dimethylformamide (123 ml) was stirred at room temperature under an argon atmosphere and a 60% suspension of sodium hydride (6.31 g 0.158 g mole) was added. The reaction was stirred at ambient temperature for 22.5 hours. The reaction mixture was poured into 600 ml of water and the aqueous mixture extracted with ethyl acetate (4*500 ml). The ethyl acetate extracts were combined and dried over anhydrous sodium sulfate and the ethyl acetate evaporated in vacuo yielding the crude product as a yellow oil. The material was purified on a 2-liter Merck silica gel column eluding with 3 liters of hexane, followed by 5% ethyl acetate/hexane. The fractions containing the desired product were combined and the volatiles evaporated in vacuo yielding 28.6 g of the title compound as a pale yellow oil.

Statistics shows that 15963-47-0 is playing an increasingly important role. we look forward to future research findings about (3-Chlorocyclobutyl)methanol.

Reference:
Patent; E. R. Squibb & Sons, Inc.; US4918075; (1990); A;,
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Application of 626-95-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 626-95-9, name is 1,4-Pentanediol. A new synthetic method of this compound is introduced below.

Referential Example 2: 4-(t-Butyldiphenylsilyloxy)-1-methyl-1-butanol In N,N-dimethylformamide (200 ml) were dissolved 1,4-pentanediol (10.0 g, 96.0 mmol) and imidazole (6.6 g, 96.9 mmol).. Under ice cooling, t-butyl chlorodiphenylsilane (25.2 ml, 96.4 mmol) was added dropwise.. After completion of the dropwise addition, the reaction mixture was stirred at room temperature for 2 days.. To the reaction mixture was added diethyl ether, followed by washing with water.. The organic layer was dried over anhydrous magnesium sulfate.. After filtration, the residue obtained by concentrating the filtrate under reduced pressure was purified by silica gel chromatography (hexane:ethyl acetate=5:1), whereby the title compound (32.0 g, 97%) was obtained as a colorless oil. IR (ATR) nu: 3350, 2929, 2856, 1427, 1105, 822, 739, 698, 609, 501 cm-1.1H-NMR (400MHz, CDCl3) delta: 1.05(9H,S), 1.19(3H,d,J=6.3Hz), 1.46-1.72(4H,m), 2.02-2.08(1H,m), 3.69(2H,t,J=6.0Hz), 3.78-3.90(1H,m), 7.30-7.50(6H,m), 7.62-7.88(4H,m). MS (m/z): 343 (M++H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,626-95-9, 1,4-Pentanediol, and friends who are interested can also refer to it.

Reference:
Patent; DAIICHI PHARMACEUTICAL CO., LTD.; EP1466898; (2004); A1;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 813-99-0, name is 3-Chloro-2,2-bis(chloromethyl)propan-1-ol. This compound has unique chemical properties. The synthetic route is as follows. category: alcohols-buliding-blocks

3-Chloro-2,2-bis (chloromethyl) propan-1-ol (15.4 g, 80.4 mmol) obtained in the above step 1 was dissolved in 98% ethanol (28 ml) and potassium hydroxide (5.0 g, mmol) was added, and the mixture was heated and refluxed for 30 minutes.The reaction solution was cooled with ice water and stirred for 10 minutes. The resulting solid was filtered off,The pH was adjusted to 7.5 with 2N aqueous hydrochloric acid solution. After removing the solvent by distillation under reduced pressure, water (100 ml) was added to the residue and extracted twice with ethyl acetate (150 ml). The obtained organic layers were combined, washed with brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure.The obtained residue was purified by silica gel column chromatography (hexane: ethyl acetate = 4: 1) to obtain pure 3,3-bis (chloromethyl) oxetane (9.2 g, 74%).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 813-99-0, 3-Chloro-2,2-bis(chloromethyl)propan-1-ol.

Reference:
Patent; Korea Research Institute of Chemical Technology; Eseuti Pam Co., Ltd.; Kim Bong-jin; Kim Jae-hak; Lee Il-yeong; Lee Sang-ho; Lee Jong-gyo; Kim Gyeong-jin; Kim Uk-il; Nam Hwa-jeong; (56 pag.)KR101592370; (2016); B1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 81335-87-7, name is (2-Amino-4-methylphenyl)methanol. A new synthetic method of this compound is introduced below., Safety of (2-Amino-4-methylphenyl)methanol

General procedure: A solution of 4-toluene sulfonyl chloride (4.58 g, 1.2 equiv) or methanesulfonyl chloride (1.9 mL, 1.2 equiv) and pyridine (2 mL, 1.3 equiv) in 20 mL CH2Cl2 was added slowly to the solution of compound 11 (0.02 mol) in 40 mL CH2Cl2. The mixture was stirred overnight at room temperature. Then 30 mL diluted HCl solution was added to the reaction mixture, the organic layer was separated using separating funnel. Subequently, the aqueous phase was extracted with 15 mL CH2Cl2 three times, the combined organic layers were washed separately with saturated NaHCO3 (30 mL) and saturated NaCl (30 mL) three times. The organic layer was dried over Na2SO4, filtered and evaporated under reduced pressure. The residue was purified by column chromatography using petroleum ether/EtOAc = 1/1 to give the product 12.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 81335-87-7, (2-Amino-4-methylphenyl)methanol.

Reference:
Article; Xu, Changrui; Wu, Zhengxing; Chen, Jianzhong; Xie, Fang; Zhang, Wanbin; Tetrahedron; vol. 73; 14; (2017); p. 1904 – 1910;,
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Synthetic Route of 6214-45-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.6214-45-5, name is (4-Butoxyphenyl)methanol, molecular formula is C11H16O2, molecular weight is 180.24, as common compound, the synthetic route is as follows.

Example 8 4-[(4-Butoxyphenyl)methyl]-1,2-dihydro-5-methyl-3 H -pyrazol-3-one The title compound was prepared in a similar manner to that described in Example 1 using 4-butoxybenzyl alcohol instead of 4-isopropoxybenzyl alcohol. 1H-NMR (500MHz, DMSO-d6) delta ppm: 0.91 (3H, t, J=7.4Hz), 1.30-1.50 (2H, m), 1.55-1.75 (2H, m), 1.98 (3H, s), 3.46 (2H, s), 3.80-3.95 (2H, m), 6.70-6.85 (2H, m), 6.95-7.10 (2H, m)

Statistics shows that 6214-45-5 is playing an increasingly important role. we look forward to future research findings about (4-Butoxyphenyl)methanol.

Reference:
Patent; Kissei Pharmaceutical Co., Ltd.; EP1213296; (2002); A1;,
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