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The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Scope and selectivity in palladium-catalyzed directed C-H bond halogenation reactions》. Authors are Kalyani, Dipannita; Dick, Allison R.; Anani, Waseem Q.; Sanford, Melanie S..The article about the compound:1-(4-Chlorophenyl)pyrrolidin-2-onecas:7661-33-8,SMILESS:O=C1N(C2=CC=C(Cl)C=C2)CCC1).Safety of 1-(4-Chlorophenyl)pyrrolidin-2-one. Through the article, more information about this compound (cas:7661-33-8) is conveyed.

Palladium-catalyzed ligand directed C-H activation/halogenation reactions have been extensively explored. Both the nature of the directing group and the substitution pattern on the arene ring of the substrate lead to different reactivity profiles, and often different and complementary products, in the presence and absence of the catalyst.

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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Heteroarylquinoxalines as thiabendazole analogs. Part 4: Synthesis of 2-thiazolylquinoxalines, published in 1983, which mentions a compound: 23002-78-0, Name is 1-(2-Methylthiazol-4-yl)ethanone, Molecular C6H7NOS, Recommanded Product: 23002-78-0.

Thiazolylquinoxalines I (R1 = H, Me, Ph, NH2, CO2Et, R2 = H; R1 = H, Ph, NH2, CO2Et, R2 = Me) and II (R1 = Me, Ph) were prepared by 2 methods. In the 1st method, acetylthiazoles III and IV (R3 = Me) were converted to glyoxals III and IV (R3 = CHO), isonitroso ketones IV (R3 = CH:NOH), or bromo ketones IV (R3 = CH2Br) which cyclized with o-(H2N)2C6H4 to I and II. In the 2nd method, acetylquinoxalines V were brominated and the products cyclized with thioamides to I. I (R1 = CO2Et, R2 = H, Me) underwent saponification, ammonolysis, aminolysis, and hydrazinolysis to give I (R1 = CO2K, CO2H, CONR4R5; R4 = H, Me, Et, Bu, NH2, R5 = H; R4 = R5 = Me; NR4R5 = morpholino, piperidino).

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Category: alcohols-buliding-blocks. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 1-(2-Methylthiazol-4-yl)ethanone, is researched, Molecular C6H7NOS, CAS is 23002-78-0, about An efficient protocol for the oxidative hydrolysis of ketone SAMP hydrazones employing SeO2 and H2O2 under buffered (pH 7) conditions. Author is Smith, Amos B. III; Liu, Zhuqing; Simov, Vladimir.

An effective oxidative protocol for the liberation of ketones from SAMP hydrazones employing peroxyselenous acid under aqueous buffered conditions (pH 7) has been developed. The procedure proceeds without epimerization of adjacent stereocenters or dehydration, in representative SAMP alkylation and aldol reaction adducts, resp.

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Synthetic Route of C7H3N3. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: Pyridine-3,5-dicarbonitrile, is researched, Molecular C7H3N3, CAS is 1195-58-0, about Correlation of 2-, 3-, 4- and disubstituted pyridine gas-phase proton affinities with ab initio calculated energies at the STO-3G basis set level.

Total energies of 2-, 3-, 4- and disubstituted pyridines were calculated for the salt and the free base using ab initio MO calculations at the STO-3G basis set level. In each set, the difference in energy, ΔEH, between the salt and the free base was calculated and plotted against exptl. derived gas-phase proton affinities. The correlation was very good for each of the substituent categories listed. All of the energies and proton affinities were then plotted together on the same graph. The result was an excellent correlation with r = 0.97. The linear equation for gas phase proton affinity, PAB = 28.51 + 435.45ΔEH kcal/mol, was derived from this plot and was used to calculate proton affinities for all 31 compounds used in this study as well as for a series of dicyanopyridines for which values of proton affinity are not available at this time.

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The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 1-(4-Chlorophenyl)pyrrolidin-2-one, is researched, Molecular C10H10ClNO, CAS is 7661-33-8, about Condensation of aniline, o-phenylenediamine, and their derivatives with lactones, the main research direction is aniline butyrolactone pyrrolidinone; benzimidazolepropanol phenylenediamine lactone.Product Details of 7661-33-8.

Heating equimol. amounts of RNH2 and γ-butyrolactone at 130-305° gave 2-pyrrolidinones (I) (R and % yield given): Ph, 80; m-MeC6H4, 75; p-MeC6H4, 78; m-BrC6H4, 60; α-naphthyl, 14; m-CF3C6H4, 19; p-ClC6H4, 77; β-naphthyl, 62. Boiling a mixture of equimol. amounts of substituted aromatic o-diamines and γ- or β-lactones in xylene gave the following 3-(2-benzimidazolyl)-1-alkanoles (II) (R1, R2, X, and % yield given): H, CCl3, CH2, 61; Cl, CCl3, CH2, 85; Me, CCl3, CH2, 87; H, H, (CH2)2, 80; Cl, H, (CH2)2, 24; Me, H, (CH2)2, 31; H, Me, (CH2)2, 78; H, Pr, (CH2)2, 78; Cl, Pr, (CH2)2, 7; Me, Pr, (CH2)2, 13; H, Bu, (CH2)2, 75; Cl, Bu, (CH2)2, 17; H, C7H15, (CH2)2, 66; H, H, CHOHCMe2, 50; H, H, CHAcCH2, 40; Cl, H, CHAcCH2, 16. Uv data for II are given.

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The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 1-(4-Chlorophenyl)pyrrolidin-2-one(SMILESS: O=C1N(C2=CC=C(Cl)C=C2)CCC1,cas:7661-33-8) is researched.Synthetic Route of C5H4O2. The article 《Scope and selectivity in palladium-catalyzed directed C-H bond halogenation reactions》 in relation to this compound, is published in Tetrahedron. Let’s take a look at the latest research on this compound (cas:7661-33-8).

Palladium-catalyzed ligand directed C-H activation/halogenation reactions have been extensively explored. Both the nature of the directing group and the substitution pattern on the arene ring of the substrate lead to different reactivity profiles, and often different and complementary products, in the presence and absence of the catalyst.

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Safety of 1-(4-Chlorophenyl)pyrrolidin-2-one. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 1-(4-Chlorophenyl)pyrrolidin-2-one, is researched, Molecular C10H10ClNO, CAS is 7661-33-8, about Hydrogen bonding of pyrrole, indole and carbazole with substituted 1-phenyl-2-pyrrolidinones. Author is Karjalainen, J.; Virtanen, P. O. I..

The equilibrium constants (K) for the 1:1 H-bonded complexes between I (R = Me, Ph, substituted Ph) with pyrrole, indole, and carbazole were determined in CCl4 by IR. Hammett LFER were observed for each K and Δ υNH (the difference between pores and associated NH stretch). I (R = Me) is a stronger H acceptor than I (R = Ph, substituted Ph). The proton donor ability increases in the order; pyrrole < indole < carbazole. The ΔG°, ΔH°, ΔS° for the complexation are determined This literature about this compound(7661-33-8)Safety of 1-(4-Chlorophenyl)pyrrolidin-2-onehas given us a lot of inspiration, and I hope that the research on this compound(1-(4-Chlorophenyl)pyrrolidin-2-one) can be further advanced. Maybe we can get more compounds in a similar way.

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Product Details of 7661-33-8. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 1-(4-Chlorophenyl)pyrrolidin-2-one, is researched, Molecular C10H10ClNO, CAS is 7661-33-8, about Carbon-13, nitrogen-15m, and oxygen-17 NMR chemical shifts of substituted 1-phenyl-2-pyrrolidinones. Author is Ruostesuo, P.; Hakkinen, A. M.; Karjalainen, J..

The C-13 and N-15 NMR chem. shifts and the direct C-proton coupling constants of 1-phenyl-2-pyrrolidinone and its 2′-Me,3′-Me,4′-Me,2′-chloro,3′-chloro,4′-chloro,3′-methoxy,4′-methoxy and 4′-nitro derivatives were measured in di-Me sulfoxidde. The O-17 NMR chem. shifts of some of the compounds were determined in acetone. The effect of substituents on the chem. shifts of carbonyl carbons correlates well with the Hammett substituent parameters and the N chem. shifts seem to follow a similar trend. The variation of the O chem. shift due to the substituents is small. The chem. shifts of aromatic carbons can mainly be derived using the substituent parameters of benzene, some deviation probably due to steric effects is observable, however.

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The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: Pyridine-3,5-dicarbonitrile(SMILESS: N#CC1=CC(C#N)=CN=C1,cas:1195-58-0) is researched.Formula: C5H11I. The article 《A study of solvent effect on photochemically induced reactions between pyridinedicarbonitriles and alkenes: an easy approach to the synthesis of cyclopenta[b or c]pyridines》 in relation to this compound, is published in Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry. Let’s take a look at the latest research on this compound (cas:1195-58-0).

Photochem. induced reactions of pyridinedicarbonitriles and alkenes showed an interesting dependence on solvent polarity. In non-polar solvents ipso-substitution of the cyano groups in positions α or γ to the heterocyclic nitrogen occurred to a larger extent, while in polar solvents the reaction provided a path to the formation of a new ring between the carbon atom of one of the cyano groups and a ring position, forming a cyclopenta[b]pyridine or cyclopenta[c]pyridine derivatives Studies on the multiplicity of the excited state controlling the reaction showed that the singlet state was involved in the ipso-substitution, while the triplet state controlled the formation of the pyridine. An explanation for the solvent effect was given in terms of shift of the excited states with the solvent used. Theor. calculations justified the position of the cyclization, although no correlation was found for the regioisomers ratio. This reaction represented an effective entry to the biol. interesting pyrindine systems.

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Name: 5-Methoxy-4-methylpyridin-3-amine. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 5-Methoxy-4-methylpyridin-3-amine, is researched, Molecular C7H10N2O, CAS is 77903-28-7, about Discovery of Azetidinyl Ketolides for the Treatment of Susceptible and Multidrug Resistant Community-Acquired Respiratory Tract Infections. Author is Magee, Thomas V.; Ripp, Sharon L.; Li, Bryan; Buzon, Richard A.; Chupak, Lou; Dougherty, Thomas J.; Finegan, Steven M.; Girard, Dennis; Hagen, Anne E.; Falcone, Michael J.; Farley, Kathleen A.; Granskog, Karl; Hardink, Joel R.; Huband, Michael D.; Kamicker, Barbara J.; Kaneko, Takushi; Knickerbocker, Michael J.; Liras, Jennifer L.; Marra, Andrea; Medina, Ivy; Nguyen, Thuy-Trinh; Noe, Mark C.; Obach, R. Scott; O’Donnell, John P.; Penzien, Joseph B.; Reilly, Usa Datta; Schafer, John R.; Shen, Yue; Stone, Gregory G.; Strelevitz, Timothy J.; Sun, Jianmin; Tait-Kamradt, Amelia; Vaz, Alfin D. N.; Whipple, David A.; Widlicka, Daniel W.; Wishka, Donn G.; Wolkowski, Joanna P.; Flanagan, Mark E..

Respiratory tract bacterial strains are becoming increasingly resistant to currently marketed macrolide antibiotics. The current alternative telithromycin (1) from the newer ketolide class of macrolides addresses resistance but is hampered by serious safety concerns, hepatotoxicity in particular. We have discovered a novel series of azetidinyl ketolides that focus on mitigation of hepatotoxicity by minimizing hepatic turnover and time-dependent inactivation of CYP3A isoforms in the liver without compromising the potency and efficacy of 1.

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