Tag: M.W=100-200

Zheng, Yanling; Nie, Xufeng; Long, Yang; Ji, Li; Fu, Haiyan; Zheng, Xueli; Chen, Hua; Li, Ruixiang published the article 《Ruthenium-catalyzed synthesis of N-substituted lactams by acceptorless dehydrogenative coupling of diols with primary amines》. Keywords: lactam preparation green chem; diol amine dehydrogenative coupling ruthenium catalyst.They researched the compound: 1-(4-Chlorophenyl)pyrrolidin-2-one( cas:7661-33-8 ).Quality Control of 1-(4-Chlorophenyl)pyrrolidin-2-one. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:7661-33-8) here.

The first example of synthesis of N-substituted lactams I (R = Ph, 4-(propan-2-yl)phenyl, 2H-1,3-benzodioxol-5-yl, naphthalen-2-yl, etc.; n = 1,2,3) and N-(p-tolyl)isoindolin-2-one via an acceptorless dehydrogenative coupling of diols HO(CH2)2(CH2)nCH2OH and [2-(hydroxymethyl)phenyl]methanol with primary amines RNH2 in one step, which was enabled by combining Ru3(CO)12 with a hybrid N-heterocyclic carbene-phosphine-phosphine ligand as the catalyst have been reported.

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Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 7661-33-8, is researched, SMILESS is O=C1N(C2=CC=C(Cl)C=C2)CCC1, Molecular C10H10ClNOJournal, Synlett called Facile CuI-catalyzed arylation of azoles and amides using simple enaminones as efficient ligands, Author is Cheng, Cungui; Sun, Gonglei; Wan, Jieping; Sun, Cuirong, the main research direction is azole aryl halide arylation copper iodide dimethylaminopropenone hydroxyphenyl; arylated azole preparation; aryl halide amide arylation copper iodide dimethylaminopropenone hydroxyphenyl; amide arylated preparation; copper iodide arylation catalyst; dimethylaminopropenone hydroxyphenyl catalytic arylation ligand.Safety of 1-(4-Chlorophenyl)pyrrolidin-2-one.

(E)-3-(Dimethylamino)-1-(2-hydroxyphenyl)prop-2-en-1-one was found to be an excellent ligand for copper-catalyzed N-arylation of azoles and amides with aryl halides under mild conditions. The reaction took place at 82 °C in MeCN with broad functional-group compatibility. A combination of the ligand and CuI proved to be an efficient catalytic system to promote the coupling reactions of aryl halides with azoles and amides.

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Quality Control of Pyridine-3,5-dicarbonitrile. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: Pyridine-3,5-dicarbonitrile, is researched, Molecular C7H3N3, CAS is 1195-58-0, about Vanadium-titanium-tin oxide catalyst for oxidative ammonolysis of alkylbenzenes and alkylpyridines. Author is Suvorov, B. V.; Belova, N. A.; Stepanova, L. A..

Oxidative ammonolysis of alkylbenzenes and alkylpyridines (p-xylene, pseudocumene, 2-, 3-, and 4-picoline, 2,6- and 3,5-lutidine, 3-ethylpyridine, 2-methyl-5-ethylpyridine, and 2-methyl-5-vinylpyridine) on SnO2-modified Ti V oxide catalyst gave the corresponding nitriles in high yields. The catalyst is activated by water vapor.

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Name: 1-(4-Chlorophenyl)pyrrolidin-2-one. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 1-(4-Chlorophenyl)pyrrolidin-2-one, is researched, Molecular C10H10ClNO, CAS is 7661-33-8, about Lactams. VIII. Conformation of N-aryl lactams. Author is Manhas, Maghar S.; Jeng, Stella J.; Bose, Ajay K..

N-Aryl β-lactams were characterized by strong uv maximum at about 250 mμ. Some N-aryl γ-lactams also show similar absorption maximum but heavily substituted γ-lactams or N-phenyl δ-lactam display only low absorption in this region. A study of uv and N.M.R. spectra indicates that in N-aryl β-lactams, the heterocyclic ring and the three valences of N are planar and the N-aryl ring lies in the plane of the β-lactam. This planarity as well as the strong uv absorption are the result of an extended conjugation between the aryl ring and the amide function. Ortho substitution on the aryl ring causes a slight departure from this planarity and reduces the intensity of the uv absorption. In case of N-aryl γ-lactams, ortho substitution on the aryl ring causes enough departure from planarity to eliminate altogether the absorption maximum near 250 mμ. 22 references.

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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 1-(4-Chlorophenyl)pyrrolidin-2-one( cas:7661-33-8 ) is researched.Reference of 1-(4-Chlorophenyl)pyrrolidin-2-one.Prince, Robin J.; Gao, Fang; Pazienza, Jessica E.; Marx, Isaac E.; Schulz, Jurgen; Hopkins, Brian T. published the article 《Utilization of Cyclic Amides as Masked Aldehyde Equivalents in Reductive Amination Reactions》 about this compound( cas:7661-33-8 ) in Journal of Organic Chemistry. Keywords: cyclic amide masked aldehyde equivalent reductive amination. Let’s learn more about this compound (cas:7661-33-8).

An operationally simple protocol has been discovered that couples primary or secondary amines with N-aryl-substituted lactams to deliver differentiated diamines in moderate to high yields. The process allows for the partial reduction of a lactam in the presence of Cp2ZrHCl (Schwartz’s reagent), followed by a reductive amination between the resulting hemiaminal and primary or secondary amine. These reactions can be telescoped in a one-pot fashion to significantly simplify the operation. The scope of amines and substituted lactams of various ring sizes was demonstrated through the formation of a range of differentiated diamine products. Furthermore, this methodol. was expanded to include N-aryl pyrrolidinone substrates with an enantiopure ester group at the 5-position, and α-amino piperidinones were prepared with complete retention of stereochem. information. The development of this chem. has enabled the consideration of lactams as useful synthons.

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Quality Control of Pyridine-3,5-dicarbonitrile. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: Pyridine-3,5-dicarbonitrile, is researched, Molecular C7H3N3, CAS is 1195-58-0, about Proton chemical shifts of the symmetrically disubstituted pyridines. Author is Wu, Ting Kai.

3,5-Disubstituted pyridines (R2C5H3N, where R = CN, Br, Cl, and Me) and 2,6-disubstituted pyridines (R’2C5H3N, where R’ = NH2, OMe, Me, Cl, Br, and COMe) were studied by N.M.R. spectra to determine the substituent effects on the chem. shifts for further insight into the nature of the shielding mechanisms in the pyridine π-electron system. The additive substituent effects on the proton chem. shifts of the sym. disubstituted pyridines provide further supporting evidence for the interpretation of Wu and Dailey [J. Chem. Phys. 41, 3307(1964)] that the shielding mechanisms in the pyridines are virtually the same as those in benzenes.

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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Zhukovsky, Daniil; Dar’in, Dmitry; Kantin, Grigory; Krasavin, Mikhail researched the compound: 1-(4-Chlorophenyl)pyrrolidin-2-one( cas:7661-33-8 ).Application of 7661-33-8.They published the article 《Synthetic Exploration of α-Diazo γ-Butyrolactams》 about this compound( cas:7661-33-8 ) in European Journal of Organic Chemistry. Keywords: diazobutyrolactam pyrrolinone preparation; alc oxalylation hydride shift dimerization oxygen hydrogen insertion. We’ll tell you more about this compound (cas:7661-33-8).

Diazo transfer reaction onto γ-butyrolactams (activated by α-ethyloxalylation) gave rare α-diazo-γ-butyrolactams. Decomposition of the latter by Rh2(OAc)4 in the presence of alcs. and water gave products of O-H insertion of the resp. metal-cabene species. Silver triflate (1 mol%) was found to convert the investigated γ-butyrolactams into 1,5-dihydro-2H-pyrrol-2-ones which represent versatile building blocks. Particular instability was noted for α-diazo γ-butyrolactams bearing alkyl or o-substituted aryl substituents on the nitrogen atom. These were found to dimerize in solution or upon storage at room temperature to give fully conjugated bis-hydrazones along with the loss of a nitrogen mol.

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The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Lipase kinetic enantiomeric resolution of 1-heteroarylethanols》. Authors are Kucher, Olexandr V.; Kolodyazhnaya, Anastasiya O.; Smolii, Oleg B.; Nazarenko, Nadiya K.; Kubyshkin, Vladimir; Mykhailiuk, Pavel K.; Tolmachev, Andrey A..The article about the compound:1-(2-Methylthiazol-4-yl)ethanonecas:23002-78-0,SMILESS:CC(C1=CSC(C)=N1)=O).Quality Control of 1-(2-Methylthiazol-4-yl)ethanone. Through the article, more information about this compound (cas:23002-78-0) is conveyed.

The use of lipases offers a simple and straightforward method toward various chiral secondary alcs. Here we examined the lipase resolution of 1-heteroarylethanols. Racemic substrates were subjected to a two step resolution strategy. The difference between the substituent sizes around the chiral fragment allowed the successful isolation of the (S)-alcs. with assistance of the Burkholderia cepacia lipase (ee ≥ 96%). The (R)-isomers were obtained after hydrolysis of the enantioenriched O-acetylated alcs. either with Candida antarctica lipase B or with potassium carbonate. The performance of the latter step was found to be substrate dependent.

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Category: alcohols-buliding-blocks. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 1-(4-Chlorophenyl)pyrrolidin-2-one, is researched, Molecular C10H10ClNO, CAS is 7661-33-8, about Hydrogen bonding of pyrrole, indole and carbazole with substituted 1-phenyl-2-pyrrolidinones.

The equilibrium constants (K) for the 1:1 H-bonded complexes between I (R = Me, Ph, substituted Ph) with pyrrole, indole, and carbazole were determined in CCl4 by IR. Hammett LFER were observed for each K and Δ υNH (the difference between pores and associated NH stretch). I (R = Me) is a stronger H acceptor than I (R = Ph, substituted Ph). The proton donor ability increases in the order; pyrrole < indole < carbazole. The ΔG°, ΔH°, ΔS° for the complexation are determined I hope my short article helps more people learn about this compound(1-(4-Chlorophenyl)pyrrolidin-2-one)Category: alcohols-buliding-blocks. Apart from the compound(7661-33-8), you can read my other articles to know other related compounds.

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The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: Pyridine-3,5-dicarbonitrile, is researched, Molecular C7H3N3, CAS is 1195-58-0, about Substituted thieno[2,3-d]pyrimidines as adenosine A2A receptor antagonists, the main research direction is thienopyrimidine preparation adenosine A2A antagonist.Category: alcohols-buliding-blocks.

A novel series of benzyl substituted thieno[2,3-d]pyrimidines, e.g. I, were identified as potent A2A receptor antagonists. Several five- and six-membered heterocyclic replacements for the optimized methylfuran were explored. Select compounds effectively reverse catalepsy in mice when dosed orally.

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