Tag: M.W=100-150

Yamaguchi, Kazuya published the artcileHeterogeneously Catalyzed Aerobic Cross-Dehydrogenative Coupling of Terminal Alkynes and Monohydrosilanes by Gold Supported on OMS-2, Category: alcohols-buliding-blocks, the publication is Angewandte Chemie, International Edition (2013), 52(21), 5627-5630, database is CAplus and MEDLINE.

Aerobic cross-dehydrogenative coupling of terminal alkynes, e.g., RCCH (R = 1-naphthyl, 4-XC₆H₄, X = Me, F, Br, CF₃, NO₂, NH₂), with monohydrosilanes, e.g., R’₃SiH (R’₃ = Et₃, PhMe₂, iPr₃, tBuMe₂, tBuPh₂, (EtO)₃) gave alkynylsilanes, RCCSiR’₃ in the presence of gold catalyst supported on a cryptomelane-type manganese oxide-based octahedral mol. sieve OMS-2 (Au/OMS-2, average particle size of gold: 4.5 nm).

Angewandte Chemie, International Edition published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C14H12N2S, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Li, Chunxiang published the artcilePhotoluminescence properties of a novel cyclometalated iridium(III) complex with coumarin-boronate and its recognition of hydrogen peroxide, Related Products of alcohols-buliding-blocks, the publication is Dalton Transactions (2014), 43(14), 5595-5602, database is CAplus and MEDLINE.

A novel neutral iridium(III) complex-based phosphorescent probe (Ir-2) for hydrogen peroxide (H₂O₂) has been designed and synthesized by incorporating a benzeneboronic acid pinacol ester (bpe) moiety into 3-(benzothiazol-2-yl)-7-hydroxy-coumarin (Bthc) as a cyclometalated ligand (Bthc-bpe). The photophys. behavior of Ir-2 was investigated by UV-Vis absorption spectroscopy, photoluminescence spectroscopy, and quantum mech. calculations The absorption spectra of the complex Ir-2 are dominated by the cyclometalated ligand; thus it shows an intense absorption band in the visible region at 460 nm with a molar extinction coefficient (ε) of about 3 × 10⁴ M^-1 cm^-1, which is rarely found for typical polypyridine iridium(III) complexes. The complex Ir-2 displays efficient phosphorescent emission at 560 nm at room temperature originating from a mixed triplet metal-to-ligand charge-transfer (³MLCT, dπ(Ir) π* (Bthc-bpe)) and triplet intraligand (³ILCT, π-π* (Bthc-bpe)) excited states as suggested by the DFT computational studies. Upon reaction with H₂O₂, the complex displays an emission decrease induced by an intense intermol. aggregation due to the cleavage of the bulky benzeneboronic acid pinacol ester substituent, indicating that Ir-2 could act as an ON-OFF-type phosphorescent probe for H₂O₂. Addnl., selectivity studies reveal that the complex Ir-2 possesses high selectivity toward H₂O₂ over other reactive oxygen species (ROS).

Dalton Transactions published new progress about 25240-59-9. 25240-59-9 belongs to alcohols-buliding-blocks, auxiliary class Boronic acid and ester,Boronic Acids,Boronate Esters, name is 4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-ol, and the molecular formula is C6H13BO3, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Li, Yanrui published the artcileThermodynamic parameters and infinite dilution activity coefficients for organic solutes in deep eutectic solvent: Choline Chloride + 1,5-Pentanediol, HPLC of Formula: 111-29-5, the publication is Journal of Chemical Thermodynamics (2022), 106784, database is CAplus.

A series of thermodn. parameters related to choline chloride + 1,5-pentanediol deep eutectic solvent were studied through inverse gas chromatog. at 303.15-343.15 K. The infinite dilution activity coefficient (γ∞12) was used to predict the solute separation ability and the intermol. interaction strength of DES. The interaction between mols. was further described by partial molar excess properties (ΔH^E,∞₁,TΔS^E,∞₁, ΔG^E,∞₁). The value of γ∞12 was also used to compute the separation parameters for common separation problems benzene (1)/methanol (2), n-hexane (1)/benzene (2) and benzene (1)/thiophene (2). The miscibility of organic solutes and DES was evaluated using the Flory-Huggins interaction parameter, and the result showed alcs. were good solvents for the DES. Moreover, the Hildebrand solubility parameters (I₂) of the DES were calculated, and the result revealed that the value showed a downward trend with the increase of temperature

Journal of Chemical Thermodynamics published new progress about 111-29-5. 111-29-5 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ploymers, name is Pentane-1,5-diol, and the molecular formula is C5H12O2, HPLC of Formula: 111-29-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Zhuangqing published the artcileSelective hydrogenolysis of tetrahydrofurfuryl alcohol to 1,5-pentanediol over PrO_x promoted Ni catalysts, SDS of cas: 111-29-5, the publication is Catalysis Today (2022), 79-87, database is CAplus.

Catalytic conversion of furfural and its derivatives to value-added C₅ mols. has attractive much attention in the field of biomass conversion. In this paper, the selective hydrogenolysis of tetrahydrofurfuryl alc. to 1,5-pentanediol has been studied over a series of PrO_x promoted Ni/Al₂O₃ catalysts. The catalytic performances and the promoting effects of PrO_x, as well as the role of Ni and PrO_x species have been discussed. The surface properties and structure of catalysts were examined by TEM, XRD, XPS, H₂-TPR, H₂-TPD, in-situ DRIFTS, etc. The presence of PrO_x species promotes the reaction rate and changes product selectivity significantly, and a 79.2% 1,5-pentanediol selectivity can be obtained at 88.4% conversion over the NiPr_1.2/Al₂O₃ catalyst. The synergistic effect between defect-rich PrO_x and the adjacent active Ni species has been confirmed to contribute to the superior catalytic performances. These results provide useful knowledge for the activation of cyclic ether bonds and the design of heterogeneous catalysts with lanthanide oxide supports.

Catalysis Today published new progress about 111-29-5. 111-29-5 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ploymers, name is Pentane-1,5-diol, and the molecular formula is C9H6FNO, SDS of cas: 111-29-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Guo, Yinghua published the artcileImaging of lysosomal oxidative stress during autophagy with a ratiometric probe featuring a large probe-product spectral separation, Recommanded Product: 2-Morpholinoethanol, the publication is Sensors and Actuators, B: Chemical (2021), 129713, database is CAplus.

Autophagy is a physiol. process governing proteostasis and implicated in many diseases. Enhanced ROS levels was known to be associated with lysosomal autophagy and therefore a lyso-specific ROS probe could find applications in autophagy related studies. Following the probe-design principle of bridging-group modification, we previously developed a ROS probe capable of detect a broader range of reactive species than the existing probes. Addnl. merits of the probe include ratiometry-capability, minimal probe-product spectral crosstalk, resistance toward autoxidation at lysosomal acidity, and structural simplicity. It is the aim of this manuscript to render this probe lyso-specificity and examine its potentials to monitor autophagy-related ROS generation in HeLa cells treated by H2O2 or 6-OHDA.

Sensors and Actuators, B: Chemical published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C6H13NO2, Recommanded Product: 2-Morpholinoethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Jun published the artcile(E)-β-Trifluoromethyl vinylsulfones as antitumor agents: Synthesis and biological evaluations, Category: alcohols-buliding-blocks, the publication is European Journal of Medicinal Chemistry (2022), 114197, database is CAplus and MEDLINE.

A three-component reaction of phenylacetylene, trifluoromethyl thianthrenium triflate (TT-CF+3OTf-) and sodium sulfinates under extremely mild conditions is developed, leading to various trifluoromethyl-substituted vinyl sulfones in moderate to good yields with excellent stereoselectivity. Addnl., elaboration of trifluoromethyl-substituted vinyl sulfone by palladium-catalyzed amination is performed. These trifluoromethyl-substituted vinyl sulfones are further evaluated for several assays against different tumor cells and the antitumor mechanism in cytotoxic autophagy induced by PI3K/Akt/mTOR signal is investigated.

European Journal of Medicinal Chemistry published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C9H9NO6S, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yu, Zhipeng published the artcilePotential mechanisms of the anti-hypertensive effects of RVPSL on spontaneously hypertensive rats using non-targeted serum metabolomics, Recommanded Product: 4-Propylphenol, the publication is Food & Function (2021), 12(18), 8561-8569, database is CAplus and MEDLINE.

The study aimed to investigate potential mechanisms for the anti-hypertensive effects of RVPSL on spontaneously hypertensive rats (SHRs) using a non-targeted metabonomic approach. In this study, UPLC/MS-based non-targeted metabolomics was performed to discover metabolite variation of serum in SHRs with RVPSL treatment. As a result, the serum metabolites of SHRs that were administered RVPSL for four weeks exhibited distinct alterations. Nine potential biomarkers, i.e., choline, adenosine, adrenic acid, L-tryptophan, niacinamide, glycocholic acid, propiolic acid, D-glyceraldehyde 3-phosphate, and phosphoglycolic acid, were significantly altered, which were mainly involved in lipid metabolism, vitamin and amino acid metabolism, purine metabolism, the MAPK signaling pathway, and the renin-angiotensin system. This study suggested that RVPSL potentially exerted potent effects of alleviating hypertension in the SHRs mainly via integrated regulations of metabolism and production of choline, L-tryptophan, nicotinamide, and adenosine.

Food & Function published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is Al2H32O28S3, Recommanded Product: 4-Propylphenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Lei published the artcileCobalt-Catalyzed Diastereo- and Enantioselective Reductive Allyl Additions to Aldehydes with Allylic Alcohol Derivatives via Allyl Radical Intermediates, Recommanded Product: (E)-4,4,4-Trifluorobut-2-en-1-ol, the publication is Journal of the American Chemical Society (2021), 143(32), 12755-12765, database is CAplus and MEDLINE.

Herein an unprecedented cobalt-catalyzed highly site-, diastereo- and enantioselective protocol for stereoselective formation of nucleophilic allyl-Co(II) complexes followed by addition to aldehydes RCHO (R = Ph, 2-furyl, cyclohexyl, etc.) is presented. The reaction features diastereo- and enantioconvergent conversion of easily accessible allylic alc. derivatives, e.g., 2-(3,4-dihydro-1(2H)-naphthalenylidene)ethanol to diversified enantioenriched homoallylic alcs. e.g., I with remarkably broad scope of allyl groups that can be introduced. Mechanistic studies indicated that allyl radical intermediates were involved in this process. These new discoveries establish a new strategy for development of enantioselective transformations through capture of radicals by chiral Co complexes, pushing forward the frontier of Co complexes for enantioselective catalysis.

Journal of the American Chemical Society published new progress about 83706-94-9. 83706-94-9 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethylated Building Blocks, name is (E)-4,4,4-Trifluorobut-2-en-1-ol, and the molecular formula is C10H10O3, Recommanded Product: (E)-4,4,4-Trifluorobut-2-en-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wu, Guolin published the artcileSynthesis and structure-activity relationship studies of MI-2 analogues as MALT1 inhibitors, Name: 2-Morpholinoethanol, the publication is Bioorganic & Medicinal Chemistry (2018), 26(12), 3321-3344, database is CAplus and MEDLINE.

Recent studies revealed that MALT1 is a promising therapeutic target for the treatment of ABC-DLBCL. Among several reported MALT1 inhibitors, MI-2 as an irreversible inhibitor represents a new class of ABC-DLBCL therapeutics. Due to its inherent potential cross-reactivity, further structure-activity relationship (SAR) study is imperative. Five focused compound libraries based on the chem. structure of MI-2 are designed and synthesized. The systematic SARs revealed that the side chain of 2-methoxyethoxy has little impact on the activity and can be replaced by other functionalized groups, providing new MI-2 analogs with retained or enhanced potency. Compounds 81-83 with terminal hydroxyl group as side chain displayed enhanced activities against MALT1. Replacement of triazole core with pyrazole is also tolerant, while structural modifications on other sites are detrimental. These findings will facilitate further development of small-mol. MALT1 inhibitors.

Bioorganic & Medicinal Chemistry published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C15H16O3, Name: 2-Morpholinoethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Xiao-Ru published the artcileDiscovery, Synthesis, and Evaluation of Oxynitidine Derivatives as Dual Inhibitors of DNA Topoisomerase IB (TOP1) and Tyrosyl-DNA Phosphodiesterase 1 (TDP1), and Potential Antitumor Agents, Recommanded Product: 2-Morpholinoethanol, the publication is Journal of Medicinal Chemistry (2018), 61(22), 9908-9930, database is CAplus and MEDLINE.

Tyrosyl-DNA phosphodiesterase 1 (TDP1) is a recently discovered enzyme repairing DNA lesions resulting from stalled topoisomerase IB (TOP1)-DNA covalent complex. Inhibiting TDP1 in conjunction with TOP1 inhibitors can boost the action of the latter. Herein, we report the discovery of the natural product oxynitidine scaffold as a novel chemotype for the development of TOP1 and TDP1 inhibitors. Three kinds of analogs, benzophenanthridinone, dihydrobenzophenanthridine, and benzophenanthridine derivatives, were synthesized and evaluated for both TOP1 and TDP1 inhibition and cytotoxicity. Benzophenanthridinone I showed high TOP1 inhibition (+++) and induced the formation of cellular TOP1cc and DNA damage, resulting in cancer cells apoptosis at nanomolar concentration range. In vivo studies indicated that I exhibits antitumor efficiency in HCT116 xenograft model. Benzophenanthridine II exhibited addnl. TDP1 inhibition with IC₅₀ value of 7 μM and synergistic effect with camptothecin in MCF-7 cells. This work will facilitate future efforts for the discovery of natural product-based TOP1 and TDP1 inhibitors.

Journal of Medicinal Chemistry published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C5H10OS, Recommanded Product: 2-Morpholinoethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts