Tag: M.W=100-150

Sun, Han published the artcileFluorinated Poly-oxalate Electrolytes Stabilizing both Anode and Cathode Interfaces for All-Solid-State Li/NMC811 Batteries, Application In Synthesis of 111-29-5, the publication is Angewandte Chemie, International Edition (2021), 60(33), 18335-18343, database is CAplus and MEDLINE.

The relatively narrow electrochem. steady window and low ionic conductivity are two critical challenges for Li⁺-conducting solid polymer electrolytes (SPE). Here, a family of poly-oxalate(POE) structures were prepared as SPE; among them, POEs composed from diols with an odd number of carbons show higher ionic conductivity than those composed from diols with an even number of carbons, and the POE composed from propanediol (C5-POE) has the highest Li⁺ conductivity The HOMO (HOMO) electrons of POE were found located on the terminal units. When using trifluoroacetate as the terminating unit (POE-F), not only does the HOMO become more neg., but also the HOMO electrons shift to the middle oxalate units, improving the antioxidative capability. Furthermore, the interfacial compatibility across the Li-metal/POE-F is also improved by the generation of a LiF-based solid-electrolyte-interlayer(SEI). With the trifluoroacetate-terminated C5-POE (C₅-POE-F) as the electrolyte and Li⁺-conducting binder in the cathode, the all-solid-state Li/LiNi_0.8Mn_0.1Co_0.1O₂(NMC811) cells showed significantly improved stability than the counterpart with poly-ether, providing a promising candidate for the forthcoming all-solid-state high-voltage Li-metal batteries.

Angewandte Chemie, International Edition published new progress about 111-29-5. 111-29-5 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ploymers, name is Pentane-1,5-diol, and the molecular formula is C7H13NO2, Application In Synthesis of 111-29-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Pedrick, E. A. published the artcileReductive silylation of a uranyl dibenzoylmethanate complex: an example of controlled uranyl oxo ligand cleavage, Application of Triethylsilanol, the publication is Chemical Science (2014), 5(8), 3204-3213, database is CAplus.

Reaction of UO₂(dbm)₂(THF) (dbm = OC(Ph)CHC(Ph)O) with 1 equiv of R₃SiH (R = Ph, Et), in the presence of B(C₆F₅)₃, gave U(OB{C₆F₅}₃)(OSiR₃)(dbm)₂(THF) (R = Ph, 1; Et, 2), which were isolated as red-orange crystalline solids in good yields. The addition of 1 equiv of H(dbm) to 2 results in protonation of the -OSiEt₃ ligand and formation of U(OB{C₆F₅}₃)(dbm)₃ (4) in 33% yield, along with formation of HOSiEt₃. Furthermore, addition of HOSiEt₃ and 1 equiv of THF to 4, results in the formation 2, revealing that this process is reversible. The two-step conversion of UO₂(dbm)₂(THF) to 4 represents a rare example of controlled uranyl oxo ligand cleavage at ambient temperature and pressure. Comparison of diffraction and d. functional theory data for 4 suggests the inverse trans influence (ITI), with a very shallow potential energy well for distortion along the trans U-O bond.

Chemical Science published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C6H16OSi, Application of Triethylsilanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chen, Yanru published the artcilePoly(1,5-pentylene-co-2,2,4,4-tetramethyl cyclobutylene terephthalate) copolyesters with high T_g and improved ductility and thermal stability, Related Products of alcohols-buliding-blocks, the publication is Polymer (2021), 124152, database is CAplus.

Poly(1,5-pentylene-co-2,2,4,4-tetramethyl cyclobutylene terephthalate) (PPecBT) random copolyesters glass transition temperature up to 136°C were synthesized through two-step melting polycondensation of di-Me terephthalate (DMT) or terephthalic acid (TPA), 2,2,4,4-tetramethyl-1,3-cyclobutanediol (CBDO) and 1,5-pentanediol (PeDO). They were characterized and assessed with intrinsic viscosity, ¹H NMR, DSC, TGA, tensile and impact testing as well as melt foaming observation. Using PeDO as a diol comonomer was helpful to depress CBDO sublimation and pipeline blocking, and to reduce the composition and cis-trans ratio deviations between monomer and copolymer. The presence of PeT repeat unit in PPecBT was beneficial to improve the thermal stability of PPecBT and to reduce undesired melt foaming and volume expansion during melt processing. The T^g of these amorphous copolymers is determined by intrinsic viscosity, copolymer composition and cis-cB unit fraction, and a quant. relationship among them is established. Futhermore, these PPecBTs showed superior tensile ductility as well as strength and modulus.

Polymer published new progress about 111-29-5. 111-29-5 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ploymers, name is Pentane-1,5-diol, and the molecular formula is C5H12O2, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Xin published the artcileN-Bridged Pincer Iridium Complexes for Highly Efficient Alkane Dehydrogenation and the Relevant Linker Effects, Quality Control of 14703-69-6, the publication is ACS Catalysis (2020), 10(11), 6475-6487, database is CAplus.

Ir complexes (RPOCR’NP)-HCl (4-HCl) and (RPSCR’NP)Ir-HCl (5-HCl) (R = substituent on P; R’ = substituent on N) supported by N-linked pincer ligands, with the other linker of being O- or S-atom, were synthesized. Among them, complexes with phosphino-iPr substituents (iPrPOCR’NP)Ir (4b, 4e, 4g) exhibit very high catalytic activity for transfer dehydrogenation (TD) of both cyclic and linear alkanes. In the prototypical TD reaction of cyclooctane (COA) with tert-butylethylene (TBE), for example, 4g affords 14720 turnovers at 200°, which are >2-fold of that obtained by the most efficient catalyst reported so far. Also, these complexes are highly effective for acceptorless dehydrogenation of 1,2,3,4-tetrahydronaphthalene, giving a turnover frequency of 8.8 min-1 for H₂ production within the 1st 4 h. The effects of the linkers at the positions ortho to the Ir center were elucidated by a systematic comparison of electronic and steric properties of these O/N- and S/N-linked pincer systems to those of C/C-linked iPrPCP, O/O-linked iPrPOCOP, and S/O-linked iPrPSCOP systems. Examination of the structure-activity relations reveals that alkane C-H bond addition to the 14e (pincer)Ir fragment (the rate-determining step in the TD reaction) is more favored by iPrPOCR’NP relative to other pincers, largely due to strong N-linker C(aryl) -donation. Compared to the parent iPrPOCOP complex with similarly -donating O-linkers, the energy of the alkene-bound out-of-cycle resting state is raised by iPrPOCR’NP primarily due to steric factors. Consequently, the incorporation of N-linker exerts an overall favorable effect on the catalytic rates. The authors found the thermal stability of these catalysts with different linker-combinations differs significantly.

ACS Catalysis published new progress about 14703-69-6. 14703-69-6 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Phenol, name is 3-(Methylamino)phenol, and the molecular formula is C11H23NO3, Quality Control of 14703-69-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Lin, Wen-Hsing published the artcileIdentification of a Multitargeted Tyrosine Kinase Inhibitor for the Treatment of Gastrointestinal Stromal Tumors and Acute Myeloid Leukemia, Application In Synthesis of 622-40-2, the publication is Journal of Medicinal Chemistry (2019), 62(24), 11135-11150, database is CAplus and MEDLINE.

Gastrointestinal stromal tumors (GISTs) are prototypes of stem cell factor receptor (c-KIT)-driven cancer. Two receptor tyrosine kinases, c-KIT and fms-tyrosine kinase (FLT3), are frequently mutated in AML patients, and these mutations are associated with poor prognosis. In this study, the authors discovered a multitargeted tyrosine kinase inhibitor, (6-(4-ethylpiperazin-1-yl)-2-methylpyrimidin-4-yl)(5-pyridin-4-ylthiazol-2-yl)amine Hydrochloride [2581827-29-2] (15a), with potent inhibition against single or double mutations of c-KIT developed in GISTs. Moreover, crystal structure anal. revealed the unique binding mode of (15a) with c-KIT and may elucidate its high potency in inhibiting c-KIT kinase activity. (15A) inhibited cell proliferation and induced apoptosis by targeting c-KIT in c-KIT-mutant GIST cell lines. The antitumor effects of (15a) were also demonstrated in GIST430 and GIST patient-derived xenograft (PDX) models. Further studies demonstrated that (15a) inhibited the proliferation of c-KIT- and FLT3-driven AML cells in vitro and in vivo. The results of this study suggest that (15a) may be a potential anticancer drug for the treatment of GISTs and AML.

Journal of Medicinal Chemistry published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C6H13NO2, Application In Synthesis of 622-40-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ding, Tao published the artcilePromoted Production of Phenolic Monomers from Lignin-First Depolymerization of Lignocellulose over Ru Supported on Biochar by N,P-co-Doping, Category: alcohols-buliding-blocks, the publication is ACS Sustainable Chemistry & Engineering (2022), 10(7), 2343-2354, database is CAplus.

Co-doping of heteroatoms into the support of metal-supported catalysts is a prevalent method to improve the catalytic performance by adjusting metal-support interactions. This paper investigated the catalytic performances of Ru supported on biomass-derived char (Ru@Char), N-doped char (Ru@N-Char), and N,P-co-doped char (Ru@NP-Char) in the emerging lignin-first depolymerization for both poplar (hardwood) and pine (softwood) samples, with an emphasis on the production of phenolic monomers. Various characterizations of the prepared catalysts showed that the codoping of N,P not only facilitated the formation of micropores in the char, but also introduced weak and moderate acid sites. Furthermore, the sizes of Ru nanoparticles on the codoped char became smaller and the proportion of metallic Ru species was increased, resulting from electron transfer from Ru to the codoped char. The yields of the phenolic monomers from poplar and pine over Ru@NP-Char were as high as 57.98 and 17.53 weight %-Klason lignin, resp., which were improved by factors of 1.4-2.5 in comparison to Ru@Char and Ru@N-Char. Full delignification during the depolymerization of both poplar and pine was also achieved over Ru@NP-Char.

ACS Sustainable Chemistry & Engineering published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C9H12O, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gentles, Robert G. published the artcileStandardization Protocols and Optimized Precursor Sets for the Efficient Application of Automated Parallel Synthesis to Lead Optimization: A Mitsunobu Example, Recommanded Product: 3,3,3-Trifluoropropan-1-ol, the publication is Journal of Combinatorial Chemistry (2002), 4(5), 442-456, database is CAplus and MEDLINE.

Mitsunobu reactions of alcs. and phenols to give aryl alkyl ethers are optimized for automated parallel synthesis with potential use in lead optimization for drug discovery. Phenols are first selected to eliminate reactants with mol. weights > 210 g/mol, reactants with other potential reactive moieties which could interfere with biol. activity, labeled mols., reactants which might be incompatible with conditions for the Mitsunobu reaction, and reactants which are not com. available in multigram quantities from major vendors. Once the candidate phenols are selected, reactions of a set of alcs. with a single phenol substrate and reactions of a single alc. substrate with a variety of phenols are studied to compare the manual and automated versions of the Mitsunobu reaction. Both the automated and manual Mitsunobu reactions use di-tert-Bu azodicarboxylate (DBAD) and resin-bound triphenylphosphine as reagents. The resin-bound triphenylphosphine works best when exposure to air is minimized; in addition, use of resin-bound triphenylphosphine with consistent loading is important. With the automated and standardized methodol., a variety of aryl alkyl ethers are prepared

Journal of Combinatorial Chemistry published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C3H5F3O, Recommanded Product: 3,3,3-Trifluoropropan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Souers, Andrew J. published the artcileSynthesis and evaluation of 2-amino-8-alkoxy quinolines as MCHr1 antagonists. Part 1, Computed Properties of 2240-88-2, the publication is Bioorganic & Medicinal Chemistry Letters (2004), 14(19), 4873-4877, database is CAplus and MEDLINE.

A high-throughput screen was performed in order to identify compounds that were bound by the melanin concentrating hormone receptor-1. 2-Amino-8-(cyclohexylmethyloxy)quinoline was identified and subsequently optimized using a parallel and automated procedure for the rapid production of multiple analogs. The structure-activity relationships that emerged from this effort are described, along with selected pharmacokinetic parameters of (d)-I when dosed orally in diet-induced obese mice.

Bioorganic & Medicinal Chemistry Letters published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C12H13F2N3O4S, Computed Properties of 2240-88-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gasior, Robert published the artcileKey Aroma Compounds in Roasted White Koluda Goose, Recommanded Product: 2-Phenylethanethiol, the publication is Journal of Agricultural and Food Chemistry (2021), 69(21), 5986-5996, database is CAplus and MEDLINE.

Aroma-active compounds in the roasted leg meat of White Koluda goose were assayed by gas chromatog.-olfactometry, using aroma extract dilution anal. and solvent-assisted flavor evaporation Quantitation, recombination-omission tests, and sensory evaluation were carried out. Thirty aroma compounds, for which odor activity values (OAVs) were calculated and for which the flavor dilution factors were greater than or equal to 1, were identified. The concentration of aroma compounds ranged from 0.06 to 633 (μg/kg). The highest OAVs (>1024) were for 2-furfurylthiol, 2-acetyl-1-pyrroline, and 1-octen-3-one. Nine key aroma compounds were: 2-furfurylthiol, 2-acetyl-2-thiazoline, 1-octen-3-one, 2-phenylethanethiol, 4,5-dimethyl-3-hydroxy-2(5H)-furanone, 4-hydroxy-2,5-dimethyl-3(2H)-furanone, (E,E)-2,4-decadienal, 2-acetyl-1-pyrroline, and 3-(methylthio)propanal. The intensity of the dominating roasted, meaty/broth, and fatty notes in the recombination model consisting of the key odorants were rated (10-point scale) at 4.6-5.8 points, relative to the original roasted goose (5.2-6.2). The aroma compounds defined predominantly the meaty, roasted, and fatty flavors during the descriptive sensory evaluation of the roasted goose meat.

Journal of Agricultural and Food Chemistry published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H10S, Recommanded Product: 2-Phenylethanethiol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Karsai, Syrus published the artcileComparison of novel aluminium lactate versus aluminium chloride-based antiperspirant in excessive axillary perspiration: First prospective cohort study, Product Details of C5H12O2, the publication is Dermatologic Therapy (2021), 34(4), e15020, database is CAplus and MEDLINE.

Aluminum chloride-based antiperspirants are an effective topical therapeutic option for mild to moderate states of excessive perspiration. Its use is primarily limited by the occurrence of skin irritation, especially in sensitive skin types. The objective of this study was to compare the antiperspirant efficacy and tolerability of a novel antiperspirant with 12.5% aluminum lactate, and a 12.5% aluminum chloride-based antiperspirant. This cohort study was conducted as a two-sided self-assessment comparison between both preparations in healthy volunteers to generate selfcare-related data. Almost half of the participants stated that aluminum chloride was more efficacious than aluminum lactate; 22% stated aluminum lactate was more efficacious than aluminum chloride; 28% observed no difference in the efficacy of both preparations (p = 0.04). However, 88% described greater tolerability with aluminum lactate (p < 0.0001). In this study, aluminum lactate showed significantly greater tolerability than aluminum chloride, although the latter tended to show slightly greater efficacy.

Dermatologic Therapy published new progress about 111-29-5. 111-29-5 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ploymers, name is Pentane-1,5-diol, and the molecular formula is C5H12O2, Product Details of C5H12O2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts