Tag: M.W=100-150

Guo, Rui published the artcileBarbier-type anti-Diastereo- and Enantioselective Synthesis of β-Trimethylsilyl, Fluorinated Methyl, Phenylthio Homoallylic Alcohols, Recommanded Product: (E)-4,4,4-Trifluorobut-2-en-1-ol, the publication is Scientific Reports (2017), 7(1), 1-12, database is CAplus and MEDLINE.

Catalytic Asym. allylation of aldehydes with functionalized allylic reagents represents an important process in synthetic organic chem. because the resulting chiral homoallylic alcs. are valuable building blocks in diverse research fields. Despite the obvious advantages of allyl halides as allylation reagent under Barbier-type conditions, catalytic asym. version using functionalized allyl halides remains largely underdeveloped. Here, authors addressed this issue by employing a chromium-catalysis system. The use of readily available allyl bromides with γ substitutions including trimethylsilyl, fluorinated Me and phenylthio groups provided an efficient and convenient method to introduce those privileged functionalities into homoallylic alcs. Good yields, high anti-diastereo- and excellent enantioselectivities were achieved under mild reaction conditions.

Scientific Reports published new progress about 83706-94-9. 83706-94-9 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethylated Building Blocks, name is (E)-4,4,4-Trifluorobut-2-en-1-ol, and the molecular formula is C4H5F3O, Recommanded Product: (E)-4,4,4-Trifluorobut-2-en-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Guo, Dengkang published the artcileModification mechanism of plantation wood via grafting epoxy monomers onto cell walls, Computed Properties of 645-56-7, the publication is Wood Science and Technology (2022), 56(3), 813-831, database is CAplus.

The range of application for fast-growing plantation wood is limited by its dimensional instability, susceptibility to biodegradation and low mech. strength. In this study, a novel method based on in situ reaction of a hydrophilic epoxy monomer (1,4-butanediol diglycidyl ether) in the wood cell walls was proposed to improve the performance of plantation wood. The effects of curing agent on the reaction mechanism and performance of treated wood were discussed in detail. The results demonstrated that after curing using Me hexahydro phthalic anhydride (MHHPA), an epoxy oligomer with a higher mol. weight and superior water resistance was formed inside the wood cell wall compared to curing with the 2-methylimidazole (2-MI). Moreover, the epoxy group was able to react with alc. and phenolic hydroxyl in wood through 2-MI catalysis resulting in a higher grafting ratio. After the modification reaction, notable improvements were observed in the dimensional stability (anti-swelling efficiency of more than 65%), fungal (Gloeophyllum trabeum) decay resistance (weight loss of < 6%) and compressive strength (increased by 17%) of the wood.

Wood Science and Technology published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C9H12O, Computed Properties of 645-56-7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chen, Ting-Sheng published the artcileEffects of mesopore introduction on the stability of zeolites for 4-iso-Propylphenol dealkylation, Name: 4-Propylphenol, the publication is Catalysis Today (2021), 40-49, database is CAplus.

Low rank coal- and biomass-derived liquids generally contain a mixture of alkylphenols, which can be dealkylated over zeolites into phenol as a basic chem. Zeolites with different pore structures were evaluated for the dealkylation of 4-iso-propylphenol as a model alkylphenol, among which HZSM-5 and HMCM-22 displayed the highest phenol selectivity above 96%. However, HZSM-5 deactivated fastest among the catalysts due to coke deposition. Thus, mesopores were introduced by desilication into HZSM-5 catalysts to improve the catalytic stability. The mesopore incorporation enhanced the connectivity of the micropores with the crystal surface, and shortened the diffusion lengths. Coke location anal. revealed that micropore occlusion by the coke shell occurred on the parent HZSM-5, whereas the acid sites in the desilicated catalysts were more accessible for fully utilization, even though the coke mainly deposited in the micropores. Furthermore, the coke on the desilicated HZSM-5 displayed a lower graphitization degree.

Catalysis Today published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C9H12O, Name: 4-Propylphenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Cao, Jilei published the artcileMetal-free hydrogen evolution cross-coupling enabled by synergistic photoredox and polarity reversal catalysis, Computed Properties of 597-52-4, the publication is Green Chemistry (2021), 23(22), 8988-8994, database is CAplus.

A synergistic combination of photoredox and polarity reversal catalysis enabled a hydrogen evolution cross-coupling of silanes with H₂O, alcs., phenols, and silanols, which afforded the corresponding silanols, monosilyl ethers, and disilyl ethers, resp., in moderate to excellent yields. The dehydrogenative cross-coupling of Si-H and O-H proceeded smoothly with broad substrate scope and good functional group compatibility in the presence of only an organophotocatalyst 4-CzIPN and a thiol HAT catalyst, without the requirement of any metals, external oxidants and proton reductants, which is distinct from the previously reported photocatalytic hydrogen evolution cross-coupling reactions where a proton reduction cocatalyst such as a cobalt complex is generally required. Mechanistically, a silyl cation intermediate is generated to facilitate the cross-coupling reaction, which therefore represents an unprecedented approach for the generation of silyl cation via visible-light photoredox catalysis.

Green Chemistry published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C6H16OSi, Computed Properties of 597-52-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Jaumaux, Pauline published the artcileLocalized Water-In-Salt Electrolyte for Aqueous Lithium-Ion Batteries, Name: Pentane-1,5-diol, the publication is Angewandte Chemie, International Edition (2021), 60(36), 19965-19973, database is CAplus and MEDLINE.

Water-in-salt (WIS) electrolytes using super-concentrated organic lithium (Li) salts are of interest for aqueous Li-ion batteries. However, the high salt cost, high viscosity, poor wettability, and environmental hazards remain a great challenge. Herein, we present a localized water-in-salt (LWIS) electrolyte based on low-cost lithium nitrate (LiNO₃) salt and 1,5-pentanediol (PD) as inert diluent. The addition of PD maintains the solvation structure of the WIS electrolyte, improves the electrolyte stability via hydrogen-bonding interactions with water and NO₃^– mols., and reduces the total salt concentration By in situ gelling the LWIS electrolyte with tetraethylene glycol diacrylate (TEGDA) monomer, the electrolyte stability window can be further expanded to 3.0 V. The as-developed Mo₆S₈|LWIS gel electrolyte|LiMn₂O₄ (LMO) batteries delivered outstanding cycling performance with an average Coulombic efficiency of 98.53% after 250 cycles at 1 C.

Angewandte Chemie, International Edition published new progress about 111-29-5. 111-29-5 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ploymers, name is Pentane-1,5-diol, and the molecular formula is C5H12O2, Name: Pentane-1,5-diol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Li, Jun published the artcileSynthesis, properties and drug potential of the photosensitive alkyl- and alkylsiloxy-ligated silicon phthalocyanine Pc 227, SDS of cas: 597-52-4, the publication is Photochemical & Photobiological Sciences (2014), 13(12), 1690-1698, database is CAplus and MEDLINE.

The photosensitive, alkyl- and alkylsiloxy-ligated Si phthalocyanine, SiPc[(CH₂)₃SH][OSiMe₂(CH₂)₃NMe₂], Pc 227, was prepared and characterized. This phthalocyanine yields the exptl. photodynamic therapy (PDT) drug Pc 4, SiPc[OH][OSiMe₂(CH₂)₃NMe₂], when irradiated with red light. To provide an understanding of the process by which Pc 227 and other alkyl-alkylsiloxysilicon phthalocyanines such as Pc 227 are photolyzed, bond dissociation energy, natural bond orbital (NBO) charge distribution, spin d. distribution, nucleus-independent chem. shift (NICS), and electron localization function (ELF) calculations were carried out on two models related to it. These show that the lowest energy pathway for the photolysis of Pc 227 is a homolysis involving a phthalocyanine π radical having a low Si_Pc-C bond dissociation energy. The promise of the results of this study for synthetic chem. and drug development is discussed.

Photochemical & Photobiological Sciences published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C6H16OSi, SDS of cas: 597-52-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Qi, Xiao-ru published the artcileAnalysis on phenolic compounds and aroma components in four kinds of fruit concentrated juice, Safety of Triethylsilanol, the publication is Shipin Keji (2018), 43(2), 279-285, database is CAplus.

In 4 different kinds of fruit concentrated juice as raw materials, using high performance liquid chromatog. (HPLC) and gas chromatog. mass spectrometry (GC-MS) determination of the content of the 12 monomer phenols and aromatic components, and then analyzes the characteristics of 4 kinds of phenolic substances in fruit concentrated juice and aroma components. HPLC anal. results showed that the total amount of monomeric phenols in the concentrated red jujube juice was the highest, up to 17.6847 mg/L. Followed by concentrated hawthorn juice, the content of 16.4618 mg/L. The concentrated grape juice was 5.5437 mg/L, the concentrated red jujube juice treated with decoloration and deacidification was 4.4181 mg/L. GC-MS anal. results showed that 102 kinds of aroma compounds were detected from 4 kinds of concentrated juice, including 29 kinds of concentrated grape juice, 23 kinds of decolorization and deacidifica concentrated jujube juice, 51 kinds of concentrated hawthorn juice and 53 kinds of common concentrated red date juice, the experiments provided a theor. basis for the evaluation of the quality of the concentrated juice.

Shipin Keji published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C6H16OSi, Safety of Triethylsilanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Meng, Qinglei published the artcileSustainable production of benzene from lignin, Category: alcohols-buliding-blocks, the publication is Nature Communications (2021), 12(1), 4534, database is CAplus and MEDLINE.

Benzene is a widely used commodity chem., which is currently produced from fossil resources. Lignin, a waste from lignocellulosic biomass industry, is the most abundant renewable source of benzene ring in nature. Efficient production of benzene from lignin, which requires total transformation of Csp2-Csp3/Csp2-O into C-H bonds without side hydrogenation, is of great importance, but has not been realized. Here, we report that high-silica HY zeolite supported RuW alloy catalyst enables in situ refining of lignin, exclusively to benzene via coupling Bronsted acid catalyzed transformation of the Csp2-Csp3 bonds on the local structure of lignin mol. and RuW catalyzed hydrogenolysis of the Csp2-O bonds using the locally abstracted hydrogen from lignin mol., affording a benzene yield of 18.8% on lignin weight basis in water system. The reaction mechanism is elucidated in detail by combination of control experiments and d. functional theory calculations The high-performance protocol can be readily scaled up to produce 8.5 g of benzene product from 50.0 g lignin without any saturation byproducts. This work opens the way to produce benzene using lignin as the feedstock efficiently.

Nature Communications published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C9H12O, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Guo, Liulong published the artcileHyperbranched Polyborate: A Non-conjugated Fluorescent Polymer with Unanticipated High Quantum Yield and Multicolor Emission, Synthetic Route of 111-29-5, the publication is Angewandte Chemie, International Edition (2022), 61(29), e202204383, database is CAplus and MEDLINE.

Non-conjugated fluorescent polymers have attracted great attention due to their excellent biocompatibility and environmental friendliness. However, it remains a huge challenge to obtain a polymer with high fluorescence quantum yield (QY) and multicolor emission simultaneously. Herein, we reported three kinds of nonaromatic hyperbranched polyborates (P1-P3) with multicolor emission, surprisingly, P2 also exhibits an unanticipated high QY (54.1%). The natural bond orbital (NBO) anal. and d. functional theory (DFT) calculation results revealed that the synergistic effect of rigid BO₃ planar and flexible carbon chain, as well as the through-space dative bond in supramol. aggregate, were the key factors contributing to the ultrahigh QY of P2. Moreover, the applications of P2 in Fe³⁺ ions detection and cell imaging were also investigated. This work provides a new perspective for designing non-conjugated fluorescent polymers with both high QY and multicolor emission.

Angewandte Chemie, International Edition published new progress about 111-29-5. 111-29-5 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ploymers, name is Pentane-1,5-diol, and the molecular formula is C5H12O2, Synthetic Route of 111-29-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yu, Qian published the artcileSynthesis, cytotoxicity and structure-activity relationship of indolizinoquinolinedione derivatives as DNA topoisomerase IB catalytic inhibitors, Category: alcohols-buliding-blocks, the publication is European Journal of Medicinal Chemistry (2018), 195-207, database is CAplus and MEDLINE.

A series of indolizinoquinolinedione derivatives I [X₁ = N; X₂ = X₃ = X₄ = CH; n = 2, 3; R¹ = H, F, Cl; R² = NMe₂, pyrrolidinyl, piperidinyl, morpholinyl, 4-methylpiperazinyl] and II [R3 = NMe₂, pyrrolidinyl, piperidinyl, morpholinyl] was synthesized. TOP1-mediated relaxation, nicking and unwinding assays revealed that three fluorinated derivatives I [X₁ = N; X₂ = X₃ = X₄ = CH; n = 2, 3; R¹ = F; R² = pyrrolidinyl, piperidinyl] and one N,N-trans derivative I [X₁ = X₂ = X₃ = CH; X₄ = N; n = 2; R² = morpholinyl] act as TOP1 catalytic inhibitors with higher TOP1 inhibition (++++) than camptothecin (+++) and without TOP1-mediated unwinding effect. MTT assay against five human cancer cell lines indicated that the highest cytotoxicity was II [R³ = piperidinyl] for CCRF-CEM cells, I [X₁ = N; X₂ = X₃ = X₄ = CH; n = 3; R¹ = F; R² = NMe2] for A549 and DU-145 cells, I [X₁ = N; X₂ = X₃ = X₄ = CH; n = 2; R¹ = F; R² = pyrrolidinyl] for HCT116 cells, and I [X₁ = N; X₂ = X₃ = X₄ = CH; n = 3; R¹ = F; R² = 4-methylpiperazinyl] for Huh7 cells with GI₅₀ values at nanomolar range. The drug-resistant cell assay indicated that compound I [X₁ = N; X₂ = X₃ = X₄ = CH; n = 2; R¹ = F; R² = pyrrolidinyl] may mainly act to TOP1 in cells and was less of Pgp substrates. Flow cytometric anal. showed that compounds I [X₁ = N; X₂ = X₃ = X₄ = CH; n = 2, 3; R¹ = F; R² = pyrrolidinyl, piperidinyl] could obviously induce apoptosis of HCT116 cells. Moreover, the structure-activity relationship (SAR) of indolizinoquinolinedione derivatives was analyzed.

European Journal of Medicinal Chemistry published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C20H21ClN4O4, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts