Tag: M.W=100-150

Xiao, Qian published the artcileDirecting-Group-Assisted Markovnikov-Selective Hydrothiolation of Styrenes with Thiols by Photoredox/Cobalt Catalysis, Safety of 2-Phenylethanethiol, the publication is Organic Letters (2021), 23(9), 3604-3609, database is CAplus and MEDLINE.

In contrast with the well-developed radical thiol-ene reaction to access anti-Markovnikov-type products, the research on the catalytic Markovnikov-selective hydrothiolation of alkenes is very restricted. Because of the catalyst poisoning of metal catalysts by organosulfur compounds, limited examples of transition-metal-catalyzed thiol-ene reactions have been reported. However, in this work, a directing-group-assisted hydrothiolation of styrenes with thiols by photoredox/cobalt catalysis is found to proceed smoothly to afford Markovnikov-type sulfides with excellent regioselectivity.

Organic Letters published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H10S, Safety of 2-Phenylethanethiol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Guo, Xuan published the artcileHydro-deoxygenation at atmospheric pressure converts the phenolic-rich pyrolysis liquid fraction into aromatics, Synthetic Route of 645-56-7, the publication is Journal of Environmental Management (2022), 114429, database is CAplus and MEDLINE.

Ambient pressure hydro-deoxygenation (HDO) of the phenolic-rich pyrolysis liquid fraction is a complex task due to the presence multiple phenolic compounds and light oxygenates. The phenolic-rich fraction differs from the overall pyrolysis liquid, known to be prone to re-polymerization and coking in the reactor or of the catalyst. In the present research, hydro-deoxygenation of oxygen-containing compounds in the phenolic fraction over Mo-based catalysts was carried out for the first time. It was found that Mo-based catalysts can successfully upgrade the phenolics into aromatics, the conversion rate was nearly 100%. The small amount of light oxygenates in the phenolic-rich fraction had no obvious effect on the hydro-deoxygenation reaction, the phenolic conversion was more than 95%. After assessing the performance for a representative phenolic model compound, the reaction was also successfully carried out on the phenolic fraction of the real pyrolysis liquid It can be concluded that the catalysts can also be used for the HDO of the real pyrolysis liquid fraction at atm. pressure.

Journal of Environmental Management published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C9H12O, Synthetic Route of 645-56-7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Jiao, Yang published the artcileA cofactor-substrate-based supramolecular fluorescent probe for the ultrafast detection of nitroreductase under hypoxic Conditions, Quality Control of 622-40-2, the publication is Angewandte Chemie, International Edition (2020), 59(15), 6021-6027, database is CAplus and MEDLINE.

Identifying the location and expression levels of enzymes under hypoxic conditions in cancer cells is vital in early-stage cancer diagnosis and monitoring. By encapsulating a fluorescent substrate, L-NO₂, within the NADH mimic-containing metal-organic capsule Zn-MPB, we developed a cofactor-substrate-based supramol. luminescent probe for ultrafast detection of hypoxia-related enzymes in solution in vitro and in vivo. The host-guest structure fuses the coenzyme and substrate into one supramol. probe to avoid control by NADH, switching the catalytic process of nitroreductase from a double-substrate mechanism to a single-substrate one. This probe promotes enzyme efficiency by altering the substrate catalytic process and enhances the electron transfer efficiency through an intra-mol. pathway with increased activity. The enzyme content and fluorescence intensity showed a linear relationship and equilibrium was obtained in seconds, showing potential for early tumor diagnosis, biomimetic catalysis, and prodrug activation.

Angewandte Chemie, International Edition published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C6H13NO2, Quality Control of 622-40-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Xue, Si-tu published the artcileSubstituted benzothiophene and benzofuran derivatives as a novel class of bone morphogenetic protein-2 upregulators: Synthesis, anti-osteoporosis efficacies in ovariectomized rats and a zebrafish model and ADME properties, Computed Properties of 622-40-2, the publication is European Journal of Medicinal Chemistry (2020), 112465, database is CAplus and MEDLINE.

This study optimized the structure of the anti-osteoporosis compound I [R¹ = H; R² = OMe; R⁵ = OEt; X = O] by balancing its lipophilicity and improving its stability. Substituted benzothiophenes/benzofurans derivatives I [R¹ = H; R² = OMe; R¹R² = OCH₂O; R⁵ = Cl, OH, OEt; X = O, S] and II [R¹ = H; R² = OMe; R¹R² = OCH₂O; R³ = n-Pr, P(O)(OH)₂, CH₂N(CH₃)₂, etc.; X = O, S; Y = O, NH, NMe] which were not reported in the literature were designed and synthesized. The ovariectomized rat model of osteoporosis was selected to evaluate the therapeutic effects, compound II [R¹ = H; R² = OMe; R³ = CH₂N(CH₃)₂, etc.; X = O; Y = NH] showed better therapeutic efficacy than that of compound I [R¹ = H; R² = OMe; R⁵ = OEt; X = O]. The anti-osteoporosis activity and BMP-2 (bone morphogenetic protein-2) protein upregulation after treatment with compound II [R¹ = H; R² = OMe; R³ = CH₂N(CH₃)₂, etc.; X = O; Y = NH] in a zebrafish osteoporosis model was verified. Compound II [R¹ = H; R² = OMe; R³ = CH₂N(CH₃)₂, etc.; X = O; Y = NH] improved the ADME properties, therapeutic efficacy and pharmacokinetics of the drug than that of compound I [R¹ = H; R² = OMe; R⁵ = OEt; X = O]. Overall, the anti-osteoporosis effects of the compounds I and II of this type, preliminarily determined the target patient population, verified the mechanism of action, clarified the level of toxicity and provided preliminary ADME data was evaluated. These compounds I and II could both correct bone loss that was already occurring in patients and had broad clin. applicability.

European Journal of Medicinal Chemistry published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C6H4ClNO2, Computed Properties of 622-40-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Li, Dan published the artcileDesymmetrization Process by Mg(II)-Catalyzed Intramolecular Vinylogous Michael Reaction, Recommanded Product: 4-Propylphenol, the publication is Organic Letters (2020), 22(23), 9229-9233, database is CAplus and MEDLINE.

Chiral magnesium catalyzed intramol. vinylogous Michael reaction of novel cyclohexadienones via a desymmetrization process is reported. (R)-BINOL derived ligand and an achiral amide were employed in the current in situ generated magnesium catalyst, giving the corresponding hydrogenated benzofuranone skeletons in good to excellent enantioselectivities with high yields. This simple and efficient strategy could be utilized for the synthesis of aromatized α,β-unsaturated ester and Br-substituted hydrogenated benzofuranone in good yields under mild conditions.

Organic Letters published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C9H12O, Recommanded Product: 4-Propylphenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wen, Shang-Pin published the artcileRAFT miniemulsion polymerisation of benzyl methacrylate using non-ionic surfactant, Formula: C8H10S, the publication is Polymer Chemistry (2021), 12(14), 2122-2131, database is CAplus.

Miniemulsion polymerization has become widely recognized as a versatile and efficient strategy to prepare well-defined polymer latexes. In this article, we report the synthesis of poly(benzyl methacrylate) (PBzMA) latexes via reversible addition-fragmentation chain-transfer (RAFT) mediated miniemulsion polymerization using non-ionic Lutensol TO 20 surfactant. The influence of hydrophobe, initiator, and RAFT agent on particle diameter, particle number, rate of polymerization, and molar mass were investigated systematically. In all cases well-controlled RAFT polymerizations were observed, as indicated by kinetic studies and GPC anal. Higher concentrations of hexadecane lead to an increase in the of number of particles per unit volume and a decrease in PBzMA latex diameter The rate of polymerization with respect to initiator concentration follows a power-law relationship R_p α [initiator]^1/2 but only negligible differences in molar mass, molar mass dispersity, and particle diameter values were observed for a range of initiator concentrations Targeting lower PBzMA degrees of polymerization increases the overall rate of polymerization and latex diameter

Polymer Chemistry published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C21H20BrNO4S, Formula: C8H10S.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Jeon, Minseok published the artcileStereoselective Synthesis of Cyclohexane Derivatives: Tandem Lithium Iodide Mediated Intramolecular Conjugate Addition of Thiols to α,β-Bisenones, Synthetic Route of 4410-99-5, the publication is Synthesis (2022), 54(12), 2865-2875, database is CAplus.

A tandem intramol. conjugate addition reaction was conducted with α,β-bisenones as selected Michael acceptors which were converted into 1,2,3-trisubstituted six-membered rings in the presence of activated sulfur nucleophiles. The products were obtained in good to excellent yields (maximum yield: 99%). Various substituted α,β-bisenones and sulfur nucleophiles were examined to understand the substrate scope of the reaction. Only one diastereomer was isolated, as lithium iodide mediated enolate trapping reactions improve the stereoselectivity of reactions involving 1,2,3-trisubstituted cyclohexanes.

Synthesis published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H10S, Synthetic Route of 4410-99-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gudun, Kristina A. published the artcileCobalt-Catalyzed Deoxygenative Hydroboration of Nitro Compounds and Applications to One-Pot Synthesis of Aldimines and Amides, Category: alcohols-buliding-blocks, the publication is Advanced Synthesis & Catalysis (2022), 364(3), 601-611, database is CAplus.

The com. available and bench-stable Co(acac)₂ ligated with bis[(2-diphenylphosphino)phenyl] ether (dpephos) was employed for selective room temperature hydroboration of nitro compounds with HBPin (TOF up to 4615 h^-1), tolerating halide, hydroxy, amino, ether, ester, lactone, amide and heteroaromatic functionalities. These reactions offered a direct access to a variety of N-borylamines RN(H)BPin, which were in situ treated with aldehydes and carboxylic acids to produce a series of aldimines and secondary carboxamides without the need for dehydrating and/or coupling reagents. Combination of these transformations in a sequential one-pot manner allowed for direct and selective synthesis of aldimines and secondary carboxamides from readily available and inexpensive nitro compounds

Advanced Synthesis & Catalysis published new progress about 25240-59-9. 25240-59-9 belongs to alcohols-buliding-blocks, auxiliary class Boronic acid and ester,Boronic Acids,Boronate Esters, name is 4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-ol, and the molecular formula is C6H13BO3, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Anderson, Ryan T. published the artcileDirect Conversion of Hydride- to Siloxane-Terminated Silicon Quantum Dots, Related Products of alcohols-buliding-blocks, the publication is Journal of Physical Chemistry C (2016), 120(45), 25822-25831, database is CAplus.

Peripheral surface functionalization of hydride-terminated silicon quantum dots (SiQD) is necessary in order to minimize their oxidation/aggregation and allow for solution processability. Historically thermal hydrosilylation addition of alkenes and alkynes across the Si-H surface to form Si-C bonds has been the primary method to achieve this. The authors demonstrate a mild alternative approach to functionalize hydride-terminated SiQDs using bulky silanols in the presence of free-radical initiators to form stable siloxane (∼Si-O-SiR₃) surfaces with hydrogen gas as a byproduct. This offers an alternative to existing methods of forming siloxane surfaces that require corrosive Si-Cl based chem. with HCl byproducts. A 52 nm blue shift in the photoluminescent spectra of siloxane vs. alkyl-functionalized SiQDs is observed that we explain using computational theory. Model compound synthesis of silane and silsesquioxane analogs is used to optimize surface chem. and elucidate reaction mechanisms. Thorough characterization on the extent of siloxane surface coverage is provided using FTIR and XPS. TEM is used to demonstrate SiQD size and integrity after surface chem. and product isolation.

Journal of Physical Chemistry C published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C6H16OSi, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Rajesh, Sarigama published the artcileSynthetic ionizable aminolipids induce a pH dependent inverse hexagonal to bicontinuous cubic lyotropic liquid crystalline phase transition in monoolein nanoparticles, Recommanded Product: 2-Morpholinoethanol, the publication is Journal of Colloid and Interface Science (2021), 85-95, database is CAplus and MEDLINE.

A prospective class of materials for drug delivery is lyotropic liquid crystalline (LLC) nanoparticles, such as cubosomes and hexosomes. Efforts are being made to generate a pH dependent system, which exhibits slow release hexosomes (H2) at physiol. pH and relatively fast release cubosomes (Q2) at acidic disease sites such as in various cancers and bacterial infection (pH ∼ 5.5-6.5). Herein, we report the synthesis of nine ionizable aminolipids, which were doped into monoolein (MO) lipid nanoparticles. Using high throughput formulation and synchrotron small angle X-ray scattering (SAXS), the effects of aminolipid structure and concentration on the mesophase of MO nanoparticles at various pHs were determined As the pH changed from neutral to acidic, mesophases, could be formed in an order L2 (inverse micelles) → H2 → Q2. Specifically, systems with heterocyclic oleates exhibited the H2 to Q2 transition at pH 5.5-6.5. Furthermore, the phase transition pH could be fine-tuned by incorporating two aminolipids into the nanoparticles. Nanoparticles with a pH dependent phase transition as described in this study may be useful as drug delivery carriers for the treatment of cancers and certain bacterial infection.

Journal of Colloid and Interface Science published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C6H13NO2, Recommanded Product: 2-Morpholinoethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts