Tag: M.W=100-150

Wong, S. published the artcileCatalysis in competing isocyanate reactions, HPLC of Formula: 2212-32-0, the main research area is butanol phenylisocyanate reaction model polyurethane; chromatog butanol phenylisocyanate reaction; catalysis isocyanate reaction; water phenylisocyanate reaction model polyurethane.

High-performance liquid chromatog. was used to determine the products given by the reaction of phenyl isocyanate  [103-71-9] with butanol  [71-36-3], and the reaction was a model for the main and side reactions occurring in the preparation of polyurethanes. The reaction in the presence of dibutyltin dilaurate  [77-58-7] gave only Bu N-phenylcarbamate (I) [1538-74-5], but PhNHCONPhCO2Bu [21367-12-4] was detected in very early stages of the reaction. The reaction in the presence of N,N’,N”-tris(3-dimethylaminopropyl)hexahydrotriazine  [15875-13-5] gave I and N,N’,N”-triphenylisocyanurate (II) [1785-02-0] simultaneously, but the reaction in the presence of N,N,N’-trimethylaminoethyl ethanolamine  [2212-32-0] gave I and II in sequence. The reaction of Ph isocyanate with water gave mainly PhNHCONHPh [26763-63-3], with 5% PhNHCONPhCO2Bu and PhNHCONPhCONHPh [2645-39-8].

Polymeric Materials Science and Engineering published new progress about Carbamoylation. 2212-32-0 belongs to class alcohols-buliding-blocks, name is N2-(2-Hydroxyethyl)-N1,N1,N2-trimethyl-1,2-ethylenediamine, and the molecular formula is C7H18N2O, HPLC of Formula: 2212-32-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Vazquez-Martinez, Olivia published the artcileMitochondrial Oxidation of the Cytoplasmic Reducing Equivalents at the Onset of Oxidant Stress in the Isoproterenol-Induced Rat Myocardial Infarction, Synthetic Route of 97-67-6, the main research area is myocardial infarction mitochondrial oxidation cytoplasm NADH oxidant stress; cardiac infarction; isoproterenol; malate-aspartate shuttle; oxidative stress; sequential alterations.

We have developed and characterized a model of isoproterenol (ISO)-induced myocardial necrosis, identifying three stages of cardiac damage: a pre-infarction (0-12 h), infarction (24 h), and post-infarction period (48-96 h). Using this model, we have previously found alterations in calcium homeostasis and their relationship with oxidant stress in mitochondria, which showed deficient oxygen consumption and coupled ATP synthesis. Therefore, the present study was aimed at assessing the mitochondrial ability to transport and oxidize cytoplasmic reducing equivalent (NADH), correlating the kinetic parameters of the malate-aspartate shuttle, oxidant stress, and mitochondrial functionality. Our results showed only discreet effects during the cardiotoxic ISO action on the endogenous malate-aspartate shuttle activity, suggesting that endogenous mitochondrial NADH oxidation capacity (Nohl dehydrogenase) was not affected by the cellular stress. On the contrary, the reconstituted system showed significant enhancement in maximal capacity of the malate-aspartate shuttle activity only at later times (post-infarction period), probably as a compensatory part of cardiomyocytes′ response to the metabolic and functional consequences of the infarcted tissue. Therefore, these findings support the notion that heart damage associated with myocardial infarction suffers a set of sequential biochem. and metabolic modifications within cardiomyocytes, where mitochondrial activity, controlling the redox state, could play a relevant role.

Antioxidants published new progress about Cardiac injury. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Synthetic Route of 97-67-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Norris, Marie K. published the artcileTutorial: Triheptanoin and Nutrition Management for Treatment of Long-Chain Fatty Acid Oxidation Disorders, Recommanded Product: (S)-2-hydroxysuccinic acid, the main research area is triheptanoin nutrition management treatment long chain fatty acid oxidation; anaplerotic; carnitine-acylcarnitine translocase deficiency; fatty acid oxidation disorder; medical nutrition therapy; triheptanoin; very long-chain acyl-CoA dehydrogenase deficiency.

Patients with severe long-chain fatty acid oxidation disorders (LC-FAODs) experience serious morbidity and mortality despite traditional dietary management including medium-chain triglyceride (MCT)-supplemented, low-fat diets. Triheptanoin is a triglyceride oil that is broken down to acetyl-CoA (CoA) and propionyl-CoA, which replenishes deficient tricarboxylic acid cycle intermediates. We report the complex medical and nutrition management of triheptanoin therapy initiated emergently for 3 patients with LC-FAOD. Triheptanoin (Ultragenyx Pharmaceutical, Inc, Novato, CA, USA) was administered to 3 patients with LC-FAOD on a compassionate-use basis. Triheptanoin was mixed with non-MCT-containing low-fat formula. Patients were closely followed with regular cardiac and laboratory monitoring. Cardiac ejection fraction normalized after triheptanoin initiation. Patients experienced fewer hospitalizations related to metabolic crises while on triheptanoin. Patient 1 has tolerated oral administration without difficulty since birth. Patients 2 and 3 experienced increased diarrhea. Recurrent breakdown of the silicone gastrostomy tube occurred in patient 3, whereas the polyurethane nasogastric tube for patient 2 remained intact. Patient 3 experiences recurrent episodes of elevated creatine kinase levels and muscle weakness associated with illness. Patient 3 had chronically elevated C10-acylcarnitines while on MCT supplementation, which normalized after initiation of triheptanoin and discontinuation of MCT oil. Triheptanoin can ameliorate acute cardiomyopathy and increase survival in patients with severe LC-FAOD. Substituting triheptanoin for traditional MCT-based treatment improves clin. outcomes. MCT oil might be less effective in carnitine-acylcarnitine translocase deficiency patients compared with other FAODs and needs further investigation.

JPEN, Journal of Parenteral and Enteral Nutrition published new progress about Cardiomyopathy. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Recommanded Product: (S)-2-hydroxysuccinic acid.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Prestes, Alessandro de Souza published the artcileMethylglyoxal disrupts the functionality of rat liver mitochondria, SDS of cas: 97-67-6, the main research area is liver mitochondria superoxide phosphorylation bioenergetics methylglyoxal; High-resolution respirometry; Methylglyoxal; Mitochondria; Oxidative stress.

Methylglyoxal (MG) is a reactive metabolite derived from different physiol. pathways. Its production can be harmful to cells via glycation reactions of lipids, DNA, and proteins. But, the effects of MG on mitochondrial functioning and bioenergetic responses are still elusive. Then, the effects of MG on key parameters of mitochondrial functionality were examined here. Isolated rat liver mitochondria were exposed to 0.1-10 mM of MG to determine its toxicity in the mitochondrial viability, membrane potential (Δψm), swelling and the superoxide (O·-2) production Besides, mitochondrial oxidative phosphorylation parameters were analyzed by high-resolution respiratory (HRR) assay. In this set of experiments, routine state, PM state (pyruvate/malate), oxidative phosphorylation (OXPHOS), LEAK respiration, electron transport system (ETS) and oxygen residual (ROX) states were evaluated. HRR showed that PM state, OXPHOS CI-Linked, LEAK respiration, ETS CI/CII-Linked and ETS CII-Linked/ROX were significantly inhibited by MG exposure. MG also inhibited the complex II activity, and decreased Δψm and the viability of mitochondria. Taken together, our data indicates that MG is an inductor of mitochondrial dysfunctions and impairs important steps of respiratory chain, effects that can alter bioenergetics responses.

Chemico-Biological Interactions published new progress about Cell viability. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, SDS of cas: 97-67-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hu, Kai published the artcileFruity aroma modifications in Merlot wines during simultaneous alcoholic and malolactic fermentations through mixed culture of S. cerevisiae, P. fermentans, and L. brevis, Safety of 3-(Methylthio)propan-1-ol, the main research area is alc malolactic fermentation Lactobacillus brevis Saccharomyces cerevisiae Pichia fermentans.

As a group of wine lactic acid bacteria, Lactobacillus has gained growing interest in malolactic fermentation due to possessing diverse aroma-related enzymes. In this study, a Lactobacillus brevis 26 with high β-glucosidase activity was isolated, and co-inoculated with yeasts (Saccharomyces cerevisiae and Pichia fermentans) to characterize fruity aroma modifications in Merlot wine. Compared with the traditional inoculation (sequential inoculation of L. brevis 26 after alc. fermentation by yeasts), co-inoculation of the three species induced simultaneous alc. and malolactic fermentations, leading to a pronounced reduction in total fermentation duration. P. fermentans increased L. brevis 26 cell viability when co-fermented with the predominant species S. cerevisiae. Meanwhile, the β-glucosidase activity of L. brevis 26 elevated terpene contents, and P. fermentans induced the production of higher alc. acetates and fatty acid Et esters. Sensory anal. showed that co-inoculation-based wines had enhanced complexity of fruity aroma profiles associated with jammy and temperate fruity notes.

LWT–Food Science and Technology published new progress about Cell viability. 505-10-2 belongs to class alcohols-buliding-blocks, name is 3-(Methylthio)propan-1-ol, and the molecular formula is C4H10OS, Safety of 3-(Methylthio)propan-1-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Pinheiro, Fernanda C. published the artcileDispersive liquid-liquid microextraction of Cd, Hg and Pb from medicines prior to ICP OES determination according to the United States Pharmacopeia, Application In Synthesis of 111-87-5, the main research area is cadmium mercury lead tablet dispersive liquid microextraction ICPOES.

A simple, sensitive and matrix-effect free anal. method for simultaneous determination of Cd, Hg and Pb in drug samples (i.e., com. dosage tablets) by inductively coupled plasma optical emission spectrometry (ICP OES) has been developed. According to the USP (USP) Chapter 232, those metals are considered elemental impurities from class 1 and they must be assessed in pharmaceutical production as well as in quality control evaluation. In order to increase the sensitivity of the anal., dispersive liquid-liquid microextraction (DLLME) was performed and seven factors affecting analyte extraction were optimized by multivariate anal. A microvolume of analyte enriched phase was directly introduced into the plasma using a multi-nebulizer, providing a high enrichment factor. When compared to conventional ICP OES anal., DLLME improves the limit of quantitation (LOQ) values on average 40-fold for all analytes. Consequently, LOQ values were significantly lower than their permissible daily exposure limits for oral drugs. Accuracy was evaluated by addition and recovery experiments following USP recommendations in eight com. drug samples. Recovery and RSD values were within the range of 90-108% and 1-9%, resp.

Analytical Methods published new progress about Centrifugation. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Application In Synthesis of 111-87-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Gomez, Sara published the artcileA molecular twist on hydrophobicity, COA of Formula: C8H18O, the main research area is organic solvent water binary system mol twist hydrophobicity.

A thorough exploration of the mol. basis for hydrophobicity with a comprehensive set of theor. tools and an extensive set of organic solvent S/water binary systems is discussed in this work. Without a single exception, regardless of the nature or structure of S, all quantum descriptors of bonding yield stabilizing S···water interactions, therefore, there is no evidence of repulsion and thus no reason for etymol. hydrophobicity at the mol. level. Our results provide mol. insight behind the exclusion of S mols. by water, customarily invoked to explain phase separation and the formation of interfaces, in favor of a complex interplay between entropic, enthalpic, and dynamic factors. S···water interfaces are not just thin films separating the two phases; instead, they are non-isotropic regions with d. gradients for each component whose macroscopic stability is provided by a large number of very weak dihydrogen contacts. We offer a definition of interface as the region in which the d. of the components in the A/B binary system is not constant At a fundamental level, our results contribute to better current understanding of hydrophobicity.

Chemical Science published new progress about Binary systems. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, COA of Formula: C8H18O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhao, Jianjian published the artcileArene-perfluoroarene interaction induced chiroptical inversion and precise ee% detection of chiral acids in a benzimidazole-involved ternary coassembly, Name: (S)-2-hydroxysuccinic acid, the main research area is pyrenecarboxylate octafluoronaphthalene hydrogen bond chiral recognition CD.

Flexible regulation of chirality and handedness of chiral functional materials and quant. sensing of natural chiral compounds remains a considerable challenge. Herein, an achiral fluorescent 1-pyrenecarboxylic acid-benzimidazole derivative (PBI) was synthesized and its chiroptical properties upon coassembly with chiral acids (TA and MA) and octafluoronaphthalene (OFN) through hydrogen bonds between benzimidazole and chiral acids as well as an arene-perfluoroarene (AP) interaction between a pyrene moiety and OFN were systemically studied. The binary assemblies of PBI/TA and PBI/MA displayed opposite chiroptical properties including CD and circularly polarized luminescence (CPL) signals. Interestingly, the handedness of CPL was further inverted in ternary assemblies due to the synergistic effect of the AP interaction and hydrogen bonds. Besides, the highly accurate chiral sensing of chiral acids via binary assemblies was successfully achieved with a high correlation coefficient This work provides a simple method for regulating the handedness of chiroptical active materials and quant. sensing of chiral acids through orthogonal multiple component coassemblies.

Nanoscale published new progress about Binary systems. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Name: (S)-2-hydroxysuccinic acid.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Srivastava, Ashutosh published the artcileDeep eutectic solvents based on imidazolium cation and probing redox speciation of uranium oxides by electrochemical and theoretical simulation, Recommanded Product: 2,2′-Oxydiacetic acid, the main research area is imidazolium deep eutectic solvent electrochem thermogravimetric mol dynamics.

Two new deep eutectic solvents, different from hitherto known and based on common choline chloride, were prepared 1-methyl-3-decylimidazolium bromide mixed with hydrogen bond donors, malonic acid and diglycolic acid to form DES. Dissolution of uranium oxides (UO3 and UO2) was explored in both of them and characterization of the resultant solutions was carried out by IR, TGA and UV-Vis spectroscopy. Redox speciation of dissolved uranium oxides was probed in these redox-active DES through cyclic voltammetry, differential pulse voltammetry and in situ spectroelectrochem. measurements. Interestingly, the formation of uranium oxo species was observed through the dissolution of UO3 in both the DES. The electrochem. characteristics via redox thermodn. (peak potential and formal redox potential), transport property (diffusion coeffecient D0), heterogeneous electron transfer kinetic parameters (αn and k0) and mechanistic electron transfer of the dissolved uranium species in two DES were investigated. The speciation of uranium was decoded through the electronic absorption spectra of uranium in its lower oxidation states [U(V) and U(IV)] acquired through in situ spectroelectrochem. electrolysis with varying cathodic potentials. Studies were also carried out using mol. dynamics (MD) and d. functional theory (DFT) simulations to authenticate the electrochem. outcomes and to acquire the binding energy, optimized structure and MO diagram of dissolved uranium species. Further, the MD simulation sheds light on the probable equatorial coordinating atoms of dissolved uranium species. This is the first report, to the best of our knowledge, on imidazolium-based DES and actinide ions.

Journal of Electroanalytical Chemistry published new progress about Binding energy. 110-99-6 belongs to class alcohols-buliding-blocks, name is 2,2′-Oxydiacetic acid, and the molecular formula is C4H6O5, Recommanded Product: 2,2′-Oxydiacetic acid.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Pakrieva, E. published the artcileGreen Oxidation of n-octanol on Supported Nanogold Catalysts: Formation of Gold Active Sites under Combined Effect of Gold Content, Additive Nature and Redox Pretreatment, Safety of n-Octanol, the main research area is green oxidation n octanol supported nanogold catalyst gold pretreatment.

The combined influence of gold content (0.5 or 4 weight %), modifying additives (La or Ce oxides) and redox pretreatments (H2 or O2) on catalytic properties and formation of active sites of Au/TiO2 in the selective oxidation of n-octanol under mild conditions was studied. Samples were characterized by BET, XRD, EDX, ICP, TEM, STEM-HAADF, CO2-TPD, H2-TPR and XPS methods. The order of catalytic activity depended on the support nature for all treated samples, as follows: Au/La2O3/TiO2>Au/CeO2/TiO2>Au/TiO2. The catalytic activity enhanced with the increase of gold loading in the samples with hydrogen pretreatment, while after the oxidative pretreatment of the catalysts the opposite dependence of the activity with the gold content was found. This catalytic behavior was explained by a change in the surface concentration of monovalent gold ions, which seemed to be the active sites. The most active catalyst, 0.5 % Au/La2O3/TiO2, pretreated in oxidative atm., had the highest surface concentration of monovalent gold ions.

ChemCatChem published new progress about Binding energy. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Safety of n-Octanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts