Tag: M.W=100-150

Xue, Mingshan published the artcileMetabolomic profiling of anaerobic and aerobic energy metabolic pathways in chronic obstructive pulmonary disease, Computed Properties of 97-67-6, the main research area is human chronic obstructive pulmonary disease metabolomics; Chronic obstructive pulmonary disease; anaerobic glycolysis; energy metabolism cycle; metabolomics; tricarboxylic acid cycle.

While there is no cure for chronic obstructive pulmonary disease (COPD), its progressive nature and the formidable challenge to manage its symptoms warrant a more extensive study of the pathogenesis and related mechanisms. A new emphasis on COPD study is the change of energy metabolism For the first time, this study investigated the anaerobic and aerobic energy metabolic pathways in COPD using the metabolomic approach. Metabolomic anal. was used to investigate energy metabolites in 140 COPD patients. The significance of energy metabolism in COPD was comprehensively explored by the Global Initiative for Chronic Obstructive Lung Disease-GOLD grading, acute exacerbation vs. stable phase (either clin. stability or four-week stable phase), age group, smoking index, lung function, and COPD Assessment Test (CAT) score. Through comprehensive evaluation, we found that COPD patients have a significant imbalance in the aerobic and anaerobic energy metabolisms in resting state, and a high tendency of anaerobic energy supply mechanism that correlates pos. with disease progression. This study highlighted the significance of anaerobic and low-efficiency energy supply pathways in lung injury and linked it to the energy-inflammation-lung ventilatory function and the motion limitation mechanism in COPD patients, which implies a novel therapeutic direction for this devastating disease.

Experimental Biology and Medicine (London, United Kingdom) published new progress about Aging, animal. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Computed Properties of 97-67-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Halling, Jens Frey published the artcilePGC-1α regulates mitochondrial properties beyond biogenesis with aging and exercise training, Category: alcohols-buliding-blocks, the main research area is PGC biogenesis aging exercise training mitochondrial property; ADP sensitivity; PGC-1α; ROS; aging; exercise; mitochondria.

Impaired mitochondrial function has been implicated in the pathogenesis of age-associated metabolic diseases through regulation of cellular redox balance. Exercise training is known to promote mitochondrial biogenesis in part through induction of the transcriptional coactivator peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α). Recently, mitochondrial ADP sensitivity has been linked to reactive oxygen species (ROS) emission with potential impact on age-associated physiol. outcomes, but the underlying mol. mechanisms remain unclear. Therefore, the present study investigated the effects of aging and exercise training on mitochondrial properties beyond biogenesis, including respiratory capacity, ADP sensitivity, ROS emission, and mitochondrial network structure, in myofibers from inducible muscle-specific PGC-1a- knockout mice and control mice. Aged mice displayed lower running endurance and mitochondrial respiratory capacity than young mice. This was associated with intermyofibrillar mitochondrial network fragmentation, diminished submaximal ADP-stimulated respiration, increased mitochondrial ROS emission, and oxidative stress. Exercise training reversed the decline in maximal respiratory capacity independent of PGC-1α, whereas exercise training rescued the age-related mitochondrial network fragmentation and the impaired submaximal ADP-stimulated respiration in a PGC-1α-dependent manner. Furthermore, lack of PGC-1α was associated with altered phosphorylation and carbonylation of the inner mitochondrial membrane ADP/ATP exchanger adenine nucleotide translocase 1. In conclusion, the present study provides evidence that PGC-1α regulates submaximal ADPstimulated respiration, ROS emission, and mitochondrial network structure in mouse skeletal muscle during aging and exercise training.

American Journal of Physiology published new progress about Aging, animal. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Karro, Niina published the artcileRespiration of permeabilized cardiomyocytes from mice: no sex differences, but substrate-dependent changes in the apparent ADP-affinity, Safety of (S)-2-hydroxysuccinic acid, the main research area is cardiomyocyte respiration intracellular diffusion restriction.

Sex differences in cardiac physiol. are getting increased attention. This study assessed whether isolated, permeabilized cardiomyocytes from male and female C57BL/6 mice differ in terms of their respiration with multiple substrates and overall intracellular diffusion restriction estimated by the apparent ADP-affinity of respiration. Using respirometry, we recorded 1) the activities of respiratory complexes I, II and IV, 2) the respiration rate with substrates fuelling either complex I, II, or I + II, and 3) the apparent ADP-affinity with substrates fuelling complex I and I + II. The respiration rates were normalized to protein content and citrate synthase (CS) activity. We found no sex differences in CS activity (a marker of mitochondrial content) normalized to protein content or in any of the respiration measurements. This suggests that cardiomyocytes from male and female mice do not differ in terms of mitochondrial respiratory capacity and apparent ADP-affinity. Pyruvate modestly lowered the respiration rate, when added to succinate, glutamate and malate. This may be explained by intramitochondrial compartmentalization caused by the formation of supercomplexes and their association with specific dehydrogenases. To our knowledge, we show for the first time that the apparent ADP-affinity was substrate-dependent. This suggests that substrates may change or regulate intracellular barriers in cardiomyocytes.

Scientific Reports published new progress about Aging, animal. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Safety of (S)-2-hydroxysuccinic acid.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Qaisar, Rizwan published the artcileRestoration of sarcoplasmic reticulum Ca2+ ATPase (SERCA) activity prevents age-related muscle atrophy and weakness in mice, Computed Properties of 97-67-6, the main research area is muscle atrophy weakness SERCA gastrocnemius CDN1163 sarcopenia MEF2C; sarcopenia; sarcoplasmic reticulum calcium-transporting ATPase; skeletal muscle.

Sarcopenia has a significant neg. impact on healthspan in the elderly and effective pharmacol. interventions remain elusive. We have previously demonstrated that sarcopenia is associated with reduced activity of the sarcoplasmic reticulum Ca2+ ATPase (SERCA) pump. We asked whether restoring SERCA activity using pharmacol. activation in aging mice could mitigate the sarcopenia phenotype. We treated 16-mo male C57BL/6J mice with vehicle or CDN1163, an allosteric SERCA activator, for 10 mo. At 26 mo, maximal SERCA activity was reduced 41% in gastrocnemius muscle in vehicle-treated mice but maintained in old CDN1163 treated mice. Reductions in gastrocnemius mass (9%) and in vitro specific force generation in extensor digitorum longus muscle (11%) in 26 vs. 16-mo-old wild-type mice were also reversed by CDN1163. CDN1163 administered by intra-peritoneal injection also prevented the increase in mitochondrial ROS production in gastrocnemius muscles of aged mice. Transcriptomic anal. revealed that these effects are at least in part mediated by enhanced cellular energetics by activation of PGC1-α, UCP1, HSF1, and APMK and increased regenerative capacity by suppression of MEF2C and p38 MAPK signaling. Together, these exciting findings are the first to support that pharmacol. targeting of SERCA can be an effective therapy to counter age-related muscle dysfunction.

International Journal of Molecular Sciences published new progress about Aging, animal. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Computed Properties of 97-67-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Fu, Huijie published the artcileEffect of cadmium stress on inorganic and organic components in xylem sap of high cadmium accumulating rice line (Oryza sativa L.), SDS of cas: 97-67-6, the main research area is Oryza xylem sap cadmium stress; Cd; Inorganic anion; Organic component; Rice; Xylem sap.

Physiol. properties involved in cadmium (Cd) transport were investigated in the high Cd accumulating rice line (Lu527-8) in comparison with the normal rice line (Lu527-4) through a soil culture experiment The results showed that Cd contents in xylem saps of Lu527-8 were 1.68-2.55 times higher than those of Lu527-4 under Cd stress. A high-pos. correlation between Cd contents in xylem saps and Cd contents in shoots was observed Lu527-8 owned a more rapid and effective transport of Cd to above-ground part. By analyzing the relationship between inorganic anions, organic components and Cd contents in xylem saps, the lower HPO2-4 and oxalate contents were considered to be related to the higher Cd transport in xylem sap of Lu527-8. As for citrate, tartaric and histidine content, significant increases were observed with the increasing Cd contents in xylem saps of two rice lines, and their contents of Lu527-8 were significantly higher than those of Lu527-4. Citrate, tartaric and histidine could take part in root-to-shoot Cd transport in xylem.

Ecotoxicology and Environmental Safety published new progress about Growth (plant). 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, SDS of cas: 97-67-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kaneko, Kazuyoshi published the artcileDynamic and static properties of mixtures of 1-butyl-3-methylimidazolium tetrafluoroborate and alcohols with various alkyl chain lengths, Recommanded Product: n-Octanol, the main research area is butyl methylimidazolium tetrafluoroborate ionic liquid alc mixture self diffusion.

The dynamic and static properties of mixtures of 1-butyl-3-methylimidazolium tetrafluoroborate ([BMIM][BF4]) and alcs. with various alkyl chain lengths were investigated. For alc. concentrations of 20 mol% or less, where the alc./ionic liquid system maintains a nano-heterogeneous structure, the self-diffusion coefficient and the chem. shift of anions and cations in the alc./[BMIM][BF4] system were not dependent on the alkyl chain length of the alc., but were almost coincident with each other when comparing the same solvent concentration This indicates that the solution structure of pure [BMIM][BF4] was almost maintained in the alc./ionic liquid system. Moreover, alc. having short alkyl chain length and water moved clearly faster than the IL, but the movement of alc. having long alkyl chain length moved close to that of the IL suggesting that the alcs. may not be able to move significantly in the IL.

Journal of Molecular Liquids published new progress about Hydrophobicity. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Recommanded Product: n-Octanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Schoettl, Sebastian published the artcileSolubilization power of surfactant-free microemulsions, Recommanded Product: n-Octanol, the main research area is solubilization microemulsion propane.

Hydrophobe solubilization concepts rely on the shielding of solutes from water in nonpolar domains comprising traditional surfactants. We show how an octanol/ethanol/water surfactant-free microemulsion solvates hydrophobic propane in small octanol/ethanol aggregates similar to traditional micelles. These aggregates have the comparable solvent quality as bulk octanol/ethanol with the same composition

Physical Chemistry Chemical Physics published new progress about Microemulsions. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Recommanded Product: n-Octanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kumari, Bharti published the artcileEfficient Referencing of FSLG CPMAS HETCOR Spectra Using 2D 1H-1H MAS FSLG, Computed Properties of 111-87-5, the main research area is octanol FSLG CPMAS HETCOR spectrum.

FSLG CPMAS HETCOR is a 2D solid-state NMR experiment which provides structural information and conformational correlation between a 1H and an X-nucleus. However, practical application of the experiment suffers from the chem. shift referencing problem on the indirect 1H dimension. In our paper, we present a novel 1H-1H MAS FSLG-based approach and its application to reference the FSLG CPMAS HETCOR which overcomes the 1H referencing in the 2D 1H-X HETCOR experiment This approach works excellently irresp. of the sample type over a wide range of temperature

Applied Magnetic Resonance published new progress about Microstructure. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Computed Properties of 111-87-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Minnaar, Phillip published the artcileEffect of alcoholic and acetous fermentations on the phenolic acids of Kei-apple (Dovyalis caffra L.) fruit, Product Details of C4H6O5, the main research area is Dovyalis caffra fruit phenolic acid alc acetous fermentation; Saccharomyces cerevisiae; Schizosaccharomyces pombe; acetic acid bacteria; liquid chromatography; phenolics.

The Kei apple is a tree found on the African continent. Limited information exists on the effect of alc. and acetous fermentation on the phytochems. of Kei apple. The fruit has increased concentrations of L-malic, ascorbic, and phenolic acids among other compounds Juice was co-inoculated with Schizosaccharomyces pombe (Sp) and Saccharomyces cerevisiae (Sc) to induce alc. fermentation (AF). Acetous fermentation followed AF, using an acetic acid bacteria (AAB) consortium. Saccharomyces cerevisiae + Sp wines and vinegars had the highest pH. Total acidity, soluble solids and L-malic acid decreased during AF and acetous fermentation, and was highest in Sc wines and vinegars. Volatile acidity (VA) concentration was highest in Sp vinegars but was not significantly different from Sc and Sc + Sp vinegars. Gallic acid was highest in Sp wines and vinegars, whereas syringic acid was highest in Sc wines and vinegars. The Sc + Sp wines were highest in caffeic, p-coumaric, and protocatechuic acids. Schizosaccharomyces pombe vinegars were highest in caffeic and p-coumaric acids. Highest concentrations of ferulic and sinapic acids were found in Sp and Sc wines, resp. Chlorogenic acid was most abundant phenolic acid in both wines and vinegars. Saccharomyces cerevisiae + Sp and Sc fermentation had a pos. effect on most phenolic acids; Sc + AAB had an increased effect on syringic and chlorogenic acids, whereas Sp + AAB resulted in an increase in gallic, caffeic, and p-coumaric acids. The AAB selected had minimal performance with respect to VA production in comparison to com. vinegars. Acetic acid bacteria selection for acetous fermentation should therefore be reconsidered and the decrease of certain phenolic acids during acetous fermentation needs to be investigated.

Journal of the Science of Food and Agriculture published new progress about Aberia caffra. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Product Details of C4H6O5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Shilei published the artcileConstruction of synthetic microbiota for reproducible flavor compound metabolism in Chinese light-aroma-type liquor produced by solid-state fermentation, Computed Properties of 505-10-2, the main research area is microbiota flavor metabolism aroma liquor solid state fermentation; Chinese liquor; cooccurring network; core microbiota; environmental factors; flavor compounds; food fermentation.

Natural microbiota plays an essential role in flavor compounds used in traditional food fermentation; however, the fluctuation in natural microbiota results in inconsistency in food quality. Thus, it is critical to reveal the core microbiota for flavor compound production and to construct a synthetic core microbiota for use in constant food fermentation Here, we reveal the core microbiota based on their flavor production and cooccurrence performance, using Chinese light-aroma-type liquor as a model system. Five genera, Lactobacillus, Saccharomyces, Pichia, Geotrichum, and Candida, were identified to be the core microbiota. The synthetic core microbiota of these five genera presented a reproducible dynamic profile similar to that in the natural microbiota. A Monte Carlo test showed that the effects of five environmental factors (lactic acid, ethanol, and acetic acid contents, moisture, and pH) on the synthetic microbiota distribution were highly significant (P < 0.01), similar to those effects on a natural fermentation system. In addition, 77.27% of the flavor compounds produced by the synthetic core microbiota showed a similar dynamic profile (ρ > 0) with that in the natural liquor fermentation process, and the flavor profile presented a similar composition It indicated that the synthetic core microbiota is efficient for reproducible flavor metabolism This work established a method for identifying core microbiota and constructing a synthetic microbiota for reproducible flavor compounds This work is of great significance for the tractable and constant production of various fermented foods.

Applied and Environmental Microbiology published new progress about Achromobacter. 505-10-2 belongs to class alcohols-buliding-blocks, name is 3-(Methylthio)propan-1-ol, and the molecular formula is C4H10OS, Computed Properties of 505-10-2.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts