Tag: M.W=100-150

Peng, Jingjing published the artcileDesign, synthesis, and biological evaluation of 2-(phenoxyaryl)-3-urea derivatives as novel P2Y₁ receptor antagonists, Application of 2-Morpholinoethanol, the publication is European Journal of Medicinal Chemistry (2018), 302-310, database is CAplus and MEDLINE.

A novel series of 2-(phenoxyaryl)-3-urea derivatives I [R¹ = H, Me; R² = n-Bu, 4-F₃COC₆H₄, 5-methoxycarbonyl-2-thienyl, etc.; X = CH, N] were designed, synthesized and biol. evaluated for their anti-thrombotic activity and antiplatelet aggregation study. Most of compounds exhibited good inhibition against P2Y₁ receptor among them, compounds I [R¹ = H, Me; R² = 2-methylcyclohexyl, 2-adamantyl, 4-F₃COC₆H₄; X = N] demonstrated good P2Y₁ receptor antagonistic potency in vitro (IC₅₀ = 0.62 μM, 0.82 μM, and 0.21 μM, resp.). Four compounds I [R¹ = H, Me; R² = 4-methylcyclohexyl, 4-F₃COC₆H₄, 5-ethoxycarbonyl-2-thienyl, 5-benzyloxycarbonyl-2-thienyl, etc.; X = N] showed good antiplatelet activity. The possible binding modes of compounds with P2Y₁ receptor were also explored by mol. docking simulation. The docking studies demonstrated that compound I [R¹ = Me; R² = 4-F₃COC₆H₄; X = N] interacted well with Phe119 through hydrophobic interaction and modestly improved the P2Y₁ receptor antagonistic activity.

European Journal of Medicinal Chemistry published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C6H13NO2, Application of 2-Morpholinoethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Dou, Zhaolin published the artcilePhotocatalytic Upgrading of Lignin Oil to Diesel Precursors and Hydrogen, SDS of cas: 645-56-7, the publication is Angewandte Chemie, International Edition (2021), 60(30), 16399-16403, database is CAplus and MEDLINE.

Producing renewable biofuels from biomass is a promising way to meet future energy demand. Here, we demonstrated a lignin to diesel route via dimerization of the lignin oil followed by hydrodeoxygenation. The lignin oil undergoes C-C bond dehydrogenative coupling over Au/CdS photocatalyst under visible light irradiation, co-generating diesel precursors and hydrogen. The Au nanoparticles loaded on CdS can effectively restrain the recombination of photogenerated electrons and holes, thus improving the efficiency of the dimerization reaction. About 2.4 mmol g_catal^-1 h^-1 dimers and 1.6 mmol g_catal^-1 h^-1 H₂ were generated over Au/CdS, which is about 12 and 6.5 times over CdS, resp. The diesel precursors are finally converted into C16-C18 cycloalkanes or aromatics via hydrodeoxygenation reaction using Pd/C or porous CoMoS catalyst, resp. The conversion of pine sawdust to diesel was performed to demonstrate the feasibility of the lignin-to-diesel route.

Angewandte Chemie, International Edition published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C9H12O, SDS of cas: 645-56-7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Hariri, Ali published the artcileMolecular imaging of oxidative stress using an LED-based photoacoustic imaging system, Recommanded Product: 4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-ol, the publication is Scientific Reports (2019), 9(1), 1-10, database is CAplus and MEDLINE.

LED-based photoacoustic imaging has practical value in that it is affordable and rugged; however, this technol. has largely been confined to anat. imaging with limited applications into functional or mol. imaging. Here, we report mol. imaging reactive oxygen and nitrogen species (RONS) with a near-IR (NIR) absorbing small mol. (CyBA) and LED-based photoacoustic imaging equipment. CyBA produces increasing photoacoustic signal in response to peroxynitrite (ONOO^–) and hydrogen peroxide (H₂O₂) with photoacoustic signal increases of 3.54 and 4.23-fold at 50μM of RONS at 700 nm, resp. CyBA is insensitive to OCl^–, NO, NO₂^–, NO₃^–, tBuOOH, O₂^–, C₄H₉O , HNO, and OH, but can detect ONOO^– in whole blood and plasma. CyBA was then used to detect endogenous RONS in macrophage RAW 246.7 cells as well as a rodent model; these results were confirmed with fluorescence microscopy. Importantly, CyB suffers photobleaching under a Nd:YAG laser but the signal decrease is <2% with the low-power LED-based photoacoustic system and the same radiant exposure time. To the best of our knowledge, this is the first report to describe mol. imaging with an LED-based photoacoustic scanner. This study not only reveals the sensitive photoacoustic detection of RONS but also highlights the utility of LED-based photoacoustic imaging.

Scientific Reports published new progress about 25240-59-9. 25240-59-9 belongs to alcohols-buliding-blocks, auxiliary class Boronic acid and ester,Boronic Acids,Boronate Esters, name is 4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-ol, and the molecular formula is C6H13BO3, Recommanded Product: 4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Xiong, Dazhen published the artcileTemperature-switchable deep eutectic solvents for selective separation of aromatic amino acids in water, SDS of cas: 645-56-7, the publication is Separation and Purification Technology (2021), 118479, database is CAplus.

Amino acids are vital compounds in animal and human nutrition. However, it is still a great challenge to develop a cost-effective process for selective separation of amino acids. In the present study, a class of deep eutectic solvents (DESs) with short-chain alkanolamines as hydrogen bond acceptors (HBAs) and phenolic compounds as hydrogen bond donors (HBDs) have been explored for selective separation of aromatic amino acids for the first time. It is found that these DESs exhibit upper critical solution temperature (UCST)-type phase behavior in water, and their phase transition temperature is related with the pK_a values of HBAs and HBDs as well as the hydrophobicity of HBDs. The UCST-type phase separation process is investigated by dynamic light scattering (DLS), FT-IR spectroscopy and temperature-variable ¹H NMR in details, and the stability of the DESs in water is also examined Interestingly, these UCST-type DESs/water systems are applicable to selective separation of aromatic amino acids. The separation factor between L-tryptophan and L-tyrosine as well as between L-tryptophan and L-phenylalanine can reach up to 476.1 and 87.9, resp., which is about 20 and 19 times that reported in ionic liquids-based extraction solvents.

Separation and Purification Technology published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C10H18O4, SDS of cas: 645-56-7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Ruipu published the artcileBio-inspired lanthanum-ortho-quinone catalysis for aerobic alcohol oxidation: semi-quinone anionic radical as redox ligand, Related Products of alcohols-buliding-blocks, the publication is Nature Communications (2022), 13(1), 428, database is CAplus and MEDLINE.

Oxidation reactions are fundamental transformations in organic synthesis and chem. industry. With oxygen or air as terminal oxidant, aerobic oxidation catalysis provides the most sustainable and economic oxidation processes. Most aerobic oxidation catalysis employs redox metal as its active center. While nature provides non-redox metal strategy as in pyrroloquinoline quinone (PQQ)-dependent methanol dehydrogenases (MDH), such an effective chem. version is unknown. Inspired by the recently discovered rare earth metal-dependent enzyme Ln-MDH (methanol dehydrogenases), this study shows that an open-shell semi-quinone anionic radical species in complexing with lanthanum could serve as a very efficient aerobic oxidation catalyst under ambient conditions. In this catalyst, the lanthanum(III) ion serves only as a Lewis acid promoter and the redox process occurs exclusively on the semiquinone ligand. The catalysis is initiated by 1e^–-reduction of lanthanum-activated ortho-quinone to a semiquinone-lanthanum complex La(SQ^-.)₂, which undergoes a coupled O-H/C-H (PCHT: proton coupled hydride transfer) dehydrogenation for aerobic oxidation of alcs. such as benzyl alc., 1,4-butane-diol, 1-(2-furyl)ethanol, etc. with up to 330 h^-1 TOF.

Nature Communications published new progress about 111-29-5. 111-29-5 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ploymers, name is Pentane-1,5-diol, and the molecular formula is C23H43NP2, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Cao, Yang published the artcileCatalytic Asymmetric 1,4-Reduction of α-Branched 2-Vinyl-azaarenes by a Chiral SPINOL-Derived Borophosphate, Synthetic Route of 25240-59-9, the publication is ACS Catalysis (2020), 10(19), 10914-10919, database is CAplus.

The catalytic asym. 1,4-reduction of α-branched 2-vinylazaarenes by a SPINOL-derived borophosphate has been realized. A SPINOL-derived phosphoric acid is used to form a bifunctional phosphoryl boronate catalyst in situ in the presence of pinacolborane. This asym. 1,4-reduction reaction provides a convenient procedure to access chiral alkylated quinolines I (R¹ = 4-Cl, 4-CF₃, 3-OMe, etc.; R² = H, 6-CO₂Me, 6-NO₂, 7-F, etc.) and benzothiazoles II (R³ = 6-Me, 5-Cl, 6-CO₂Me, etc.) in high yields (up to 94%) and with good stereoselectivities (up to 98%).

ACS Catalysis published new progress about 25240-59-9. 25240-59-9 belongs to alcohols-buliding-blocks, auxiliary class Boronic acid and ester,Boronic Acids,Boronate Esters, name is 4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-ol, and the molecular formula is C6H13BO3, Synthetic Route of 25240-59-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Li, Lingxiao published the artcileUnraveling the Role of Metal in M/NiAl₂O₄ (M = Pt, Pd, Ru) Catalyst for the Self-Reforming-Driven Hydrogenolysis of Lignin, Quality Control of 645-56-7, the publication is Industrial & Engineering Chemistry Research (2021), 60(31), 11699-11706, database is CAplus.

Previously, we found that, by self-reforming-driven hydrogenolysis of lignin or lignin oils, 4-alkylphenols can be produced directly under hydrogen-free conditions over Pt//NiAl₂O₄ catalyst (ACS Catal. 2020, 10, 15197-15206). That work mainly focused on the exploration of a new strategy and the reaction pathways of the hydrogen contained in lignin during its valorization. In this work, we use M/NiAl₂O₄ (M = Pt, Pd, Ru) catalysts to investigate the rate-determined step, structure-activity relationships, the adsorbed species, and the essence of different metals and finally screen a good catalyst with excellent performance. A temporal profile of reaction using a model compound and kinetic measurements disclosed that demethoxylation is the rate-determined step, in which Ru/NiAl₂O₄ has superior ability probably due to the faster removal of products that enables the rapid recovery of active sites for demethoxylation when compared to Pt/NiAl₂O₄. In contrast, side reactions and a low rate of demethoxylation were observed over Pd/NiAl₂O₄. In the self-reforming-driven hydrogenolysis of birch lignin and lignin oil, Ru/NiAl₂O₄ exhibited again its excellence in gaining 4-alkylphenols with yields of 40.7 and 92.8 mol % (5.7 and 44.5 weight %), from lignin and lignin oil, resp. This comprehensive study would help to design catalysts with higher activity for the self-reforming process of biomass resources.

Industrial & Engineering Chemistry Research published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C9H12O, Quality Control of 645-56-7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Sun, Li published the artcileReactive polyurethane hot melt adhesives based on polycarbonate and sebacic acid-based polyester polyols, Formula: C5H12O2, the publication is Journal of Adhesion Science and Technology, database is CAplus.

Reactive polyurethane hot melt adhesives (HMPURs) containing a blend of polyester and polycarbonate diols can typically exhibit balanced performance, such as bonding properties, tensile strength, and heat resistance. Two series of HMPURs made from poly(1,4-butylene adipate) or sebacic acid (SeA)-based polyester diols with different mol. weights were prepared and investigated. Increasing the mol. weight of the SeA-based polyester diols was found to significantly improve their mech. properties and lap shear strengths. Moreover, the HMPURs made from SeA-based polyester diol exhibited better performances than those made from poly(1,4-butylene adipate). Also, the HMPURs were more suitable for bonding on PC substrate.

Journal of Adhesion Science and Technology published new progress about 111-29-5. 111-29-5 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ploymers, name is Pentane-1,5-diol, and the molecular formula is C6H5NO, Formula: C5H12O2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Ting published the artcileSelective hydroconversion of 2-methylfuran to pentanols on MWNT-supported Pt catalyst at ambient temperature, Application In Synthesis of 111-29-5, the publication is Rare Metals (Beijing, China) (2022), 41(3), 889-900, database is CAplus.

The selective hydrogenolysis of C-O bond in furfural and its derivatives provides a sustainable route for transforming biomass-derived feedstocks into valued chems. Currently, the development of efficient catalysts which can effectively cleavage C-O bond under mild conditions remains a critical challenge. The present work reports Pt catalysts supported on multi-walled carbon nanotubes (MWNT) which are active in 2-methylfuran (2-MF) hydrogenolysis to form pentanols in liquid phase under mild conditions. The impact of various catalyst supports, active metals and reaction conditions in terms of metal loadings, solvent, time, pressure, etc. were explored. The 5 wt% Pt/MWNT catalyst demonstrated an excellent activity and selectivity with 100% 2-MF conversion and 53% pentanols (POLs) yield under 1 MPa H2 at an exceptional low temperature of 25°C. The reaction mechanism was studied combing both the reactivity tests and characterization results, and it is found that the better catalytic performances of Pt/MWNT were correlated closely to the size of Pt nanoparticles and their interactions with the underlying MWNT support. Accordingly, a reaction pathway involving the adsorption of 2-MF parallel to the Pt nanoparticles and its subsequently selective C-O hydrogenolysis was proposed. This work showcases a promising catalyst for room-temperature biofuel production

Rare Metals (Beijing, China) published new progress about 111-29-5. 111-29-5 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ploymers, name is Pentane-1,5-diol, and the molecular formula is C13H10N2S, Application In Synthesis of 111-29-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Li, Zhiwen published the artcileHighly selective oxidation of organosilanes with a reusable nanoporous silver catalyst, COA of Formula: C6H16OSi, the publication is Catalysis Communications (2014), 53-56, database is CAplus.

Room temperature highly selective oxidation of organosilanes to organosilanols and organosilyl ethers is achieved in liquid-phase with dealloyed nanoporous silver catalysts. In both cases, aromatic and aliphatic silanes can be effectively converted into the corresponding silanols and silyl ethers by using water and alcs. as oxidant, resp. Moreover, hydrogen gas is the only byproduct and the catalyst can be recycled for several times without evident loss of activity and selectivity.

Catalysis Communications published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C6H16OSi, COA of Formula: C6H16OSi.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts