Tag: M.W=0-100

Adding a certain compound to certain chemical reactions, such as: 4415-82-1, Cyclobutylmethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 4415-82-1, blongs to alcohols-buliding-blocks compound. 4415-82-1

Synthesis of 4-Cyclobutylmethoxy-1 H-indole-2-carboxylic acid (16a):(1) Step A: 4-Cyclobutylmethoxy-1 H-indole-2-carboxylic acid ethyl ester (15a); DEAD (2.1 ml, 13.65 mmol) is slowly added to a solution of 4-hydroxy-1 H-indole-2-carboxylic acid ethyl ester (2 g, 9.75 mmol), triphenylphosphine (3.58 g, 13.65 mmol) and cyclobutyl- methanol (1.25 ml, 12.26 mmol) in 20 ml of THF, so that the temperature always remains beiow 3O0C. Stirring is continued for 2 hours and the solvent is then evaporated. The crude residue is purified by chromatography (cyclohexane: EtOAc / 95:5).MS (ESI): 274.2 [M+H]+, 1 H-NMR (CDCI3): delta (ppm) 8.83 (s, 1 H), 7.35 (s, 1 H)1 7.21 (t, 1 H), 6.98 (d, 1 H), 6.49 (d, 1 H), 4.4 (q, 2H), 4.07 (d, 2H), 2.85 (m, 1 H), 2.17 (m, 2H), 1.95 (m, 4H), 1.42 (t, 3H).

With the rapid development of chemical substances, we look forward to future research findings about 4415-82-1.

Reference:
Patent; NOVARTIS AG; WO2008/101905; (2008); A1;,
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2516-33-8 ,Some common heterocyclic compound, 2516-33-8, molecular formula is C4H8O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

0.49 g (6.82 mmoi) cyclopropane methanol in 10 mL THF are charged with 0.42 g (11.4 mmoi) NaH and the reaction mixture is stirred at r.t. for 20 min. Then 1.00 g (5.68 mmoi) 5-bromo-2-fluoropyridine are added and the mixture is stirred at r.t. over night. The reaction is quenched by the addition of water and extracted with EtOAc. The organic layers are combined, dried over MgS04l filtered and the solvent is removed in vacuo. The crude product is purified by HPLC (MeOH/H20/FA). CgH-ioBrNO (M= 228.1 g/mol) ESI-MS: 228/229 [M+H]+ Rt (HPLC):1.14 min (method C)

According to the analysis of related databases, 2516-33-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; FLECK, Martin; HEINE, Niklas; NOSSE, Bernd; ROTH, Gerald Juergen; WO2014/114578; (2014); A1;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 764-48-7, name is Ethylene Glycol Vinyl Ether. This compound has unique chemical properties. The synthetic route is as follows. 764-48-7

General procedure: To a stirred mixture of alcohol, 2-oxo-4-aryl-but-3-enoic acid and DMAP in dichloromethane at 0 C was added dropwise DCC in dichloromethane. After 10 min, the reaction mixture was allowed to warm to room temperature and stirred for 10 h. After filtration of the resulting mixture, solvent was removed under reduced pressure and the crude product was purified by column chromatography on silica gel using CH2Cl2 as eluant.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,764-48-7, Ethylene Glycol Vinyl Ether, and friends who are interested can also refer to it.

Reference:
Article; Dong, Xiaomei; Wang, Qingxia; Zhang, Qian; Xu, Shuai; Wang, Zhihong; Tetrahedron; vol. 69; 52; (2013); p. 11144 – 11154;,
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764-48-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 764-48-7, name is Ethylene Glycol Vinyl Ether, molecular formula is C4H8O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: A dry and argon-flushed 10 mL Schlenk tube, equipped with a stirring bar and septum, wascharged with 2-(vinyloxy)ethanol (5, 132 mg, 1.50 mmol, 1.50 equiv) in Et2O (1.5 mL). Then,iPrMgBr (1.55 mmol, 1.55 equiv) was added dropwise at 25 C. After 5 min of stirring,Sc(OTf)3 (49.2 mg, 0.10 mmol, 0.10 equiv) and aldehyde 6 (1.00 mmol, 1.00 equiv) weresuccessively added and the reaction mixture was stirred at 40 C for the given time. After afull conversion was detected by GC-analysis, sat. aq. NH4Cl (15 mL) was added and theaqueous layer was extracted with EtOAc (3 x 15 mL). The combined organic layers weredried over Na2SO4, filtered and solvent was removed under reduced pressure. Purification viacolumn chromatography (SiO2) afforded expected products 4.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 764-48-7, Ethylene Glycol Vinyl Ether, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Quinio, Pauline; Kohout, Laura; Roman, Daniela Sustac; Gaar, Jakob; Karaghiosoff, Konstantin; Knochel, Paul; Synlett; vol. 27; 11; (2016); p. 1715 – 1719;,
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2516-33-8, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 2516-33-8 as follows.

General procedure: The gas-phase oxidation of alcohols is performed on a fixed-bed quartz tube reactor (600mm length by 14 mm inner diameter) under atmospheric pressure. Catalyst used in each test is 0.27 g (200-300 mesh). Other conditions are described in the previous literature elaborately [16]. The products are analyzed by Gas Chromatography (Shimadzu GC-2014 with a Rtx-5 column) as well as GC-MS (Agilent 6890 equipped with a HP-5 column).

The chemical industry reduces the impact on the environment during synthesis 2516-33-8, I believe this compound will play a more active role in future production and life.

Reference:
Article; Liu, Kun; Chen, Zhaoxiang; Zou, Peipei; Wang, Yuanyuan; Dai, Liyi; Catalysis Communications; vol. 67; (2015); p. 54 – 58;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 616-29-5, name is 1,3-Diaminopropan-2-ol. This compound has unique chemical properties. The synthetic route is as follows. 616-29-5

Synthesis of 2,2,12,12-t-methyl-3,11-dioxo-4,10-dioxa-5,9-diazatridecan-7-ol (N,N’-di-t-boc-2-hydroxy-1,3-diaminopropane) Sodium hydrogencarbonate (8.3 g, 99 mmol) was dissolved in 1:1 acetonitrile:water mixture (190 mL) and the solution cooled to 4 C. in an ice bath. 1,3-diamino-2-hydroxypropane (2.5 g, 27 mmol) and di-tert-butyldicarbonate (12.8 g, 59 mmol) were dissolved in the same solvent system (65 mL). This mixture was then added to the chilled sodium hydrogencarbonate solution and stirred on ice for two hours. The reaction was then heated to room temperature and stirred overnight. The acetonitrile was removed by rotary evaporation and the protected amine extracted into dichloromethane (3*75 mL portions). The organic portions were combined, dried over sodium carbonate, and evaporated to dryness by rotary evaporation. The resulting oil was re-crystallised from diethylether/hexane,38 giving colourless crystals (7.2 g, 91% yield). The compound was characterised by 1H and 13C NMR and FT-IR spectroscopy. IR (cm-1): 3316 m br v(OH and NH), 2971 m and 2930 m v(CH3 and CH), 1681 s v(C=O). 1H NMR (400 MHz, CDCl3, 298 K) [delta, ppm]: 1.45 (s, 18H, H-1), 3.20 (m, 4H, H-5), 3.75 (m, 2H, H-6 and H-7), 5.20 (s br, 2H, H-4). 13C NMR (100 MHz, CDCl3, 298K) [delta, ppm]: 28.55 (C-1), 43.72 (C-2), 71.07 (C-5), 79.87 (C-6), 157.24 (C-3).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 616-29-5, 1,3-Diaminopropan-2-ol.

Reference:
Patent; UNIVERSITY OF KWAZULU-NATAL; Munro, Orde Quentin; Akerman, Kate Julie; Akerman, Piers; US2013/90472; (2013); A1;,
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2854-16-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2854-16-2, name is 1-Amino-2-methylpropan-2-ol, molecular formula is C4H11NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a suspension of 2,4,6,8-tetrachloro-pyrimido[5,4-djpyrimidine (1) (3.50 g,i3.Oi mmol) in THF (200 mL) at -78¡ãC, i-amino-2-methyl-propan-2-ol (i.i7 mL, i2.36 mmol) in THF (20 mL) was added via syringe pump (during about 30 mm) followed byDIPEA (2.93 mL, i6.9i mmol) in THF (20 mL). The reaction mixture was stirred at -78¡ãC for additional 30 mi and then allowed to reach the room temperature. Water (250 mL) was added and the resulting suspension was extracted with EtOAc (3 x iOO mL). The combined organic extracts were washed with water (iSO mL), then with brine (iSO mL) and dried over solid anhydrous MgSO4. After filtration, the solvent was removed and the residue waspurified by flash column chromatography using gradient elution from PE/EtOAc (iO:4) toPE/EtOAc (i : i) to give 2-methyl-i -(2,6,8-trichloro-pyrimido[5,4-djpyrimidin-4-ylamino)-propan-2-ol (29)(3.67 g, 92percent yield). 300 MHz ?H NMR (CDC13, ppm): 7.70-7.58 (iH, m)3.70 (2H, d, J=6.i Hz) i.80 (iH, s) i.36 (6H, s). ESI-MS (m/z): 322, 324, 326, 328 [M+Hf?.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 2854-16-2, 1-Amino-2-methylpropan-2-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; GALLEON PHARMACEUTICALS, INC.; DAX, Scott L.; MENCEL, James Joseph; OZOLA, Vita; SUNA, Edgars; SHUBIN, Kirill; (294 pag.)WO2017/3822; (2017); A1;,
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627-30-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 627-30-5, name is 3-Chloropropan-1-ol. This compound has unique chemical properties. The synthetic route is as follows.

In a flask, 10.0 g (0.058 mol) of the compound represented by the formula (I-1a), 7.10 g (0.075 mol) of 3-chloropropanol, potassium carbonate 11.99 g (0.087 mol), and 100 mL of ethanol were added and heated under reflux for 5 days. After filtration, the solvent was distilled off and redissolved in toluene. After washing with brine, purification by column chromatography (silica gel) gave 10.7 g (0.046 mol) of the compound represented by the formula (I-11a).

Statistics shows that 627-30-5 is playing an increasingly important role. we look forward to future research findings about 3-Chloropropan-1-ol.

Reference:
Patent; DIC CORPORATION; HORIGUCHI, MASAHIRO; HAYASHI, MASANAO; KUSUMOTO, TETSUO; (90 pag.)JP6102423; (2017); B2;,
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56-81-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 56-81-5, name is Propane-1,2,3-triol, molecular formula is C3H8O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: Diols and polyol reactants (100 mg) were allowed to react with benzoic anhydride (1.1 equiv) in acetonitrile (1 mL) at 40C for 8-12 h in the presence of TBAOBz (0.2 equiv). The reaction mixture was directly purified by flash column chromatography (hexanes/EtOAc=2:1 to 1:1), affording the pure selectively protected derivatives.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 56-81-5, Propane-1,2,3-triol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Zhang, Xiaoling; Ren, Bo; Ge, Jiantao; Pei, Zhichao; Dong, Hai; Tetrahedron; vol. 72; 7; (2016); p. 1005 – 1010;,
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Adding some certain compound to certain chemical reactions, such as: 4415-82-1, name is Cyclobutylmethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 4415-82-1. 4415-82-1

General procedure: To a stirred solution of alcohol 9 (8.00mmol) in toluene (40mL) under argon were added sequentially diethyl phosphonoacetic acid (1.35mL, 8.40mmol), DIPEA (3.62mL, 20.8mmol) and propyl phosphonic anhydride (6.62g, 10.4mmol, 50% w/w solution in ethyl acetate/THF). The solution was stirred at rt for 4h after which time it was diluted with water (50mL) and extracted with ethyl acetate (3¡Á100mL) followed by sequential washing of the combined organic extracts with 10% aqHCl (50mL), satd aqNaHCO3 (50mL) and brine (50mL). The organic extracts were dried over MgSO4 and concentrated in vacuo, affording the alpha-(diethoxyphosphoryl)acetate product 10, which was used without further purification.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 4415-82-1.

Reference:
Article; Lloyd, Matthew G.; D’Acunto, Mariantonietta; Taylor, Richard J.K.; Unsworth, William P.; Tetrahedron; vol. 71; 39; (2015); p. 7107 – 7123;,
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