Tag: M.W=0-100

Zhang, Zhipeng; He, Zhiqin; Xie, Yuxing; He, Tiantong; Fu, Yaofeng; Yu, Yang; Huang, Fei published the artcile< Bronsted acid-catalyzed homogeneous O-H and S-H insertion reactions under metal- and ligand-free conditions>, Application of C4H8O, the main research area is alkoxy acetate preparation; alc diazo compound OH bond insertion Bronsted acid catalyzed; phenylethylidene amino oxy acetate preparation; oximes with diazo compound OH insertion Bronsted acid catalyzed; thio aryl acetate preparation; thiol diazo compound SH insertion Bronsted acid catalyzed.

Under metal- and ligand-free conditions, the economical and accessible CF3SO3H successfully catalyzed homogeneous O-H bond insertion reactions between hydroxyl compounds and diazo compounds to afford alkoxy acetates. Including phenols, alcs., water and oximes, these O-H bond insertion reactions were very general and functional-group tolerant. Here, the O-H bond insertion of oximes (ketoximes and aldoximes) to gave phenylethylidene(amino(oxy)acetates) was reported and their structures were characterized by X-ray crystallog. Moreover, a simple and effective method for S-H insertion reactions of thiols to gave thio(aryl)acetates was also developed, delivering the desired C-S bond products with good to excellent yields. It was worth noting that the efficacy of the developed methodol. could be further shown by the expeditious synthesis of the PPAR agonist MBX-102 acid.

Organic Chemistry Frontiers published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Application of C4H8O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Liu, Tong-Xin; Zhu, Xue; Xia, Shilu; Wang, Xin; Zhang, Pengling; Zhang, Guisheng published the artcile< NHC-Catalyzed Three-Component Hydroalkylation Reactions of [60]Fullerene: An Umpolung Approach to Diverse Monoalkylated Hydrofullerenes>, COA of Formula: C4H8O, the main research area is alkyl fullerene preparation green chem; fullerene reductive alkylation chloroalkyl benzaldehyde unsaturated aldehyde alc thiol.

A novel N-heterocyclic carbene-catalyzed three-component umpolung hydroalkylation of [60]fullerene with 4-(chloromethyl)benzaldehydes/α,β-unsaturated aldehydes and alcs./thiols has been developed for the flexible and efficient preparation of diverse monoalkylated hydrofullerenes. Organic catalysis, broad substrate scope, excellent functional group tolerance, and products with high diversity and complexity levels are attractive features of this protocol.

Organic Letters published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, COA of Formula: C4H8O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Cruz, Daniel A.; Sinka, Victoria; de Armas, Pedro; Steingruber, Hugo Sebastian; Fernandez, Israel; Martin, Victor S.; Miranda, Pedro O.; Padron, Juan I. published the artcile< Iron(II) and Copper(I) Control the Total Regioselectivity in the Hydrobromination of Alkenes>, Reference of 627-27-0, the main research area is alkyl bromide preparation regioselective; alkene hydrobromination.

A new method that allowed the complete control of the regioselectivity of the hydrobromination reaction of alkenes was described. Herein, a radical procedure with TMSBr and oxygen as common reagents, where the formation of the anti-Markovnikov product occurs in the presence of ppm amounts of the Cu(I) species and the formation of the Markovnikov product occurred in the presence of 30 mol % iron(II) bromide was reported. D. functional theory calculations combined with Fukui’s radical susceptibilities support the obtained results.

Organic Letters published new progress about Alkenes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Reference of 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Johansen, Martin B.; Donslund, Bjarke S.; Kristensen, Steffan K.; Lindhardt, Anders T.; Skrydstrup, Troels published the artcile< Tert-Amyl Alcohol-Mediated Deconstruction of Polyurethane for Polyol and Aniline Recovery>, COA of Formula: C4H8O, the main research area is amyl alc deconstruction polyurethane polyol aniline.

Polyurethane (PU) is a highly engineered and crosslinked polymer found in a plethora of materials such as mattresses, shoes, windmills, and insulation of refrigerating appliances and buildings. Because of PU’s inherent stability, chem. recycling is difficult and often affords a secondary feed with different characteristics and properties compared to the original input. In this work, a simple chem. recycling of PU via a solvolysis process using tert-amyl alc. both as the solvent and reagent is demonstrated. The devised methodol. is showcased for the deconstruction of 20 different PU materials with examples of all four cornerstones of PU (rigid solid, rigid foamed, flexible foamed, and flexible solid). The solvolysis affords both polyol and dianiline fractions, constituting monomeric precursors of PU. The methodol. is used for the depolymerization of 50 g flexible PU foam affording a polyol within specification of the original virgin polyol (OH value) and an aniline fraction isolated as the precipitated di-HCl salt with a combined mass recovery of 89 wt%. As the solvolysis process provides access to both the polyol and the aniline precursors of the original isocyanate of PU, the procedure presented in this study could pave the way toward a viable circular economy for PU. A further potential utilization of the method is showcased by valorization of a waste stream from split-phase glycolysis, which is another promising method for recovering polyol from flexible PU foam. Finally, preliminary mechanistic investigations are undertaken to probe the intriguing utility of a hindered tertiary alc. in a solvolysis procedure.

ACS Sustainable Chemistry & Engineering published new progress about Board insulators (Recitcel). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, COA of Formula: C4H8O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Lianglin; Lin, Shuwei; Li, Yi; Li, Baozong; Yang, Yonggang published the artcile< Ala-Ala dipeptides with a semi-perfluoroalkyl chain: Chirality driven molecular packing difference and self-assembly driven chiral transfer>, Reference of 627-27-0, the main research area is perfluoroalkyl dipeptide synthesis self assembly helical conformation chirality VCD; solid phase peptide synthesis acylation self assembly xerogel nanoribbon; supramol aggregate gelation crystal structure mol packing; mol structure HOMO LUMO perfluoroalkylated dipeptide solubility.

Four Ala-Ala dipeptides with a semi-perfluoroalkyl chain were synthesized. The intermol. hydrogen bonding among amide groups and carboxyl groups as well as the hydrophobic association of semi-perfluoroalkyl chains drove the self-assembly of dipeptides. Homochiral dipeptides were able to self-assemble into coiled nanoribbons in a mixed solvent of DMSO/H2O (5/5, volume/volume), while entangled twisted nanofibers formed for heterochiral ones in a mixed solvent of DMSO/H2O (4/6, volume/volume). The handedness of self-assemblies and the stacking chirality of phenylene groups were controlled by the chirality of the alanine residue at the C-terminal. The vibration CD investigation indicated that the helicity of the semi-perfluoroalkyl chain was controlled by the handedness of dipeptide self-assemblies. The X-ray diffraction study showed that homochiral and heterochiral dipeptides underwent distinct mol. packing during the self-assembly. Our results clearly demonstrated that, through supramol. self-assembly, the chirality transferred from the amino acid building block to the self-assemblies and eventually to the semi-perfluoroalkyl chain.

New Journal of Chemistry published new progress about Acylation. 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Reference of 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Jarret, Maxime; Abou-Hamdan, Hussein; Kouklovsky, Cyrille; Poupon, Erwan; Evanno, Laurent; Vincent, Guillaume published the artcile< Bioinspired Early Divergent Oxidative Cyclizations toward Pleiocarpamine, Talbotine, and Strictamine>, Synthetic Route of 627-27-0, the main research area is talbotine formal synthesis oxidative cyclization.

Toward the mavacurane and akuammilane monoterpene indole alkaloids, we developed divergent oxidative couplings between the indole nucleus (at N1 or C7) and the C16-malonate of a common tricyclic model related to strictosidine according to a biosynthetic hypothesis postulated by Hesse and Schmid. These oxidative cyclizations led selectively to the formation of the N1-C16 bond of pleiocarpamine or to the C7-C16 bond of strictamine. We were then able to obtain the scaffold I of talbotine.

Organic Letters published new progress about Enantioselective synthesis. 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Synthetic Route of 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Jiang, Siyuan; Liu, Yufei; Zou, Xiaoyu; He, Min; Zhang, Kai; Xu, Guomin; Qin, Shuhao published the artcile< Synthesis and application of new macromolecular hindered phenol antioxidants of polyamide 6>, Product Details of C4H8O, the main research area is nylon 6 antioxidant hydroxyphenyl propionate phenylmaleimide alternting copolymer preparation.

The two macromol. antioxidants, P(3,5-di-tert-butyl-4-hydroxy cinnamic acid-N-phenylmaleimide) (PCN) and P(3-butene-1-yl-3,5-di-tert-Bu -4-hydroxyphenyl propionate-N-phenylmaleimide) (PPN) were designed and synthesized via free radical copolymerization The structures of the resulting PCN and PPN antioxidants were characterized by Fourier transform IR spectroscopy, NMR spectroscopy (1H NMR), and gel permeation chromatog. In addition, the effect of the two macromol. antioxidants on the thermal oxidation aging resistance of polyamide 6 (PA6) was studied. According to the anal. of differential scanning calorimetry, thermogravimetric anal., dynamic mech. anal., dynamic viscosity, and the mech. property of PA6 and its blends, these two types of macromol. antioxidants protected the mol. chain of PA6 from breaking, protected the crystallization of PA6 and maintained the stability of PA6 crystal form, improved the activation energy of thermal degradation and thermal stability of PA6, enhanced the strength and elasticity of PA6 and maintained the mech. properties of PA6 during aging to a certain extent.

Journal of Applied Polymer Science published new progress about Antioxidants. 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Product Details of C4H8O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Mengxun; Chen, Tie; Fang, Shisong; Wu, Weihua; Wang, Xin; Wu, Haiqiang; Xiong, Yongai; Song, Jun; Li, Chenyang; He, Zhendan; Lee, Chi-Sing published the artcile< Peroxide- and transition metal-free electrochemical synthesis of α,β-epoxy ketones>, Quality Control of 627-27-0, the main research area is epoxy ketone preparation antitumor activity diastereoselective green chem electrochem.

A novel electrochem. method for the synthesis of α,β-epoxy ketones I (R = 2-methylphenyl, 3-iodophenyl, 2,3-dihydro-1-benzofuran-6-yl, etc.; R1 = 4-methylphenyl, 5-fluoro-2-methoxyphenyl, naphthalen-2-yl, etc.) is reported. With KI as the redox mediator, Me ketones RC(O)CH3 reacted with aldehydes R1CHO under peroxide- and transition metal-free electrolytic conditions and afforded α,β-epoxy ketones I in one pot (36 examples, 52-90% yield). This safe and environmental-friendly method has a broad substrate scope and can readily provide a variety of α,β-epoxy ketones I in gram-scales for evaluation of their anti-cancer activities.

Organic & Biomolecular Chemistry published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Quality Control of 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Yu-Feng; Mellah, Mohamed published the artcile< Samarium(II)-electrocatalyzed chemoselective reductive alkoxylation of phthalimides>, Safety of But-3-en-1-ol, the main research area is phthalimide alkanol samarium catalyst electrochem selective reductive alkoxylation; alkoxy isoindolinone preparation.

The unprecedented samarium electrocatalyzed reductive alkoxylation of phthalimides in a single step was presented. Under mild conditions, using electrogenerated Sm(II) with TMSCl (tri-Me chlorosilane), N-substituted 3-alkoxyl isoindolin-1-ones were isolated in good to excellent yields with high functional group tolerance.

Organic Chemistry Frontiers published new progress about Aliphatic alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Safety of But-3-en-1-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ibert, Quentin; Cauwel, Madeleine; Glachet, Thomas; Tite, Tony; Le Nahenec-Martel, Patricia; Lohier, Jean-Francois; Renard, Pierre-Yves; Franck, Xavier; Reboul, Vincent; Sabot, Cyrille published the artcile< One-Pot Synthesis of Diazirines and 15N2-Diazirines from Ketones, Aldehydes and Derivatives: Development and Mechanistic Insight>, COA of Formula: C4H8N2O, the main research area is ketone aldehyde imine ammonia butyl hypochlorite phenyliodine diacetate cyclization; diazirine one pot preparation.

Broad scope one-pot diazirine synthesis strategies have been developed using two different oxidants depending on the nature of the starting material. In all cases, an inexpensive com. solution of ammonia (NH3) in methanol (MeOH) was employed, avoiding the difficult use of liquid ammonia. With aliphatic ketones, t-Bu hypochlorite (t-BuOCl) was found to be the best oxidant whereas it is preferable to use phenyliodine diacetate (PIDA) with aromatic ketones, aldehydes and imines. The nature of the imine-protecting group is essential and only t-Bu imine allowed the synthesis of 15N2-diazirine with complete 15N incorporation, emphasizing a key trans-imination step in the reaction mechanism. These methods are operationally simple, and tolerant to most functional groups, providing diazirines with yields ranging from 20 to 99%.

Advanced Synthesis & Catalysis published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 25055-82-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8N2O, COA of Formula: C4H8N2O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts