Tag: M.W=0-100

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 2854-16-2, name is 1-Amino-2-methylpropan-2-ol. This compound has unique chemical properties. The synthetic route is as follows. 2854-16-2

Example 15. 6-Bromo-8-cvclopentyl-2-(2-hvdroxy-2-methylpropylamino)-4-methylpyridof2.3-ty|pyrimidin- 7(betaH)-one; To a solution of 6-bromo-8-cyclopentyl-4-methyl-2-(methylsulfinyl)pyrido[2,3-cdpyrimidin-7(8/-/)- one (600 mg, 1.62 mmol) and 1-amino-2-methylpropan-2-ol (294 mg, 2.34 mmol) in dioxane (6 ml_) was added triethylamine (1.2 ml_, 8.6 mmol). The mixture was then heated at 110 0C in a sealed tube for 1 h. The solution was poured into brine and extracted with ethyl acetate. The organic was dried (anhydrous sodium sulfate), filtered and concentrated to dryness. The crude product was purified by silica gel flash chromatography to give the title compound as a solid (565 mg, 88percent).LRMS: 395, 397 (M+H)+.1H NMR (CDCI3, 400 MHz): 8.07 (1 H, s), 5.91-6.13 (1 H, m), 5.46-5.90 (1 H, m), 3.52 (2H, d, J = 6.32 Hz), 2.54 (3H, s), 2.17-2.43 (2H, m), 1.95-2.16 (2H, m), 1.76-1.95 (2H, m), 1.56-1.74 (3H, m), 1.30 (6H, s).

Statistics shows that 2854-16-2 is playing an increasingly important role. we look forward to future research findings about 1-Amino-2-methylpropan-2-ol.

Reference:
Patent; PFIZER PRODUCTS INC.; WO2008/32162; (2008); A1;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 124-68-5, name is 2-Amino-2-methyl-1-propanol. This compound has unique chemical properties. The synthetic route is as follows. 124-68-5

N-methyl-2-amino-2-methyl-propan-1 -ol (4)2-Amino-2-methylpropanol (3) (10 g, 0.11 mol), Na2CO3 (0.41 g), NaHCO3 (0.41 g) and 3:1 dioxane/water (41 ml) were stirred together at 00C. Boc anhydride (29.4 g, 0.13 mol) was added slowly and the reaction was stirred at room temperature for 6 h. The salts formed were filtered and washed with DCM. The filtrate was diluted with water (50ml) and extracted with DCM (3 x 50 ml), dried (Na2SO4) and evaporated to dryness, giving a white solid. This was dissolved in THF (100 ml) and added dropwise to a mixture of lithium aluminium hydride (12.7 g, 0.33 mol) in THF (200 ml). The mixture was heated to reflux overnight then cooled to room temperature. Water (15 ml) was added slowly with ice-cooling followed by 4 M NaOH (15 ml), and then more water (45 ml). The white solids were filtered, washed with THF, and the filtrate was evaporated to dryness, giving a pink solid (8.9 g, 77%). 1H NMR (400 MHz, CDCI3): 0.97 (6H, s), 2.24 (3H, s), 3.26 (2H, s); 13C NMR (100 MHz, CDCI3): 23.27, 28.41 , 53.62, 68.26.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 124-68-5, 2-Amino-2-methyl-1-propanol.

Reference:
Patent; BIOCOPEA LIMITED; BANNISTER, Robin Mark; WO2010/103312; (2010); A1;,
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The common heterocyclic compound, 616-29-5, name is 1,3-Diaminopropan-2-ol, molecular formula is C3H10N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route. 616-29-5

Example 1 11- {[tert-Butyl (dimethyl) silyl] oxy}-9- (methylsulfonyl)-9, 10,11, 12-tetrahydro-8H [1, 4] diazepino [1′, 2′ : 1, 2] imidazo [4,5-c] quinolin-6-amine Part A Under a nitrogen atmosphere, a solution of di-tert-butyl dicarbonate (145. 35 g, 665.98 mmol) in 1,4-dioxane (400 mL) was added dropwise with stirring to a solution of 2-hydroxy-1, 3-diaminopropane (300.00 g, 332.85 mmol) in methanol (500 mL) over a period of six hours. The reaction was stirred overnight at ambient temperature and then concentrated under reduced pressure. The residue was dissolved in 10% citric acid in water, and additional citric acid was added to adjust the solution to pH 4. The resulting solution (1-1.5 L) was washed with dichloromethane (3 x 500 mL) and then adjusted to pH 12 with the addition of 50% aqueous sodium hydroxide. The basic solution was extracted with chloroform (7 x 500 mL), and the combined extracts were concentrated under reduced pressure and dried overnight under high vacuum to provide 108. 19 g of tert-butyl 3-amino-2-hydroxypropylcarbamate as a white solid.

The synthetic route of 616-29-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; 3M INNOVATIVE PROPERTIES COMPANY; WO2005/66172; (2005); A1;,
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Adding some certain compound to certain chemical reactions, such as: 764-48-7, name is Ethylene Glycol Vinyl Ether, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 764-48-7. 764-48-7

Intermediate 2; O-(2-(vinyloxy)ethyl)hydroxylamine; Step A: 2-(2-(vinyloxy)ethoxy)isoindoline-1,3-dione To a solution of 2-(vinyloxy)ethanol (20.4 mL, 227 mmol), triphenylphosphine (59.5 g, 227 mmol), and N-hydroxyphthalimide (37.0 g, 227 mmol) in THF (450 mL) was added DEAD (35.9 mL, 227 mmol) at 0 C. under a N2 atmosphere. After stirring for 16 h at room temperature, the reaction mixture was concentrated in vacuo. The residue was filtered, washed with chloroform and the filtrate was concentrated in vacuo. The residue was purified by column chromatography on SiO2 (Hex: EtOAc=2:1) to give 2-(2-(vinyloxy)ethoxy)isoindoline-1,3-dione (32.5 g, 61.4%) as a yellow solid. 1H NMR (CDCl3, Varian 400 MHz) delta 4.04-4.08 (3H, m), 4.19 (1H, dd, J=14.4, 2.2 Hz), 4.45-4.48 (2H, m), 6.47 (1H, dd, J=14.0, 6.8 Hz), 7.53-7.78 (2H, m), 7.80-7.87 (2 m, m).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 764-48-7.

Reference:
Patent; CHEMIZON, A DIVISION OF OPTOMAGIC CO., LTD.; US2012/238599; (2012); A1;,
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616-29-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 616-29-5, name is 1,3-Diaminopropan-2-ol. This compound has unique chemical properties. The synthetic route is as follows.

To a vigorously stirred ethanolic solution of salicylaldehyde (0.106 mL, 1 mmol) an ethanolic solution (20 mL) of 1,3-diamino-2-propanol (0.046 g, 0.5 mmol) was added dropwisely. The solution turned to light yellow and the mixture refluxed for 4 h. The resulting yellow powder was collected by filtration, washed with cold ethanol and ether and dried in the air ( Scheme 1 ). L2 was synthesized in order to compare with L1 from the point of view of the effect of substituent on DNA-binding measurements, cleavage activity, and cytotoxicity. Yield >70%; m.p. >250omicronC; F.W: 298.20, Color: yellow. Anal. calcd for C17H18N2O3: C, 68.44; H, 6.08; N,9.39%. Found: C, 68.04; H, 5.73, N, 9.56%. FT-IR (KBr, cm-1): 3394 (nuOH), 2893 (nuC-H), 1635 (nuC=N). UV-Vis (H2O): lambdamax (nm) = 386, 324. 1HNMR (250 MHz, DMSO-d6, room temperature): delta(ppm) = 13.52 (s, 2H, OH), 8.50 (s, 2H, HC=N), 7.42-6.85 (m, 8H, ArH), 5.17 (s, 1H, CHOH), 3.97 (s, 1H, CHOH), 3.76 (d, 2H, CH2), 3.57 (d, 2H, CH2).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 616-29-5, 1,3-Diaminopropan-2-ol.

Reference:
Article; Asadi, Zahra; Nasrollahi, Neda; Journal of Molecular Structure; vol. 1147; (2017); p. 582 – 593;,
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616-29-5 , The common heterocyclic compound, 616-29-5, name is 1,3-Diaminopropan-2-ol, molecular formula is C3H10N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Example 13 delta-CS-BromophenvD-S-hvdroxy-delta-^-methoxyphenylVS^J^-tetrahydroimidazorLS- alpyrimidine-6(2H)-thione4-(3-Bromophenyl)-4-(4-methoxyphenyl)-l,3-thiazolidine-2,5-dithione (82 mg, 0.20 mmol), l,3-diaminopropan-2-ol (54 mg, 0.60 mmol) and triethylamine (139 muL, 1 mmol), was heated to 70 C in ethanol (2 mL) for 1 h. The mixture was concentrated in vacuo and the residue was diluted with ethyl acetate and washed with aqueous sodium carbonate, brine, dried over sodium sulfate and concentrated in vacuo. The crude product was purified by column chromatography using an eluent with ethyl acetate in heptane (0-100 %) to give 83 mg (96 % yield): MS (AP) m/z 433 [M+l]+.

According to the analysis of related databases, 616-29-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ASTRAZENECA AB; ASTEX THERAPEUTICS LTD; WO2007/145571; (2007); A1;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.616-29-5, name is 1,3-Diaminopropan-2-ol, molecular formula is C3H10N2O, molecular weight is 90.12, as common compound, the synthetic route is as follows.616-29-5

Example 110; 8-r3-Bromophenyl)-3-hydroxy-8-(4-methoxvphenvD-3,4,7,8-tetrahydroimidazo[l,5- fllpvrimidine-6(2H)-thione0; 4-(3-Bromophenyl)-4-(4-methoxyphenyl)-l,3-thiazolidine-2,5-dithione (82 mg, 0.20 mmol), l,3-diaminopropan-2-ol (54 mg, 0.60 mmol) and triethylamine (139 muL, 1 mmol), was heated to 70 C in ethanol (2 mL) for 1 h. The mixture was concentrated in vacuo and the residue was diluted with ethyl acetate and washed with aqueous sodium carbonate, 0 brine, dried over sodium sulfate and concentrated in vacuo. The crude product was purified by column chromatography using an eluent with ethyl acetate in heptane (0-100 %) to give 83 mg (96 % yield): MS (AP) m/z 433 [M+l]+.

Statistics shows that 616-29-5 is playing an increasingly important role. we look forward to future research findings about 1,3-Diaminopropan-2-ol.

Reference:
Patent; ASTRAZENECA AB; ASTEX THERAPEUTICS LTD; WO2007/145569; (2007); A1;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 4415-82-1, name is Cyclobutylmethanol, molecular formula is C5H10O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. 4415-82-1

Step 1 : Into a 20-L 4-necked round-bottom flask was placed a solution of cyclobutylmethanol (1000 g, 1 1 .61 mol) in dichloromethane (10 L). This was followed by the addition of Dess-Martin periodinane (4683 g, 1 1 .04 mol) in several batches at 10-15 C over 120 min. The resulting solution was stirred for 2 h at room temperature and then quenched by the addition of 20 L of cold, saturated aqueous sodium bicarbonate solution. Solids were removed by filtration and washed with 5 L of dichloromethane. The filtrate was extracted with dichloromethane. The organic layers were combined, dried over anhydrous sodium sulfate and concentrated under vacuum. The residue was applied onto a silica gel column and eluted with DCM:PE (2:1 ). This resulted in 100 L of cyclobutanecarbaldehyde in dichloromethane and petroleum ether solution.

The chemical industry reduces the impact on the environment during synthesis 4415-82-1, I believe this compound will play a more active role in future production and life.

Reference:
Patent; MERCK SHARP & DOHME CORP.; DINSMORE, Christopher; FRADERA LLINAS, Francesc Xavier; KUDALE, Amit Ashokrao; MACHACEK, Michelle; REUTERSHAN, Michael Hale; THOMPSON, Christopher Francis; TROTTER, B. Wesley; YANG, Liping; ALTMAN, Michael, D.; BOGEN, Stephane, L.; DOLL, Ronald, J.; VOSS, Matthew, E.; WO2014/100071; (2014); A2;,
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616-29-5 ,Some common heterocyclic compound, 616-29-5, molecular formula is C3H10N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: The mixture of 1,2,3,4-tetrahydroacridine [38] (3/4; 1 eq) and different diaminoalkanes was heatedin phenol (0.5 eq) at 165-170 C for a period of 35¡À60 min in the presence of potassium iodide ina catalytic amount. After the completion of reactions, monitored on TLC and on consumption ofstarting material, the reaction mixture was allowed to come at room temperature. After cooling, thereaction mixture was dissolved into DCM and washed with 5% NaOH (3 75 mL) and brine solution,respectively. Finally, the DCM layer so obtained was dried over the anhydrous Na2SO4 and thenconcentrated under reduced pressure to give desired product in crude form. The column purificationof the crude product over silica gel (100-200 mesh) in 4-6% methanol/dichloromethane afforded thealkyl substituted tacrine amines (5-10) in a 60-75 % yield and their spectral data are presented in ourprevious publication [23].

According to the analysis of related databases, 616-29-5, the application of this compound in the production field has become more and more popular.

Reference:
Article; Rajeshwari, Rajeshwari; Chand, Karam; Candeias, Emanuel; Cardoso, Sandra M.; Chaves, Silvia; Amelia Santos; Molecules; vol. 24; 3; (2019);,
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Adding some certain compound to certain chemical reactions, such as: 124-68-5, name is 2-Amino-2-methyl-1-propanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 124-68-5. 124-68-5

1-a. A mixture of 2-amino-2-methyl-1-propanol (53 g), di-t-butyl dicarbonate (65 g) and water (500 ml) was stirred at room temperature for 1 hour. The reaction mixture was extracted with chloroform, and the chloroform layer was dried over MgSO4. The solvent was evaporated under reduced pressure. The residue was recrystallized from hexane to give 2-(t-butoxycarbonylamino)-2-methyl-1-propanol (44.4 g). NMR (CDCl3)delta: 1.25 (6H, singlet), 1.43 (9H, singlet), 3.20-5.50 (2H, multiplet), 3.56 (2H, singlet).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 124-68-5.

Reference:
Patent; Teikoku Hormone Mfg. Co., Ltd.; US4843072; (1989); A;,
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