Tag: M.W=0-100

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 33420-52-9, name is 2,2-Difluoropropan-1-ol. This compound has unique chemical properties. The synthetic route is as follows. category: alcohols-buliding-blocks

To a solution of 2,2-difluoropropanol (500 mg, 5.2 mmol) and triethylamine (632 mg, 6.2 mmol) in dichloromethane (5 mL) was added trifluoromethanesulfonic anhydride (1.76 g, 6.2 mmol) at -50 C. The reaction mixture was stirred at -50 C. for 2 h and then diluted with dichloromethane (20 mL). The organic layer was washed with water (10 mL), 1 M citric acid (10 mL), saturated aqueous sodium bicarbonate (10 mL), dried over anhydrous sodium sulfate and concentrated under reduced pressure (water bath temperature 0 C.) to give the crude 2,2-difluoropropyl trifluoromethanesulfonate (600 mg, 51%) as a pink oil, used in the next step without further purification.

With the rapid development of chemical substances, we look forward to future research findings about 33420-52-9.

Reference:
Patent; Genentech, Inc.; Patel, Snahel; Hamilton, Gregory; (73 pag.)US2018/170927; (2018); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.6153-05-5, name is (Z)-3-Methylpent-2-en-4-yn-1-ol, molecular formula is C6H8O, molecular weight is 96.13, as common compound, the synthetic route is as follows.Safety of (Z)-3-Methylpent-2-en-4-yn-1-ol

n-BuLi (4.2 mL, 10 mmol, 2.4 mol/L) was added dropwise to a solution of (Z)-3-methylpent-2-en-4-yn-1-ol (0.48 g, 5 mmol) in THF (10 mL) at ?78 ¡ãC under a N2 atmosphere, andthen the mixture was stirred for 1 h at ?78 ¡ãC. A solution of 4e (1.01 g, 5 mmol) in THF (5 mL) wasadded slowly, the mixture was stirred for 0.5 h at ?78 ¡ãC, and then it was warmed to room temperatureand stirred for 2 h. The reaction was quenched with saturated aqueous NH4Cl solution (10 mL) andextracted with EtOAc (3 ¡Á 30 mL). The combined organics were washed with brine (2 ¡Á 20 mL), driedover anhydrous Na2SO4 and concentrated. The residue was purified by silica gel columnchromatography (petroleum ether/EtOAc, 1:1) to afford 6i (1.40 g, 94percent) as a yellow oil.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,6153-05-5, (Z)-3-Methylpent-2-en-4-yn-1-ol, and friends who are interested can also refer to it.

Reference:
Article; Han, Xiaoqiang; Wan, Chuan; Yang, Dongyan; Yuan, Xiaoyong; Du, Shijie; Xiao, Yumei; Qin, Zhaohai; Molecules; vol. 18; 9; (2013); p. 10776 – 10788;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of 14320-38-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 14320-38-8, name is Cyclopent-3-enol, molecular formula is C5H8O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a stirred ice-cooled solution of 3-cyclopentene-1-oi (3.60 rnL, 42.8mrnol) in DCM (80 mL) was added iniidazole, 99-F%, crystalline (6.70 g, 98mmoi) followed by slow addition of tert-butvidimethvisilvi chloride, 1.0 Msolution in dichioroinethane (47.1 mE, 47.1 mrnoi) via a syringe. The resultingmixture was stirred at 0 C for 0.5 h and at ambient temperature overnight (16 h).The reaction was poured into ice water and extracted with DCM (3 X). Thecombined organics were washed with brine (1 X), dried over anhydrous sodiumsulfate and concentrated in vacuo. The crude residue was purified by silica gelchromatography (EtOAc/1-Iexanes. 5 mm at 0 % and 30 mm from 0 to 10 %. 80 g ISCO silica gel column) to give tert-butyl (cy ciopent-3-en- 1 -yloxy)dimethyisiiane in nearly quantitative yield as a colorless liquid, taken directly onto the next step.

According to the analysis of related databases, 14320-38-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; AMGEN INC.; BROWN, Sean P.; BEDKE, David Karl; DEGRAFFENREID, Michael R.; FU, Jiasheng; LI, Zhihong; GONZALEZ LOPEZ DE TURISO, Felix; GONZALEZ BUENROSTRO, Ana; GRIBBLE, Jr., Michael W.; JOHNSON, Michael G.; KOHN, Todd J.; LI, Kexue; LI, Yunxiao; LIZARZABURU, Mike Elias; REW, Yosup; TAYGERLY, Joshua; WANG, Yingcai; YAN, Xuelei; YU, Ming; ZHU, Jiang; ZANCANELLA, Manuel; JIAO, Xian Yun; ZHU, Liusheng; WANG, Xianghong; MEDINA, Julio C.; DUQUETTE, Jason A.; HOUZE, Jonathan B.; VIMOLRATANA, Marc; CARDOZO, Mario G.; CHENG, Alan C.; (2426 pag.)WO2017/147410; (2017); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 110-73-6, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 110-73-6 as follows.

2-Bromothiophene (1.19 mL, 12.3 mmol, CAS 1003-09-4), copper(I) iodide (350 mg, 15 mol %), copper powder (117 mg, 15 mol %, CAS 7440-50-8) and potassium phosphate tribasic (5.22 g, 24.6 mmol) were suspended in 2-(ethylamino)ethanol (12 mL) and heated at 80 C. for 20 h under Ar. After this time, the reaction mixture was allowed to cool to room temperature and water (40 mL) added. The solution was extracted with diethyl ether (3¡Á40 mL), and the combined organic fractions washed with brine (1¡Á60 mL), dried over MgSO4 and the solvent removed in vacuo. Purification was undertaken by silica gel column chromatography (column loaded using 3% Et3N/hexane) using 2:1 hexane/ethyl acetate to elute the product as an orange oil (1.02 g, 5.96 mmol, 48%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,110-73-6, its application will become more common.

Reference:
Patent; University of Notre Dame du Lac; Smith, Bradley; US2015/5501; (2015); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 2854-16-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2854-16-2, name is 1-Amino-2-methylpropan-2-ol, molecular formula is C4H11NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of [2-(7-methyl-5-{[6-(methylsulfonyl)pyridin-3-yl]oxy}-1H-indol-2-yl)-4,5-dihydro-1,3-thiazol-5-yl]acetic acid (300 mg) and 2-amino-2-methyl-2-propanol (90 mg) in N,N-dimethylformamide (20 mL) were added 1-hydroxybenzotriazole (137 mg) and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (194 mg) under ice-cooling, and the mixture was stirred under ice-cooling and then at room temperature for 15 hr. Water was added to the reaction solution, and the mixture was extracted with ethyl acetate. The organic layer was washed with aqueous sodium hydrogen carbonate solution and saturated brine, dried over magnesium sulfate, filtered and concentrated under reduced pressure. The obtained residue was subjected to silica gel column chromatography (ethyl acetate:methanol = 100:0 to 90:10, volume ratio) to give colorless crystals. The obtained crystals were recrystallized from tetrahydrofuran-ethyl acetate to give the title compound (280 mg, yield 81percent) as colorless crystals. melting point 184-186¡ãC. MS 517 (MH+).

According to the analysis of related databases, 2854-16-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Takeda Pharmaceutical Company Limited; EP2371826; (2011); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 534-03-2, name is 2-Aminopropane-1,3-diol, molecular formula is C3H9NO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Application In Synthesis of 2-Aminopropane-1,3-diol

(1) N-(4-Phenoxybenzenesulfonyl)serinol After triethylamine (10.12 g, 100 mmol) was added dropwise to a solution of serinol (3.64 g, 40 mmol) in a mixture of dioxane (100 ml) and water (200 ml), the mixture was stirred at room temperature for 30 minutes.. To the reaction mixture, a solution of 4-phenoxybenzenesulfonyl chloride (10.75 g, 40 mmol) in dioxane (100 ml) was added dropwise and this was stirred for 3 hours.. Most of the solvent was evaporated under reduced pressure and the residue was extracted with ethyl acetate.. The organic layer was washed with water, dried over anhydrous magnesium sulfate and concentrated under reduced pressure to afford the desired compound (10.62 g, yield 82%) as a white powder. 1H-Nuclear magnetic resonance spectrum (400 MHz, CDCl3-DMSO-d6) delta ppm: 7.84 (2H, d, J=8 Hz), 7.41 (2H, t, J=8 Hz), 7.22 (2H, t, J=7 Hz), 7.09-7.01 (4H, m), 6.69 (1H, d, J=7 Hz), 4.10-4.06 (1H, m), 3.63-3.45 (4H, m).

With the rapid development of chemical substances, we look forward to future research findings about 534-03-2.

Reference:
Patent; Sankyo Company, Limited; US6673804; (2004); B1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 110-73-6 ,Some common heterocyclic compound, 110-73-6, molecular formula is C4H11NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Reference Synthetic Example 19 tert-Butyl ethyl(2-hydroxyethyl)carbamate To a mixture of 2-(ethylamino)ethanol (8.91 g) and ethyl acetate (100 mL) was added di-tert-butyl dicarbonate (21.8 g) under ice-cooling. The reaction mixture was stirred at room temperature for 3 days, and washed with saturated brine, then, dried over anhydrous magnesium sulfate. The solution was concentrated under reduced pressure to give title compound as colorless oil (19.0 g). 1H-NMR (CDCl3): 1.11 (3H, t, J=7.0Hz), 1.47(9H,s), 3. 27 (2H, q, J=7. 0Hz), 3. 37 (2H, t, J=5.2Hz), 3. 73 (2H, q, J=5. 2Hz).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 110-73-6, 2-(Ethylamino)ethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Takeda Pharmaceutical Company Limited; EP1602362; (2005); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of 627-30-5, Adding some certain compound to certain chemical reactions, such as: 627-30-5, name is 3-Chloropropan-1-ol,molecular formula is C3H7ClO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 627-30-5.

Example 5: Production of polymer particles by treating a mixture of azide-modified PAA and alkyne-modified PAA with acid; Synthesis of 3-azidopropanol: In a 100 ml_ round bottom flask, liquid 3- chloropropanol (10.0 g, 1.0 equiv), solid sodium azide (17.19 g, 2.5 equiv) were reacted in DMF for 40 hours at 100 0C. The reaction mixture was cooled to room temperature, poured into a reparatory funnel and extracted with diethyl ether (300 ml_) and brine solution (500 ml_). The organic layer was separated and dried over MgSO4. Rotary evaporation removed the diethyl ether solvent at room temperature and yielded crude 3-azidopropanol (12.5 g). 1H-NMR (delta, ppm) CDCI3: 3.76 – 3.73 (t, 2H, HOCH2CH2CH2N3), 3.46 – 3.43 (t, 2H, HOCH2CH2CH2N3), 2.09 (br-s, 1 H, OH), 1.86 – 1.80 (m, 2H, HOCH2CH2CH2N3). IR neat (cm”1): 2100 (N=N=N).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 627-30-5, 3-Chloropropan-1-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; VIVE NANO, INC.; LI, Fugang; PHAM, Hung; ANDERSON, Darren, J.; WO2010/35118; (2010); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 2566-44-1, name is 2-Cyclopropylethanol. This compound has unique chemical properties. The synthetic route is as follows. HPLC of Formula: C5H10O

To a solution of triphosgene (68 mg, 0.23 mmol) in dichloromethane (0.5 mL) was added 2-cyclopropylethanol (69 mg, 0.80 mmol). After the solution was stirred for 45 min at ambient temperature N,N-diisopropyl ethyl amine (156 mul, 0.912 mmol) and rac-{4-[(3S,4R)-3-(3,4-dichloro-phenyl)-4-methylamino-pyrrolidine-1-carbonyl]-piperidin-1-yl}-(1-methyl-cyclopropyl)-methanone (50 mg, 0.11 mmol) were added and the solution was stirred for 3 d at ambient temperature. It was diluted with ethyl acetate (15 mL) and washed with aqueous sodium carbonate (1 M, 15 mL) and brine (15 mL). The aqueous layers were extracted with ethyl acetate, dried over sodium sulfate and concentrated. Purification by chromatography (SiO2, ethyl acetate_methanol=100:0 to 80:20) afforded the title compound (59 mg, 94%) as an off-white foam. MS m/e: 550.3 [M]+.

With the rapid development of chemical substances, we look forward to future research findings about 2566-44-1.

Reference:
Patent; Knust, Henner; Koblet, Andreas; Nettekoven, Matthias; Ratni, Hasane; Riemer, Claus; Vifian, Walter; US2011/144081; (2011); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 504-63-2 ,Some common heterocyclic compound, 504-63-2, molecular formula is C3H8O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure A: Synthesis of acetal protected aldehydes 1,3-Propanediol (1.5 eq.) and p-TSA (0.1 eq.) were added to a solution of aldehyde (5.0 mmol, 1.0 eq.) in toluene. The reaction was heated to reflux and left to stir for 7 hours. After cooling to room temperature, the reaction was washed with three portions of H2O, dried over MgSO4 and the solvent removed under reduced pressure to afford the crude acetal protected product. General procedure A was followed using 2-bromobenzaldehyde (925 mg, 5.00 mmol), followed by recrystallization from petrol:ether, to provide the title compound as white needles in 88% yield (1.07g, 4.40 mmol). m.p. 83-84 C; 1H NMR (300 MHz, CDCl3) deltaH: 7.69 (1H, dd, J = 7.8, 1.7 Hz, ArH), 7.52 (1H, dd, J = 8.0, 1.3 Hz, ArH), 7.33 (1H, td, J = 7.6, 1.2 Hz, ArH), 7.19 (1H, td, J = 7.7, 1.7 Hz, ArH), 5.76 (1H, s, CH), 4.29 (1H, dd, J = 5.1, 1.3 Hz, OCHAHB), 4.25 (1H, dd, J = 5.1, 1.3 Hz, OCHAHB), 4.03 (2H, td, J = 12.2, 2.4 Hz, OCH2), 2.32-2.16 (1H, m, CH2CHAHBCH2), 1.48-1.41 (1H,m, CH2CHAHBCH2); 13C{1H} NMR (75.5 MHz CDCl3) deltaC: 137.5, 132.6, 130.3, 128.0, 127.5, 122.3, 100.9, 67.6, 25.7; I.R (thinfilm) nu max (cm-1): 1594 (ArC=C), 1570 (ArC=C); HRMS (ESI): m/z calculated for C10H11BrO2: requires: 264.9840 for [M+Na]+; found: 264.9839.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,504-63-2, its application will become more common.

Reference:
Article; Peacock, Lucy R.; Chapman, Robert S. L.; Sedgwick, Adam C.; Bull, Steven D.; Mahon, Mary F.; Amans, Dominique; Organic Letters; vol. 17; 4; (2015); p. 994 – 997;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts