Tag: M.W=0-100

Related Products of 2854-16-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 2854-16-2, name is 1-Amino-2-methylpropan-2-ol. A new synthetic method of this compound is introduced below.

General procedure: The proper 1,4-pentanedione 48 (2.28 mmol) and the suitableamine (2.28 mmol) were dissolved in ethanol (2 ml) in a sealedglass tube equipped with a stirring bar in the presence of p-toluenesulfonicacid (30 mg, 0.17 mmol). The tube was heated in thecavity of the microwave reactor for 30 min (150W, internal temperature160 ¡ãC, and internal pressure 150 psi). At the end, thereaction mixture was cooled down and concentrated. The crudematerial was purified by chromatography on aluminum oxide(activity II-III, according to Brockmann) with cyclohexane to givethe expected pyrroles 49a-n? as solids in satisfactory yields.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,2854-16-2, 1-Amino-2-methylpropan-2-ol, and friends who are interested can also refer to it.

Reference:
Article; Poce, Giovanna; Cocozza, Martina; Alfonso, Salvatore; Consalvi, Sara; Venditti, Giulia; Fernandez-Menendez, Raquel; Bates, Robert H.; Barros Aguirre, David; Ballell, Lluis; De Logu, Alessandro; Vistoli, Giulio; Biava, Mariangela; European Journal of Medicinal Chemistry; vol. 145; (2018); p. 539 – 550;,
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Adding a certain compound to certain chemical reactions, such as: 2854-16-2, 1-Amino-2-methylpropan-2-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 2854-16-2, blongs to alcohols-buliding-blocks compound. SDS of cas: 2854-16-2

General procedure: By the same conditions as the example 2 of an experiment, the compound 7 was synthesized except having replaced with isobutyl amine and having used 2-hydroxy-2-methylpropyl amine. Yield was 67percent. The compound 7 was obtained like the example 7-1 of an experiment except having changed reaction conditions, such as a catalyst, a solvent, reaction temperature, and time, like the following table 2 description. Yield is shown in Table 2

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,2854-16-2, its application will become more common.

Reference:
Patent; TSUMURA & CO; IGARASHI, YASUSHI; (20 pag.)JP5742190; (2015); B2;,
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Application of 110-73-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 110-73-6, name is 2-(Ethylamino)ethanol, molecular formula is C4H11NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

EXAMPLE 8This example illustrates the preparation of certain compounds of the present invention. The amines used were commercial samples supplied by Fisher Scientific or Sigma Aldrich. Amines were reacted with one of the following: (-)-Ethyl(S)-2-hydroxypropionate (Ethyl-5-lactate, Ex Sigma Aldrich, 98%) (-)-Ethyl(S)-2-hydroxypropionate (Ethyl-L-lactate, Ex Fluka, >99%) 3,6-dimethyl-1,4-dioxane-2,5-dione (Lactide, Ex Aldrich, 99%) Initially reactions were performed in a microwave reactor under the conditions listed in Table 5. Due to the restricted volumes possible and in light of the rapid reactions seen, further reactions were carried out under ambient conditions and over an increased timescale. Reactions were monitored using FT-IR spectroscopy via the reduction in the ester band from ethyl-lactate at ~1750 cm-1 and the corresponding increase in the amide bands at ~1630 cm-1 and ~1550 cm-1. Selected samples were purified via preparatory HPLC and the compounds were identified via GC-MS and NMR. A cleaner, novel synthetic route was later utilised where the amines were reacted with lactide (3,6-dimethyl-1,4-dioxane-2,5-dione). TABLE 5 Reacted Amine Moles With Moles Reaction Conditions Yield Ethylamine 0.126 Ethyl-S- 0.126 Microwave Reactor, 200 C., 20 >75% lactate Bar, 3 minutes Ethanolamine 0.164 Ethyl-S- 0.164 Microwave Reactor, 200 C., 15 >95% lactate Bar, 30 minutes Isopropylamine 0.116 Ethyl-S- 0.116 Microwave Reactor, 200 C., 18 >75% lactate Bar, 30 minutes Diethanolamine 0.104 Ethyl-S- 0.104 Microwave Reactor, 200 C., 15 >75% lactate Bar, 30 minutes Morpholine 0.114 Ethyl-S- 0.114 Microwave Reactor, 200 C., 9 Bar, >75% lactate 30 minutes Benzylamine 0.091 Ethyl-S- 0.091 Microwave Reactor, 200 C., 13 >75% lactate Bar, 30 minutes Diethylamine 0.096 Ethyl-S- 0.096 Microwave Reactor, 200 C., >50% lactate 15 Bar, 30 minutes N-methyl-tert- 0.037 Ethyl-S- 0.037 Microwave Reactor, 200 C., >25% butylamine lactate 12 Bar, 30 minutes N-ethylisopropylamine 0.037 Ethyl-S- 0.037 Microwave Reactor, 175 C., 8 >25% lactate Bar, 30 minutes sec-Butylamine 0.098 Ethyl-S- 0.098 Microwave Reactor, 200 C., >75% lactate 14 Bar, 30 minutes 1-ethylpropylamine 0.085 Ethyl-S- 0.085 Microwave Reactor, 200 C., >75% lactate 12 Bar, 30 minutes N- 0.096 Ethyl-S- 0.096 Microwave Reactor, 150 C., 3 >25% isopropylmethylamine lactate Bar, 30 minutes tert-Butylamine 0.095 Ethyl-S- 0.095 Microwave Reactor, 200 C., >95% lactate 17 Bar, 30 minutes Pyrrolidine 0.119 Ethyl-S- 0.119 Microwave Reactor, 200 C., >75% lactate 14 Bar, 30 minutes 1,3-dimethylbutylamine 0.030 Ethyl-S- 0.030 Microwave Reactor, 200 C., >50% lactate 10 Bar, 30 minutes 2-(ethylamino)ethanol 0.204 Ethyl-L- 0.183 4 days at Ambient >75% lactate Temperature & Pressure 2-amino-1-butanol 0.208 Ethyl-L- 0.188 4 days at Ambient >75% lactate Temperature & Pressure allylamine 0.267 Ethyl-L- 0.240 4 days at Ambient >75% lactate Temperature & Pressure Isobutylamine 0.199 Ethyl-L- 0.179 4 days at Ambient >75% lactate Temperature & Pressure 1-ethylpropylamine 0.171 Ethyl-L- 0.154 4 days at Ambient >25% lactate Temperature & Pressure tert-amylamine 0.170 Ethyl-L- 0.153 3 days at Ambient <25% lactate Temperature & Pressure Dipropylamine 0.146 Ethyl-L- 0.131 2 days at Ambient Negligible lactate Temperature & Pressure Hexylamine 0.151 Ethyl-L- 0.136 3 days at Ambient >75% lactate Temperature & Pressure DL-2-amino-1-pentanol 0.044 Ethyl-L- 0.039 3 days at Ambient >75% lactate Temperature & Pressure N-hexylmethylamine 0.130 Ethyl-L- 0.117 2 days at Ambient >50% lactate Temperature & Pressure N-methylpropylamine 0.047 Ethyl-L- 0.042 4 days at Ambient >50% lactate Temperature & Pressure Dipropylamine 0.047 Lactide 0.025 2 hours at 50 C. <10% Benzylamine 0.053 Lactide 0.028 1 hour at 40 C. >95% 2-benzylaminoethanol 0.069 Lactide 0.035 5 hours at 55 C. >25% N-methylbenzylamine 0.074 Lactide 0.038 12 days at Ambient >50% Temperature & Pressure N-methylbutylamine 0.078 Lactide 0.040 12 days at Ambient >50% Temperature & Pressure 3-diethylamino-propylamine 0.065 Lactide 0.033 12 days at Ambient >75% Temperature & Pressure 2-Ethyl-1-Hexylamine 0.166 Lactide 0.108 4 days at Ambient >95% Temperature & Pressure 3-N-Butoxy Propylamine 0.056 Lactide 0.034 4 days at Ambient >25% Temperature & Pressure 3-Pentylamine 0.059 Lactide 0.040 4 days at Ambient >95% Temperature & Pressure N-(3-Aminopropyl)Morpholine 0.067 Lactide 0.035 4 days at Ambient >95% Temperature & Pressure N-Methylaniline 0.081 Lactide 0.042 4 days at Ambient >25% Temperature & Pressure

According to the analysis of related databases, 110-73-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; SYNGENTA LIMITED; US2009/227453; (2009); A1;,
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Electric Literature of 109-83-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.109-83-1, name is 2-(Methylamino)ethanol, molecular formula is C3H9NO, molecular weight is 75.1097, as common compound, the synthetic route is as follows.

[Step 2] Fabrication of 2-Acetyl-6-[(2-hydroxyethyl)methylamino]naphthalene 0.4 g (2.1 mmol) of the second compound 2 is obtained to be mixed with 1.8 g (24.0 mmol) of 2-methylaminoethanol (CH3NHCH2CH2OH), 2.0 g (19.2 mmol) of sodium bisulfite (Na2O5S2) and 4 mL of water to be heated to 140 celsius degrees ( C.) with vigorous stirring and refluxed for 76 hrs. After cooling, 50 mL of dichloromethane is added for phase separation after sufficient stirring. Therein, after being dried with anhydrous sodium sulfate, an organic phase is concentrated under reduced pressure and separated and purified by liquid chromatography (SiO2, EtOAc_CH2Cl2=1:3), with 0.15 g (0.81 mmol) of the second compound 2 recycled. Thus, a solid product, 2-acetyl-6-[(2-hydroxyethyl)methylamino]naphthalene 3 (hereinafter referred to as third compound 3), is obtained, which has a weight of 0.276 g and a yield of 88.0%.

Statistics shows that 109-83-1 is playing an increasingly important role. we look forward to future research findings about 2-(Methylamino)ethanol.

Reference:
Patent; INSTITUTE OF NUCLEAR ENERGY RESEARCH, ATOMIC ENERGY COUNCIL, Executive Yuan, R.O.C.; Lin, Wuu-Jyh; Farn, Shiou-Shiow; Tu, Yean-Hung; Huang, Li-Yuan; Chen, Dow-Che; Chu, Kuo-Yuan; Chang, Mao-Hsung; Duh, Ting-Shien; Chen, Jenn-Tzong; Shiue, Chyng-Yann; US9186423; (2015); B1;,
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Application of 2919-23-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.2919-23-5, name is Cyclobutanol, molecular formula is C4H8O, molecular weight is 72.1057, as common compound, the synthetic route is as follows.

To a solution of cyclobutanol (500 mg, 6.93 mmol), methane sulfonyl chloride (0.810 mL, 10.40 mmol) in DCM (5.0 mL) was added TEA (2.90 mL, 20.80 mmol) at 0 C. The mixture was stirred at 25 C for 3 h. TLC showed that the reaction was completed. The reaction mixture was diluted with EhO (50 ml) and DCM (30 ml), organic layer was separated, washed with EhO (20 mL *3), dried and concentrated. The residue was purified by silica gel column (pet. ether/EtOAc = 10: 1) to afford cyclobutyl methane sulfonate (350 mg, 1.864 mmol, 26.9 % yield) as yellow oil.

The chemical industry reduces the impact on the environment during synthesis 2919-23-5, I believe this compound will play a more active role in future production and life.

Reference:
Patent; VIIV HEALTHCARE UK (NO.5) LIMITED; BELEMA, Makonen; BOWSHER, Michael S.; GILLIS, Eric P.; IWUAGWU, Christiana; KADOW, John F.; NAIDU, B. Narasimhulu; PARCELLA, Kyle E.; PEESE, Kevin M.; (367 pag.)WO2019/244066; (2019); A2;,
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Synthetic Route of 2919-23-5, Adding some certain compound to certain chemical reactions, such as: 2919-23-5, name is Cyclobutanol,molecular formula is C4H8O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2919-23-5.

General procedure: Solutions of OTMPDMeCN-(X)2 and OTMPDPhCN-(X)2 (10mM, 5mL in CH2Cl2) were prepared from the pre-mixed 1:1 Cu(I)-ligand precursors by addition of excess O2 (1atm) at 193K. Two equiv of substrate per oxidant were used unless otherwise noted. For anaerobic substrate oxidations, excess O2 was removed and the solution was flushed with N2 prior to substrate addition. Similar product distributions were obtained for alcohol oxidation reactions performed under O2 and N2 at 233K. Alcohol oxidations without NEt3 were carried out at 233K, and all other reactions were carried out under N2 at 193K unless otherwise noted. The resulting reaction mixtures were quenched by dropwise addition of aqueous ammonia (30%) until the CH2Cl2 layer turned colorless, and passed through a column of neutral activated alumina (Brockmann I, ?150 mesh, 58A) followed by MeOH (2mL). The copper product is retained, and the organic products elute. The reaction mixture was analyzed by GC/GC-MS. Mass recovery of the products was >90% based on addition of an internal calibrant (benzonitrile for alcohols, acetophenone for amines).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 2919-23-5, Cyclobutanol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Large, Tao A.G.; Mahadevan, Viswanath; Keown, William; Stack, T. Daniel P.; Inorganica Chimica Acta; vol. 486; (2019); p. 782 – 792;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 96-35-5, name is Methyl 2-hydroxyacetate, molecular formula is C3H6O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. name: Methyl 2-hydroxyacetate

A certain amount of methacryloyl chloride (0.144 mol) dissolved in anhydrous DCM (60 mL) was added dropwise to methyl glycolate (at a temperature of ?0 C and an argon (Ar) atmosphere) 0.144 mol), TEA (0.288 mol), anhydrous DCM (100 mL), stir overnight, wash and purify, and obtain pure product by column chromatography.

With the rapid development of chemical substances, we look forward to future research findings about 96-35-5.

Reference:
Patent; Southwest University; Xu Zhigang; Shi Xiaoxiao; Ma Xiaoqian; Bai Shuang; Xue Peng; Kang Yuejun; (15 pag.)CN107596383; (2019); B;,
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Adding a certain compound to certain chemical reactions, such as: 2854-16-2, 1-Amino-2-methylpropan-2-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C4H11NO, blongs to alcohols-buliding-blocks compound. Formula: C4H11NO

THF (290 mL), 4-chloro-6-(6-(trifluoromethyl)pyridin-2-yl)-N-(2-(trifluoro-methyl)-pyridin-4-yl)-1,3,5-triazin-2-amine (29.0 g, 0.06893 mol), sodium bicarbonate (8.68 g, 0.1033 mol), and 1,1-dimethylaminoethanol (7.37 g, 0.08271 mol) were added to the reaction vessel at 20-35¡ã C. The resulting slurry was heated to reflux (75-80¡ã C.) for 16-20 h. The reaction was cooled to 30-40¡ã C. and THF was evaporated at below 45¡ã C. under reduced pressure. The reaction mixture was cooled to 20-35¡ã C., rinsed with ethyl acetate and water, and the ethyl acetate layer was collected. The organic layer was concentrated under vacuum at below 45¡ã C. then rinsed with dichloromethane and hexanes, filtered and washed with hexanes and dried for 8-10 h at 45-50¡ã C. under vacuum to provide 2-methyl-1-(4-(6-(trifluoromethyl)pyridin-2-yl)-6-(2-(trifluoromethyl)-pyridin-4-ylamino)-1,3,5-triazin-2-ylamino)propan-2-ol.

The synthetic route of 2854-16-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Celgene Corporation; Agios Pharmaceuticals, Inc.; Bhat, Sreenivas S.; Burnside, Scott; Parikh, Darshan; Gu, Chong-Hui; Altaf, Syed; (34 pag.)US2018/64715; (2018); A1;,
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Electric Literature of 14320-38-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 14320-38-8, name is Cyclopent-3-enol. This compound has unique chemical properties. The synthetic route is as follows.

Cyclopent-3-enol (2.1 g, 24.97 mmol) was dissolved in CH2CI2 (30 ml,). TIPS-Cl (10.58 mL, 49.9 mmol) was added, followed by imidazole (3.40 g, 49.9 mmol). The mixture was stirred at room temperature for 2 days. White solid was filtered out and washed with small amount of DCM. The organic solution was evaporated and the residue was purified by silica gel chromatography (80 g silica gel column, 0-50% EtOAc/hexane gradient). Removing solvent gave (cyclopent-3-en-l -y]oxy)triisopropylsilane (4.92 g, 20.46 mmol, 82 % yield) as a colorless oil. NMR (400 MHz, CDCb): delta ppm 5.67 (2 H, s), 4.63 (1 H, t, ./ 3.63 Hz), 2.62 (2 H, dd, ./ 14.97. 6.82 Hz), 2.20 – 2.45 (2 H, m), 1.00 – 1.13 (21 H, m).

According to the analysis of related databases, 14320-38-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; FU, Qinghong; ZHANG, Xiaojun; PRIESTLEY, Eldon Scott; HALPERN, Oz Scott; REZNIK, Samuel Kaye; RICHTER, Jeremy M.; (184 pag.)WO2018/13770; (2018); A1;,
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Electric Literature of 33420-52-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 33420-52-9, name is 2,2-Difluoropropan-1-ol. This compound has unique chemical properties. The synthetic route is as follows.

Trifluoromethanesulfonic anhydride (3.29 ml, 19.5 mmol) was added dropwise to a solution of 2,2-difluoropropan-1-ol (1.7 g, 18 mmol) in DCM (40 mL) at -10 C. (salt/ice bath). 2,6-Dimethylpyridine (2.5 mL, 21 mmol) was then added, and the reaction was stirred for 1 hour under these conditions. The reaction was then washed with water (*2), and the organic layer was dried over Na2SO4, filtered and concentrated under reduced pressure (vacuum ?200 mbars) to afford 2,2-difluoropropyl trifluoromethanesulfonate (2.1 g, 52%) as a red oil. 1H NMR (400 MHz, CHLOROFORM-d, 27 C.) 4.48 (2H, t), 1.73 (3H, t).

According to the analysis of related databases, 33420-52-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; AstraZeneca AB; BARLAAM, Bernard Christophe; O’DONOVAN, Daniel Hillebrand; HUGHES, Samantha Jayne; MOSS, Thomas Andrew; NISSINK, Johannes Wilhelmus Maria; SCOTT, James Stewart; YANG, Bin; (148 pag.)US2018/111931; (2018); A1;,
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