Tag: M.W=0-100

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 16545-68-9, name is Cyclopropanol, molecular formula is C3H6O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. COA of Formula: C3H6O

A solution of cyclopropanol (0.060 g, 1.03 mmol) in CH2CI2 (2 mL) was cooled to 0 C, treated with K2CO3 (0.43 g, 3.10 mmol) followed by phosgene (20% wt in toluene, 0.54 mL, 1.03 mmol), and stirred vigorously overnight at 0 C to room temperature. Unreacted phosgene was removed by purging the solution with N2 gas (passed through a KOH solution to dry) for 30 min. The reaction mixture was filtered through anhydrous MgS04, and concentrated at 0 C to afford cyclopropyl chloroformate as a colorless oil (~0.3 mL) that was used directly as a toluene solution for the next step (cyclopropyl chloroformate/cyclopropanol = 1:0.19, theoretical concentration = 2.8 M). 1 H NMR (400 MHz, CDCL) d 4.41-3.36 (m, 1 H), 0.98-0.82 (m, 4 H); 13C NMR (100 MHz, CDCL) d 151.3, 56.2, 5.49.

With the rapid development of chemical substances, we look forward to future research findings about 16545-68-9.

Reference:
Patent; UNIVERSITY OF PITTSBURGH – OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION; WIPF, Peter; (79 pag.)WO2019/203951; (2019); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 2867-59-6, 3-Aminobutan-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 2867-59-6, blongs to alcohols-buliding-blocks compound. name: 3-Aminobutan-1-ol

A mixture of 2,4-dichloro-6-nitro-quinazoline (80 mg, 0.33 mmol), THF (3.3 mL), 3- aminobutan-1-ol (35 mg, 0.39 mmol) and DIPEA (0.14 mL, 0.82 mmol) was stirred at RT for lh. LCMS (Method T2) Rt = 1.18 mins, mlz 297.08 [M+H]. Acetic acid (4 mL) was added directly to the mixture which was stirred at 70 00 for 16h. LCMS (Method T2) Rt = 0.85 mins, mlz 279.08 [M+H]. The solution was concentrated and the residue was taken up in methanol (5 mL). The solution was then purified using SCX-2 cartridge. The product was eluted with methanolic ammonia, affording 4-[(3-hydroxy-1-methyl-propyl)amino]-6-nitro-1 H-quinazolin-2- one (50 mg).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,2867-59-6, its application will become more common.

Reference:
Patent; CANCER RESEARCH TECHNOLOGY LIMITED; BELLENIE, Benjamin Richard; CHEUNG, Kwai Ming Jack; DAVIS, Owen Alexander; HOELDER, Swen; HUCKVALE, Rosemary; LLOYD, Matthew Garth; (360 pag.)WO2018/215798; (2018); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of 110-73-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 110-73-6, name is 2-(Ethylamino)ethanol. A new synthetic method of this compound is introduced below.

To a vial containing 6-[4-({[6-(3-fluorophenyl)pyridin-3-yl]carbonyl}amino)piperidin-1-yl]nicotinic acid (63.07 mg, 0.15 mmol) was added 0.375 mL of DMA, EDC (31.6 mg, 0.16 mmol), HOBt (20.3 mg, 0.15 mmol), NMM (0.04 mL, 0.37 mmol) and 2-(ethylamino)ethanol (13.4 mg, 0.15 mmol). The reaction mixture was stirred at room temperature for 12 hours and then diluted with water and ethyl acetate. The layers were separated and the organic layer collected and concentrated to give an oil, which was purified by RP-HPLC to give N-ethyl-6-[4-({[6-(3-fluorophenyl)pyridin-3-yl]carbonyl}amino)piperidin-1-yl]-N-(2-hydroxyethyl)nicotinamide (32 mg, 43%). HRMS (TOF, ES+) calculated for C27H30FN50 +H: 492.2333; observed 492.2611.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,110-73-6, 2-(Ethylamino)ethanol, and friends who are interested can also refer to it.

Reference:
Patent; Blake, Tanisha D.; Hamper, Bruce C.; Huang, Wei; Kiefer, James R.; Moon, Joseph B.; Neal, Bradley E.; Olson, Kirk L.; Pelc, Matthew J.; Schweitzer, Barbara A.; Thorarensen, Atli; Trujillo, John I.; Turner, Steven R.; US2008/146569; (2008); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 110-73-6, name is 2-(Ethylamino)ethanol, molecular formula is C4H11NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 110-73-6

General procedure: (A) 2-(Alkylamino)ethanol2a or 2b (6 mmol) and Et3N (1.0 ml) were added with stirring tothe solution of diferrocenylcyclopropenylium tetrafluoroborate 1 (3 mmol)in dry benzene or acetonitrile (70 ml). After stirring for 6-12 h at ~80C,the volatiles were removed in vacuo; the residue was chromatographed ona column with Al2O3 (activity III) (hexane-diethyl ether, 3 :1) to affordthe reaction products 3a,b (30-32%) and 4a,b (43-44%), respectively.(B) Following the general procedure, reaction of 1b (1 mmol) in MeCN(30 ml, 80C, 6-12 h) in the presence of Et3N (0.3 ml) with amino alcohols2a,b (1 mmol) afforded compounds 3a (62-71%) or 3b (67-74%) and4a,b (3-10%).(C) Reaction of 1b (1 mmol) in dry benzene (30 ml, 80C, 6-12 h) inthe presence of Et3N (0.3 ml) with amino alcohols 2a,b (3 mmol) affordedcompounds 3a,b (5-7%) and 4a (58-77%), 4b (61-80%)

With the rapid development of chemical substances, we look forward to future research findings about 110-73-6.

Reference:
Article; Sanchez Garcia, Jessica J.; Flores-Alamo, Marcos; Chirinos Flores, Denis E.; Klimova, Elena I.; Mendeleev Communications; vol. 27; 1; (2017); p. 26 – 28;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of 109-83-1, Adding some certain compound to certain chemical reactions, such as: 109-83-1, name is 2-(Methylamino)ethanol,molecular formula is C3H9NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 109-83-1.

10 g (calculated on the basis of the dry substance) of a Pd-doped copper catalyst on active carbon (Degussa AG, CE 1015 OY/W) suspended in water was placed first analogously to example 1 in an autoclave and 61 g ethanolamine and 272 g sodium hydroxide solution (15% by weight) were added. The autoclave was closed and the contents were heated to 160 C. The pressure was kept at 12 bar (absolute) and the hydrogen that formed was continuously discharged by a pressure control valve. After the end of the reaction (which is evident from the decrease in gas release) it was cooled to 90 C. and the catalyst was removed from the product solution by filtration. 315 g filtrate which contained 29.8 g % by weight Na glycinate was obtained (corresponds to a yield of 96.7% of theory).The filtered catalyst was suspended in 10 g water and fed back into subsequent batches.

According to the analysis of related databases, 109-83-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Thalhammer, Franz; Gastner, Thomas; US2009/163739; (2009); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 25125-21-7, 1-Hydroxymethyl-3-cyclopentene, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 25125-21-7, blongs to alcohols-buliding-blocks compound. Recommanded Product: 25125-21-7

To a solution of cyclopent-3-enylmethanol 146-2 (4.0 g, 41 mmol) in dichloromethane (150 mL) at 0C was added 3-chloroperbenzoic acid (10 g, 45 mmol, 77% purity) by portion. The reaction was stirred overnight. Dichloromethane (150 mL) was added. The organics was washed with sodium thiosulfate (12 g in 10 mL water), followed by saturated NaHCCb (40 mL). This was repeated till all the remaining 3-chloroperbenzoic acid was washed away. The organic was dried over MgSC. Evaporation of solvent gave a mixture of cis- and trans- 6- oxabicyclo[3.1.0]hexan-3-ylmethanol 146-3 (2.6 g, 57 %) as a yellow oil. GC-MS: m/z 114 (5) (M+), 95 (15), 88 (100), 81 (15).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,25125-21-7, 1-Hydroxymethyl-3-cyclopentene, and friends who are interested can also refer to it.

Reference:
Patent; ARBUTUS BIOPHARMA CORPORATION; MENDEZ, Patricia; SYMONDS III, William T.; DIETERICH, Douglas; (290 pag.)WO2019/51257; (2019); A2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 33420-52-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 33420-52-9, name is 2,2-Difluoropropan-1-ol, molecular formula is C3H6F2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Preparation of Intermediate Trifluoromethanesulfonic acid 2,2-difluoropropyl ester (I-4A-4c): To a solution of 2,2-difluoro-propan-1-ol (I-4A-4b, 1.76 g, 18.3 mmol), DMAP (157 mg, 1.3 mmol), and NEt3 (2.20 g, 3.1 ml, 22 mmol) in CH2Cl2 (15 ml) at 0 C. was added trifluoromethanesulfonic anhydride (Tf2O, 6.20 g, 3.7 ml, 22 mmol). The reaction mixture initially turned a pink color, then a yellow color following the complete addition of Tf2O. The reaction mixture was stirred at 0 C. for 2 h and diluted with CH2Cl2. The organic solution was washed with H2O, 1 M citric acid, and saturated aqueous NaHCO3, dried, and concentrated under reduced pressure (225 mm/Hg; water bath temperature -30 C.) to give the desired product, trifluoromethanesulfonic acid 2,2-difluoro-propyl ester (I-4A-4c), as a pink oil (3 g, 72%): 1H NMR (400 MHz, CDCl3): delta 4.49 (t, 2H, J=10.8 Hz), 1.74 (t, 3H).

According to the analysis of related databases, 33420-52-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Pfizer Inc; US2004/214838; (2004); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 616-29-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 616-29-5, name is 1,3-Diaminopropan-2-ol, molecular formula is C3H10N2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

1 ,3-diaminopropan-2-ol (200mg, 2.22mmols) was dissolved in 20ml methanol and triethylamine (20ml) was added dropwise. Boc anhydride (3eq) was then added and heated at 50C for 20min and 1 hr at room temperature. This was monitored by TLC (9:1) DCM:methanol. After completion saturated solution of NaHCC was added (40ml) and extracted with ethyl acetate. The solvent was evaporated in vacuo and used in the next step without purification.

According to the analysis of related databases, 616-29-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; UNIVERSITY OF LINCOLN; SINGH, Ishwar; TAYLOR, Edward; (137 pag.)WO2018/162922; (2018); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 124-68-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 124-68-5, name is 2-Amino-2-methyl-1-propanol. A new synthetic method of this compound is introduced below.

(3a) (2-Hydroxy-1,1-dimethylethyl)carbamic acid t-butyl ester 230.4 ml of di-t-butyl dicarbonate (1.00 mol) was added to a solution of 98.05 g of 2-amino-2-methyl-1-propanol (1.10 mol) and 154 ml of triethylamine (1.10 mol) in methylene chloride (500 ml) at room temperature over 20 minutes, and the mixture was stirred at room temperature for 2.5 hours. The reaction mixture was concentrated under reduced pressure and diluted with a 10% citric acid aqueous solution, followed by extraction with ethyl acetate. Then, the organic layer was washed with water and brine and dried over anhydrous magnesium sulfate. After filtration, the solvent was evaporated under reduced pressure to obtain 189.25 g of the crude title compound (yield: quant.). Colorless solid. 1H NMR spectrum (CDCl3, 400 MHz), delta: 4.64 (br s, 1H), 4.01 (br s, 1H), 3.59 (d, 2H, J = 6.3 Hz), 1.43 (s, 9H), 1.25 (s, 6H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,124-68-5, 2-Amino-2-methyl-1-propanol, and friends who are interested can also refer to it.

Reference:
Patent; Daiichi Sankyo Company, Limited; EP2036896; (2009); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 3279-95-6, name is 2-(Aminooxy)ethanol. A new synthetic method of this compound is introduced below., Recommanded Product: 3279-95-6

General procedure: 4a-c (1 equiv) were dissolved in ethanol (10mL). O-(2-hydroxyethyl)hydroxylamine (14, 2 equiv), acetic acid (2 equiv), pyridine (2 equiv) were added to the solution. After being refluxed for 5h, ethanol was removed under reduced pressure. The products were extracted with CH2Cl2. The combined extracts were washed with 2M HCl aqueous solution and brine. The organic layer was dried with anhydrous Na2SO4. The solvent was removed under reduced pressure and the residue was purified by column chromatography (PE: EtOAc=6: 1) to yield 15a-c.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 3279-95-6, 2-(Aminooxy)ethanol.

Reference:
Article; Li, Haihong; Wang, Ke; Wan, Qi; Chen, Ying; Steroids; vol. 141; (2019); p. 81 – 95;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts