Tag: M.W=0-100

Adding a certain compound to certain chemical reactions, such as: 616-29-5, 1,3-Diaminopropan-2-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 1,3-Diaminopropan-2-ol, blongs to alcohols-buliding-blocks compound. Safety of 1,3-Diaminopropan-2-ol

General Procedure for the Synthesis of the BOC-Protected Amino Alcohols 35a-eA solution of the appropriate amino alcohol (6.0 mmol), di-tert-butyl dicarbonate (1.96 g, 9.0 mmol) and NaHCO3 (2.5 g, 30.0 mmol) in 10 ml of dioxane and 10 ml H2O was stirred overnight at room temperature. Ethyl acetate (50 ml) was then added and the organic phase was washed with saturated NaHCO3 (2¡Á50 ml), 10% HCl (2¡Á50 ml), and brine (50 ml). The organic phase was then dried with MgSO4, filtered and evaporated. The product was purified as indicated.Di-tert-butyl 2-hydroxypropane-1,3-diyldicarbamate 35aThe title compound 35a was prepared in 35% yield (610 mg) using the general procedure and employing 3.92 g of di-tert-butyl dicarbonate instead of the indicated amount and the product was obtained as white solid after recrystalized from hexanes.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,616-29-5, 1,3-Diaminopropan-2-ol, and friends who are interested can also refer to it.

Reference:
Patent; METHYLGENE INC.; US2008/132525; (2008); A1;,
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Adding a certain compound to certain chemical reactions, such as: 96-35-5, Methyl 2-hydroxyacetate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of Methyl 2-hydroxyacetate, blongs to alcohols-buliding-blocks compound. Safety of Methyl 2-hydroxyacetate

To 17.09 g of Compound (5) shown below (methyl glycolate, manufactured by TCI), 30,00 g of tetrahydrofuran (THF) was added, and 21.15 g of triethylamine was further added. The mixture was cooled to 0C, and 20.85 g of methacrylic acid chloride was then added dropwise. After returning the temperature to room temperature, the mixture was stirred for 2 hours. A sodium hydrogencarbonate aqueous solution was added, followed by extraction with ethyl acetate. Organic layers were gathered, to which was then added MgSO4, and the resulting mixture was filtered and concentrated to obtain 28.51 g of Compound (6) (yield: 95 %). 1H-NMR, (400 MHz in (CD3)2CO): ? (ppm) = 1.94 to 2.04 (3H), 3.71 to 3.72 (3H), 4.73 (2H), 5.72 (1H), 6.15 (1H)

The synthetic route of 96-35-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Fujifilm Corporation; EP2196462; (2010); A1;,
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Reference of 2516-33-8 ,Some common heterocyclic compound, 2516-33-8, molecular formula is C4H8O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Sodium hydride (4.83 g, 0.12 mol) was added into cyclopropanemethanol (CAN 2516-33-8, 30 g) at 0 C. and the mixture was stirred at 0 C. for 1 h. Then to the mixture was added methyl 5-bromo-6-chloro-pyridine-2-carboxylic acid methyl ester (3 g, 12.75 mmol). The obtained solution was heated to 90 C. for 2 h. Then the mixture was evaporated to dryness, the residue was dissolved in 40 mL of water, and adjusted to pH=4 with hydrochloric acid (3 N), and extracted with ethyl acetate (3¡Á30 mL). The combined organic layer was washed with water (2¡Á30 mL) and brine (2¡Á50 mL) then evaporated to dryness to obtain the product as a white solid (2.5 g, 76.7%); MS (EI): m/e=272.0 [M+H]+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,2516-33-8, its application will become more common.

Reference:
Patent; Bissantz, Caterina; Grether, Uwe; Hebeisen, Paul; Kimbara, Atsushi; Liu, Qingping; Nettekoven, Matthias; Prunotto, Marco; Roever, Stephan; Rogers-Evans, Mark; Schulz-Gasch, Tanja; Ullmer, Christoph; Wang, Zhiwei; Yang, Wulun; US2012/316147; (2012); A1;,
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Adding a certain compound to certain chemical reactions, such as: 16545-68-9, Cyclopropanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C3H6O, blongs to alcohols-buliding-blocks compound. HPLC of Formula: C3H6O

A mixture of intermediate 525 (858 mg; 2.83 mmol), cyclopropanol (717 jiL; 11.3mmol) and cesium carbonate (1.84 g; 5.66 mmol) in 1,4-dioxane (9.5 mL) was heatedat 100C for 2h. The reaction mixture was heated at 100C overnight, cooled to roomtemperature and diluted with DCM. Water was added and the reaction mixture was extracted with DCM (three times). The combined organic layers were washed withwater, dried over MgSO4, filtered and evaporated to dryness. The residue was purified by chromatography over silica gel (irregular SiOH, 40 g; mobile phase: gradient from10% EtOAc, 90% heptane to 20% EtOAc, 80% heptane). The pure fractions were collected and evaporated to dryness yielding 581 mg (60%) of intermediate 526.

The synthetic route of 16545-68-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; JANSSEN PHARMACEUTICA NV; STANSFIELD, Ian; QUEROLLE, Olivier Alexis Georges; PONCELET, Virginie Sophie; GROSS, Gerhard Max; JACOBY, Edgar; MEERPOEL, Lieven; KULAGOWSKI, Janusz Jozef; MACLEOD, Calum; MANN, Samuel Edward; GREEN, Simon Richard; HYND, George; (477 pag.)WO2017/125530; (2017); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 109-83-1, name is 2-(Methylamino)ethanol. A new synthetic method of this compound is introduced below., Application In Synthesis of 2-(Methylamino)ethanol

A mixture of 4.50 g (19.17 mmol) of product from 1a, 1.69 g (21.10 mmol) of N-methylaminoethanol (BASF), 6.68 ml (47.90 mmol) of triethylamine and 150 ml dichloromethane is stirred overnight at ambient temperature. The reaction mixture is then washed with 0.5 M HCl, saturated sodium hydrogen carbonate solution, water and saturated sodium chloride solution, dried on sodium sulphate and evaporated to dryness in vacuo.C12H19NO4S (273.35)[M+H]+=274TLC: silica gel, dichloromethane/ethanol 19:1, Rf value=0.43

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 109-83-1, 2-(Methylamino)ethanol.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; US2010/197664; (2010); A1;,
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Adding a certain compound to certain chemical reactions, such as: 14320-38-8, Cyclopent-3-enol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 14320-38-8, blongs to alcohols-buliding-blocks compound. Product Details of 14320-38-8

Step (i): l-[(cyclopent-3-en-l-yloxy)methyl]-4-methoxybenzene To a solution of cyclopent-3-en-l-ol (CAS number 14320-38-8; 15 g, 178 mmol) in dry THF (357 ml) at 0 C under nitrogen was added sodium hydride (60%, 9.27 g, 232 mmol). After fizzing had ceased, to this was then added dropwise l-(chloromethyl)-4- methoxybenzene (CAS number 824-94-2; 31.4 ml, 232 mmol). The reaction was then allowed to warm to room temperature for 17 hours. The reaction mixture was quenched by the addition of methanol and then concentrated in vacuo. The organics were partitioned between ethyl acetate and water. The organics were dried over magnesium sulfate, concentrated in vacuo and purified by column chromatography (silica, 0-50%dichloromethane / petrol) to afford the title compound.1H NMR (400 MHz, OCM-d2) delta ppm 2.33 – 2.47 (m, 2 H), 2.49 – 2.66 (m, 2 H), 3.79 (s, 3 H), 4.20 – 4.32 (m, 1 H), 4.40 (s, 2 H), 5.62 – 5.75 (m, 2 H), 6.86 (d, 7=8.59 Hz, 2 H), 7.24 (d, 7=8.59 Hz, 2 H)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,14320-38-8, its application will become more common.

Reference:
Patent; TAKEDA CAMBRIDGE LIMITED; TAKEDA PHARMACEUTICAL COMPANY LIMITED; FIELDHOUSE, Charlotte; GLEN, Angela; ROBINSON, John Stephen; FUJIMOTO, Tatsuhiko; WO2015/55994; (2015); A1;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 110-73-6, name is 2-(Ethylamino)ethanol, the common compound, a new synthetic route is introduced below. Application In Synthesis of 2-(Ethylamino)ethanol

1.0 g (11.22 mmol) of 2- (ethylamino) ethanol,10 mL of acetonitrile,0.77 g (5.61 mmol) of potassium carbonate was added to the reaction flask,Warmed to 60 C,A solution of 1.98 g (11.22 mmol) of benzyl bromide and 10 mL of acetonitrile was added dropwise for 15 min.Continue to react for 30 minutes,HPLC detection reaction was complete,After treatment, the reaction solution was evaporated to dryness,Add 20mL water,Extraction with ethyl acetate,The combined organic phases were dried over anhydrous sodium sulfate,Of 1.47 g of a brown oil (II)Yield 75.0%.

The synthetic route of 110-73-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Kebeiyuan (Beijing) Bio-pharmaceutical Technology Co., Ltd.; Beijing Zhiyuan Technology Co., Ltd.; Liu Qi; Cheng Zengjiang; (46 pag.)CN107468685; (2017); A;,
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Reference of 534-03-2, Adding some certain compound to certain chemical reactions, such as: 534-03-2, name is 2-Aminopropane-1,3-diol,molecular formula is C3H9NO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 534-03-2.

General procedure: To a stirred mixture of serinol 8 (1 equivalent) and K2CO3 (3 equivalents) in DMSO at 70-80 oC wasadded the appropriate fluoroaromatic 7d-f in portions over 5 minutes. The resulting colouredmixture was stirred (typically 3 hours), allowed to cool to room temperature, and then poured intoice-water with stirring. The resulting diol 9c-f was collected, washed with water and allowed to dry inair.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 534-03-2, 2-Aminopropane-1,3-diol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Chappel, Lucy; Leong, Chee-Onn; Mai, Chun-Wai; Meikle, Ian T.; Stanforth, Stephen P.; Truong, Thang V.; Wong, Lai Chun; Bioorganic and medicinal chemistry letters; (2019);,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 764-48-7, name is Ethylene Glycol Vinyl Ether. This compound has unique chemical properties. The synthetic route is as follows. SDS of cas: 764-48-7

General procedure: A dry and argon-flushed 10 mL Schlenk tube, equipped with a stirring bar and septum, wascharged with 2-(vinyloxy)ethanol (5, 132 mg, 1.50 mmol, 1.50 equiv) in Et2O (1.5 mL). Then,iPrMgBr (1.55 mmol, 1.55 equiv) was added dropwise at 25 C. After 5 min of stirring,Sc(OTf)3 (49.2 mg, 0.10 mmol, 0.10 equiv) and aldehyde 6 (1.00 mmol, 1.00 equiv) weresuccessively added and the reaction mixture was stirred at 40 C for the given time. After afull conversion was detected by GC-analysis, sat. aq. NH4Cl (15 mL) was added and theaqueous layer was extracted with EtOAc (3 x 15 mL). The combined organic layers weredried over Na2SO4, filtered and solvent was removed under reduced pressure. Purification viacolumn chromatography (SiO2) afforded expected products 4.

With the rapid development of chemical substances, we look forward to future research findings about 764-48-7.

Reference:
Article; Quinio, Pauline; Kohout, Laura; Roman, Daniela Sustac; Gaar, Jakob; Karaghiosoff, Konstantin; Knochel, Paul; Synlett; vol. 27; 11; (2016); p. 1715 – 1719;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 124-68-5, name is 2-Amino-2-methyl-1-propanol. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 124-68-5

General procedure: A microwave tube was charged with 2i (1 mmol), NaOH (120 mg, 3 mmol), and EtOH (10 mL). The tube was sealed, placed in a microwaveoven and heated (T = 135 C; t = 10 min). After release, Boc2O(655 mg, 3 mmol) was added at r.t. and the reaction mixture wasstirred for 2 h at 40 C. H2O (10 mL) and Et2O (20 mL) were added andthe layers were separated. The aqueous phase was extracted withEt2O (2 ¡Á 20 mL) and the combined organic layers were dried overMgSO4, filtered, and the solvent was removed in vacuo. The crude residuewas purified on silica gel chromatography (cyclohexane-EtOAc,95:5 to 40:60) to afford the desired N-Boc-protected amino alcohol 4.

With the rapid development of chemical substances, we look forward to future research findings about 124-68-5.

Reference:
Article; Boukattaya, Fatma; Caille, Julien; Ammar, Houcine; Rouzier, Florian; Boeda, Fabien; Pearson-Long, Morwenna S. M.; Bertus, Philippe; Synthesis; vol. 48; 6; (2016); p. 906 – 916;,
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