Tag: M.W=0-100

Adding a certain compound to certain chemical reactions, such as: 627-30-5, 3-Chloropropan-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 627-30-5, blongs to alcohols-buliding-blocks compound. SDS of cas: 627-30-5

A mixture of 3-chloro-1-propanol (10 g), and sodium azide (13.7 g) in water (50 mL) was heated at 90 C. overnight. Compound 3 was obtained by ether extraction

At the same time, in my other blogs, there are other synthetic methods of this type of compound,627-30-5, 3-Chloropropan-1-ol, and friends who are interested can also refer to it.

Reference:
Patent; Life Technologies Corporation; Yue, Stephen; Huang, Shih-Jung; Bradford, Jolene; US8999965; (2015); B2;,
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Related Products of 2854-16-2 , The common heterocyclic compound, 2854-16-2, name is 1-Amino-2-methylpropan-2-ol, molecular formula is C4H11NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of the compound (53 mg, 0.1 mmol) obtained in Reference Example 28 in dichloromethane (2 mL) were added 1-amino-2-methylpropan-2-ol (18 mg, 0.2 mmol) and PyBOP [registered trade mark, benzotriazol-1-yl-oxy-tris(pyrrolidino)phosphonium hexafluorophosphate (benzotriazal-1-yl-oxy-tris(pyrrolidino)phosphonium hexafluorophosphate)] (52 mg, 0.1 mmol), and the mixture was stirred at room temperature.After 16 hr, 10percent aqueous citric acid solution was added to the reaction mixture, and the mixture was extracted with ethyl acetate.The organic layer was extracted, washed with water and saturated brine, and dried over sodium sulfate.After concentration under reduced pressure, the residue was purified by silica gel column (chloroform:methanol=100:0 – 98:2) to give the object product (51 mg, 89percent).The product was dissolved in ethyl acetate (1 mL), 4 mol/L hydrogen chloride-ethyl acetate solution (1 ml, 4 mmol) was added thereto, and the mixture was stirred at room temperature.After 14 hr, the mixture was concentrated under reduced pressure.To the obtained residue was added 2 mol/L aqueous sodium hydroxide solution, and the mixture was extracted with chloroform.The organic layer was extracted, washed with saturated brine, and dried over sodium sulfate.After concentration under reduced pressure, the residue was purified by silica gel column (chloroform :methanol=100:0 – 95:5) to give the object product (32 mg, 76percent).1H-NMR (CDCl3) delta 1.10(t, J = 7.0Hz, 3H), 1.29(s, 6H), 1.36(d, J = 6.8Hz, 3H), 3.21(dd, J= 5.3, 3.6Hz, 1H), 3.29-3.51(m, 4H), 3.61-3.73(m, 2H), 3.97(d, J = 14.3Hz, 1H), 4.11(d, J = 14.3Hz, 1H), 4.21(dt, J = 15.3, 4.2Hz, 1H), 4.33(m, 1H), 6.90-7.07(m, 6H), 7.68(dd, J = 8.3, 0.9Hz, 1H), 7.83(brt, J = 6.0Hz, 1H).

The synthetic route of 2854-16-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Dainippon Sumitomo Pharma Co., Ltd.; EP2380881; (2011); A1;,
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Related Products of 627-30-5, Adding some certain compound to certain chemical reactions, such as: 627-30-5, name is 3-Chloropropan-1-ol,molecular formula is C3H7ClO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 627-30-5.

General procedure: A 250 mL round-bottom flask equipped with aTeflon-coated magnetic stirring bar, reflux condenser and drying tube wascharged with 3.46 g (20.0 mmol, 1.0 eq) 4-bromophenol (13). It was dissolved in 100 mLDMF and 5.54 g (40.0 mmol, 2.0 eq) K2CO3, 332 mg(2.00 mmol, 10 mol%) KI and 30.0 mmol (1.5 eq) of thedesired chloroalcohol were added, respectively. Afterwards the colorlesssuspension was heated in an oil bath to 120 C and vigorously stirred atthis temperature until reaction control viaTLC showed full conversion of the starting material (20 h to 40 h).The resulting brownish suspension was cooled to room temperature and thesolvent was carefully removed in the vacuum of an oil pump. Afterwards200 mL EtOAc were added to the brownish residue, the organic phase was washedwith H2O (2 x 100 mL), brine (1 x 100 mL), dried over MgSO4,filtered and concentrated on a rotary evaporator. Finally, the brownish, oilyresidue was purified via flash column chromatography (250 g SiO2,21.0 x 6.0 cm) and the colorless liquid dried under high vacuum

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 627-30-5, 3-Chloropropan-1-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Leypold, Mario; Wallace, Paal W.; Kljajic, Marko; Schittmayer, Matthias; Pletz, Jakob; Illaszewicz-Trattner, Carina; Guebitz, Georg M.; Birner-Gruenberger, Ruth; Breinbauer, Rolf; Tetrahedron Letters; vol. 56; 41; (2015); p. 5619 – 5622;,
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Related Products of 2566-44-1, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 2566-44-1 as follows.

5-Fluoro-3-iodo-indazole (524 mg, 2.0 mmol), 2-cylcopropylethanol (344 mg, 4.0 mmol), and triphenylphosphine (1.05 g, 4.0 mmol) were combined in dry THF (40 mL). Di-tert-butyl azodicarboxylate (921 mg, 4.0 mmol) was added, and the reaction was stirred for 16 h at rt. The solution was concentrated and purified by silica gel chromatography (0% to 20% EtOAc/hexanes) to give two product isomers: 1-(cyclopropylethyl)-5-fluoro-3-iodo-1H-indazole (390 mg, 59%) was isolated as the major isomer eluting first. 1H NMR (400 MHz, CDCl3): delta 0.03-0.01 (2H, m), 0.29-0.41 (2H, m), 0.55-0.62 (1H, m), 1.76-1.82 (2H, m), 4.45 (2H, t, J=7.0 Hz), 7.09 (1H, dd, J=8.4, 2.3 Hz), 7.19 (1H, td, J=8.9, 2.4 Hz), 7.35 (1H, dd, J=9.1, 4.0 Hz). [M+H] calc’d for C12H12FIN2, 331. found 331. 2-(cyclopropylethyl)-5-fluoro-3-iodo-2H-indazole (216 mg, 33%) was isolated as the minor isomer eluting second. 1H NMR (400 MHz, CDCl3): delta 0.03-0.01 (2H, m), 0.29-0.42 (2H, m), 0.61-0.69 (1H, m), 1.79-1.85 (2H, m), 4.53 (2H, t, J=7.2 Hz), 6.95 (1H, dd, J=8.7, 2.4 Hz), 7.06 (1H, td, J=9.2, 2.4 Hz), 7.59 (1H, dd, J=9.3, 4.55 Hz). [M+H] calc’d for C12H12FIN2, 331. found 331.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,2566-44-1, its application will become more common.

Reference:
Patent; Quanticel Pharmaceuticals, Inc.; Kanouni, Toufike; Stafford, Jeffrey Alan; Veal, James Marvin; Wallace, Michael Brennen; US2014/171432; (2014); A1;,
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Electric Literature of 627-30-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 627-30-5, name is 3-Chloropropan-1-ol. This compound has unique chemical properties. The synthetic route is as follows.

IMB105 (1.0g, 2.5mmol), 2-bromoethanol (0.22mL, 3.0mmol) or 3-chloropropanol (0.25mL, 3.0mmol), and PPh3 (1.3g, 5.0mmol) were added to dried THF (20mL) under Ar2. The obtained solution was cooled on an ice-water bath. DEAD (2.0mL, 4.25mmol, 40% in tulene) was added to the solution, and the reaction mixture was then allowed to warm to room temperature and stirred for 12h. The solvent was removed in vacuo, and the obtained residue was extracted into ethyl acetate (100mL). The organic layer was washed consecutively with water (50mL), brine (50mL), dried over MgSO4, filtered, and concentrated in vacuo. The residue was purified on silica gel using Petroleumether (60-90C)/ethyl acetate in different proportions to afford 5 or 6.

According to the analysis of related databases, 627-30-5, the application of this compound in the production field has become more and more popular.

Reference:
Article; Gu, Yuxi; Hu, Laixing; Liu, Yonghua; Sun, lianqi; Wu, Yanbin; European Journal of Medicinal Chemistry; vol. 191; (2020);,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2854-16-2, name is 1-Amino-2-methylpropan-2-ol, the common compound, a new synthetic route is introduced below. Recommanded Product: 2854-16-2

To a solution of 2-fluorobenzene-1-sulfonyl chloride (15 g, 77 mmol) in tetrahydrofuran (THF) (300 ml.) at 0C was added potassium carbonate (13.85 g, 100 mmol), water (110 ml.) and 1-amino-2-methylpropan-2-ol (6.87 g, 77 mmol) and was stirred for 4 h at 25 C. The reaction mixture was quenched with ice cold water (200 mL) and extracted with ethyl acetate (2 X 200ml_), washed with brine (100ml_) then concentrated to provide the title compound as a white solid. (17 g, 67.9 mmol, 88% yield). LCMS m/z 248.2 (M+H)+,1.678min (ret.time).

The synthetic route of 2854-16-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; ASTEX THERAPEUTICS LIMITED; COOPER, Anthony William James; GOODWIN, Nicole Cathleen; GRIFFITHS-JONES, Charlotte Mary; HEIGHTMAN, Thomas Daniel; KERNS, Jeffrey K.; WILLEMS, Hendrika Maria Gerarda; YAN, Hongxing; (215 pag.)WO2018/109649; (2018); A1;,
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Synthetic Route of 110-73-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 110-73-6, name is 2-(Ethylamino)ethanol, molecular formula is C4H11NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a flask under a nitrogen atmosphere15 g (1 eq) of 4,4-difluorobenzophenone and 31.1 g of 2-ethylamino ethanol (5 eq) was added thereto,And the temperature was raised while stirring at 160 C.The reaction was carried out at 160 DEG C for 48 hours and then cooled to room temperature.Distilled water was added thereto, followed by extraction with methylene chloride or ethyl acetate, followed by drying under reduced pressure.The residue was recrystallized from ethyl acetate at room temperature to obtain an off-white Compound A. (20 g, 82% yield)

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 110-73-6, 2-(Ethylamino)ethanol.

Reference:
Patent; LG CHEM, LTD.; Lee, Dami; Park, Jong-Ho; (30 pag.)KR2017/3170; (2017); A;,
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Application of 2002-24-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.2002-24-6, name is 2-Aminoethanol hydrochloride, molecular formula is C2H8ClNO, molecular weight is 97.544, as common compound, the synthetic route is as follows.

9-(2′-hydroxyethylamino)-4-methyl-1-nitroacridine 4-Methyl-1-nitro-9-phenoxyacridine (0.33 g) is dissolved in phenol (10 g), ethanolamine hydrochloride (0.2 g) is added and the mixture is heated at 80 C. for 0.5 hour. The reaction mixture is cooled to room temperature, diluted with ether, slowly poured into dry ether (200 ml) and acidified with ethereal solution of hydrogen chloride. The resulting precipitate is filtered off, washed with ether and crystallized from absolute ethanol to give 9-(2′-hydroxyethylamino)-4-methyl-1-nitroacridine monohydrochloride as orange crystals (0.27 g, 84%), m.p. 238 C. (decomp.) 1H NMR (d6DMSO): delta2.45 (s, 3H, CH3), 3.48(q, 2H, H-2′), 3.65 (t, 2H, H-1′), 4.3 (t, 1H, OH), 7.1 (t, 1H, H-7), 7.24 (d, 1H, J=7.8 Hz, H-2), 7.35 (d, 1H, J=7.8 Hz, H-3), 7.5 (t, 1H, H-6), 7.65 (d, 1H, J=8 Hz, H-5), 7.75 (d, 1H, J=8.0 Hz, H-8).

The chemical industry reduces the impact on the environment during synthesis 2002-24-6, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Tiwari, Raj; Miller, Daniel G.; Konopa, Jerzy Kazimierz; Wysocka-Skrzela, Barbara; US2002/37831; (2002); A1;,
Alcohol – Wikipedia,
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Application of 2516-33-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 2516-33-8, name is Cyclopropylmethanol. This compound has unique chemical properties. The synthetic route is as follows.

1.09 g (15.1 mmol) of cyclopropylmethanol,Ionic liquid 1-hexyl-3-methyl-imidazolium bromide 3.73 g (15.1 mmol)Was placed in a flask equipped with a thermometer and a magnetic stirrer,While stirring, 1.35 g (16.7 mmol) of hydrogen bromide gas was blown in over 20 minutes at an internal temperature of 25 C.As a result of analyzing the obtained reaction solution,The conversion of cyclopropylmethanol was 99.0 mol%The desired composition of bromomethyl cyclopropane isIt was 91.0 mol% (NMR).Also,Compositions of the reaction isomerization products bromocyclobutane and 4-bromo-1-butene were 5.0 mol% (NMR) and 3.0 mol% (NMR), respectively.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 2516-33-8, Cyclopropylmethanol.

Reference:
Patent; TOSOH ORGANIC CHEMICAL COMPANY LIMITED; SHIMANE UNIVERSITY; NISHIGAICHI, YUTAKA; TABAKODANI, HIROSHI; NAGASAKI, NORITAKA; (15 pag.)JP5979791; (2016); B2;,
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Application of 2566-44-1, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 2566-44-1 as follows.

EXAMPLE 3 Preparation of a Compound of Formula (VI): 2-cyclopropylethanal Oxalyl chloride (1.24 ml; 14.18 mmol) was dissolved in 10 ml of methylene chloride; after cooling to -60 C. a solution of 1.02 g (11.9 mmol) of 2-cyclopropylethanol, prepared according to example 2, in 10 ml of methylene chloride was added dropwise. The mixture was maintained under stirring for 30 minutes at the same temperature, then 8.3 ml (59.5 mmol) of triethylamine were added. After 2 hours at 0 C. water was added. The mixture was diluted with methylene chloride and washed successively with 1M hydrochloric acid, water, saturated sodium bicarbonate and finally with brine. The organic layer was dried over sodium sulfate and evaporated to dryness to give 0.31 g (30% yield) of the title compound.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,2566-44-1, its application will become more common.

Reference:
Patent; Pevarello, Paolo; Amici, Raffaella; Traquandi, Gabriella; Villa, Manuela; Vulpetti, Anna; Isacchi, Antonella; US2003/187040; (2003); A1;,
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