Tag: M.W=0-100

Lim, Bumhee; Lee, Jinah; Kim, Byungjin; Lee, Rang; Park, Jaehyun; Oh, Dong-Chan; Gam, Jongsik; Lee, Jeeyeon published the artcile< Target Identification of a 1,3,4-Oxadiazin-5(6H)-One Anticancer Agent via Photoaffinity Labelling>, Application In Synthesis of 25055-82-7, the main research area is oxadiazinone protein anticancer agent photoaffinity labeling probe.

Rational design and synthetic feasibility are critical factors for the photoaffinity labeling (PAL) approach, which can identify protein targets of bioactive small mols. under native cellular conditions. In this study, we developed photoaffinity labeling probes derived from 1,3,4-oxadiazin-5(6H)-ones (OPALs) for LL-2003, a previously reported potential anticancer agent against IGF-1R and Src. Our photoaffinity labeling strategy enabled successful photo-crosslinking of the probes (OPAL-6 and OPAL-8) with the target proteins in both mammalian cell lysates and live MCF7, A549, HepG2 and HeLa cells in situ. In vitro and in situ labeling demonstrated different patterns and expression levels of the proteome, and the strongest band for Src appeared in the A549 cell line. An in-gel fluorescence scan combined with MS/MS anal. of the IGF-1R overexpressed insect proteome labeled by OPAL-6 and OPAL-8 identified the binding location of the synthesized probes.

Asian Journal of Organic Chemistry published new progress about Antitumor agents. 25055-82-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8N2O, Application In Synthesis of 25055-82-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Liu, Zhen; Wei, Yin; Shi, Min published the artcile< A concise method for cyclic gem-difluoroacyl scaffolds via visible-light-mediated redox-neutral cascade radical cyclization of alkenes>, Application of C4H8O, the main research area is cyclic gem difluoroacyl arene preparation; bromodifluoroacyl alkene redox neutral cascade radical cyclization photoredox catalysis.

In this paper, a series of diverse alkenes were engaged in radical tandem cyclization initiated by a CF2 radical precursor via photoredox catalysis, affording various cyclic gem-difluoroacyl arenes in good to excellent yields. This photo-induced protocol features a redox-neutral process to access a variety of gem-difluoroacyl arenes with a broad substrate scope and the structural motifs are important in pharmaceutical and agrochem. products. The mechanistic paradigm has been proposed on the basis of control and Stern-Volmer anal. experiments

Catalysis Science & Technology published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Application of C4H8O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Bedenko, S. P.; Dement’ev, K. I.; Tret’yakov, V. F. published the artcile< Kinetics of Liquid-Phase Condensation of Propylene with Formaldehyde over H-MFI and H-BEA Zeolites>, Name: But-3-en-1-ol, the main research area is propylene formaldehyde zeolite liquid phase condensation kinetic.

This study investigated the kinetic patterns of the liquid-phase Prins condensation of propylene with formaldehyde in the range of 120-180°C over H-MFI and H-BEA zeolites. The apparent reaction order with respect to formaldehyde was found to vary between 0.1 and 0.2 for H-BEA and to be close to zero for H-MFI. The apparent activation energy for H-MFI and H-BEA was 26.1±0.6 kJ/mol and 20.0±4.0 kJ/mol, resp. Based on these results, the reaction was demonstrated to occur in the intradiffusion or transition region; the calculated Thiele modulus and effectiveness factor further confirmed this fact. The diffusion limitations were partially removed by raising the initial formaldehyde concentration, as indicated by an increase in the apparent order of formaldehyde conversion to 1.0 for H-BEA and to 0.4 in the H-MFI case. To describe the substrate transformations observed, a modernized reaction mechanism was proposed.

Petroleum Chemistry published new progress about Ammonium-exchanged zeolites, NH4-beta Role: CAT (Catalyst Use), USES (Uses) (CP 814E). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Name: But-3-en-1-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Fernandes, Rodney A.; Yadav, Sandhya S.; Kumar, Praveen published the artcile< Palladium-catalyzed anti-Markovnikov oxidative acetalization of activated olefins with iron(III) sulphate as the reoxidant>, Application of C4H8O, the main research area is styrene pinacole palladium catalyst regioselective oxidative acetalization green chem; arylmethyl tetramethyl dioxolane preparation; arylallyl ether pinacole palladium catalyst regioselective acetalization green chem; aryloxyethyl tetramethyl dioxolane preparation; arylacrylate pinacole palladium catalyst regioselective oxidative acetalization green chem; phenyl tetramethyl dioxolanyl acetate preparation; arylhomoallyl alc pinacole palladium catalyst regioselective acetalization green chem; aryltetramethyl dioxolanyl propanol preparation.

This paper disclosed the efficient palladium-catalyzed anti-Markovnikov oxidative acetalization of activated terminal olefins with iron(III) sulfate as the reoxidant. This methodol. required mild reaction conditions and shows high regioselectivity toward anti-Markovnikov products and compatibility with a wide range of functional groups. Iron(III) sulfate was the sole reoxidant used in this method. Various olefins like vinylarenes, aryl-allylethers, aryl or benzyl acrylates and homoallylic alcs. all reacted well providing anti-Markovnikov acetals, some of which represent orthogonally functionalized 1,3- and 1,4-dioxygenated compounds

Organic & Biomolecular Chemistry published new progress about Acetalization (regioselective). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Application of C4H8O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Park, Yunjeong; Ryu, Jae-Sang published the artcile< Formal synthesis of (±)-sedamine through gold(I)-catalyzed intramolecular dehydrative amination of sulfamate esters tethered to allylic alcohols>, Application of C4H8O, the main research area is dehydrative amination cyclization alkylation ring closing metathesis gold catalyst; sedamine formal synthesis.

A concise formal synthesis of (±)-sedamine (I) has been accomplished. The synthesis is straightforward and demonstrates high efficiency. Key steps involve gold(I)-catalyzed cyclization of sulfamate esters tethered to allylic alcs., sulfamate N-alkylation, and ring-closing metathesis.

Tetrahedron Letters published new progress about Alkylation. 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Application of C4H8O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hendy, Cecilia M.; Smith, Gavin C.; Xu, Zihao; Lian, Tianquan; Jui, Nathan T. published the artcile< Radical Chain Reduction via Carbon Dioxide Radical Anion (CO2•-)>, Recommanded Product: But-3-en-1-ol, the main research area is radical chain reduction carbon dioxide radical anion.

We developed an effective method for reductive radical formation that utilizes the radical anion of carbon dioxide (CO2•-) as a powerful single electron reductant. Through a polarity matched hydrogen atom transfer (HAT) between an electrophilic radical and a formate salt, CO2•- formation occurs as a key element in a new radical chain reaction. Here, radical chain initiation can be performed through photochem. or thermal means, and we illustrate the ability of this approach to accomplish reductive activation of a range of substrate classes. Specifically, we employed this strategy in the intermol. hydroarylation of unactivated alkenes with (hetero)aryl chlorides/bromides, radical deamination of arylammonium salts, aliphatic ketyl radical formation, and sulfonamide cleavage. We show that the reactivity of CO2•- with electron-poor olefins results in either single electron reduction or alkene hydrocarboxylation, where substrate reduction potentials can be utilized to predict reaction outcome.

Journal of the American Chemical Society published new progress about Aliphatic aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent) (radical reduction of aliphatic aldehydes). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Recommanded Product: But-3-en-1-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Hanhan; Hu, Mengjun; Wang, Xiao-Na; Chang, Junbiao published the artcile< Metal-free hydroalkoxylation of ynesulfonamides with alcohols>, COA of Formula: C4H8O, the main research area is alkoxy enamide preparation regioselective diastereoselective; ynesulfonamide alc hydroalkoxylation triflic acid catalyst.

Efforts for developing a convenient and expeditious method for synthesizing alkoxy-substituted enamides RS(O)2N(R1)C(OR3)=CHR2 (R = Me, 4-methylphenyl, 4-nitrophenyl, 4-chlorophenyl, 4-methoxyyphenyl; R1 = Me, n-Bu, Bn, allyl; R2 = Me, Ph, thiophen-2-yl, etc.; R3 = Et, Bn, cyclopentyl, etc.) via nucleophilic addition of alcs. R3OH to ynesulfonamides RS(O)2N(R1)CCR2 were described. This sequence is completely regioselective and highly stereoselective, and leads to the hydroalkoxylation products in high yields under mild reaction conditions.

Organic & Biomolecular Chemistry published new progress about Alkoxylation catalysts, reductive (regioselective). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, COA of Formula: C4H8O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhu, Kaili; Xu, Xudong; Xu, Mengqiu; Deng, Ping; Wu, Wenbo; Ye, Wei; Weng, Zihui; Su, Yue; Wang, Huijie; Xiao, Fei; Fang, Zeping; Gao, Peng published the artcile< One-Pot Synthesis of Tensile-Strained PdRuCu Icosahedra toward Electrochemical Hydrogenation of Alkene>, HPLC of Formula: 627-27-0, the main research area is alkene lead ruthenium copper icosahedra one pot synthesis.

Electrochem. hydrogenation (ECH) uses electricity to drive proton (H+) reduction for hydrogenation, which can greatly reduce energy supply and environmental pollution, representing an ideal alternative to traditional thermal hydrogenation. In this work, we put forward tensile-strained PdRuCu alloy to promote ECH. Tensile strain promotes the adsorption of C=C by changing the d-band center. Meanwhile, alloying Ru and Cu into Pd lattice facilitates hydrogenation by weakening Pd-H bonding. Therefore, PdRuCu icosahedra display excellent ECH performance of 2-methyl-3-buten-2-ol (MBE) with specific activity of 227.4μmolMBE nm-2 min-1 at -0.3 V vs. reversible hydrogen electrode (RHE), about 16.1 and 10.5 times higher than that of com. Pd/C and Ru/C, resp. In addition, PdRuCu icosahedra was excellent in the scaling up of substrate concentration combined with anisyl alc. oxidation to produce high-value added anisaldehyde at anode. This work provides a guideline for the rational design of highly active and durable metallic catalyst in ECH.

ChemElectroChem published new progress about Adsorption. 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, HPLC of Formula: 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

An, Taeyang; Lee, Yan published the artcile< Nucleophilic Substitution at the Guanidine Carbon Center via Guanidine Cyclic Diimide Activation>, Category: alcohols-buliding-blocks, the main research area is guanidine carbon center preparation; amine guanidine cyclic diimide nucleophilic substitution; alc guanidine cyclic diimide nucleophilic substitution.

Despite the electron-deficient nature of the guanidine carbon centers R1NHC(NH2)=NH+R2Cl- (R1 = n-Bu, Ph, cyclohexyl, etc.; R2 = Ph, naphthalen-1-yl, 2H-1,3-benzodioxol-5-yl, etc.) and R1NHC(O)NHC(O)(CH2)2C(O)OR2, nucleophilic reactions at these sites have been underdeveloped due to the resonance stabilization of the guanidine group. A guanidine C-N bond substitution strategy entailing the formation of guanidine cyclic diimide (GCDI) structures I, which effectively destabilize the resonance structure of the guanidine group was proposed. In the presence of acid additives, the guanidine carbon center of GCDIs I undergoes nucleophilic substitution reactions with various amines R2NH2 and alcs. R2OH.

Organic Letters published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Han, Ming-Liang; Chen, Jun-Jie; Xu, Hui; Huang, Zhi-Cong; Huang, Wei; Liu, Yu-Wen; Wang, Xing; Liu, Min; Guo, Zi-Qiong; Dai, Hui-Xiong published the artcile< Palladium/Norbornene-Catalyzed Decarbonylative Difunctionalization of Thioesters>, Category: alcohols-buliding-blocks, the main research area is aryl thioester nucleophile haloalkane palladium norbornene catalyst decarbonylaive Catellani; alkyl nucleophilic arene preparation.

Herein, a novel decarbonylative Catellani reaction via palladium-catalyzed, norbornene (NBE)-mediated polyfunctionalization of aromatic thioesters, which served as readily available carboxylic acid derivs was reported. A variety of alkenyl, alkyl, aryl and sulfur moieties was conveniently introduced into the ipso-positions of the aromatic thioesters. By combining carboxyl-directed C-H functionalization and the classical Catellani reaction, this protocol allows for the construction of 1,2,3-trisubstituted and 1,2,3,4-tetrasubstituted arenes from simple aromatic acids. Furthermore, the late-stage functionalization of a series of drug mols. highlights the potential utility of the reaction.

JACS Au published new progress about Alkenes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts