Tag: M.W=0-100

Application of 534-03-2, Adding some certain compound to certain chemical reactions, such as: 534-03-2, name is 2-Aminopropane-1,3-diol,molecular formula is C3H9NO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 534-03-2.

General procedure: A stirred solution of 2-amino-1,3-propanediol (serinol) 1 (1 eq) andtriethylamine in MeOH (10 ml) was cooled at 220C and treateddropwise with a solution of the corresponding acyl chloride (1.1 eq) intetrahydrofurane (THF) (5 ml). The reaction mixture was allowed towarm to room temperature and stirred overnight. Then it was pouredinto brine and extracted with dichloromethane (3 10 ml). Thecombined organic phases were washed with brine, dried over MgSO4,and concentrated under reduced pressure. The residue was purified byflash column chromatography on silica gel using as eluent EtOAc/MeOH (10:1 to 7:1) to provide the corresponding N-acyl serinolderivatives.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 534-03-2, 2-Aminopropane-1,3-diol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Gomez de Cedron, Marta; Vargas, Teodoro; Madrona, Andres; Jimenez, Aranza; Perez-Perez, Maria-Jesus; Quintela, Jose-Carlos; Reglero, Guillermo; San-Felix, Ana; Ramirez de Molina, Ana; Journal of Pharmacology and Experimental Therapeutics; vol. 366; 2; (2018); p. 377 – 389;,
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Synthetic Route of 33420-52-9, Adding some certain compound to certain chemical reactions, such as: 33420-52-9, name is 2,2-Difluoropropan-1-ol,molecular formula is C3H6F2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 33420-52-9.

Example 2305- [9-(2,2-Difluoropropoxy)-6-methanesulfonyl-5- [(S)-oxan-4-yl(phenyl)methylj -5H-pyrido [3 ,2-bj indol-3-ylj -4-(2H3)methyl- 1-methyl- 1H-1 ,2,3-triazole To a stirred solution of 5- {9-fluoro-6-methanesulfonyl-5 – [(S)-oxan-4-yl(phenyl)methyl] -5H-pyrido [3 ,2-b]indol-3 -yl} -4-(2H3)methyl- 1-methyl-i H- 1,2,3 -triazole (31.0 mg, 0.0600 mmol) and 2,2-difluoropropan-2-ol (27.8 mg, 0.290 mmol) inNMP (0.30 mL) was added t-BuOK (25.9 mg, 0.230 mmol). This mixture was heated at65 C for 1 h and cooled to room temperature. The mixture was diluted with MeOH andpurified via preparative LC/MS with the following conditions: Column: Waters XBridgePhenyl, 19 x 200 mm, 5-rim particles; Mobile Phase A: 5:95 acetonitrile: water with 10-mM ammonium acetate; Mobile Phase B: 95:5 acetonitrile: water with 10-mMammonium acetate; Gradient: 15-70% B over 20 mm, then a 5-mm hold at 100% B; Flow: 20 mL/min. Fractions containing the desired product were combined and dried via centrifugal evaporation to give 5- [9-(2,2-difluoropropoxy)-6-methanesulfonyl-5 – oxan-4-yl(phenyl)methyl]-5H-pyrido [3 ,2-b]indol-3 -yl]-4-(2H3)methyl- i-methyl-i H15 1,2,3-triazole (13.8 mg, 37%). ?H NMR (500MHz, DMSO-d6) oe 8.60 (s, 1H), 8.29 (d,J8.8 Hz, 1H), 7.74 (s, 1H), 7.56 (br d, J7.7 Hz, 2H), 7.36-7.29 (m, 2H), 7.28-7.22 (m,1H), 7.18 (d, J=8.9 Hz, 1H), 6.74 (s, 1H), 4.67 (br t, J=12.0 Hz, 2H), 3.86 (br d, J15.iHz, 1H), 3.73 (s, 3H), 3.60-3.55 (m, 1H), 3.49 (brt,J=ii.5 Hz, 1H), 3.33 (br d,J11.8Hz, 1H), 3.23-3.16 (m, 1H), 2.54 (s, 3H), 1.95 (brt,J=19.4 Hz, 3H), 1.69 (br d,J10.8Hz, 1H), i.62-i.50(m, 1H), i.22(brd,J=8.8 Hz, 1H), 0.43 (brd,J=12.OHz, 1H).LCMS: RT = 1.731 mm; (ES): mlz (M+H)+ = 613.15, LCMS: Column: Waters Acquity UPLC BEH C 18, 2.1 x 50 mm, 1 .7-tim particles; Mobile Phase A: 5:95 acetonitrile:water with 10mM ammonium acetate; Mobile Phase B: 95:5 acetonitrile:water with 10mM ammonium acetate; Temperature: 50 C; Gradient: 0-100% B over 3 mm, then a 0.75-mmhold at 100% B; Flow: 1.11 mL/min. HPLC Purity at 220 nm: 95 %.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 33420-52-9, 2,2-Difluoropropan-1-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; NORRIS, Derek J.; DELUCCA, George V.; GAVAI, Ashvinikumar V.; QUESNELLE, Claude A.; GILL, Patrice; O’MALLEY, Daniel; VACCARO, Wayne; LEE, Francis Y.; DEBENEDETTO, Mikkel V.; DEGNAN, Andrew P.; FANG, Haiquan; HILL, Matthew D.; HUANG, Hong; SCHMITZ, William D.; STARRETT, JR, John E.; HAN, Wen-Ching; TOKARSKI, John S.; MANDAL, Sunil Kumar; WO2015/100282; (2015); A1;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2002-24-6, name is 2-Aminoethanol hydrochloride. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 2002-24-6

9-(2′-hydroxyethylamino)-4-methyl-1 -nitroacridine 4-Methyl-1-nitro-9-phenoxyacridine (0.33 g) is dissolved in phenol (10 g), ethanolamine hydrochloride (0.2 g) is added and the mixture is heated at 80 C. for 0.5 hour. The reaction mixture is cooled to room temperature, diluted with ether, slowly poured into dry ether (200 ml) and acidified with ethereal solution of hydrogen chloride. The resulting precipitate is filtered off, washed with ether and crystallized from absolute ethanol to give 9-(2′-hydroxyethylamino)-4-methyl-1-nitroacridine monohydrochloride as orange crystals (0.27 g, 84%), m.p. 238 C. (decomp.) 1H NMR (d6DMSO): delta2.45 (s, 3H, CH3), 3.48 (q, 2H, H-2′), 3.65 (t, 2H, H-1′), 4.3 (t, 1H, OH), 7.1 (t, 1H, H-7), 2), 7.35 (d, 1H, J=7.8 Hz, H-3), 7.5 (t, 1H, H-6), 7.65 (d, 1H, J=8 Hz, H-5), 7.75 (d,1H, J=8.0 Hz, H-8).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 2002-24-6, 2-Aminoethanol hydrochloride.

Reference:
Patent; Konopa, Jerzy Kazimierz; Wysocka-Skrzela, Barbara; Tiwari, Raj; US2002/99211; (2002); A1;,
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Related Products of 56-81-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 56-81-5, name is Propane-1,2,3-triol. A new synthetic method of this compound is introduced below.

General procedure: 2.2 Adsorption of glycerol on silica gel (0009) Glycerol was adsorbed as follows: 1g of glycerol and 2g of silica gel were mechanically mixed until total adsorption on the solid. 2.3 Lipase-catalyzed esterification (0010) Esterification of glycerol was performed in 10mL flasks, which were kept in a thermostatic bath with temperature control and magnetic stirring. The reaction time was 6h. The reaction was carried out as follows: 110mg of capric acid were dissolved in 3mL n-heptane, then the amount of glycerol adsorbed onto silica fixed to each reaction under study was added. When the reactant mixture reached the selected temperature, the reaction was started by adding 50% of the total amount of enzyme to be added (time 0). The remaining 50% of the biocatalyst was added after 3h of reaction. The values of glycerol, immobilized lipase dosage and reaction temperature were established according to the experimental design explained below. Highly hydrophilic polyols cause loss of enzymatic activity. This may be due to two factors: (1) in a hydrophobic reaction medium, polyols adhere to the support of the lipase impeding access of the acid to the active site, or (2) the hydroxyl groups of the polyol strongly interact with the active site of the enzyme.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,56-81-5, its application will become more common.

Reference:
Article; Sanchez, Daniel Alberto; Tonetto, Gabriela Marta; Ferreira, Maria Lujan; Journal of Molecular Catalysis B: Enzymatic; vol. 100; (2014); p. 7 – 18;,
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Electric Literature of 1072-52-2 ,Some common heterocyclic compound, 1072-52-2, molecular formula is C4H9NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Example 5 (Table 1, entry 2, and Scheme 6). Preparation of 2-[2-(aminocarbonyl)(2- bromoethyl)-4,6-dinitroanilino] ethyl methanesulfonate (13b); A slurry of 2-chloro-3,5- dinitrobenzamide (U) (237 mg, 1.1 mmol) in dry 3-methyl-2-butanone (20 mL) was cooled to below 5 0C, and LiBr (1.5 g) was added, keeping the temperature below 15 0C. Aziridineethanol (240 mg, 2.76 mmol) was added to the stirred mixture, which was then kept at 20 0C overnight. Water (50 mL) was added, followed by EtOAc (100 mL). The organic layer was washed with water, 10% aqueous NaBr, and then passed through a short column of silica gel, eluting with heptane/EtOAc (1:1), to give 2-[(2-bromoethyl)(2-hydroxyethyl)amino]-3,5- dinitrobenzamide (12b) (360 mg, 87%) as a yellow solid: mp (EtOAc/petroleum ether) 138- 140 C; 1H NMR [(CD3)2SO] delta 8.69 (dj = 2.8 Hz, 1 H), 8.43 (s, 1 H), 8.35 (dj = 2.8 Hz, 1 H), 8.10 (s, 1 H), 5.15 (t, / = 5.6 Hz, 1 H), 3.61 (m, 4 H), 3.53 (m, 2 H), 3.14 (m, 2 H); 13C NMR delta 167.6, 146.4, 143.8, 139.8, 134.2, 128.2, 123.0, 57.8, 54.1, 53.6, 29.8; Anal. Calcd for C11H13BrN4O6: C, 35.0; H, 3.5; N, 14.9. Found: C, 35.0; H, 3.5; N, 14.6%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1072-52-2, 2-(Aziridin-1-yl)ethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; AUCKLAND UNISERVICES LIMITED; WO2008/30112; (2008); A1;,
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Electric Literature of 6153-05-5, Adding some certain compound to certain chemical reactions, such as: 6153-05-5, name is (Z)-3-Methylpent-2-en-4-yn-1-ol,molecular formula is C6H8O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6153-05-5.

n-BuLi (4.2 mL, 10 mmol, 2.4 mol/L) was added dropwise to a solution of (Z)-3-methylpent-2-en-4-yn-1-ol (0.48 g, 5 mmol) in THF (10 mL) at ?78 °C under a N2 atmosphere, and then the mixturewas stirred for 1 h at ?78 °C. A solution of 4g (0.94 g, 5 mmol) in THF (5 mL) was added slowly, themixture was stirred for 0.5 h at ?78 °C, and then it was warmed to room temperature and stirred for 2 h.The reaction was quenched with saturated aqueous NH4Cl solution (10 mL) and extracted with EtOAc(3 × 30 mL). The combined organics were washed with brine (2 × 20 mL), dried over anhydrousNa2SO4 and concentrated. The residue was purified by silica gel column chromatography (petroleumether/EtOAc, 1:2) to afford 6c (1.35 g, 95percent) as a yellow oil.

According to the analysis of related databases, 6153-05-5, the application of this compound in the production field has become more and more popular.

Reference:
Article; Han, Xiaoqiang; Wan, Chuan; Yang, Dongyan; Yuan, Xiaoyong; Du, Shijie; Xiao, Yumei; Qin, Zhaohai; Molecules; vol. 18; 9; (2013); p. 10776 – 10788;,
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Electric Literature of 764-48-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 764-48-7, name is Ethylene Glycol Vinyl Ether. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: A dry and argon-flushed 10 mL Schlenk tube, equipped with a stirring bar and septum, wascharged with 2-(vinyloxy)ethanol (5, 132 mg, 1.50 mmol, 1.50 equiv) in Et2O (1.5 mL). Then,iPrMgBr (1.55 mmol, 1.55 equiv) was added dropwise at 25 C. After 5 min of stirring,Sc(OTf)3 (49.2 mg, 0.10 mmol, 0.10 equiv) and aldehyde 6 (1.00 mmol, 1.00 equiv) weresuccessively added and the reaction mixture was stirred at 40 C for the given time. After afull conversion was detected by GC-analysis, sat. aq. NH4Cl (15 mL) was added and theaqueous layer was extracted with EtOAc (3 x 15 mL). The combined organic layers weredried over Na2SO4, filtered and solvent was removed under reduced pressure. Purification viacolumn chromatography (SiO2) afforded expected products 4.

According to the analysis of related databases, 764-48-7, the application of this compound in the production field has become more and more popular.

Reference:
Article; Quinio, Pauline; Kohout, Laura; Roman, Daniela Sustac; Gaar, Jakob; Karaghiosoff, Konstantin; Knochel, Paul; Synlett; vol. 27; 11; (2016); p. 1715 – 1719;,
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Adding a certain compound to certain chemical reactions, such as: 2867-59-6, 3-Aminobutan-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 2867-59-6, blongs to alcohols-buliding-blocks compound. HPLC of Formula: C4H11NO

6-(4-Chlorophenyl)-2-(3-fluorophenyl)-3-oxo-2,3-dihydropyridazine-4-carboxylic acid (70 mg, 0.20 mmol) was dissolved in anhydrous DMF (1.5 mL). (3RS)-3-Aminobutan-1 -ol (36.2 mg, 0.41 mmol), N-ethyl-N-isopropylpropan-2-amine (0.159 mL, 0.91 mmol), and propane phosphonic acid anhydride (T3P, 178 mu, 50% in DMF, 305mueta-iotaomicronIota) were successively added. It was stirred at rt overnight. The crude reaction mixture was purified by RP-HPLC (column: X-Bridge C18 5muetaiota 100x30mm, mobile phase: (water + 0.2 vol% aqueous ammonia (32%)) / acetonitrile, gradient) to yield 47 mg (56%) of the title compound. 1H-NMR (400MHz, DMSO-d6): delta [ppm] = 1 .19 (d, 3H), 1.59 – 1 .74 (m, 2H), 3.48 (t, 2H), 4.08 – 4.20 (m, 1 H), 4.50 (br s, 1 H), 7.34 – 7.42 (m, 1 H), 7.52 – 7.66 (m, 5H), 7.96 – 8.03 (m, 2H), 8.63 (s, 1 H), 9.31 (d, 1 H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,2867-59-6, its application will become more common.

Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; DEUTSCHES KREBSFORSCHUNGSZENTRUM (DKFZ); SCHMEES, Norbert; GUTCHER, Ilona; IRLBACHER, Horst; BADER, Benjamin; ZHAO, Na; PLATTEN, Michael; (437 pag.)WO2017/202816; (2017); A1;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2919-23-5, name is Cyclobutanol, molecular formula is C4H8O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: Cyclobutanol

Intermediate 12Carbonic acid cvclobutyl ester 4-nitro-phenyl esterA solution of 4-nitrophenyl chloroformate (6.00 g) in dichloromethane (12 mL) is added dropwise to an ice-cooled mixture of cyclobutanol (2.00 g), and pyridine (2.4 mL) in dichloromethane (10 mL). The resulting mixture is stirred over night at room temperature. Water and dichloromethane are added and the organic phase is separated, washed with brine and dried over MgS04. The solvent is evaporated leaving the title compound as an oil, which is used without further purification. Yield: 6.61 g (crude); LC (method 2): tR = 1 .30 min; Mass spectrum (EST): m/z = 260[M+Na]+.

With the rapid development of chemical substances, we look forward to future research findings about 2919-23-5.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; HIMMELSBACH, Frank; ECKHARDT, Matthias; HEINE, Niklas; LANGKOPF, Elke; NOSSE, Bernd; WO2012/80476; (2012); A1;,
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Related Products of 109-83-1, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 109-83-1, name is 2-(Methylamino)ethanol. A new synthetic method of this compound is introduced below.

EXAMPLE 2 N-Methyl-N-(2-chloroethyl)amine, hydrochloride salt Hydrogen chloride was bubbled into a stirred solution of 2-(methylamino)ethanol (10 g, 133 mmol) in CH2 Cl2 (25 ml) until the mixture turned wet litmus paper red. The mixture was cooled to 0 C., and thionyl chloride (15.82 g, 133 mmol) was added dropwise. The mixture was allowed to stir overnight at room temperature. The solvent was removed under reduced pressure to give product as a white solid (16.60 g, 96% yield): mp 95-100 C.; 1 H NMR (DMSO-d6) 4.00(t, 2H, J=6.28 Hz), 3.36(t, 2H, J=6.29 Hz), 2.81(s, 3H)ppm; IR (KBr) 3400, 2960, 2750, 2420, 1730, 1580, 1460, 1390, 1310, 1270, 1200, 1150, 1165, 1005, 990, 900, 860, 710 cm-1.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,109-83-1, its application will become more common.

Reference:
Patent; University of Rochester; US5233031; (1993); A;,
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