Some tips on 109-83-1

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 109-83-1, 2-(Methylamino)ethanol, other downstream synthetic routes, hurry up and to see.

Related Products of 109-83-1, Adding some certain compound to certain chemical reactions, such as: 109-83-1, name is 2-(Methylamino)ethanol,molecular formula is C3H9NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 109-83-1.

Triethylamine (80 mmol) was added to a solution of the amino alcohol (35 mmol) in MC (200 ml) and the mixture was cooled to 00C using an ice bath. The sulfonyl chloride (32 mmol) was then added and the mixture was stirred at RT for 3 h. After addition of 0.5 M HCI (100 ml), the organic phase was separated off, washed with water, dried over Na2SO4 and filtered and the solvent was removed in vacuo. The crude product was used in the next stage without further purification

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 109-83-1, 2-(Methylamino)ethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; GRUeNENTHAL GMBH; WO2009/109364; (2009); A1;,
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Sources of common compounds: Cyclobutanol

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,2919-23-5, its application will become more common.

Adding a certain compound to certain chemical reactions, such as: 2919-23-5, Cyclobutanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 2919-23-5, blongs to alcohols-buliding-blocks compound. Formula: C4H8O

To a solution of N-Boc-L-alanine (4: 15.5 g, 81.9 mmol) in dichloromethane (300 ml), DCC (16.9 g, 81.9 mmol)was added at 0C and 5 min later, cyclobutanol (3: 5.6 g, 78.0 mmol) and DMAP (2.0 g, 16.4 mmol). The mixture wasstirred overnight evaporated in vacuum , and the residue was treated with ethyl acetate (300 ml). The residue was filteredoff and washed with ethyl acetate. The filtrate was washed with a 5% solution of citric acid (2 x 100 ml), a saturatedNaHCO3 solution (2 x 100 ml), and brine, dried over Na2SO4, and evaporated in vacuum to afford 19.6 g (98 %) of(S)-cyclobutyl 2-(tert-butoxycarbonylamino)-propanoate (5) as a white powder. 1H NMR (400 MHz, DMSO-d6) delta 7.22(d, J = 7.2 Hz, 0.85H), 6.87 (m, 0.15H), 4.89 (p, J = 7.2 Hz, 1H), 3.94 (m, 1H), 2.26 (m, 2H), 1.98 (m, 2H), 1.74 (m, 1H),1.59 (m, 1H), 1.38 (s, 7.5H), 1.34 (brs, 1.5H), 1.22 (d, J = 7.2Hz, 3H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,2919-23-5, its application will become more common.

Reference:
Patent; Alla Chem, LLC; Ivachtchenko, Alexandre Vasilievich; Ivashchenko, Andrey Alexandrovich; Ivachtchenko, Alena Alexandrovna; Savchuk, Nikolay Filippovich; IVACHTCHENKO, Alexandr Vasilievich; MITKIN, Oleg Dmitrievich; (24 pag.)EP3400946; (2018); A1;,
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Application of 2-(Methylamino)ethanol

According to the analysis of related databases, 109-83-1, the application of this compound in the production field has become more and more popular.

Reference of 109-83-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 109-83-1, name is 2-(Methylamino)ethanol, molecular formula is C3H9NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

4-fluoro benzaldehyde in dry DMSO (35ml) (5.0g, 40.29mmol) and 2- To a stirred solution of (methylamino) ethanol (3.63g, 48.34mmol), under an argon atmosphere K2CO3 ( 6.68g, 48.34mmol) was added. The reaction mixture was then heated for 3 days at 120 . Then added to the reaction mixture which was cooled in water (400ml), and extracted with EtOAc (7 × 100ml). The combined organic layers were washed with brine (2 × 100ml), dried (Na2SO4), the solvent was removed under reduced pressure to give an oil of high viscosity orange. Which solidified slowly at room temperature. This solid was dissolved in DCM (40ml) and then a yellow solid precipitated by adding the solution to hexanes (200 ml), was collected yellow solid by filtration under vacuum. Recrystallization from toluene, the title compound (4.47g, 62%) was obtained as small yellow thin plate material.

According to the analysis of related databases, 109-83-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; WISTA LABORATORIES LIMITED; KEMP, STEVEN JOHN; STOREY, LYNDA JANE; STOREY, JOHN MERVYN DAVID; RICKARD, JANET; HARRINGTON, CHARLES ROBERT; WISCHIK, CLAUDE MICHEL; CLUNAS, SCOTT; HEINRICH, TOBIAS KERST; (269 pag.)JP5667058; (2015); B2;,
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Some tips on 109-83-1

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 109-83-1, 2-(Methylamino)ethanol, other downstream synthetic routes, hurry up and to see.

Electric Literature of 109-83-1, Adding some certain compound to certain chemical reactions, such as: 109-83-1, name is 2-(Methylamino)ethanol,molecular formula is C3H9NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 109-83-1.

Triethylamine (80 mmol) was added to a solution of the amino alcohol (35 mmol) in MC (200 ml) and the mixture was cooled to 00C using an ice bath. The sulfonyl chloride (32 mmol) was then added and the mixture was stirred at RT for 3 h. After addition of 0.5 M HCI (100 ml), the organic phase was separated off, washed with water, dried over Na2SO4 and filtered and the solvent was removed in vacuo. The crude product was used in the next stage without further purification

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 109-83-1, 2-(Methylamino)ethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; GRUeNENTHAL GMBH; WO2009/109364; (2009); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sources of common compounds: Cyclobutanol

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,2919-23-5, its application will become more common.

Adding a certain compound to certain chemical reactions, such as: 2919-23-5, Cyclobutanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 2919-23-5, blongs to alcohols-buliding-blocks compound. Recommanded Product: 2919-23-5

To a solution of N-Boc-L-alanine (4: 15.5 g, 81.9 mmol) in dichloromethane (300 ml), DCC (16.9 g, 81.9 mmol)was added at 0C and 5 min later, cyclobutanol (3: 5.6 g, 78.0 mmol) and DMAP (2.0 g, 16.4 mmol). The mixture wasstirred overnight evaporated in vacuum , and the residue was treated with ethyl acetate (300 ml). The residue was filteredoff and washed with ethyl acetate. The filtrate was washed with a 5% solution of citric acid (2 x 100 ml), a saturatedNaHCO3 solution (2 x 100 ml), and brine, dried over Na2SO4, and evaporated in vacuum to afford 19.6 g (98 %) of(S)-cyclobutyl 2-(tert-butoxycarbonylamino)-propanoate (5) as a white powder. 1H NMR (400 MHz, DMSO-d6) delta 7.22(d, J = 7.2 Hz, 0.85H), 6.87 (m, 0.15H), 4.89 (p, J = 7.2 Hz, 1H), 3.94 (m, 1H), 2.26 (m, 2H), 1.98 (m, 2H), 1.74 (m, 1H),1.59 (m, 1H), 1.38 (s, 7.5H), 1.34 (brs, 1.5H), 1.22 (d, J = 7.2Hz, 3H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,2919-23-5, its application will become more common.

Reference:
Patent; Alla Chem, LLC; Ivachtchenko, Alexandre Vasilievich; Ivashchenko, Andrey Alexandrovich; Ivachtchenko, Alena Alexandrovna; Savchuk, Nikolay Filippovich; IVACHTCHENKO, Alexandr Vasilievich; MITKIN, Oleg Dmitrievich; (24 pag.)EP3400946; (2018); A1;,
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Simple exploration of 2-(Aziridin-1-yl)ethanol

The synthetic route of 1072-52-2 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 1072-52-2, 2-(Aziridin-1-yl)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C4H9NO, blongs to alcohols-buliding-blocks compound. Computed Properties of C4H9NO

2-Methyl-3,4-dihydro-2H-spiro[isoquinoline-1 ,4?-piperidine] (compound obtained in example 65 step a, 268 mg, 1.23 mmol) and 2-(aziridin-1-yl)ethanol (43 jtL, 0.49mmol) were dissolved in dichioromethane in a process vial. The reaction was stirredfor few minutes and then the solvent was removed with a stream of nitrogen.Amberlyst (6 mg) was added, the vial was sealed with a septum and the reaction mixture was subjected to microwave irradiation for 3 h at 1000 C. After cooling back to r.t., the reaction was diluted with dichloromethane, and NaHCO3 was added. The phases were separated and the aqueous phase additionally extracted with DCM. The aqueous phase was then basified with NaOH solution and again extracted twice withDCM. The combined organic fractions were dried over sodium sulphate, filtered and the solvent removed to give a crude product which was purified under preparative HPLC (Column X-Bridge C18, H20+ 0.05% formic acid : ACN + 0.05% formic acid from (98:2 to 5:95), flow 20 mI/mm, rt).HPLC-MS (Method H): Ret, 1.23 mm; ESl-MS m/z, 304.2 (M+i).

The synthetic route of 1072-52-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; LABORATORIOS DEL DR. ESTEVE, S.A.; ALMANSA-ROSALES, Carmen; GARCIA-LOPEZ, Monica; CAAMANO-MOURE, Ana-Maria; (282 pag.)WO2016/78770; (2016); A1;,
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The origin of a common compound about 616-29-5

The synthetic route of 616-29-5 has been constantly updated, and we look forward to future research findings.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 616-29-5, name is 1,3-Diaminopropan-2-ol, the common compound, a new synthetic route is introduced below. category: alcohols-buliding-blocks

Preparation of (3-tert-Butoxycarbonylamino-2-hydroxy-propyl)-carbamic Acid Tert-Butyl Ester: To a solution of 1,3 diamino-2-hydroxypropane (10 g, 0.11 mol) in methanol (500 ml) was added di-tert-butyl dicarbonate (48 g, 0.22 mumol) and the reaction stirred for 2 hours at room temperature under a N2 atmosphere. The mixture was concentrated to afford the product as a light yellow oil (31.9 g, 100%). 1H-NMR (CD3OD) delta 1.44 (s, 18H), 3.10 (m, 4H), 3.63 (m, 1H).

The synthetic route of 616-29-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Bridger, Gary; Kaller, Al; Harwig, Curtis; Skerlj, Renato; Bogucki, David; Wilson, Trevor R.; Crawford, Jason; McEachern, Ernest J.; Atsma, Bem; Nan, Siqiao; Zhou, Yuanxi; Schols, Dominique; Smith, Christopher D.; Di Fluri, Maria R.; US2004/19058; (2004); A1;,
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Introduction of a new synthetic route about Cyclopent-3-enol

The synthetic route of 14320-38-8 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 14320-38-8 , The common heterocyclic compound, 14320-38-8, name is Cyclopent-3-enol, molecular formula is C5H8O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Add ieri-butylchlorodiphenylsilane (36.66 g, 133.38 mmol) to 3-cyclopenten-l-ol (10.2 g, 121.26 mmol) and lH-imidazole (18.16 g, 266.77 mmol) in dry DMF (100 mL) drop wise at -20 C. After complete addition, allow the reaction temperature to gradually warm to ambient temperature and stir under nitrogen overnight. Add water, ammonium chloride, and EtOAc to the reaction mixture and stir the mixture for 1 hour. Separate the organic layer and wash with ammonium chloride (5x) until pH is acidic, water (2x), and brine, dry over sodium sulfate, filter, and concentrate under reduced pressure to give the title compound (40.22 g, 93%). ES/MS (m/z): 405.2 (M+2 MeCN+H).

The synthetic route of 14320-38-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ELI LILLY AND COMPANY; BROOKS, Harold Burns; DALLY, Robert Dean; DURHAM, Timothy Barrett; FALES, Kevin Robert; FRIMPONG, Kwame; MCCOWAN, Jefferson Ray; NJOROGE, Frank George; SHEPHERD, Timothy Alan; SI, Chong; THRASHER, Kenneth Jeff; TOTH, James Lee; WU, Zhipei; (106 pag.)WO2016/89670; (2016); A1;,
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Application of Cyclobutylmethanol

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 4415-82-1, Cyclobutylmethanol.

Related Products of 4415-82-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 4415-82-1, name is Cyclobutylmethanol. This compound has unique chemical properties. The synthetic route is as follows.

A. To a solution of cyclobutanemethanol (4.00 g, 46.4 mmol) in dichloromethane (60 mL) was added pyridine (10mL), followed by the addition of p-toluenesulfuryl chloride (7.20 g, 37.8 mmol) at 0 C. The reaction mixture wasstirred for 23 h at ambient temperature, and then diluted with diethyl ether (350 mL), washed sequentially with water,1% aqueous HCl solution, water and brine. The organic layer was dried over Na2SO4 and concentrated in vacuoto give the product (9.00 g, 80.7%).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 4415-82-1, Cyclobutylmethanol.

Reference:
Patent; Xenon Pharmaceuticals Inc.; Abreo, Melwyn; Chafev, Mikhail; Chakka, Nagasree; Chowdhury, Sultan; Fu, Jian-Min; Gschwend, Heinz, W.; Holladay, Mark, W.; Hou, Duanjie; Kamboj, Rajender; Kodumuru, Vishnumurthy; Li, Wenbao; Liu, Shifeng; Raina, Vandna; Sun, Sengen; Sun, Shaoyi; Sviridov, Serguei; Tu, Chi; Winther, Michael, D.; Zhang, Zaihui; (94 pag.)EP2316827; (2016); B1;,
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The origin of a common compound about Methyl 2-hydroxyacetate

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 96-35-5, Methyl 2-hydroxyacetate, other downstream synthetic routes, hurry up and to see.

Application of 96-35-5 ,Some common heterocyclic compound, 96-35-5, molecular formula is C3H6O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Example 1Reduction of Methyl Glycolate in Methanol to Ethylene Glycol The following example shows the positive effect of adding a promoter to the catalyst mixture. Run 1 in the table below is a comparative example. Runs 2-9 represent variants of the current invention.A 300-milliliter autoclave was charged with Ru(Acac)3 (0.10 mmole), TRIPHOS (0.50 mmole), and the promoter in the amount specified in the table. Methanol (32 milliliters) and methyl glycolate (0.156 mole) were added, and the reactor was sealed under N2. The reactor was pressurized to 250 psig (1.7 MPa) with H2 and heated to 200 C. Upon reaching 200 C., the H2 pressure was raised to 2000 psig (13.8 MPa). The autoclave was stirred and held at 200 C., 2000 psig (13.8 MPa) for a total of 3 hours. The autoclave was then cooled, excess gas vented, and the contents recovered. The contents were analyzed by the use of an internal standard gas chromatography method for the presence of methyl glycolate (?MG?) and ethylene glycol (?EG?). The results are shown in the table below. Catalyst Activity Rate Amount of Conversion of Selectivity to (moles EG per Promoter MG EG mole of Ru Run Promoter (mmole) (%) (%) per hr) 1 none none 39.5 88.4 205 2 Zn 0.25 49.3 88.9 228 Acetonylacetonate 3Me4NBF4 0.025 99.7 98.2 509 4Me4NBF4 0.001 96.8 98.2 394 5NH4PF6 0.025 100 96.9 504 6NH4OAc 0.150 67.8 94.8 334 7Ph4PBr 0.025 84.1 97.8 428 8NaPh4B 0.500 81.1 93.5 394 9BuN4PF6 0.025 97.8 95.8 487 Analysis of the run without a promoter showed a 39.5% conversion of the methyl glycolate with 88.4% selectivity to ethylene glycol. The catalyst activity rate for this experiment was 205 moles of EG per mole of ruthenium per hour. On the other hand, runs with a promoter showed MG conversions of 49-100%, EG selectivities of 89-98%, and catalyst activity rates of 230-510 moles of EG per mole of ruthenium per hour. This data show the positive effects of adding a promoter to the reaction mixture.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 96-35-5, Methyl 2-hydroxyacetate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; EASTMAN CHEMICAL COMPANY; US2009/143612; (2009); A1;,
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